17-ketosteroids and Puberty--Precocious

Eight cases of adrenocortical tumor are presented with a review of the literature. Although such tumors are rare, they are important causes of inappropriate virilization and Cushing's syndrome in childhood. Clinical virilization with or without hypercortisolism was found in all eight children, who were 5 years old or younger. Excessive linear growth was noted, despite evidence of hypercortisolism. Serum levels of dehydroepiandrosterone, dehydroepiandrosterone sulfate, testosterone, and cortisol were elevated in all cases tested and appear to be useful diagnostic alternatives to the more traditional determinations of urine 17-ketosteroids and 17-hydroxycorticosteroids. Abdominal sonography and computed tomography have proven to be reliable tools for tumor localization. Surgical resection was the definitive therapy in all patients, and perioperative steroid replacement was essential. Histologic diagnosis appeared to have little bearing on prognosis, and the majority of pediatric patients have had clinically benign disease. At a mean follow-up of 3 years, seven of the eight children were alive and had no evidence of tumor recurrence.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adenoma; Adrenal Cortex Neoplasms; Child, Preschool; Cushing Syndrome; Dehydroepiandrosterone; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Male; Puberty, Precocious; Testosterone; Virilism

Topics: 17-Ketosteroids; Adolescent; Child; Chorionic Gonadotropin; Clomiphene; Dehydroepiandrosterone; Estrogens; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hair; Humans; Luteinizing Hormone; Male; Puberty; Puberty, Precocious; Testis; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenocortical Hyperfunction; Androgen-Insensitivity Syndrome; Child; Cushing Syndrome; Endocrine Glands; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Menstruation; Ovary; Pituitary Gland, Anterior; Pituitary Hormones; Puberty; Puberty, Precocious; Reproduction; Turner Syndrome

Topics: 17-Ketosteroids; Age Factors; Body Height; Brain Diseases; Choriocarcinoma; Dysgerminoma; Ejaculation; Female; Granulosa Cell Tumor; Humans; Hydrocephalus; Male; Menarche; Ovarian Neoplasms; Ovulation; Pregnancy; Prognosis; Psychosexual Development; Puberty, Precocious; Reproduction; Sex Factors; Teratoma; Testicular Neoplasms; Thecoma

The effect of leuprolide acetate (D-Leu6-[des-Gly10-NH2]-LH-RH ethylamide acetate) for depot suspension (TAP-144-SR), a synthetic analog of luteinizing hormone-releasing hormone, was examined in three doses in 36 patients (34 girls, 2 boys) with central precocious puberty. TAP-144-SR was injected subcutaneously every four weeks for twelve weeks, and clinical symptoms and plasma and urinary levels of various hormones were followed every four weeks. Eleven girls given 10 micrograms/kg showed a significant decrease in peak plasma LH and FSH responses to LH-RH test, but basal plasma LH and FSH did not change significantly. In 13 patients (11 girls and 2 boys) given 30 micrograms/kg and 12 girls given 90 micrograms/kg, both basal and peak LH and FSH were significantly suppressed. Urinary excretion of LH decreased significantly in all groups except in the 10 micrograms/kg group. Urinary excretion of FSH did not change significantly in the 10 and 30 micrograms/kg groups, but it decreased significantly in the 90 micrograms/kg group. In girls, plasma and urinary estradiol also fell greatly, but the difference was insignificant except in the 90 micrograms/kg group. Regression of sexual characteristics was observed in almost half of the patients at the 12th week of the treatment. Side effects were minimal. A dose of more than 30 micrograms/kg of TAP-144-SR is effective in suppressing gonadotropins and causing improvement of clinical symptoms, and appears to be useful in treating children with central precocious puberty.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Analysis of Variance; Child; Child, Preschool; Dehydroepiandrosterone; Delayed-Action Preparations; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Humans; Immunoradiometric Assay; Infant; Insulin-Like Growth Factor I; Leuprolide; Luteinizing Hormone; Male; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Acetates; Adenoma; Androgen-Insensitivity Syndrome; Androgens; Androsterone; Carbon Isotopes; Chemistry, Clinical; Chromatography, Paper; Clinical Trials as Topic; Cushing Syndrome; Etiocholanolone; Female; Hirsutism; Humans; Hyperaldosteronism; Male; Methods; Myoma; Puberty, Precocious; Testosterone; Tritium; Uterine Neoplasms

