17-ketosteroids and Prostatic-Neoplasms

The ongoing development and gradual availability of the new anti-androgens hold exciting clinical implications for the future. The biosynthesis and interchangeability of the sex steroids, the roles of the ovaries and adrenals and the value and interpretation of biochemical assays in clinical practice are briefly discussed. Because the anti-androgens are used primarily for seborrhoea/acne/hirsutism/oligomenorrhoea, the pathophysiological basis of this socially debilitating syndrome is discussed. The classification of the anti-androgens, their indications, side-effects, dosage schemes and results of treatment are reviewed. Finally, a summary of a possible clinical management regimen is presented.

Topics: 17-Ketosteroids; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Androsterone; Contraceptives, Oral, Hormonal; Cyclopentanes; Cyproterone; Dermatitis, Seborrheic; Dihydrotestosterone; Estradiol Congeners; Female; Follicle Stimulating Hormone; Glucocorticoids; Hirsutism; Humans; Hydroxysteroids; Luteinizing Hormone; Male; Medroxyprogesterone; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; Sex Hormone-Binding Globulin; Steroids; Testosterone

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Castration; Cortisone; Gold Isotopes; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Pituitary Irradiation; Prolactin; Prostate; Prostatic Neoplasms; Radioisotopes; Rats; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acid Phosphatase; Adrenal Gland Neoplasms; Alkaline Phosphatase; Amino Acids; Amylases; Bone Neoplasms; Breast Neoplasms; Carcinoid Tumor; Catecholamines; Chorionic Gonadotropin; Clinical Enzyme Tests; Clinical Laboratory Techniques; Female; Glucose-6-Phosphate Isomerase; Humans; Hydroxyindoleacetic Acid; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Neoplasms; Neoplasms, Nerve Tissue; Neuroblastoma; Nucleotidases; Pancreatic Neoplasms; Pheochromocytoma; Pregnancy; Prostatic Neoplasms; Trophoblastic Neoplasms; Vanilmandelic Acid

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenal Cortex Hormones; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Geriatrics; Humans; Hypophysectomy; Male; Neoplasm Metastasis; Prostatic Neoplasms; Surgical Procedures, Operative; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenal Insufficiency; Adult; Androgens; Androsterone; Castration; Chemistry, Clinical; Clinical Trials as Topic; Clomiphene; Estrogens; Etiocholanolone; Female; Glucocorticoids; Gonadotropins, Pituitary; Humans; Male; Middle Aged; Orchitis; Pregnanetriol; Prostatic Neoplasms; Stimulation, Chemical; Testosterone; Tuberculosis, Urogenital

The endocrine effects of ketoconazole (400 mg orally every 8 h) were studied in 9 previously untreated patients with advanced prostatic cancer. Five of these patients were followed for 12 months. A rapid fall in the serum concentration of testosterone was noted in all patients studied. Minimal values were observed on day 4 of treatment but thereafter serum testosterone increased slowly. The effect of the drug on unbound testosterone was relatively more important, since sex hormone binding globulin increased markedly during treatment. An increase in progesterone and LH was observed in all patients. This suggests that ketoconazole limits the conversion of C21-precursors into androgens. This block is compensated in part by activation of the hypothalamo-hypophyseal feedback system. Urinary 17-ketosteroids were decreased but 17-hydroxysteroids were unaffected by the treatment. In 5 patients followed monthly over a period of 12 months the mean testosterone concentration ranged from 69 ng/100 ml in one patient to 428 ng/100 ml in another. An excellent inverse correlation could be demonstrated between the mean serum concentration of testosterone and the mean concentration of ketoconazole. The change of serum dehydroepiandrosterone sulphate also correlated inversely with the mean ketoconazole level. Increased concentrations of oestradiol were noted in 2 patients with slight gynaecomastia. It is concluded that long-term suppression of androgen production can be realized by high-dose ketoconazole treatment and that the degree of suppression is proportional to the serum levels of the drug.

