1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Aging studies

1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Aging

1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
"Arginase, expressed in endothelial cells and upregulated in aging blood vessels, competes with NO synthase (NOS) for l-arginine, thus modulating vasoreactivity and attenuating NO signaling."	3.73	Knockdown of arginase I restores NO signaling in the vasculature of old rats. ( Berkowitz, DE; Champion, HC; Hare, JM; Li, D; Nyhan, D; Ryoo, S; Shoukas, AA; Steppan, J; Wang, D; White, AR, 2006)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

3 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
White, AR	1
Ryoo, S	1
Li, D	1
Champion, HC	1
Steppan, J	1
Wang, D	1
Nyhan, D	1
Shoukas, AA	1
Hare, JM	2
Berkowitz, DE	1
Zieman, SJ	1
Gerstenblith, G	1
Lakatta, EG	1
Rosas, GO	1
Vandegaer, K	1
Ricker, KM	1
Leamey, CA	1
Ho-Pao, CL	1
Sur, M	1

Studies

White, AR

Ryoo, S

Li, D

Champion, HC

Steppan, J

Wang, D

Nyhan, D

Shoukas, AA

Hare, JM

Berkowitz, DE

Zieman, SJ

Gerstenblith, G

Lakatta, EG

Rosas, GO

Vandegaer, K

Ricker, KM

Leamey, CA

Ho-Pao, CL

Sur, M

Other Studies

3 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Aging

Article	Year
Knockdown of arginase I restores NO signaling in the vasculature of old rats. Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:2 Topics: Acetylcholine; Aging; Animals; Aorta; Arginase; Arginine; Calcium; Drug Synergism; Enzyme Inhibitors	2006
Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine. Circulation research, 2001, Jan-19, Volume: 88, Issue:1 Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; In Vitro Tech	2001
Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jun-01, Volume: 21, Issue:11 Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhi	2001

Article

Year

Knockdown of arginase I restores NO signaling in the vasculature of old rats.

Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:2

Topics: Acetylcholine; Aging; Animals; Aorta; Arginase; Arginine; Calcium; Drug Synergism; Enzyme Inhibitors

2006

Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine.

Circulation research, 2001, Jan-19, Volume: 88, Issue:1

Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; In Vitro Tech

2001

Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jun-01, Volume: 21, Issue:11

Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhi

2001