Page last updated: 2024-09-03

18-hydroxycortisol and Hyperaldosteronism

18-hydroxycortisol has been researched along with Hyperaldosteronism in 35 studies

*Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA. [MeSH]

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (20.00)	18.7374
1990's	9 (25.71)	18.2507
2000's	8 (22.86)	29.6817
2010's	7 (20.00)	24.3611
2020's	4 (11.43)	2.80

Authors

Authors	Studies
Bian, J; Cai, J; Lou, Y; Ma, W; Rao, M; She, X; Zhao, B	1
Chang, CC; Chang, YL; Chen, GY; Chen, PT; Lee, BC; Lin, YH; Liu, KL; Weng, TI; Wu, VC	1
Ozeki, Y; Shibata, H	1
Beuschlein, F; Feuchtinger, A; Gomez-Sanchez, C; Kirchner, T; Knösel, T; Kunzke, T; Ludwig, P; Murakami, M; Reincke, M; Rhayem, Y; Strom, TM; Sun, N; Walch, AK; Williams, TA	1
Ishii, K; Morimoto, R; Sasano, H; Satoh, F; Tezuka, Y; Turcu, AF; Udager, AM; Yamazaki, Y; Zhao, L	1
Gomez-Sanchez, CE; Lenders, JWM; Reincke, M; Williams, TA	1
Chiba, H; Fuda, H; Fujikawa, M; Hui, SP; Ikegawa, S; Jin, S; Kurosawa, T; Sakurai, T; Takahashi, Y; Takeda, S; Wada, N; Yanagisawa, K	1
Arai, Y; Gomez-Sanchez, CE; Honma, S; Ito, S; Iwakura, Y; Kudo, M; Morimoto, R; Nakamura, Y; Okuyama, M; Omata, K; Ono, Y; Rainey, WE; Sasamoto, H; Sasano, H; Satoh, F; Seiji, K; Takase, K; Yamashita, K	1
Mulatero, P	1
Chiba, H	3
Haag, C; Kamrath, C; Maser-Gluth, C; Schulze, E	1
di Cella, SM; Gomez-Sanchez, CE; Gomez-Sanchez, EP; Manzo, M; Mengozzi, G; Monticone, S; Mulatero, P; Rabbia, F; Schiavone, D; Terzolo, M; Veglio, F	1
Aycock, K; Christensen, V; Gomez-Sanchez, CE; Gomez-Sanchez, EP; Morra di Cella, S; Mulatero, P; Veglio, F; Zhu, Z	1
De Iasio, R; Fallo, F; Montanari, P; Morra Di Cella, S; Mulatero, P; Pilon, C; Sonino, N; Veglio, F; Williams, TA	1
Dick, B; Ferrari, P; Frey, FJ; Nicod, J	1
Reynolds, RM; Sandhu, K; Shakerdi, LA; Walker, BR; Wallace, AM; Wood, PJ	1
Chu, MD; Ulick, S	2
Chiba, H; Ikegawa, S; Kobayashi, K; Kohno, H; Kurosawa, T; Sato, S; Tohma, M	1
Chiba, H; Ikegawa, S; Ito, Y; Kobayashi, K; Kurosawa, T; Matsuno, K; Tohma, M; Yoshimura, T	1
Chiba, H; Ikegawa, S; Ito, Y; Kobayashi, K; Kurosawa, T; Mahara, R; Matsuno, K; Tohma, M	1
Gómez-Sánchez, CE	1
Aupetit-Faisant, B; Corvol, P; Curnow, KM; Foekling, M; Gomez-Sanchez, C; Jeunemaitre, X; Mulatero, P; Pascoe, L; Veglio, F	1
Fardella, C; Foecking, MF; Gómez-Sánchez, CE; Mosso, L	1
Chiandussi, L; di Cella, SM; Gomez-Sanchez, CE; Mengozzi, G; Milan, A; Mulatero, P; Veglio, F; Williams, TA	1
Iki, K; Itoh, Y; Miyamori, I; Takasaki, H; Takeda, R; Takeda, Y	1
Budd, PS; Connell, JM; Corrie, JE; Fraser, R; Kenyon, CJ	1
Ulick, S	1
Ganguly, A; Gill, JR; Gomez-Sanchez, CE; Gordon, RD	1
Gomez-Sanchez, CE; Gordon, RD; Hamlet, SM; Klemm, SA; Tunny, TJ	1
Budd, PS; Corrie, JE; Edwards, CR; Jones, DB; Padfield, PL	1
Burt, D; Corrie, JE; Davis, JR; Edwards, CR; Sheppard, MC	1
Budd, PS; Corrie, JE; Edwards, CR	1

