17-ketosteroids and Pituitary-Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hyperplasia; Male; Middle Aged; Pituitary Neoplasms; Precancerous Conditions

Transsphenoidal adenomectomy is currently the first choice for treatment of patients with pituitary ACTH-dependent Cushing's syndrome. However, pharmacotherapy is prescribed for some patients, e.g., unsuccessful surgery. We treated a woman in whom pituitary Cushing's syndrome was improved while she was on antimuscarinic cholinergic agents, atropine sulphate and pirenzepine hydrochloride. The diminished effect of anticholinergics on ACTH and cortisol was incidentally identified in an inferior petrosal sinus sampling procedure. A single intramuscular injection of atropine significantly decreased both ACTH (43.9 pg/ml to less than 12.0; normal, 12.0-40.0 pg/ml) and cortisol (29.9 microg/dl to 13.6; normal, 7.6-23.6 microg/dl). An M1-muscarinic receptor specific antagonist, pirenzepine hydrochloride, also had a diminishing effect on these hormones and this inhibiting effect was partially blocked by the simultaneous administration of an anticholinesterase agent, pyridostigmine bromide. Chronic oral ingestion of these agents led to improvement in clinical symptoms, and urinary 17-hydroxycorticosteroid and 17-ketosteroid levels were at normal to upper-normal levels. This is the first documentation of involvement of the cholinergic system in the pathogenesis of pituitary Cushing's syndrome.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenocorticotropic Hormone; Atropine; Choline; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Metyrapone; Middle Aged; Muscarinic Antagonists; Petrosal Sinus Sampling; Pirenzepine; Pituitary Neoplasms

We developed a new method for measuring an unidentified ketosteroid glucuronide (US-G) detected by the method of Iwata et al. for measuring 17-ketosteroid glucuronides by reversed phase HPLC on a Capcell-Pak C8 column with three kinds of mobile phase solutions (Iwata method; Clin Chem 35: 795-799, 1989). The Iwata method inadequately separated US-G and two hydroxy 17-ketosteroides, 11 beta-hydroxyetiocholanolone and 11 beta-hydroxyandrosterone, and it exhibits insufficient sensitivity for measuring traces of US-G in the urine of healthy subjects. We solved these problems by developing a new method which measures US-G in urine, as a free type by hydrolyzing the glucuronide type enzymatically, by normal phase HPLC on a Capcell-Pak Silica column with one kind of mobile phase solution. By this method, the levels of US excreted as a glucuronide in the urine of healthy subjects and of patients with Cushing's syndrome were determined as proportions of the levels of 11 beta-hydroxyandrosterone. The average daily urinary excretion of US was 971 micrograms (125-4,995 micrograms) in patients with Cushing's syndrome (n = 22: two males and 20 females aged 26 to 65 years), and 34 micrograms (0-141 micrograms) in healthy subjects (n = 63: 49 males, and 14 females aged 21 to 54 years), and the differences were clearly significant. However, there were no differences between the urinary US levels of patients with pituitary adenoma and patients with adrenal adenoma. Furthermore, no US was detected in the urine of patients with aldosteronism (two males and eight females aged 34 to 61 years).(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: 17-Ketosteroids; Adenoma; Adult; Aged; Chromatography, High Pressure Liquid; Cushing Syndrome; Female; Glucuronates; Humans; Ketosteroids; Male; Middle Aged; Pituitary Neoplasms; Reference Values

A previously unknown HPLC peak was recently observed in urine samples from patients with Cushing's syndrome and disease. We analysed dansylated derivatives of 17keto steroid glucuronides in urine samples from patients with Cushing's syndrome, Cushing disease and from healthy subjects using high-performance liquid chromatography (HPLC) on reversed-phase Cap Cell PakC8. All urine samples from patients with Cushing's syndrome caused by adrenal adenoma and Cushing's disease showed an unknown large peak at the point between [110HE-G] and [110HA-G] peaks and at a retention time of 25.4 min. The same unknown peak was also observed in urine samples from a patient with asymptomatic cortisol-producing adrenal adenoma and two patients with ectopic ACTH-producing tumor, though the peak height was low for the former and one of the latter but high for the second of the two patients. In contrast, healthy male and female urine only showed a very small peak at the same retention time. Urine samples from a Cushing disease treated with op'DDD and Cushing's syndrome bilaterally adrenalectomized and treating with cortisol showed no such peak. The retention time of this unknown peak is clearly different from that of seven 17keto steroid standard glucuronide conjugates. The structure of this substance may be closely related to [110HE-G] or [110HA-G].

