17-ketosteroids and Psoriasis

A gas-chromatographic method for urinary steroid measurements by Chrome-5 (Prague) chromatograph with plasma ionization detector is suggested. Glass column 1.5 m long is packed with N-AW chromatone impregnated with 15% SE-30. Detector and evaporator temperature is 260 degrees C. Column temperature is programmed from 200 to 250 degrees C. Quantitative and qualitative analysis of chromatograms in 40 patients and 30 controls permitted assessment of excretion of 17-ketosteroids, hydroxyandrosterone, etiocholanolone, androsterone, dihydroepiandrosterone, beta-cortol compounds, etc., which is important in studies of psoriasis pathogenesis and in assessment of the efficacy of treatment of this and other diseases.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androsterone; Chromatography, Gas; Etiocholanolone; Humans; Male; Models, Biological; Psoriasis

Significant suppression of the hypothalamic-pituitary-adrenal axis has been found in patients hospitalized with psoriasis vulgaris and receiving topical fluorinated steroid therapy. Depression of thyroid function and involvement of autoimmune processes is also suggested by the data.

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Female; Humans; Hydrocortisone; Hydroxysteroids; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary Hormones; Psoriasis; Steroids, Fluorinated; Thyroid Hormones

The systemic effects of topically applied 0.1% hydrocortisone 17-butyrate during treatment with and without occlusion were measured in terms of the functions of the pituitary-adrenal axis. Corticosteroid levels in the blood were determined by the modified method of MURPHY, a competitive protein-binding radioassay. Circulating eosinophils were counted and the urinary 17-OHCS and 17-KS excretion were also determined. Percutaneous absorption following the topical application of 14C hydrocortisone 17-butyrate 1 (HC 17-B, Locoid) was measured by means of autoradiography. The application of the corticosteroid to the normal skin without occlusion did not induce systemic effects, whilst the application of the drug under occlusive dressing showed that systemic effects may possibly be induced. The number of circulating eosinophils, corticosteroid levels in the blood and urinary 17-OHCS excretion all decreased. However, these values returned to normal about 2 days after the withdrawal of the application, so we consider the systemic effect induced by the topical corticosteroid to be of a temporary nature. The percutaneous absorption of the corticosteroid was proved by an autoradiographic technique using 14C-labelled HC 17-B. At various intervals after the application, radioactive substances were observed as silver grains in the horny layer of the epidermis and skin appendages, and the density of the silver grains gradually increased with the course of time. It may be surmised that locally applied HC 17-B will be retained in the horny layer of the epidermis at a very early stage after the application and then absorbed in the blood via the epidermis and skin appendages. The reservoir of the corticosteroid in the skin was demonstrated 24 h after the withdrawal of the application.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Topical; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Autoradiography; Eosinophils; Humans; Hydrocortisone; Leukocyte Count; Male; Middle Aged; Pituitary-Adrenal System; Psoriasis; Skin; Sodium

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Butyrates; Carbon Radioisotopes; Female; Fluorescence; Follow-Up Studies; Humans; Hydrocortisone; Male; Middle Aged; Ointments; Pituitary-Adrenal System; Psoriasis; Triamcinolone Acetonide

Topics: 17-Ketosteroids; Adolescent; Adult; Androstenes; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hydroxysteroids; Male; Middle Aged; Psoriasis; Skin

Topics: 17-Ketosteroids; Androstenes; Androsterone; Chromatography, Thin Layer; Dehydroepiandrosterone; Fatty Alcohols; Humans; Hydroxysteroids; Male; Middle Aged; Psoriasis; Skin; Sulfuric Acids; Time Factors; Tritium

Topics: 17-Ketosteroids; Administration, Topical; Adrenal Insufficiency; Anti-Inflammatory Agents; Betamethasone; Butyrates; Drug Synergism; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Hypopituitarism; Metyrapone; Middle Aged; Occlusive Dressings; Ointments; Pituitary-Adrenal System; Psoriasis; Time Factors; Triamcinolone Acetonide; Valerates

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androstanes; Arthritis; Arthritis, Rheumatoid; Chronic Disease; Circadian Rhythm; Dehydroepiandrosterone; Delayed-Action Preparations; Female; Glucocorticoids; Humans; Hydrocortisone; Hypothalamus; Insulin; Male; Middle Aged; Pituitary Gland; Prednisolone; Psoriasis

Topics: 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Anti-Bacterial Agents; Betamethasone; Dermatitis; Fludrocortisone; Humans; Hydrocortisone; Intestinal Diseases; Intestine, Small; Ointments; Prednisolone; Psoriasis; Skin Diseases; Tetracycline

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Dermatitis, Atopic; Dermatitis, Contact; Dermatitis, Exfoliative; Female; Humans; Hydrocortisone; Male; Middle Aged; Occlusive Dressings; Pituitary-Adrenal System; Plastics; Polyethylenes; Psoriasis; Skin Absorption; Triamcinolone Acetonide

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Basophils; Eosinophils; Estrogens; Female; Humans; Menstruation; Middle Aged; Psoriasis; Vagina; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adult; Aged; Diuresis; Drug Synergism; Female; Flumethasone; Fluocinolone Acetonide; Humans; Hydroxyzine; Hypopituitarism; Hypothalamus; Lichen Planus; Male; Middle Aged; Natriuresis; Occlusive Dressings; Penicillins; Potassium; Psoriasis; Skin Absorption; Triamcinolone Acetonide

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Female; Flumethasone; Glucocorticoids; Humans; Male; Middle Aged; Neurodermatitis; Occlusive Dressings; Psoriasis; Skin Absorption; Skin Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Fluocinolone Acetonide; Humans; Psoriasis; Skin Absorption

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Bandages; Dermatitis; Dermatitis, Atopic; Dermatitis, Exfoliative; Flurandrenolone; Geriatrics; Humans; Occlusive Dressings; Pituitary-Adrenal Function Tests; Plastics; Psoriasis; Triamcinolone Acetonide; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Bandages; Drug Therapy; Fluocinolone Acetonide; Humans; Hydroxysteroids; Neurodermatitis; Nitrogen; Occlusive Dressings; Potassium; Psoriasis; Sodium; Urine

Topics: 17-Ketosteroids; Body Fluids; Humans; Psoriasis; Steroids; Urinary Tract; Urine

Topics: 17-Ketosteroids; Body Fluids; Psoriasis; Steroids; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Fever; Hydrogen-Ion Concentration; Psoriasis; Steroids