17-ketosteroids and Pituitary-Diseases

Topics: 17-Ketosteroids; Adaptation, Psychological; Addison Disease; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Cortisone; Cushing Syndrome; Dexamethasone; Female; Genitalia, Female; Glucocorticoids; Growth; Humans; Hydrocortisone; Hyperplasia; Male; Pituitary Diseases; Pituitary Gland; Prognosis; Sodium Chloride; Sodium Salicylate

Lymphocytic hypophysitis usually occurs in the antepartum or postpartum period and recovery of pituitary dysfunction has not been documented in most cases reported previously. We present a 50-year-old woman with lymphocytic hypophysitis who spontaneously recovered from panhypopituitarism over 18 months with the disappearance of an intrasellar mass. Although lymphocytic hypophysitis is thought to be an autoimmune disease, the clinical and pathogenetic significance of circulating antipituitary autoantibodies has not been clarified. Antipituitary antibodies were studied by immunofluorescence in blood samples obtained during the whole clinical course in this particular patient. Antibodies against rat pituitary cytosol were positive during the period of hypopituitarism and became negative when pituitary function recovered. Antibodies reacting with intact prolactin-secreting rat GH3 and corticotropin-secreting mouse AtT-20 cells were also positive during her period of hypopituitarism. They remained positive for several years after the recovery of pituitary function. We conclude that circulating antibodies against rat pituitary cytosol are good markers of pituitary inflammation in this patient. The other point to be emphasized in this case is the simultaneous development of painless thyroiditis and lymphocytic hypophysitis. We have discussed the pathogenic relationship of these two diseases on the basis of similar cases reported previously.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Autoantibodies; Autoimmune Diseases; Female; Growth Hormone; Humans; Hydrocortisone; Hypopituitarism; Hypothyroidism; Inflammation; Lymphocytosis; Middle Aged; Pituitary Diseases; Pituitary Gland; Pituitary Hormones; Thyroid Hormones; Thyroiditis; Thyroxine; Tomography, X-Ray Computed

A middle-aged man presented with weight loss, hypokalemic alkalosis, diabetes, hypertension, and generalized melanosis. Marked elevation of urinary free cortisol (655 micrograms/24 h) and plasma ACTH (2445 PG/ML) SUGGESTED THE DIAGNOSIS OF ECTOPIC ACTH syndrome. The plasma concentrations of cortisol and urinary 17-hydroxycorticosteroids increased paradoxically during the administration of dexamethasone without a corresponding change in the plasma ACTH level. Metyrapone administered over 24 h also markedly incrased both urinary free cortisol and 17-hydroxycorticosteroids. Selective venous sampling of plasma ACTH did not reveal a gradient between jugular vein and peripheral venous blood. The laboratory findings supported the diagnosis of ectopic ACTH syndrome. However, belated occurrence of visual changes necessitated surgical exploration, resulting in the diagnosis of pituitary carcinoma. A fluorescent antibody to ACTH reacted strongly with the atypical pituitary cells. This rare case documents that severe melanosis in Cushing's disease can occur without prior adrenalectomy and is consistent with the diagnosis of pituitary carcinoma. Furthermore, melanosis observed in patients with pituitary carcinoma is associated with ACTH levels similar to those occurrring in the ectopic ACTH or Nelson's syndrome.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Dexamethasone; Diagnosis, Differential; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged; Pituitary Diseases; Pituitary Neoplasms

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Cortisone; Female; Humans; Pituitary Diseases

The manifestations that comprise the disease known as Nelson syndrome are pituitary hyperplasia and cutaneous hyperpigmentation, which sometimes follow bilateral adrenalectomy, in patients with hypercortisolism. We present a comprehensive endocrinologic, structural study of a patient in whom the evidence obtained supports the hypotheses that: (a) the primary disorder in this form of hypercortisolism is probably hypothalamic; (b) the hyperplasia of the adenohypophysis, following adrenalectomy, is closely associated with lowered plasma cortisol levels; and (c) the cillular hyperplasia in the adenohypophysis involves primarily the corticotroph, a cell believed to be associated with the secretion of adrenocorticotrophic hormone and melanocyte-stimulating hormone.

Topics: 17-Ketosteroids; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Female; Humans; Melanocyte-Stimulating Hormones; Pigmentation Disorders; Pituitary Diseases; Pituitary Gland; Pituitary Gland, Anterior; Syndrome

Topics: 17-Ketosteroids; Administration, Oral; Adolescent; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Chromatography, Gas; Depression, Chemical; Female; Growth Hormone; Humans; Hypoglycemia; Hypothyroidism; Infant; Male; Metyrapone; Pituitary Diseases; Pregnanediol; Pregnanediones; Pregnanetriol; Stimulation, Chemical; Thyrotropin; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Blood Proteins; Child; Creatinine; Cushing Syndrome; Depression, Chemical; Dexamethasone; Female; Humans; Hydrocortisone; Kidney; Male; Metyrapone; Middle Aged; Pituitary Diseases; Protein Binding