Topics: 17-Ketosteroids; Adenoma; Adenoma, Basophil; Adrenal Gland Neoplasms; Adult; Androstane-3,17-diol; Chromatography, High Pressure Liquid; Cushing Syndrome; Female; Hormones; Humans; Male; Middle Aged; Pituitary Neoplasms

A 40-year-old white woman presented with hirsutism, amenorrhea, generalized fatigue, diffuse weight gain, acral changes, and coarsened facial features. Physical examination revealed mild diastolic hypertension, acromegalic features, hirsutism, and seborrhea. The growth hormone concentration was elevated and did not suppress after glucose administration. Urinary free cortisol excretion was increased and was not suppressed during a 2 mg low-dose dexamethasone suppression test. Magnetic resonance imaging of the sella demonstrated a 1.3 x 1.2 x 0.8 cm pituitary adenoma. Trans-sphenoidal resection was performed, and portions of the resected tumor were analyzed by routine pathologic methods. Histopathologic and immunohistochemical findings indicated discrete growth hormone- and adrenocorticotropic hormone-producing pituitary adenomas. Coexisting acromegaly and Cushing's syndrome due to pituitary neoplasia was previously reported in two patients. However, to the authors' knowledge, this represents the first description of a patient with acromegaly and Cushing's disease resulting from discrete synchronous adenomas of the pituitary gland as defined by modern histopathologic techniques.

Topics: 17-Ketosteroids; Acromegaly; Adenoma; Adult; Cushing Syndrome; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Female; Hirsutism; Humans; Hydrocortisone; Magnetic Resonance Imaging; Pituitary Neoplasms; Reference Values; Testosterone

Effects of o,p'-DDD on parameters of cortisol metabolism were studied in 3 patients with Cushing's syndrome (ectopic ACTH-syndrome, Cushing's disease, and adrenal cancer). Before o,p'-DDD treatment, plasma cortisol, urinary 17OHCS, and urinary free cortisol were elevated in all patients. These parameters correlated well with each other in ectopic ACTH-syndrome and Cushing's disease. However, in adrenal cancer, urinary 17OHCS did not correlate with either plasma cortisol or urinary free cortisol, while the latter two parameters did. During o,p'-DDD, urinary 17OHCS rapidly declined in a patient with ectopic ACTH syndrome and a patient with Cushing's disease before plasma cortisol or urinary free cortisol decreases. Consequently the positive correlations of urinary 17OHCS with the other parameters were lost. In a case of adrenal cancer, urinary 17OHCS again did not correlate with plasma cortisol or urinary free cortisol. In these conditions, plasma cortisol and urinary free cortisol still significantly correlated. The present results demonstrated the limit of urinary 17OHCS as the index of the cortisol secretion rate both in some cases of adrenal cancer and in patients taking o,p'-DDD. It is suggested that urinary free cortisol should be utilized as a more accurate index for the cortisol secretion rate in such circumstances.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoid Tumor; Cushing Syndrome; Female; Humans; Hydrocortisone; Male; Middle Aged; Mitotane; Pituitary Neoplasms; Radioimmunoassay; Thymus Neoplasms

A middle-aged man presented with weight loss, hypokalemic alkalosis, diabetes, hypertension, and generalized melanosis. Marked elevation of urinary free cortisol (655 micrograms/24 h) and plasma ACTH (2445 PG/ML) SUGGESTED THE DIAGNOSIS OF ECTOPIC ACTH syndrome. The plasma concentrations of cortisol and urinary 17-hydroxycorticosteroids increased paradoxically during the administration of dexamethasone without a corresponding change in the plasma ACTH level. Metyrapone administered over 24 h also markedly incrased both urinary free cortisol and 17-hydroxycorticosteroids. Selective venous sampling of plasma ACTH did not reveal a gradient between jugular vein and peripheral venous blood. The laboratory findings supported the diagnosis of ectopic ACTH syndrome. However, belated occurrence of visual changes necessitated surgical exploration, resulting in the diagnosis of pituitary carcinoma. A fluorescent antibody to ACTH reacted strongly with the atypical pituitary cells. This rare case documents that severe melanosis in Cushing's disease can occur without prior adrenalectomy and is consistent with the diagnosis of pituitary carcinoma. Furthermore, melanosis observed in patients with pituitary carcinoma is associated with ACTH levels similar to those occurrring in the ectopic ACTH or Nelson's syndrome.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Dexamethasone; Diagnosis, Differential; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged; Pituitary Diseases; Pituitary Neoplasms