Reviews

5 review(s) available for 18-hydroxycortisol and Hyperaldosteronism

Article	Year
DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids? European journal of endocrinology, 2018, Volume: 178, Issue:1 Topics: Biomarkers; Diagnosis, Differential; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male	2018
[18-Hydroxycortisol, 18-oxocortisol, and 6beta-hydroxycortisol]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8 Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Biomarkers; Chromatography, High Pressure Liquid; Cushing Syndrome; Diagnosis, Differential; Humans; Hydrocortisone; Hyperaldosteronism; Immunoenzyme Techniques; Pituitary ACTH Hypersecretion; Radioimmunoassay; Reference Values; Specimen Handling	2005
Primary aldosteronism and its variants. Cardiovascular research, 1998, Volume: 37, Issue:1 Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Aldosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hyperplasia; Incidence; Zona Glomerulosa	1998
[18-hydroxycortisol, 18-oxocortisol, and 6 beta-hydroxycortisol]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57 Suppl Topics: Humans; Hydrocortisone; Hyperaldosteronism	1999
Two uncommon causes of mineralocorticoid excess. Syndrome of apparent mineralocorticoid excess and glucocorticoid-remediable aldosteronism. Endocrinology and metabolism clinics of North America, 1991, Volume: 20, Issue:2 Topics: Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Mineralocorticoids; Syndrome	1991

Trials

2 trial(s) available for 18-hydroxycortisol and Hyperaldosteronism

Article	Year
ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping. The Journal of clinical endocrinology and metabolism, 2021, 09-27, Volume: 106, Issue:10 Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Cosyntropin; Diagnostic Techniques, Endocrine; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Predictive Value of Tests; Steroids; Stimulation, Chemical	2021
Monoclonal antibodies specific for 18-hydroxycortisol and their use in an enzyme immunoassay for human urinary 18-hydroxycortisol for diagnosis of primary aldosteronism. Clinical biochemistry, 1994, Volume: 27, Issue:4 Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Biomarkers; Calibration; Chromatography, Affinity; Cross Reactions; Humans; Hybridomas; Hydrocortisone; Hyperaldosteronism; Immunoenzyme Techniques; Male; Mice; Mice, Inbred BALB C	1994

Article

Year

ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping.

The Journal of clinical endocrinology and metabolism, 2021, 09-27, Volume: 106, Issue:10

Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Cosyntropin; Diagnostic Techniques, Endocrine; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Predictive Value of Tests; Steroids; Stimulation, Chemical

2021

Monoclonal antibodies specific for 18-hydroxycortisol and their use in an enzyme immunoassay for human urinary 18-hydroxycortisol for diagnosis of primary aldosteronism.

Clinical biochemistry, 1994, Volume: 27, Issue:4

Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Biomarkers; Calibration; Chromatography, Affinity; Cross Reactions; Humans; Hybridomas; Hydrocortisone; Hyperaldosteronism; Immunoenzyme Techniques; Male; Mice; Mice, Inbred BALB C