Topics: 17-Ketosteroids; Adolescent; Adult; Blood Glucose; Brain Abscess; Cerebrospinal Fluid Proteins; Corynebacterium; Female; Glucose; Gonadotropins, Pituitary; Humans; Hydroxysteroids; Pituitary Diseases; Pneumoencephalography; Sella Turcica; Staphylococcus

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocortical Hyperfunction; Adult; Amenorrhea; Androgens; Estrogens; Female; Hirsutism; Humans; Infertility, Female; Mosaicism; Obesity; Pituitary Diseases; Polycystic Ovary Syndrome; Pregnanediol; Pregnanetriol; Sex Chromosome Aberrations; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Gland Diseases; Bone Diseases; Cushing Syndrome; Dwarfism, Pituitary; Endocrine System Diseases; Female; Gigantism; Growth Hormone; Humans; Male; Ossification, Heterotopic; Pituitary Diseases; Radiography; Thyroid Diseases; Thyroid Hormones

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Amenorrhea; Body Constitution; Diabetes Complications; Dysmenorrhea; Endometrium; Estrone; Female; Fertility; Gonadotropins; Humans; Menarche; Menstruation Disturbances; Middle Aged; Ovarian Diseases; Pituitary Diseases; Pregnanediol; Puberty; Sex Chromosome Aberrations; Thyroid Diseases; Uterine Diseases; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Diabetes Complications; Female; Follicle Stimulating Hormone; Growth Hormone; Headache; Humans; Hypoglycemia; Hypopituitarism; Infarction; Iodine Isotopes; Lactation Disorders; Luteinizing Hormone; Pituitary Diseases; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Thyroid Function Tests; Thyrotropin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Child; Endocrine System Diseases; Female; Growth Hormone; Humans; Male; Middle Aged; Pharyngeal Neoplasms; Pituitary Diseases; Pituitary Neoplasms; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adult; Amenorrhea; Autopsy; Chlorides; Diagnosis, Differential; Duodenum; Female; Gastric Juice; Humans; Intestines; Jejunum; Pancreas; Parathyroid Neoplasms; Peritonitis; Pituitary Diseases; Potassium; Radiography; Sodium; Stomach; Vaginal Smears; Zollinger-Ellison Syndrome

Topics: 17-Ketosteroids; Brain Diseases; Diencephalon; Gonadotropins; Humans; Hydrocortisone; Insulin; Pituitary Diseases; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adult; Age Factors; Diabetes Insipidus; Female; Humans; Hypopituitarism; Hypothyroidism; Male; Middle Aged; Pituitary Diseases; Pituitary Neoplasms; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Biopsy; Brain Neoplasms; Cholesteatoma; Cortisone; Craniopharyngioma; Diabetes Insipidus; Female; Follicle Stimulating Hormone; Growth Disorders; Hair; Humans; Hypertonic Solutions; Hypogonadism; Hypopituitarism; Hypothalamus; Male; Metyrapone; Middle Aged; Pinealoma; Pituitary Diseases; Polyuria; Radiography; Sella Turcica; Skull; Testis; Thirst; Thyroid Function Tests; Visual Fields; Water

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acanthosis Nigricans; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Dexamethasone; Endocrine System Diseases; Female; Humans; Male; Obesity; Pituitary Diseases; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Child, Preschool; Dwarfism, Pituitary; Electrophoresis; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Insulin; Ion Exchange Resins; Male; Pituitary Diseases; Radioimmunoassay; Thyroid Diseases; Thyrotropin; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Arginine; Blood; Blood Glucose; Diabetes Complications; Female; Glucose Tolerance Test; Growth Hormone; Hemorrhage; Humans; Hydrocortisone; Insulin; Islets of Langerhans; Necrosis; Osmolar Concentration; Pituitary Diseases; Thyroxine; Tolbutamide; Urine

Topics: 17-Ketosteroids; Amenorrhea; Diagnosis, Differential; Female; Genital Diseases, Female; Gonadotropins; Humans; Pituitary Diseases; Sex Chromosomes; Turner Syndrome

Topics: 17-Ketosteroids; Adolescent; Adult; Androgens; Androsterone; Castration; Child; Chromatography; Etiocholanolone; Female; Humans; Hypothalamic Diseases; Hypothalamus; Male; Mathematics; Methods; Pituitary Diseases; Propionates; Testosterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Busulfan; Female; Humans; Male; Metyrapone; Middle Aged; Pituitary Diseases; Pituitary-Adrenal System; Polycythemia Vera; Primary Myelofibrosis; Splenectomy; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Obesity; Pituitary Diseases; Pituitary-Adrenal Function Tests; Potassium; Sodium; Turner Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing Syndrome; Diabetes Mellitus; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary Irradiation; Thyroid Function Tests; Urine; Yttrium Isotopes