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Child; Cushing Syndrome; Female; Humans; Hydrocortisone; Male; Pituitary Neoplasms; Pregnancy

Pre- and postoperative visual and endocrine functions were examined in 54 patients with so-called chromophobe pituitary adenomas operated on by the transnasal approach. The preoperative examination showed visual disturbances in 41 of 48 patients. A loss of gonadal function was present in 93% of the women and 69% of the men. Impairment of adrenal function was found in 37% and of thyroid function in 18% of patients. Hyperprolactinemia was present in 16 of 29 patients examined. The visual findings remained unchanged, normal or improved in 75% of patients. Impairment occurred in 3%. Eight patients experienced improvement of gonadal function and 3 of adrenal function, whereas no postoperative improvement of the thyroid function was observed. Deterioration of gonadal function occurred in 4, of adrenal function in 7, and of thyroid function in 9 patients. Hyperprolactinemia was reduced in all cases.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Chromophobe; Adolescent; Adult; Aged; Erectile Dysfunction; Female; Humans; Male; Menstruation; Middle Aged; Pituitary Neoplasms; Prolactin; Thyroxine; Triiodothyronine; Visual Acuity; Visual Fields

A cyclic excess of cortisol secretion was detected in a patient with diabetes insipidus and diabetes mellitus. The cycles of hypercortisolism were of 7 days' duration, but during the nadir of these cycles urinary excretion of corticosteroids and 17-ketosteroids was within the normal range. The radiological appearance of the sella turcica was normal; however, computerized axial tomography of the head revealed a small tumor immediately superior to the sella turcica. At operation a small chromophobe adenoma superior to the diaphragma sellae and involving the hypophysial stalk was partially resected. Postoperatively, the patient continued to have 7-day cycles of increased corticosteroid excretion, but the amounts excreted were less than they had been preoperatively. Other patients have been described in whom Cushing's disease has been due to cyclic hypercortisolism. These cycles have been remarkably regular in individual patients, but of variable duration in different patients. Furthermore, cyclic hormonogenesis probably occurs in a variety of endocrinopathies. (Neurosurgery, 5: 598--603, 1979).

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Chromophobe; Adrenal Cortex; Adult; Cushing Syndrome; Dexamethasone; Diabetes Insipidus; Humans; Hydrocortisone; Male; Periodicity; Pituitary Neoplasms; Vasopressins

Pituitary function has been studied sequentially after transsphenoidal removal of pituitary microadenomas in two men with Cushing's disease. Patient 1 gradually regained normal glucocorticoid levels with normal diurnal variation, metyrapone responsiveness, and low dose dexamethasone suppressibility (17-hydroxycorticosteroid, 6.5-0.9 mg/24 h). GH levels rose from 1 to 35 ng/ml during insulin hypoglycemia and from 2.3 to 27 ng/ml during arginine infusion. PRL secretion rose normally in response to thorazine, and gonadotropin and TSH levels remained normal. Patient 2 regained significant metyrapone responsiveness by 9 months postoperatively (11-deoxycortisol rose to 11.7 micrograms/dl), had a normal spontaneous nocturnal rise in PRL secretion, and normal levels of testosterone and thyroid hormones. The return to normal of cortisol-ACTH dynamics and GH responsiveness in Patient 1 and the normal nocturnal surge in PRL secretion in Patient 2 imply that in these patients the etiology of Cushing's disease was not related to hypothalamic dysfunction.