Endocrine studies in girls with precocious thelarche were compared with those of normal girls of similar ages. Girls with precocious thelarche showed breast development and oestrogenised vaginal smears as the only signs of precocious sexual development. A few of the girls were tall and some had advanced bone ages but these two findings were not consistently present in the same patient. Hormones--such as serum oestradiol, oestrone, delta 4-androstenedione, progesterone, dehydroepiandrosterone (DHEA), follicle-stimulating hormone, luteinising hormone, and prolactin, and urinary 17-ketosteroids--were measured. Only DHEA was different, being higher in girls with precocious thelarche. It is suggested that the high DHEA level may serve as a precursor for conversion to oestrogens in target tissues, breast, and vagina. This mechanism for oestrogenisation had been reported in other patients.

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Age Determination by Skeleton; Body Height; Child; Child, Preschool; Dehydroepiandrosterone; Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Infant; Puberty, Precocious

The management, investigation and treatment of 12 children with precocious puberty is described. Danazol, a synthetic derivative of ethisterone, has been used over a period of 3 1/2 years. Its clinical, endocrine and biochemical effects have been evaluated. Danazol ha a very useful clinical effect in controlling the development of secondary sexual features but does not modify the rapid linear growth and skeletal maturity seen in this condition.

Topics: 17-Ketosteroids; Body Height; Child; Child, Preschool; Danazol; Electroencephalography; Female; Follicle Stimulating Hormone; Humans; Infant; Luteinizing Hormone; Male; Pregnadienes; Puberty, Precocious

Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Child; Child, Preschool; Dexamethasone; Growth Disorders; Humans; Hydrocortisone; Male; Metyrapone; Puberty, Precocious

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child; Child, Preschool; Female; Gonadal Steroid Hormones; Humans; Infant; Male; Puberty, Precocious

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast; Child; Dehydroepiandrosterone; Female; Humans; Infant; Pregnanediol; Puberty, Precocious; Time Factors

A case of sexual precocity of unusually early onset and associated with a hypothalamic tumour is described. The effects of ethinyl oestradiol and medroxyprogesterone acetate treatment have been monitored by plasma testosterone, FSH, and LH estimations. The results suggested a partial suppression of the tumour's influence, the mechanism of which is discussed.

Topics: 17-Ketosteroids; Age Determination by Skeleton; Brain Neoplasms; Child, Preschool; Ethinyl Estradiol; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Humans; Hypothalamus; Luteinizing Hormone; Male; Medroxyprogesterone; Puberty, Precocious; Radioimmunoassay; Testosterone

Using a newly devised radioligand method for the simultaneous determination of urinary testosterone (T) and androstanediol (Adiol) nine girls with precocious adrenarche were evaluated. In the base-line state average urinary T excretion (1.29 mug/24 hr) and Adiol excretion (1.33 mug/24 hr) were significantly elevated when compared with 15 age-matched controls (0.3 and 0.33 mug/ 24 hr, respectively, P less than 0.001 for both). Adrenocorticotropic hormone (ACTH) infusion performed in five patients with precocious adrenarche produced at least a 50 greater than increase in urinary T excretion in all and a similar increase in Adiol excretion in four of five patients. Dexamethasone administration in the same five patients produced a 25 greater than fall in urinary T excretion in all and a comparable fall in Adiol in four.

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Androstane-3,17-diol; Androstanes; Child; Child, Preschool; Chromatography, Paper; Dexamethasone; Female; Humans; Methods; Puberty, Precocious; Radioligand Assay; Testosterone

The effect of Danazol, a synthetic 2,3 isoxazol derivative of 17 alpha-ethinyl testosterone, was assessed in three girls and two boys with sexual precocity. Progression of sexual development ceased during administration of Danazol; the effect upon growth rate and skeletal maturation was equivocal. Serum estrogen and progesterone concentrations in the girls were lower during treatment; serum testosterone and dehydroepiandrosterone levels in the boys were also lower. Serum and urinary luteinizing hormone concentrations were inconsistently suppressed. No effect upon follicle-stimulating hormone levels could be demonstrated. Although Danazol appears to inhibit sexual development, this study indicates that the pituitary-gonadal axis is not completely suppressed. Growth rate is not reverted to normal, and virilization may occur among girls. Because undesirable side effects may outweight desirable results, careful consideration is recommended before Danazol is prescribed in the management of sexual precocity.