Topics: 17-Ketosteroids; Dose-Response Relationship, Drug; Estradiol; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxysteroids; Ketoconazole; Luteinizing Hormone; Male; Progesterone; Prolactin; Prostatic Neoplasms; Testosterone; Transcortin

In cancer of the prostatic gland of stage II--III in males, 50--60 years, a reduced gonadial endocrine function is observed, that is manifested in a considerably reduced excretion of testosterone and estrogen. Because of the different rate of reduction in the testosterone and estrogen excretion in patients 50--69 years of age, one may observe the state of relative and in 70--80 years old patients--absolute hyperandrogenization of the organism, which is likely to be an unfavorable factor, taking into account the property of testosterone metabolites (dihydrotestosterone in particular) to enhance proliferative processes in the prostatic gland.

Topics: 17-Ketosteroids; Aged; Circadian Rhythm; Dehydroepiandrosterone; Estrogens; Humans; Male; Middle Aged; Prostatic Neoplasms; Testosterone

Specimens of ventral prostate from 37- to 46-month-old Andradurin-treated A X C rats demonstrated three primary morphologic patterns, each being divisible into two sub-groups based upon the extent of glandular alteration. The principal groups were: group 1, hyperplasia; group 2, atypical hyperplasia; and group 3, adenocarcinoma. The secondary classifications were: subgroup (+), few glands involved; and subgroup (++), most glands involved. Multiple parameters of ventral prostate testosterone metabolic potential failed to distinguish the morphologically diverse prostate specimens of groups (1+). 1(++), 2(+), 2(++), and 3(+) which predominantly metabolized testosterone to 5alpha-reduced 17beta-hydroxysteroids. By contrast, testosterone metabolism by ventral prostate specimens predominantly composed of neoplastic epithelium, group 3(++), was distinct from all other prostate specimens. The distinguishing feature was a shift to more prominent elaboration of 17-ketosteroids, principally delta4-androstenedione, and a cteroids. The change in this biochemical parameter of prostate epithelial cell function was indicated to be an early manifestation of the neoplastic transformation.

Topics: 17-Ketosteroids; Adenocarcinoma; Androstenedione; Animals; Dihydrotestosterone; Hydroxysteroids; Hyperplasia; Male; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Breast Neoplasms; Circadian Rhythm; Female; Humans; Kidney Neoplasms; Male; Mitotane; Neoplasms; Prostatic Neoplasms

The second fully documented case of ACTH-producing prostatic adenocarcinoma with elevated plasma and tissue levels of ACTH is presented. The distinguishing characteristics of ACTH-producing extrapituitary neoplasms and the various modes of therapy are discussed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Aged; Hormones, Ectopic; Humans; Hydrocortisone; Liver; Liver Neoplasms; Male; Neoplasm Metastasis; Prostate; Prostatic Neoplasms

Serum acid phosphatase activity, urinary total cholesterol, and ratio of deoxy to oxy urinary 17-ketosteroids were measured in a group of 42 patients with prostatic carcinoma and in a group of 14 age-matched normal healthy individuals. Our purpose was to evaluate whether or not the simultaneous determinations of these tests would increase the rate of detection obtained by the single assay alone. The results of single assay revealed for the following detection rate: 67 per cent (28 of 42 patients) for serum acid phosphatase, 62 per cent for urinary total cholesterol, and 22 per cent for ratio of 17-ketosteroids. A significant increase of detection rate was observed when simultaneous determinations of two assays were performed; 86 per cent for serum acid phosphatase activity and total urinary cholesterol; 74 per cent for serum acid phosphatase and ratio of 17-ketosteroids; and 74 per cent for total urinary cholesterol and ratio of 17-ketosteroids. A detection rate of 88 per cent (37 of 42 patients) was obtained as all three assays were analyzed, though it was not significantly different from a ratio of 86 per cent for simultaneous assays of acid phosphatase and total cholesterol. It was concluded that simultaneous determinations of serum acid phosphatase activity, urinary total cholesterol, and androgens are of values in diagnosis for patients with prostatic neoplasia.

