1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Alloxan Diabetes in 8 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study demonstrated that iNOS-derived superoxide generation was reduced, and that the NO bioavailability was increased, by treatment with the NOS-cofactor, tetrahydrobiopterin (BH4), before I/R in the hearts isolated from diabetic rats." | 1.37 | Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart. ( Fujita, M; Ito, S; Iwasaka, T; Katano, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K, 2011) |
| "Carbon monoxide (CO) is an endogenous gaseous factor that relaxes vascular tissues by acting on both the cGMP pathway and calcium-activated K+ (K(Ca)) channels." | 1.31 | Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms. ( Hanna, ST; Peterson-Wakeman, R; Wang, R; Wang, Z; Wu, L, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quiñonez-Bastidas, GN | 1 |
| Cervantes-Durán, C | 1 |
| Rocha-González, HI | 1 |
| Murbartián, J | 1 |
| Granados-Soto, V | 3 |
| Jiménez-Andrade, GY | 1 |
| Reyes-García, G | 2 |
| Sereno, G | 1 |
| Ceballos-Reyes, G | 1 |
| Vidal-Cantú, GC | 1 |
| Okazaki, T | 1 |
| Otani, H | 1 |
| Shimazu, T | 1 |
| Yoshioka, K | 1 |
| Fujita, M | 1 |
| Katano, T | 1 |
| Ito, S | 1 |
| Iwasaka, T | 1 |
| Araiza-Saldaña, CI | 1 |
| Bermúdez-Ocaña, DY | 1 |
| Pérez-Severiano, F | 1 |
| Di Pascoli, M | 1 |
| Rodella, L | 1 |
| Sacerdoti, D | 1 |
| Bolognesi, M | 1 |
| Turkseven, S | 1 |
| Abraham, NG | 1 |
| García, M | 1 |
| Morán, A | 1 |
| Luisa Martín, M | 1 |
| Barthelmebs, M | 1 |
| San Román, L | 1 |
| Malakul, W | 1 |
| Thirawarapan, S | 1 |
| Suvitayavat, W | 1 |
| Woodman, OL | 1 |
| Wang, R | 1 |
| Wang, Z | 1 |
| Wu, L | 1 |
| Hanna, ST | 1 |
| Peterson-Wakeman, R | 1 |
8 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Alloxan Diabetes
| Article | Year |
|---|---|
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re | 2013 |
Pyritinol reduces nociception and oxidative stress in diabetic rats.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Female; Indomethacin; Naltrexone; Oxadiazoles; | 2008 |
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothre | 2011 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Di | 2005 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitomet | 2006 |
The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Blood Pressure; Diabetes Mellitus, Experi | 2006 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha | 2008 |
Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms.
Topics: 3-O-Methylglucose; Animals; Arteries; Calcium; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Diabete | 2001 |