Topics: 17-Ketosteroids; Age Determination by Skeleton; Androgens; Body Height; Body Weight; Bone Development; Child; Child, Preschool; Danazol; Estrogens; Female; Gonadotropins; Growth; Humans; Male; Pregnadienes; Progesterone; Puberty, Precocious

Topics: 17-Ketosteroids; Cerebral Ventricle Neoplasms; Child; Choriocarcinoma; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxysteroids; Luteinizing Hormone; Male; Pregnancy; Progesterone; Puberty, Precocious; Radioimmunoassay; Testosterone; Thyrotropin; Thyroxine

Topics: 17-Ketosteroids; Adolescent; Age Factors; Child; Female; Humans; Male; Puberty, Precocious

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Age Factors; Arginine; Basal Metabolism; Cerebral Ventricle Neoplasms; Child; Child, Preschool; Craniopharyngioma; Diabetes Insipidus; Electrolytes; Female; Gonadotropins; Gonads; Growth Hormone; Humans; Hydrocortisone; Iodine Radioisotopes; Male; Metyrapone; Middle Aged; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Puberty, Precocious; Sex Factors; Thyroid Gland; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Gland Neoplasms; Aortography; Child, Preschool; Hormones, Ectopic; Humans; Luteinizing Hormone; Male; Puberty, Precocious; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Carcinoma; Child, Preschool; Estrogens; Humans; Male; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Age Factors; Amenorrhea; Body Temperature; Chorionic Gonadotropin; Clomiphene; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Infertility, Female; Luteinizing Hormone; Male; Menstruation; Ovarian Diseases; Ovulation; Pregnanediol; Progesterone; Puberty, Precocious; Radioimmunoassay; Time Factors

Topics: 17-Ketosteroids; Body Height; Body Weight; Child; Estrogens; Humans; Leydig Cell Tumor; Male; Pregnanetriol; Puberty, Precocious; Testicular Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenocortical Hyperfunction; Body Height; Bone Development; Child; Child, Preschool; Cortisone; Disorders of Sex Development; Dose-Response Relationship, Drug; Female; Glucocorticoids; Growth; Humans; Hydrocortisone; Infant; Ketosteroids; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Prednisone; Pregnanediol; Pregnanetriol; Puberty, Precocious; Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Carcinoma, Hepatocellular; Child, Preschool; Dactinomycin; Estrogens; Ethinyl Estradiol; Gonadotropins; Hormones, Ectopic; Humans; Liver; Liver Neoplasms; Luteinizing Hormone; Male; Neutralization Tests; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Age Determination by Skeleton; Androgen Antagonists; Body Height; Bone Development; Child; Child, Preschool; Cyproterone; Estrogens; Female; Gonadotropins; Growth Disorders; Humans; Male; Pregnadienes; Prognosis; Puberty, Precocious

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Body Height; Child; Child, Preschool; Cyproterone; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Hormone; Humans; Luteinizing Hormone; Pregnadienes; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Child; Child, Preschool; Estradiol; Estrogens; Estrone; Female; Follicle Stimulating Hormone; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Pituitary Hormone-Releasing Hormones; Puberty, Precocious; Radioimmunoassay; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Electroencephalography; Endocrine System Diseases; Fibrous Dysplasia of Bone; Humans; Male; Pigmentation Disorders; Puberty, Precocious; Radiography; Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Estrogens; Fallopian Tubes; Female; Follicle Stimulating Hormone; Humans; Hydrogen-Ion Concentration; Luteinizing Hormone; Ovarian Cysts; Ovary; Puberty, Precocious; Radioimmunoassay; Vagina

Topics: 17-Ketosteroids; Androstanes; Child; Chorionic Gonadotropin; Dehydroepiandrosterone; Humans; Hydrocortisone; Leydig Cell Tumor; Male; Pregnanetriol; Puberty, Precocious; Sulfates; Testicular Neoplasms; Testis; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androgens; Androstanes; Androsterone; Bromine; Carbon Isotopes; Child; Child, Preschool; Dehydroepiandrosterone; Female; Humans; Hypogonadism; Infant; Infant, Newborn; Male; Puberty; Puberty, Precocious; Radioisotopes; Sex Factors; Statistics as Topic; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Child; Chorionic Gonadotropin; Dexamethasone; Ethinyl Estradiol; Humans; Male; Medroxyprogesterone; Norethindrone; Prednisone; Pregnanetriol; Psychosexual Development; Puberty, Precocious; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Age Factors; Aldosterone; Body Height; Glucocorticoids; Humans; Hydrocortisone; Male; Puberty, Precocious; Testicular Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Body Height; Child; Child Development; Child, Preschool; Female; Gonadotropins, Pituitary; Humans; Male; Medroxyprogesterone; Menstruation; Puberty, Precocious