Topics: 17-Ketosteroids; Acid Phosphatase; Aged; Androgens; Carcinoma; Cholesterol; Humans; Ketosteroids; Male; Middle Aged; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Aged; Brain; Electroencephalography; Humans; Male; Middle Aged; Prostatic Hyperplasia; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Aged; Electroencephalography; Estrogens; Humans; Hypothalamus; Male; Middle Aged; Pituitary Gland; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenalectomy; Aged; Biopsy; Cystoscopy; Diethylstilbestrol; Humans; Hydronephrosis; Male; Neoplasm Metastasis; Penile Neoplasms; Prognosis; Prostatic Neoplasms; Skin Neoplasms; Testis; Testosterone; Urinary Bladder Neoplasms; Urination Disorders

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Aged; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Evaluation Studies as Topic; Humans; Hypophysectomy; Male; Middle Aged; Neoplasm Metastasis; Pennsylvania; Prognosis; Prostatic Neoplasms; Radiography; Recurrence; Remission, Spontaneous; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Carcinoma; Chlormadinone Acetate; Estrogens; Evaluation Studies as Topic; Humans; Male; Medroxyprogesterone; Megestrol; Progesterone; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Blood Glucose; Dexamethasone; Humans; Male; Metyrapone; Middle Aged; Mitotane; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Potassium; Prostatic Neoplasms; Psychotic Disorders; Spironolactone

Topics: 17-Ketosteroids; Aged; Alkaline Phosphatase; Androgen Antagonists; Carcinoma; Cyproterone; Humans; Hydroxysteroids; Male; Middle Aged; Pain; Pregnadienes; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenal Glands; Aged; Androstenedione; Castration; Dexamethasone; Humans; Male; Middle Aged; Prostatic Neoplasms; Testis; Testosterone; Time Factors

Topics: 17-Ketosteroids; Acid Phosphatase; Aged; Alkaline Phosphatase; Anesthesia, Local; Castration; Cortisone; Cryosurgery; Estrogens; Follicle Stimulating Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Middle Aged; Neoplasm Metastasis; Palliative Care; Prostatic Neoplasms; Remission, Spontaneous; Stereotaxic Techniques; Testosterone

Topics: 17-Ketosteroids; Acid Phosphatase; Blood Proteins; Blood Sedimentation; Humans; Male; Mucoproteins; Prostatic Hyperplasia; Prostatic Neoplasms

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Aged; Androstanes; Carbon Isotopes; Chromatography, Paper; Dehydroepiandrosterone; Humans; Hydroxyprogesterones; In Vitro Techniques; Male; Middle Aged; Pregnenolone; Progesterone; Prostatic Neoplasms; Testis; Testosterone; Time Factors; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Castration; Gonadotropins; Humans; Male; Metyrapone; Middle Aged; Pituitary Irradiation; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adrenalectomy; Castration; Estrogens; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Hypophysectomy; Luteinizing Hormone; Male; Prostatic Neoplasms; Remission, Spontaneous; Testosterone

Normal, hyperplastic and adenocarcinomatous human prostatic tissue was perfused in vitro with radioactively labelled androstenedione, testosterone and 5alpha-dihydrotestosterone with and without added oestradiol-17beta. Various parameters of tissue-steroid relationship were measured at the steady state. When oestradiol (0.11 or 0.22mumol/l) was added to the perfusing medium, the entry of the steroids into the tissue and their metabolism was increased in the majority of the glands studied. The ;uptake' of all the steroids varied, in response to the addition of oestradiol, in both normal and adenocarcinomatous glands in a way differing from the response of hyperplastic glands. As a consequence, the tissue clearance of the steroids, particularly of androstenedione and testosterone, increased in normal and adenocarcinomatous glands in the presence of oestradiol, and decreased in the hyperplastic tissues. At a concentration 0.33mumol/l, oestradiol decreased the entry of the steroids in all the tissues studied, while the clearance of steroids tended to decrease. The significance of these findings in terms of the regulation of androgen dynamics in vivo in the normal and diseased human prostate, with particular regard to the response to oestrogen treatment, is discussed.