1994

Other Studies

28 other study(ies) available for 18-hydroxycortisol and Hyperaldosteronism

Article	Year
A dilute-and-shoot liquid chromatography-tandem mass spectrometry method for urinary 18-hydroxycortisol quantification and its application in establishing reference intervals. Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:8 Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Hydrocortisone; Hyperaldosteronism; Male; Reproducibility of Results; Tandem Mass Spectrometry	2022
Optimizing adrenal vein sampling in primary aldosteronism subtyping through LC-MS/MS and secretion ratios of aldosterone, 18-oxocortisol, and 18-hydroxycortisol. Hypertension research : official journal of the Japanese Society of Hypertension, 2023, Volume: 46, Issue:8 Topics: Adrenocorticotropic Hormone; Aldosterone; Chromatography, Liquid; Humans; Hydrocortisone; Hyperaldosteronism; Retrospective Studies; Steroids; Tandem Mass Spectrometry	2023
Utility of 18-hydroxycortisol and 18-oxocortisol: potential markers of aldosterone-producing adenomas. Hypertension research : official journal of the Japanese Society of Hypertension, 2023, Volume: 46, Issue:10 Topics: Adenoma; Aldosterone; Chromatography, Liquid; Humans; Hydrocortisone; Hyperaldosteronism; Tandem Mass Spectrometry	2023
In situ metabolomics of aldosterone-producing adenomas. JCI insight, 2019, 09-05, Volume: 4, Issue:17 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Adult; Aldosterone; Calcium Channels, L-Type; Cohort Studies; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genotype; Humans; Hydrocortisone; Hyperaldosteronism; Male; Metabolomics; Middle Aged; Mutation; Phenotype; Steroid 11-beta-Hydroxylase	2019
Quantification of urinary 18-hydroxycortisol using LC-MS/MS. Annals of clinical biochemistry, 2013, Volume: 50, Issue:Pt 5 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Biomarkers, Tumor; Chromatography, Liquid; Essential Hypertension; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Limit of Detection; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry	2013
Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Biomarkers; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hyperaldosteronism; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Tomography, X-Ray Computed	2015
A new form of hereditary primary aldosteronism: familial hyperaldosteronism type III. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:8 Topics: Humans; Hydrocortisone; Hyperaldosteronism; Steroid 11-beta-Hydroxylase	2008
[18-Hydroxycortisol, 18-oxocortisol, and 6beta-hydroxycortisol]. Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68 Suppl 7 Topics: Adult; Child; Humans; Hydrocortisone; Hyperaldosteronism	2010
Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children. Hormone research in paediatrics, 2011, Volume: 76, Issue:2 Topics: Adolescent; Adult; Aldosterone; Child; Chimera; Cytochrome P-450 CYP11B2; Dexamethasone; Female; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Pedigree; Renin; Steroid 11-beta-Hydroxylase	2011
18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:3 Topics: 18-Hydroxycorticosterone; Adult; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension	2012
A time-resolved fluoroimmunoassay for 18-oxocortisol and 18-hydroxycortisol. Development of a monoclonal antibody to 18-oxocortisol. The Journal of steroid biochemistry and molecular biology, 2002, Volume: 82, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Biomarkers; Female; Fluoroimmunoassay; Humans; Hydrocortisone; Hyperaldosteronism; Male; Mice	2002
Coexistence of different phenotypes in a family with glucocorticoid-remediable aldosteronism. Journal of human hypertension, 2004, Volume: 18, Issue:1 Topics: Adult; Aged; Aldosterone; Cortodoxone; Cytochrome P-450 CYP11B2; Dexamethasone; Female; Genotype; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Pedigree; Phenotype; Renin; Steroid 11-beta-Hydroxylase	2004
Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production. Molecular and cellular endocrinology, 2004, Feb-12, Volume: 214, Issue:1-2 Topics: Adult; Aged; Cytochrome P-450 CYP11B2; DNA Mutational Analysis; Female; Gas Chromatography-Mass Spectrometry; Genetic Variation; Genotype; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Steroid 11-beta-Hydroxylase; Steroids	2004
The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism. European journal of endocrinology, 2005, Volume: 152, Issue:6 Topics: Adenoma; Adrenal Hyperplasia, Congenital; Diagnosis, Differential; Fluorometry; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Radioimmunoassay; Random Allocation; Statistics, Nonparametric	2005
Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism. The Journal of biological chemistry, 1982, Mar-10, Volume: 257, Issue:5 Topics: Humans; Hydrocortisone; Hyperaldosteronism; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet	1982
Hypersecretion of a new corticosteroid, 18-hydroxycortisol in two types of adrenocortical hypertension. Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:9-10 Topics: Adenoma; Adrenal Cortex; Aldosterone; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension	1982
A direct enzyme immunoassay for 18-hydroxycortisol in urine: a new tool for screening primary aldosteronism. The Journal of steroid biochemistry and molecular biology, 1993, Volume: 46, Issue:1 Topics: Animals; Antibody Specificity; Humans; Hydrocortisone; Hyperaldosteronism; Immunoenzyme Techniques; Immunoglobulin G; Predictive Value of Tests; Rabbits	1993
Determination of urinary 18-hydroxycortisol by isocratic normal-phase high-performance liquid chromatography. Journal of chromatography, 1993, Mar-05, Volume: 613, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Hydrocortisone; Hyperaldosteronism; Reproducibility of Results	1993
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:11 Topics: Case-Control Studies; Catalysis; Cortodoxone; Cytochrome P-450 CYP11B2; Gene Conversion; Genetic Code; Genetic Testing; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Renin; Steroid 11-beta-Hydroxylase	1998
Serum 18-hydroxycortisol in primary aldosteronism, hypertension, and normotensives. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:3 Pt 2 Topics: Adult; Cytochrome P-450 CYP11B2; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Steroid 11-beta-Hydroxylase	2001
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree. The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:7 Topics: Adult; Aldosterone; Blood Pressure; Crossing Over, Genetic; Cytochrome P-450 CYP11B2; Female; Glucocorticoids; Humans; Hydrocortisone; Hyperaldosteronism; Italy; Male; Middle Aged; Pedigree; Phenotype; Pregnancy; Pregnancy Complications; Steroid 11-beta-Hydroxylase	2002
Determination of urinary 18-hydroxycortisol in the diagnosis of primary aldosteronism. Journal of endocrinological investigation, 1992, Volume: 15, Issue:1 Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Cortex; Adrenal Cortex Neoplasms; Aldosterone; Diagnosis, Differential; Female; Glucuronates; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Male; Middle Aged; Sodium	1992
The origin and significance of 18-hydroxycortisol: studies in hyperaldosteronism and in bovine adrenocortical cells in vitro. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:5B Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Cattle; Dexamethasone; Humans; Hydrocortisone; Hyperaldosteronism; In Vitro Techniques; Potassium; Reference Values; Zona Fasciculata; Zona Glomerulosa	1991
Glucocorticoid-suppressible aldosteronism: a disorder of the adrenal transitional zone. The Journal of clinical endocrinology and metabolism, 1988, Volume: 67, Issue:3 Topics: Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Animals; Child; Dexamethasone; Female; Humans; Hydrocortisone; Hyperaldosteronism; In Vitro Techniques; Male; Middle Aged; Rana catesbeiana	1988
Adrenal transitional zone steroids, 18-oxo and 18-hydroxycortisol, useful in the diagnosis of primary aldosteronism, are ACTH-dependent. Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:4 Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chromatography, High Pressure Liquid; Dexamethasone; Humans; Hydrocortisone; Hyperaldosteronism; Radioimmunoassay; Spectrophotometry, Ultraviolet	1988
Factors affecting the secretion of 18-hydroxycortisol, a novel steroid of relevance to Conn's syndrome. Clinical endocrinology, 1985, Volume: 23, Issue:5 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Circadian Rhythm; Dexamethasone; Humans; Hydrocortisone; Hyperaldosteronism; Male; Radioimmunoassay; Sodium	1985
Dexamethasone-suppressible hyperaldosteronism: studies on overproduction of 18-hydroxycortisol in three affected family members. Clinical endocrinology, 1988, Volume: 29, Issue:3 Topics: Adrenal Cortex; Adult; Dexamethasone; Humans; Hydrocortisone; Hyperaldosteronism; Male	1988
A radioimmunoassay for 18-hydroxycortisol in plasma and urine. Clinical chemistry, 1985, Volume: 31, Issue:6 Topics: Animals; Chromatography, High Pressure Liquid; Humans; Hydrocortisone; Hyperaldosteronism; Immune Sera; Rabbits; Radioimmunoassay	1985