Topics: 17-Ketosteroids; Child; Child, Preschool; Delayed-Action Preparations; Humans; Male; Medroxyprogesterone; Progestins; Puberty, Precocious

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child; Estrogens; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Intellectual Disability; Metyrapone; Obesity; Puberty, Precocious

Topics: 17-Ketosteroids; Adult; Age Factors; Child; Child, Preschool; Germany, West; Gynecomastia; Humans; Leydig Cell Tumor; Male; Puberty, Precocious; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Body Height; Breast; Central Nervous System Diseases; Child; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Hypothyroidism; Infant; Laparoscopy; Luteinizing Hormone; Medroxyprogesterone; Menarche; Ovarian Neoplasms; Ovary; Physical Examination; Pituitary Hormone-Releasing Hormones; Puberty, Precocious; Radioimmunoassay; Sex Characteristics

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Bone Development; Brain Neoplasms; Child; Child, Preschool; Dehydroepiandrosterone; Estrogens; Female; Gold Isotopes; Hamartoma; Humans; Lynestrenol; Mammillary Bodies; Pregnanediol; Pregnanetriol; Puberty, Precocious; Sexual Behavior; Stereotaxic Techniques

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Androstanes; Child; Child, Preschool; Dehydroepiandrosterone; Dexamethasone; Female; Hair; Humans; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Age Factors; Child; Child, Preschool; Dexamethasone; Female; Follow-Up Studies; Humans; Male; Mixed Function Oxygenases; Prednisolone; Puberty, Precocious; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Endocrine System Diseases; Female; Femoral Fractures; Fibrous Dysplasia of Bone; Fractures, Spontaneous; Gonadotropins; Humans; Infant; Pigmentation Disorders; Puberty, Precocious

Topics: 17-Ketosteroids; Astrocytoma; Brain Neoplasms; Child; Chorionic Gonadotropin; Follicle Stimulating Hormone; Humans; Hypothalamus; Luteinizing Hormone; Male; Pneumoencephalography; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Dehydroepiandrosterone; Female; Humans; Middle Aged; Pregnanetriol; Puberty, Precocious; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adsorption; Adult; Chemistry, Clinical; Child; Child, Preschool; Cushing Syndrome; Disorders of Sex Development; Ethisterone; Female; Glucuronidase; Hirsutism; Humans; Infant; Magnesium; Methods; Pituitary-Adrenal Function Tests; Polycystic Ovary Syndrome; Pregnanetriol; Puberty, Precocious; Silicon Dioxide; Tetrazolium Salts

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Child; Cortisone; Dichlorodiphenyldichloroethane; Estrogens; Female; Gonadotropins; Humans; Hypertension; Pregnanediol; Pregnanetriol; Prognosis; Puberty; Puberty, Precocious; Virilism

Topics: 17-Ketosteroids; Dermatoglyphics; Electroencephalography; Gigantism; Humans; Intellectual Disability; Puberty, Precocious; Seizures; Voice

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenalectomy; Adult; Aged; Androgen-Insensitivity Syndrome; Castration; Chemistry, Clinical; Climacteric; Cryptorchidism; Disorders of Sex Development; Erectile Dysfunction; Estrogens; Eunuchism; Humans; Hypogonadism; Hypophysectomy; Hypothalamo-Hypophyseal System; Male; Middle Aged; Paraplegia; Puberty, Precocious; Spinal Cord Diseases; Testosterone

Topics: 17-Ketosteroids; Adolescent; Body Height; Child; Child, Preschool; Female; Hair; Heart Defects, Congenital; Humans; Male; Puberty, Precocious

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Height; Bone Development; Breast; Child; Child, Preschool; Estrogens; Female; Gonadotropins, Pituitary; Growth; Humans; Male; Medroxyprogesterone; Menstruation; Penis; Pregnanediol; Puberty, Precocious; Testis; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Castration; Child, Preschool; Humans; Leydig Cell Tumor; Male; Puberty, Precocious; Testicular Neoplasms

Topics: 17-Ketosteroids; Child; Child, Preschool; Female; Gonadotropins; Humans; Infant; Puberty, Precocious; Vaginal Smears