Topics: 17-Ketosteroids; Adenoma; Adult; Cushing Syndrome; Follicle Stimulating Hormone; Humans; Hydrocortisone; Insulin; Luteinizing Hormone; Male; Metyrapone; Pituitary Gland; Pituitary Neoplasms; Thyroxine

The presenting signs, symptoms, roentgenographic findings, endocrine evaluations, treatment, and results in 68 cases of presumed pituitary adenomas treated over an 18-year period are discussed. The most common symptoms were headache, acromegalic changes, visual symptoms, and amenorrhea. Most common physical findings were obesity, acromegaly, and visual field defects, usually bitemporal hemianopsia. Roentgenographic evidence of sellar erosion was almost universal but angiography and pneumoencephalography were required to evaluate suprasellar extension. Brain scan was not considered a particularly useful diagnostic tool. Endocrine status was best evaluated by a battery of tests including 17-OH, 17-KS, T3, T4, PBI, ACTH stimulation, and FSH and STH levels. (Prolactin levels are currently being obtained, also). Surgical specimens were obtained in 29 patients, with subsequent diagnoses of 22 chromophobe adenomas, five eosinophilie adenomas, one cystic adenoma, and one necrotic tumor. All five eosinophilic tumors came from acromegalic patients. Patients treated by operation alone or operation followed by radiotherapy generally had less "medical morbidity" than did patients who received radiotherapy alone.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adenoma; Adenoma, Acidophil; Adenoma, Chromophobe; Adolescent; Adult; Aged; Amenorrhea; Carotid Arteries; Female; Follow-Up Studies; Humans; Hypophysectomy; Male; Middle Aged; Neoplasm Recurrence, Local; Optic Atrophy; Pituitary Irradiation; Pituitary Neoplasms; Pneumoencephalography

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Chromophobe; Cortisone; Drinking; Ethanol; Growth Hormone; Humans; Hyponatremia; Hypopituitarism; Male; Middle Aged; Osmolar Concentration; Pituitary Neoplasms; Urination; Vasopressins

Topics: 17-Ketosteroids; Acromegaly; Adenoma, Chromophobe; Adult; Biopsy; Diagnosis, Differential; Humans; Male; Nasal Polyps; Nasopharynx; Pituitary Neoplasms; Radiography

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Chromophobe; Adrenocorticotropic Hormone; Adult; Arginine; Blood Glucose; Craniopharyngioma; Diagnosis, Differential; Female; Glucose; Glucose Tolerance Test; Gonadotropins, Pituitary; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Insulin; Male; Metyrapone; Middle Aged; Pituitary Gland; Pituitary Hormones, Anterior; Pituitary Neoplasms; Pituitary-Adrenal System; Sella Turcica; Thyroid Gland; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Aged; Circadian Rhythm; Diencephalon; Endocrine System Diseases; Female; Humans; Hypopituitarism; Male; Middle Aged; Pituitary Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Antigens; Blood Glucose; Cortisone; Creatinine; Dexamethasone; Disorders of Sex Development; Eunuchism; Gigantism; Growth Hormone; Humans; Hydrocortisone; Hypophysectomy; Insulin; Male; Metyrapone; Pituitary Neoplasms; Thyrotropin; Time Factors; Yttrium Isotopes

Topics: 17-Ketosteroids; Adenoma, Chromophobe; Adult; Amenorrhea; Clomiphene; Estradiol; Estriol; Female; Gonadotropins; Humans; Infertility, Female; Pituitary Neoplasms; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Radiography

Topics: 17-Ketosteroids; Adult; Arginine; Corticosterone; Cushing Syndrome; Diagnosis, Differential; Female; Growth Hormone; Humans; Hypothyroidism; Iodine Radioisotopes; Lactation Disorders; Luteinizing Hormone; Middle Aged; Pituitary Neoplasms; Pregnancy; Stimulation, Chemical; Thyroid Function Tests; Thyroid Gland; Triiodothyronine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Child; Endocrine System Diseases; Female; Growth Hormone; Humans; Male; Middle Aged; Pharyngeal Neoplasms; Pituitary Diseases; Pituitary Neoplasms; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adenoma; Cardiac Catheterization; Cerebral Ventriculography; Electrocardiography; Follicle Stimulating Hormone; Heart Failure; Humans; Male; Middle Aged; Pituitary Neoplasms; Thyroid Function Tests

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Female; Glucocorticoids; Humans; Male; Middle Aged; Pituitary Neoplasms

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anorexia Nervosa; Cushing Syndrome; Diagnosis, Differential; Female; Fluorometry; Hirsutism; Humans; Hypopituitarism; Injections, Intravenous; Klinefelter Syndrome; Male; Methods; Obesity; Pituitary Neoplasms; Spectrophotometry; Turner Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adult; Age Factors; Diabetes Insipidus; Female; Humans; Hypopituitarism; Hypothyroidism; Male; Middle Aged; Pituitary Diseases; Pituitary Neoplasms; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Basophil; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Chromatography, Paper; Cushing Syndrome; Dexamethasone; Female; Heart Arrest; Humans; Metyrapone; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Postoperative Complications

