17-ketosteroids and Stomach-Neoplasms

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Clinical Trials as Topic; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Rectal Neoplasms; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Testosterone

The urinary excretion of andro- and glucocorticoidogenesis metabolites was studied in 60 patients with gastric cancer (stages II-III and IV). The androgenous activity showed a significant decrease that was manifested in a reduced excretion of 17-ketosteroids (17-KS) and their androgenicity index (AI). With advance of the disease stage androsterone/ethiocholanolon ratio reduced and became less than 1 in most patients. In patients with stage II-III gastric cancer there occurred a significant increase of the glucocorticoid function of the adrenals and a decrease in patients with stage IV cancer. Comparison with the androgenous activity revealed both an absolute and a relative androgenic insufficiency in patients with gastric cancer. It is suggested that reduced production of androgens effects favourably the catabolic manifestation of the effect of glucocorticoids. Drug-stimulated increase of the production of androgens in the body of patients with gastric cancer is desired.

Topics: 17-Ketosteroids; Aged; Chromatography, Thin Layer; Densitometry; Female; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms

Excretion of corticosteroids, levels of 11-OCS in blood plasma, tests with dexasone and clinical evaluation of the pituitary-adrenal system function were studied in 354 patients with carcinomas of the esophagus and proximal stomach division. Some degree of hypocorticism with a decrease in the 11-OCS level in blood plasma and lowered excretion of corticosteroids in the urine were found in 71% of patients. These variations are accompanied by lowered hypothalamus sensitivity to dexasone. Similar disturbances though less pronounced are determined in the precancerous states and in the remote periods after operation.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Dexamethasone; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Stomach Neoplasms

The paper presents the data on marked dysfunction of hypothalamo-pituitary-adrenal system in patients with esophageal and gastric cancer. Patients revealed lowered levels of 11-hydroxycorticosteroids in blood plasma and 17-corticosteroids and 17-glucocorticosteroids in diurnal urine. It was matched by an elevated threshold of hypothalamic sensitivity to inhibition by glucocorticosteroids. Treatment for these disturbances which brought the function of this system to normal had a beneficial effect on the secretion and excretion of corticosteroids in the course of combined therapy and surgery and was followed by a significant decrease in hemodynamic complication incidence. The favorable clinical effect was in correlation with the decrease in hypothalamic resistance to the inhibitory effect of glucocorticoids.

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Cardia; Drug Therapy, Combination; Esophageal Neoplasms; Gastrectomy; Humans; Middle Aged; Palliative Care; Pituitary-Adrenal System; Postoperative Period; Stomach Neoplasms

A study was made of 74 patients with esophageal and cardiac cancer, Stages II and IV. The excretion of catecholamines, corticosteroids and their precursors was studied, tests with adrenalin before and after preoperative irradiation at a summary dose of 30 Gy were done. It has been shown that before the start of radiation therapy the excretion of catecholamines and corticosteroids is lowered, the reaction to adrenalin administration is negative in most patients, the phase syndrome of cardiac hypodynamics associated with disturbed function of the sympathoadrenal system was revealed. After irradiation DOPA and dopamine excretion gets still lower whereas adrenalin excretion remains at the initial reduced level, the level of noradrenalin increases but does not achieve the normal level, i. e. a predominant decrease of catecholamine synthesis is observed. Adrenalin tests after irradiation revealed the depletion of the reaction of the cardiovascular system interrelated, to a great extent, with the activity of the sympathoadrenal system. Preoperative irradiation in patients with esophageal and cardiac cancer results in an increased excretion of 17-ketosteroids (17-KS) and 17-ketogenic steroids, however 17-KS excretion does not reach the normal level. For better tolerance of irradiation and for a radiosensitization effect testenate is administered to patients before and during radiation therapy. The administration of testenate 7-10 days before the start and during radiotherapy proved to be effective which was confirmed by noticeable necrobiotic and necrotic changes of cancer cells.

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Aged; Cardia; Catecholamines; Circadian Rhythm; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Staging; Pituitary-Adrenal System; Preoperative Care; Stomach Neoplasms; Sympathetic Nervous System

Topics: 17-Ketosteroids; Achlorhydria; Adult; Aged; Estrogens; Gastritis; Humans; Liver; Male; Middle Aged; Phenols; Steroids; Stomach Neoplasms

Study on the balance of sex hormones in 43 males and 45 females with gastric cancer indicated the presence of some deviations from normal level of androgens and estrogens excretion in gastric cancer patients. The character and intensity of the deviations observed were dependent on patients' sex and stage of the disease. In males the leading factor in sex hormones excretion disorders is a regular decrease both of 17-KS and estrogens, and only in stage UV hyperestrogenization phenomena are observed on account of active estrogens being predominant over androsterone. In females relative hyperestrogenization was observed already in stage III on acount of androsterone decrease, while in stage IV--due to reduction of total 17-KS in normal level of total enstrogens.

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Androgens; Dehydroepiandrosterone; Estrogens; Female; Humans; Male; Middle Aged; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Humans; Stomach Neoplasms

In patients with cancer of the rectum and stomach the excretion of 17-ketosteroids was reduced, compared with the normal level, most of these patients showing a decreased adrenal glucocorticoid function too. In patients with cancer of the gastrointestinal tract adrenaline and noradrenaline excretion was lower than normal values. There is a distinct correlation between the indices of catecholamines and corticosteroids excretion in the urine of patients with rectal and gastric cancer.

Topics: 17-Ketosteroids; Adrenal Cortex; Adult; Aged; Circadian Rhythm; Epinephrine; Female; Humans; Male; Middle Aged; Norepinephrine; Rectal Neoplasms; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Aged; Androsterone; Chromatography, Gas; Humans; Male; Middle Aged; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Female; Humans; Male; Metyrapone; Middle Aged; Pituitary-Adrenal System; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Female; Fructose-Bisphosphate Aldolase; Glucose-6-Phosphate Isomerase; Humans; Hydroxysteroids; Male; Middle Aged; Stomach Neoplasms

Topics: 17-Ketosteroids; Adult; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Female; Humans; Male; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Duodenal Ulcer; Endopeptidases; Female; Humans; Male; Middle Aged; Polyps; Stomach Neoplasms; Stomach Ulcer

Topics: 17-Ketosteroids; Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Cholestasis; Cholesterol; Colonic Neoplasms; Common Bile Duct; Estradiol; Estranes; Estrogens; Estrone; Female; Feminization; Glucuronates; Humans; Liver Cirrhosis; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Stomach Neoplasms; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Female; Gastritis; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Polyps; Precancerous Conditions; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Female; Gastritis; Humans; Male; Stomach Neoplasms

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aged; Bone Neoplasms; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Stomach Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Breast Neoplasms; Chromatography, Thin Layer; Female; Fibrosarcoma; Humans; Male; Mass Screening; Methods; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Ultraviolet Rays

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Scirrhous; Adrenal Glands; Adult; Aged; Carcinoma; Endopeptidases; Female; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Stomach; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Female; Humans; Male; Middle Aged; Pituitary-Adrenal System; Stomach Neoplasms

Topics: 17-Ketosteroids; Humans; Stomach Neoplasms; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Duodenal Ulcer; Eosinophils; Gastrectomy; Humans; Laparotomy; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pituitary Gland; Pituitary-Adrenal Function Tests; Stomach Neoplasms; Stomach Ulcer