Topics: 17-Ketosteroids; Adrenal Rest Tumor; Child; Child, Preschool; Diagnosis, Differential; Estrogens; Gynecomastia; Humans; Leydig Cell Tumor; Male; Puberty, Precocious; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Chlorpromazine; Humans; Hypopituitarism; Infertility, Male; Male; Nutrition Disorders; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Androgens; Bone Development; Child; Diagnosis, Differential; Electroencephalography; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins; Humans; Hypothyroidism; Male; Ovarian Neoplasms; Physical Examination; Puberty, Precocious; Radiography; Skull; Thyroid Function Tests; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Androgens; Androsterone; Child; Child, Preschool; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Female; Humans; Male; Puberty, Precocious; Steroids; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androsterone; Carbon Isotopes; Child; Child, Preschool; Chromatography, Paper; Colorimetry; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Growth; Humans; Hydrocortisone; Hypogonadism; Infant; Infant, Newborn; Male; Pregnenolone; Progesterone; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Child; Chromatography, Paper; Dehydroepiandrosterone; Dexamethasone; Female; Hirsutism; Humans; Hydroxysteroid Dehydrogenases; Mesenchymoma; Metabolism, Inborn Errors; Puberty, Precocious; Secretory Rate

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocortical Hyperfunction; Adult; Ataxia; Child; Child, Preschool; Dwarfism; Gonads; Humans; Intellectual Disability; Myxedema; Obesity; Puberty, Precocious

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Gland Neoplasms; Child, Preschool; Humans; Male; Puberty, Precocious

Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Child; Child, Preschool; Cushing Syndrome; Female; Humans; Male; Puberty, Precocious

Topics: 17-Ketosteroids; Androgens; Body Height; Child; Child, Preschool; Epiphyses; Gonadotropins; Humans; In Vitro Techniques; Male; Medroxyprogesterone; Pregnanetriol; Puberty, Precocious; Testosterone; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Body Height; Child; Chromatography, Paper; Electroencephalography; Female; Growth; Hair; Humans; Pregnanetriol; Puberty, Precocious; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Child; Developmental Disabilities; Humans; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Aldosterone; Child; Child, Preschool; Desoxycorticosterone; Humans; Leydig Cell Tumor; Male; Puberty, Precocious; Testicular Neoplasms; Testosterone; Urine

Topics: 17-Ketosteroids; Biomedical Research; Black People; Breast; Estrogens; Gonadotropins; Infant; Infant, Newborn; Puberty, Precocious; Urine

Topics: 17-Ketosteroids; Child; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Growth; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Pituitary Diseases; Pituitary Gland; Pregnanediol; Prognosis; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Cholesterol; Chromatography; Dehydroepiandrosterone; Dexamethasone; Drug Therapy; Gonadotropins; Humans; Hydrocortisone; Lipids; Male; Pathology; Puberty; Puberty, Precocious; Sexual Maturation; Surgical Procedures, Operative; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androsterone; Dehydroepiandrosterone; Female; Hair; Humans; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Child; Humans; Hypothyroidism; Male; Papilledema; Puberty; Puberty, Precocious; Sexual Maturation; Testis; Thyroiditis; Thyroiditis, Autoimmune; Urine

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Female; Humans; Hyperplasia; Hypertrophy; Puberty; Puberty, Precocious; Sexual Maturation; Tooth; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Child; Down Syndrome; Female; Gonadotropins; Humans; Hypothyroidism; Iodine Isotopes; Medroxyprogesterone; Menstruation; Myxedema; Puberty; Puberty, Precocious; Radiography; Sella Turcica; Sexual Maturation; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Adolescent; Child; Diabetes Insipidus; Dwarfism; Dwarfism, Pituitary; Humans; Hypothyroidism; Infant; Infant, Newborn; Laurence-Moon Syndrome; Lipodystrophy; Obesity; Pituitary Diseases; Pituitary Gland; Progeria; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Cortex Neoplasms; Child; Humans; Neoplasms; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Estrogens; Female; Gonadotropins; Humans; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Child; Dwarfism; Humans; Hydroxysteroids; Infant; Obesity; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Humans; Pituitary Diseases; Pituitary Gland; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Acromegaly; Addison Disease; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androgens; Cushing Syndrome; Dehydroepiandrosterone; Endocrine System Diseases; Humans; Pituitary ACTH Hypersecretion; Puberty, Precocious; Steroids; Urine

Topics: 17-Ketosteroids; Chromatography; Female; Humans; Male; Puberty; Puberty, Precocious; Sertoli-Leydig Cell Tumor; Sexual Maturation; Steroids; Urine