Topics: 17-Ketosteroids; Adenocarcinoma; Aged; Androgens; Androstanes; Carbon Isotopes; Estradiol; Humans; In Vitro Techniques; Male; Middle Aged; Prostate; Prostatic Neoplasms; Testosterone; Tritium

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Alkaline Phosphatase; Androgens; Bone Neoplasms; Cryosurgery; Follicle Stimulating Hormone; Follow-Up Studies; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Neoplasm Metastasis; Palliative Care; Pelvic Neoplasms; Prostatic Neoplasms; Remission, Spontaneous

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Breast Neoplasms; Carbon Isotopes; Carcinoma; Child; Child, Preschool; Chromatography; Dehydroepiandrosterone; Endocrine System Diseases; Etiocholanolone; Female; Humans; Infant; Male; Methods; Middle Aged; Polycystic Ovary Syndrome; Prostatic Neoplasms; Testosterone; Tritium

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Carbon Isotopes; Castration; Chromatography; Humans; Hypogonadism; Male; Prostatic Neoplasms; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Aged; Castration; Estrogens; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Prostatic Neoplasms

Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Animals; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hydrocortisone; Male; Methods; Middle Aged; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Ketosteroids; Acetates; Acid Phosphatase; Adenocarcinoma; Adenoma, Islet Cell; Adult; Aged; Biopsy; Blood Sedimentation; Estrogens; Hematuria; Humans; Male; Middle Aged; Neoplasm Metastasis; Prostatectomy; Prostatic Neoplasms; Radionuclide Imaging; Rectum; Urinary Incontinence

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Androgens; Castration; Chromatography, Gas; Chromatography, Thin Layer; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Age Factors; Aged; Humans; Male; Middle Aged; Prostatic Neoplasms; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Androgens; Castration; Diethylstilbestrol; Follow-Up Studies; Humans; Male; Middle Aged; Prostatic Neoplasms; Time Factors

Topics: 17-Ketosteroids; Acid Phosphatase; Alkaline Phosphatase; Androgen Antagonists; Body Weight; Gonadotropins, Pituitary; Gynecomastia; Hemoglobinometry; Humans; Male; Prostatic Neoplasms; Testosterone

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Female; Genital Neoplasms, Female; Humans; Male; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vaginal Neoplasms

Topics: 17-Ketosteroids; Adrenal Glands; Animals; Carcinoma; Chlormadinone Acetate; Estrogens; Gonadotropins, Pituitary; Gonads; Hydroxyprogesterones; Luteinizing Hormone; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Age Factors; Aged; Breast Neoplasms; Carcinoma; Epithelium; Estrogens; Gynecomastia; Humans; Japan; Liver Function Tests; Male; Middle Aged; Mitosis; Prostatic Hyperplasia; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Bone Neoplasms; Chromatography; Dehydroepiandrosterone; Female; Hodgkin Disease; Humans; Injections, Intramuscular; Laryngeal Neoplasms; Male; Nasopharyngeal Neoplasms; Neoplasms; Pituitary-Adrenal System; Polarography; Prostatic Neoplasms; Tibia; Uterine Cervical Neoplasms

Topics: 17-Ketosteroids; Acromegaly; Animals; Bone Neoplasms; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hypophysectomy; Male; Methods; Neoplasm Metastasis; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Estriol; Estrone; Hormones; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Estrogens; Female; Gonadotropins; Hormones; Humans; Lung Neoplasms; Male; Pregnanediol; Prostatic Neoplasms

Topics: 17-Ketosteroids; Aged; Androgens; Humans; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Lyases; Male; Microsomes; Middle Aged; Mitochondria; Mixed Function Oxygenases; Pregnenolone; Progesterone; Prostatic Neoplasms; Testis; Testosterone

Topics: 17-Ketosteroids; Androsterone; Blood Glucose; Blood Urea Nitrogen; Creatine; Creatinine; Etiocholanolone; Humans; Male; Pregnanediol; Prostatic Hyperplasia; Prostatic Neoplasms; Urine

