18f-fluoroethyl-l-tyrosine has been researched along with Acquired-Immunodeficiency-Syndrome* in 1 studies
1 other study(ies) available for 18f-fluoroethyl-l-tyrosine and Acquired-Immunodeficiency-Syndrome
| Article | Year |
|---|---|
AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-L-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells.
We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. Ffluoroethyl-L-tyrosine (F-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of F-FET PET mimicking a brain tumor. Topics: Acquired Immunodeficiency Syndrome; Adaptor Proteins, Signal Transducing; Adult; Biological Transport; Brain Neoplasms; Diagnosis, Differential; Female; Gene Expression Regulation; Humans; Inflammation; Large Neutral Amino Acid-Transporter 1; Positron-Emission Tomography; Toxoplasmosis, Cerebral; Tyrosine | 2017 |