17-ketosteroids and Pancreatic-Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acid Phosphatase; Adrenal Gland Neoplasms; Alkaline Phosphatase; Amino Acids; Amylases; Bone Neoplasms; Breast Neoplasms; Carcinoid Tumor; Catecholamines; Chorionic Gonadotropin; Clinical Enzyme Tests; Clinical Laboratory Techniques; Female; Glucose-6-Phosphate Isomerase; Humans; Hydroxyindoleacetic Acid; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Neoplasms; Neoplasms, Nerve Tissue; Neuroblastoma; Nucleotidases; Pancreatic Neoplasms; Pheochromocytoma; Pregnancy; Prostatic Neoplasms; Trophoblastic Neoplasms; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Alkalosis; Carcinoma, Bronchogenic; Corticosterone; Cushing Syndrome; Deficiency Diseases; Desoxycorticosterone; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Pancreatic Neoplasms

Topics: 17-Ketosteroids; Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Cholestasis; Cholesterol; Colonic Neoplasms; Common Bile Duct; Estradiol; Estranes; Estrogens; Estrone; Female; Feminization; Glucuronates; Humans; Liver Cirrhosis; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Stomach Neoplasms; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adult; Aged; Angiography; Celiac Artery; Female; Gastrointestinal Hemorrhage; Glucagon; Humans; Hypoglycemia; Insulin; Intracranial Arteriosclerosis; Leucine; Mesenteric Arteries; Obesity; Pancreatectomy; Pancreatic Neoplasms; Pregnancy; Pregnancy Complications; Prognosis; Tolbutamide

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Adult; Aged; Biological Assay; Carcinoma, Squamous Cell; Child; Cushing Syndrome; Female; Humans; Lung Neoplasms; Pancreatic Neoplasms; Radioimmunoassay; Thymoma

The production of ACTH-like material by tumours arising in non-endocrine tissue may initiate severe adrenocortical hyperfunction. The pathogenesis and clinical and laboratory features of Cushing's syndrome associated with such tumours are characteristic. The autonomous production by the tumour of ACTH-like material cannot be suppressed by exogenous corticoids. The onset of clinical symptoms is rapid; muscle wasting, general weakness, thirst and peripheral edema predominate, and the classical signs of Cushing's syndrome may be absent. High levels of plasma 17-hydroxycorticosteroids and urinary 17-hydroxycorticosteroids and 17-ketosteroids, usually with normal levels of urinary aldosterone, commonly occur. Hypokalemic alkalosis unresponsive to replacement therapy may cause death. In the case reported herein, the intriguing possibility exists that two hormone-like substances were produced by the primary growth and its metastases: one, ACTH-like, to account for the adrenal hyperplasia and Cushing's syndrome; and another, gastrin-like, giving rise to the ulcerogenic diathesis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyperfunction; Autopsy; Carcinoma, Islet Cell; Chloramphenicol; Cushing Syndrome; Drug Therapy; Gastrins; Humans; Hypokalemia; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Pathology; Spironolactone; Zollinger-Ellison Syndrome

Topics: 17-Ketosteroids; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Blood; Cushing Syndrome; Dexamethasone; Endocrinology; Humans; Lung Neoplasms; Mediastinal Neoplasms; Pancreatic Neoplasms; Parotid Neoplasms; Peptides; Pheochromocytoma; Urine