17-ketosteroids and Shock

The study of metabolism of muscle electrolyte in children with the salt-losing form of congenital adrenal hyperplasia reveals two types of alterations. After admission and during initial therapy with salt and desoxycorticosterone, the changes are typical of those seen in experimental animals with adrenalectomy and excessive replacement therapy. Discontinuation of the sodium supplement after three months of therapy resulted in a return of muscle electrolyte values to normal. During the period of poor growth common to these patients a different pattern was observed. Sodium and water accumulated without alteration in tissue potassium. The mechanism of this alteration is not clear; however, it is consistent with the known effects of excess cortisone on muscle composition. These observations permit the conclusion that at least two fractions of sodium are present in muscle fibers, that which exchanges potassium and that which is independent of potassium metabolism.

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Cortisone; Desoxycorticosterone; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Mixed Function Oxygenases; Muscles; Potassium; Pregnanetriol; Shock; Sodium; Sodium Chloride; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Endopeptidases; Eosinophils; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Shock; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Humans; Mandelic Acids; Myocardial Infarction; Pituitary-Adrenal Function Tests; Shock

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Animals; Autonomic Agents; Dysautonomia, Familial; Male; Phenothiazines; Pituitary-Adrenal Function Tests; Rabbits; Shock

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Cardiovascular Diseases; Cortisone; Creatine; Creatinine; Drug Therapy; Electrocardiography; Fludrocortisone; Gonadotropins; Gonadotropins, Pituitary; Humans; Myocardial Infarction; Prednisone; Shock; Urine

Topics: 17-Ketosteroids; Shock; Shock, Surgical