17-ketosteroids and Remission--Spontaneous

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Castration; Cortisone; Gold Isotopes; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Pituitary Irradiation; Prolactin; Prostate; Prostatic Neoplasms; Radioisotopes; Rats; Remission, Spontaneous

A 15-yr-old girl was diagnosed as suffering from Cushing's disease. She was treated by bilateral adrenalectomy and autotransplantation of one third of each adrenal to the corresponding thigh. The adrenal that was embedded in the right satorius muscle started functioning after about 1 yr, as proven by significant differences in cortisol levels in both femoral veins (82.5 and 17.5 micrograms/100 ml). 19-[131I]Cholesterol scanning showed adrenal tissue in the right thigh, while no adrenal remnant was demonstrated. Eleven years after surgery, the patient is symptom free and does not require replacement therapy. We find that adrenal autotransplantation, which is a simple and nonrisky procedure, should be considered whenever bilateral adrenalectomy is chosen as a treatment for Cushing's disease.

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Cholesterol; Cushing Syndrome; Female; Humans; Hydrocortisone; Remission, Spontaneous; Transplantation, Autologous

Topics: 17-Ketosteroids; Adult; Androgens; Chronic Disease; Duodenal Ulcer; Humans; Male; Middle Aged; Remission, Spontaneous; Testosterone

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Chronic Disease; Humans; Liver Diseases; Middle Aged; Remission, Spontaneous

The effectiveness of therapy with cyproterone acetate and ethinyl estradiol was studied in 103 women. Acne and seborrhea responded best with 91.7 and 93.3% respectively, including complete and partial therapeutic success. For hirsutism complete remission and partial improvement were found in 75.3% of the treated women. Under therapy, body weight did not change in 51.9%, while 24.7% of the patients gained weight and 23.4% lost weight. The cycle length remained normal after therapy in 35.8%. Normalization or improvement was found in 54.7%. In 6.3% no improvement was noted after therapy and in 3.2% cycle irregularity developed in women with previous undisturbed pattern. According to BBT, improvement of the functional capacity of the reproductive system was found in 32.9% of the patients. Only 3% of the women studied demonstrated a deterioration. The 17-ketosteroid excretion was diminished in 35.3% after therapy and remained unchanged in 64.7%. The therapeutic regimen used for the study was well tolerated and good cycle control was obtained.

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adult; Body Temperature; Body Weight; Cyproterone; Dermatitis, Seborrheic; Ethinyl Estradiol; Female; Hirsutism; Humans; Menstruation; Menstruation Disturbances; Remission, Spontaneous

The experience of the authors demonstrated that the best results in sinakten-retard treatment were attained in patients with mild and moderate degrees of severity of the disease. However, even in patients with a protracted development, treatment by sinakten-retard increased the muscular strength in the paralyzed extremities, diminished the increased muscular tone and increased the volume of movements. All these facts permit the authors to recommend sinakten-retard for the treatment of disseminated sclerosis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Cosyntropin; Delayed-Action Preparations; Emotions; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Muscle Tonus; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Aged; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Metastasis; Prognosis; Remission, Spontaneous; Statistics as Topic

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Asthma; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Pulmonary Circulation; Remission, Spontaneous

A patient with Cushing's disease due to a chromophobe adenoma was studied for 243 days before pituitary surgery and evidence for periodicity in cortisol steroid production was found with cycles occurring every 85.8 days (peak-to-peak length), associated with laboratory remissions and paradoxical response to dexamethasone. The autonomy of ACTH secretion was suggested by the nonresponsiveness to repeated lysine-vasopressin stimulation tests and lack of increase in urinary 170HCS following metyrapone. A distinct response of the hyperplastic glands (as demonstrated by percutaneous adrenal venography) was obtained on several B1-24 corticotropin stimulation. The patient's hypercortisolism disappeared following removal of the chromophobe adenoma through transphenoidal hypophysectomy.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Cosyntropin; Cushing Syndrome; Dexamethasone; Humans; Hydrocortisone; Hypophysectomy; Lypressin; Male; Metyrapone; Periodicity; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Cushing Syndrome; Female; Follow-Up Studies; Humans; Hydrocortisone; Mitotane; Remission, Spontaneous

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Aged; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Evaluation Studies as Topic; Humans; Hypophysectomy; Male; Middle Aged; Neoplasm Metastasis; Pennsylvania; Prognosis; Prostatic Neoplasms; Radiography; Recurrence; Remission, Spontaneous; Testosterone

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Androsterone; Body Surface Area; Breast; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Palliative Care; Pregnancy; Remission, Spontaneous; Spectrophotometry; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Aminoglutethimide; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Castration; Central Nervous System; Dexamethasone; Estrogens; Female; Fludrocortisone; Humans; Neoplasm Metastasis; Ovary; Remission, Spontaneous; Skin Neoplasms

Topics: 17-Ketosteroids; 5-Aminolevulinate Synthetase; Acute Disease; Adult; Animals; Chromatography, Gas; Cycloheximide; Dactinomycin; Dexamethasone; Female; Glucuronates; Humans; Liver; Male; Middle Aged; Porphobilinogen; Porphyrias; Porphyrins; Rats; Remission, Spontaneous; Sulfuric Acids

To investigate the effect of medroxyprogesterone acetate therapy upon the immune response and endogenous status of patients with primary or recurrent endometrial adenocarcinoma, 8 patients were treated with progestin therapy as inpatients for 33-80 days. Patients were studied intermittently for up to 72 months. Serum protein electrophoresis during treatment showed no change in protein pattern. In all 8 patients, there was a suppression of pituitary gonadotrophin. There was no evidence that the adenocarcinomas were suppressed by either an immunologic mechanism or by the variation in endogenous hormone production. Investigation should be continued to study the effects of medroxyprogesterone acetate on the cellular level.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Aged; Biopsy; Blood Cell Count; Blood Protein Electrophoresis; Endometrium; Estrogens; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Humans; Immunity; Luteinizing Hormone; Lymphocytes; Medroxyprogesterone; Middle Aged; Palliative Care; Pregnanediol; Remission, Spontaneous; Time Factors; Uterine Neoplasms

Topics: 17-Ketosteroids; Acid Phosphatase; Aged; Alkaline Phosphatase; Anesthesia, Local; Castration; Cortisone; Cryosurgery; Estrogens; Follicle Stimulating Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Middle Aged; Neoplasm Metastasis; Palliative Care; Prostatic Neoplasms; Remission, Spontaneous; Stereotaxic Techniques; Testosterone

Topics: 17-Ketosteroids; Adrenalectomy; Castration; Estrogens; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Hypophysectomy; Luteinizing Hormone; Male; Prostatic Neoplasms; Remission, Spontaneous; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Circadian Rhythm; Cushing Syndrome; Female; Gestational Age; Humans; Hydrocortisone; Infant, Newborn; Pregnancy; Pregnancy Complications; Remission, Spontaneous

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Alkaline Phosphatase; Androgens; Bone Neoplasms; Cryosurgery; Follicle Stimulating Hormone; Follow-Up Studies; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Neoplasm Metastasis; Palliative Care; Pelvic Neoplasms; Prostatic Neoplasms; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Aldosterone; Blood Pressure; Female; Humans; Hyperaldosteronism; Hyperplasia; Middle Aged; Potassium; Remission, Spontaneous; Renin; Secretory Rate