Topics: 17-Ketosteroids; Castration; Estradiol; Humans; Male; Neoplasms; Orchiectomy; Prostatic Neoplasms; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenalectomy; Adrenocortical Hyperfunction; Aged; Dexamethasone; Diethylstilbestrol; Humans; Male; Neoplasm Metastasis; Neoplasms; Pathology; Prostatic Neoplasms; Surgical Procedures, Operative; Toxicology; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Castration; Estrogens; Gonadotropins; Humans; Male; Middle Aged; Pregnanediol; Prostatic Neoplasms; Testis; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Castration; Estrogens; Gonadotropins, Pituitary; Humans; Male; Middle Aged; Pituitary Irradiation; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Carcinoma; Estradiol; Estradiol Congeners; Estriol; Estrone; Geriatrics; Humans; Male; Prostatic Neoplasms; Stilbenes; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androsterone; Biopsy; Cortisone; Dehydroepiandrosterone; Diethylstilbestrol; Estriol; Estrone; Etiocholanolone; Geriatrics; Glucuronates; Humans; Male; Prednisone; Pregnanediol; Prostatectomy; Prostatic Neoplasms; Steroids; Sulfates; Testosterone; Urine; Vitamin D Deficiency

In patients with breast and prostate cancer hormone excretion patterns differ in a similar way from patterns in persons without cancer.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Androsterone; Breast Neoplasms; Creatine; Creatinine; Estradiol; Estriol; Estrone; Etiocholanolone; Gonadotropins; Humans; Male; Menopause; Metabolism; Neoplasms; Pregnanediol; Prostatic Neoplasms; Urine

Topics: 17-Ketosteroids; Castration; Cesium Isotopes; Cobalt Isotopes; Drug Therapy; Estrogens; Gonadotropins; Humans; Hypogonadism; Male; Neoplasms; Pathology; Phosphorus Isotopes; Prostatectomy; Prostatic Neoplasms; Radioisotope Teletherapy; Testis; Urine; Urography

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood Chemical Analysis; Eosinophils; Gonadotropins; Humans; Leukocyte Count; Male; Neoplasms; Neoplasms, Experimental; Physiology; Prostatic Neoplasms; Rabbits; Rats; Research; Surgical Procedures, Operative; Thymectomy; Thymus Gland; Urinary Tract; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Diagnosis, Differential; Humans; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Urine

Topics: 17-Ketosteroids; Biopsy; Estrogens; Humans; Male; Phosphorus; Phosphorus Radioisotopes; Prostatic Neoplasms; Radiography; Seminal Vesicles

Topics: 17-Ketosteroids; Castration; Chorionic Gonadotropin; Estrogens; Gonadotropins; Humans; Male; Orchiectomy; Prostatic Neoplasms; Testis

Topics: 17-Ketosteroids; Humans; Male; Prostatic Neoplasms; Urology

Topics: 17-Ketosteroids; Humans; Male; Prostatic Neoplasms

Topics: 17-Ketosteroids; Gonadal Steroid Hormones; Humans; Male; Prostatic Neoplasms

Topics: 17-Ketosteroids; Biological Transport; Body Fluids; Humans; Male; Norethandrolone; Progesterone; Prostatic Neoplasms

Topics: 17-Ketosteroids; Carcinoma; Cortisone; Hormones; Humans; Lung Neoplasms; Male; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Estradiol Congeners; Estrogens; Humans; Male; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Breast Neoplasms; Castration; Eosinophils; Humans; Leukocyte Count; Male; Mastectomy; Phosphoric Monoester Hydrolases; Prostatic Neoplasms

Topics: 17-Ketosteroids; Chronic Disease; Diagnosis, Differential; Humans; Male; Neoplasms; Prostatic Neoplasms; Prostatitis; Steroids

Topics: 17-Ketosteroids; Biological Transport; Cortisone; Humans; Male; Prostatic Neoplasms; Steroids; Urine

Topics: 17-Ketosteroids; Estrogens; Humans; Male; Pituitary Gland; Prostatic Neoplasms; Steroids; Testis; Urine

Topics: 17-Ketosteroids; Humans; Male; Prostatic Neoplasms; Steroids

Topics: 17-Ketosteroids; Eosinophils; Hormones; Humans; Leukocyte Count; Male; Prostatic Neoplasms

Topics: 17-Ketosteroids; Body Fluids; Humans; Ketosteroids; Male; Prostatic Neoplasms; Urine

Topics: 17-Ketosteroids; Adsorption; Humans; Male; Prostatic Neoplasms; Steroids; Urinary Tract; Urine