17-ketosteroids and Rectal-Neoplasms

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Clinical Trials as Topic; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Rectal Neoplasms; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Testosterone

In patients with cancer of the rectum and stomach the excretion of 17-ketosteroids was reduced, compared with the normal level, most of these patients showing a decreased adrenal glucocorticoid function too. In patients with cancer of the gastrointestinal tract adrenaline and noradrenaline excretion was lower than normal values. There is a distinct correlation between the indices of catecholamines and corticosteroids excretion in the urine of patients with rectal and gastric cancer.

Topics: 17-Ketosteroids; Adrenal Cortex; Adult; Aged; Circadian Rhythm; Epinephrine; Female; Humans; Male; Middle Aged; Norepinephrine; Rectal Neoplasms; Stomach Neoplasms

The level of 17-ketosteroids and 17-ketogenic steroids in the diurnal urine was determined in 70 patients with rectal cancer prior to and after ACTH administration. In most patients the initial excretion of the steroids under study was found to be decreased. 17-ketosteroids excretion is reduced more frequently in patients over 50 years of age and in females. In a predominant number of patients functional reserves of the adrenal cortex are decreased.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Age Factors; Female; Humans; Male; Middle Aged; Rectal Neoplasms; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Aged; Catecholamines; Female; Humans; Male; Middle Aged; Rectal Neoplasms; Sympathetic Nervous System