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Cerebral Angiography; Craniopharyngioma; Female; Growth Hormone; Humans; Male; Pituitary Neoplasms; Pneumoencephalography; Skull; Vision Disorders; Visual Fields

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Female; Humans; Male; Middle Aged; Pituitary Neoplasms

Topics: 17-Ketosteroids; Adenoma; Adult; Estrogens; Female; Gonadotropins; Humans; Hypophysectomy; Neoplasm Recurrence, Local; Pituitary Neoplasms; Pregnancy; Pregnancy Complications

Topics: 17-Ketosteroids; Adenoma, Chromophobe; Cushing Syndrome; Diabetic Nephropathies; Female; Heart Diseases; Humans; Hydrocortisone; Middle Aged; Pituitary Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenocorticotropic Hormone; Adult; Basal Metabolism; Female; Humans; Hypopituitarism; Male; Metyrapone; Pituitary Function Tests; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Postoperative Complications; Radiography

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Aldosterone; Cushing Syndrome; Diet, Sodium-Restricted; Diuresis; Humans; Hydrocortisone; Male; Natriuresis; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Potassium; Radiography; Secretory Rate; Sella Turcica; Sodium; Urea

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Cushing Syndrome; Female; Humans; Middle Aged; Pituitary Neoplasms; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Dexamethasone; Female; Growth Hormone; Humans; Hydrocortisone; Metyrapone; Pituitary Neoplasms; Urine; Virilism

Topics: 17-Ketosteroids; Adenoma, Chromophobe; Adrenalectomy; Adult; Cushing Syndrome; Female; Humans; Pituitary Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adult; Animals; Estradiol; Estrogens; Female; Follow-Up Studies; Goiter; Humans; Iodine Isotopes; Male; Metabolism, Inborn Errors; Mice; Neoplasm Metastasis; Pituitary Neoplasms; Radiography, Thoracic; Rats; Thiouracil; Thyroid Neoplasms; Thyrotropin; Thyroxine; Triiodothyronine

Topics: 17-Ketosteroids; Adenoma; Adenoma, Acidophil; Adenoma, Basophil; Adolescent; Adrenal Cortex Hormones; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Blood Chemical Analysis; Choristoma; Cushing Syndrome; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hypophysectomy; Iodine Isotopes; Myxedema; Neoplasms; Pathology; Pituitary Neoplasms; Radiography; Radioisotopes; Radionuclide Imaging; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Basal Metabolism; Brain Neoplasms; Diencephalon; Geriatrics; Gonadotropins; Menstruation; Neurology; Pituitary Neoplasms; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Biomedical Research; Clinical Laboratory Techniques; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Blood Chemical Analysis; Craniopharyngioma; Diencephalon; Laurence-Moon Syndrome; Muscle Spasticity; Paralysis; Physiology; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Amenorrhea; Chemical Phenomena; Chemistry; Chromatography; Diencephalon; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Hexestrol; Humans; Hypopituitarism; Klinefelter Syndrome; Menstruation; Ovary; Pharmacology; Physiology; Pituitary Gland; Pituitary Neoplasms; Pregnanediol; Turner Syndrome; Urine; Uterine Hemorrhage

Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Androgens; Child; Cobalt; Cobalt Isotopes; Dwarfism; Dwarfism, Pituitary; Growth Hormone; Humans; Hypopituitarism; Male; Neoplasms; Pituitary Diseases; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Laboratory Techniques; Cushing Syndrome; Cysts; Female; Humans; Hypogonadism; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Neoplasms; Ovary; Pharmacology; Pituitary Gland; Pituitary Neoplasms; Radioisotope Teletherapy; Scleroderma, Systemic; Sexual Infantilism; Toxicology; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Brain Diseases; Brain Neoplasms; Craniopharyngioma; Diencephalon; Eosinophilic Granuloma; Eosinophils; Humans; Hydrocortisone; Neoplasms; Pituitary Gland; Pituitary Irradiation; Pituitary Neoplasms; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Acromegaly; Adenoma; Chromatography; Growth Hormone-Secreting Pituitary Adenoma; Humans; Neoplasms; Pituitary Gland; Pituitary Neoplasms; Radiotherapy; Steroids