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Gonadotropins; Gonadotropins, Pituitary; Hypopituitarism; Myxedema; Pituitary Diseases; Thyroxine; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hypophysectomy; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Biomedical Research; Ketones; Metabolism; Metyrapone; Mineralocorticoid Receptor Antagonists; Physiology; Pituitary Diseases; Pituitary Gland; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Prednisolone; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Anorexia Nervosa; Humans; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Physiology; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Pituitary Diseases; Puerperal Disorders; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Adolescent; Blood Coagulation Disorders; Chromosome Aberrations; Corpus Luteum; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Metrorrhagia; Pituitary Diseases; Pituitary Gland; Puberty; Sexual Maturation; Thyroid Gland

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Biomedical Research; Creatine; Creatinine; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Neuromuscular Nondepolarizing Agents; Parasympathomimetics; Physiology; Pituitary Diseases; Pituitary Gland; Thymoma; Urine

Topics: 17-Ketosteroids; Biological Assay; Biomedical Research; Body Temperature; Chromatography; Drug Therapy; Endometrial Hyperplasia; Ethinyl Estradiol; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Megestrol; Menstruation; Ovulation; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Pregnanediol; Progestins; Urine; Vaginal Smears

Topics: 17-Ketosteroids; Child; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Growth; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Pituitary Diseases; Pituitary Gland; Pregnanediol; Prognosis; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Adolescent; Androgens; Chorionic Gonadotropin; Eunuchism; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypogonadism; Male; Metabolism; Pituitary Diseases; Pituitary Gland; Sex Chromatin; Spermatozoa

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Asthma; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Pituitary Diseases; Pituitary Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Biomedical Research; Blood; Cerebrovascular Disorders; Geriatrics; Humans; Metyrapone; Physiology; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Stroke; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Gonads; Humans; Physiology; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Pregnanediol; Schizophrenia; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Cortisone; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Prednisolone; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Communication; Drug Therapy; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Diagnosis; Gonadotropins; Gonadotropins, Pituitary; Humans; Male; Pituitary Diseases; Pituitary Gland; Testis; Urine; Urology

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amenorrhea; China; Dwarfism; Dwarfism, Pituitary; Estrogens; Female; Glucose Tolerance Test; Humans; Hypopituitarism; Infertility; Leukocyte Count; Liver Function Tests; Pituitary Diseases; Pituitary Gland; Schistosomiasis; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Adolescent; Child; Diabetes Insipidus; Dwarfism; Dwarfism, Pituitary; Humans; Hypothyroidism; Infant; Infant, Newborn; Laurence-Moon Syndrome; Lipodystrophy; Obesity; Pituitary Diseases; Pituitary Gland; Progeria; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood Chemical Analysis; Electricity; Estrogens; Gonadotropins; Hypothalamus; Pharmacology; Physiology; Pituitary Diseases; Pituitary Gland; Thyrotropin; Urine; Vasopressins

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Guinea Pigs; Hypothalamus; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Research

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Hypothyroidism; Iodine Isotopes; Ketones; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Urine

Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Androgens; Child; Cobalt; Cobalt Isotopes; Dwarfism; Dwarfism, Pituitary; Growth Hormone; Humans; Hypopituitarism; Male; Neoplasms; Pituitary Diseases; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Humans; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypophysectomy; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Antibodies; Antibodies, Heterophile; Guinea Pigs; Pituitary Diseases; Pituitary Gland; Pituitary Gland, Anterior

Topics: 17-Ketosteroids; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Humans; Pituitary Diseases; Pituitary Gland; Puberty; Puberty, Precocious; Sexual Maturation

Topics: 17-Ketosteroids; Disease; Humans; Myxedema; Pituitary Diseases; Pituitary Gland; Pituitary Gland, Anterior

Topics: 17-Ketosteroids; Castration; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Humans; Pituitary Diseases; Pituitary Gland; Steroids; Urine

Topics: 17-Ketosteroids; Diabetes Mellitus; Eosinophils; Estrogens; Hypopituitarism; Leukocyte Count; Pituitary Diseases; Pituitary Gland; Steroids

Topics: 17-Ketosteroids; Follicle Stimulating Hormone; Gonadotropins; Gonadotropins, Pituitary; Myxedema; Pituitary Diseases; Pituitary Gland; Steroids; Thyroxine; Urine

Topics: 17-Ketosteroids; Diencephalon; Humans; Pituitary Diseases; Pituitary Gland; Steroids; Urine; X-Rays

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Guinea Pigs; Pituitary Diseases; Pituitary Gland; Steroids

Topics: 17-Ketosteroids; Hypopituitarism; Pituitary Diseases; Pituitary Gland; Steroids; Urine

Topics: 17-Ketosteroids; Androgens; Body Fluids; Humans; Pituitary Diseases; Pituitary Gland; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus, Experimental; Glutathione; Humans; Male; Nitrogen; Pituitary Diseases; Pituitary Gland; Steroids; Uric Acid

Topics: 17-Ketosteroids; Adrenal Glands; Androgens; Disease; Humans; Male; Pituitary Diseases; Pituitary Gland; Testicular Diseases; Testis