17-ketosteroids and Ovarian-Neoplasms

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; Carcinoma; Child, Preschool; Cushing Syndrome; Estrogens; Female; Feminization; Glucocorticoids; Granulosa Cell Tumor; Humans; Leydig Cell Tumor; Male; Mesenchymoma; Middle Aged; Mitotane; Ovarian Neoplasms; Paraneoplastic Endocrine Syndromes; Pregnancy; Progesterone; Prognosis; Sertoli Cell Tumor; Steroids; Testicular Neoplasms; Thecoma; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Cimetidine; Dehydroepiandrosterone; Female; Hirsutism; Humans; Ovarian Neoplasms; Spironolactone; Testosterone

Topics: 17-Ketosteroids; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Androgens; Androstane-3,17-diol; Androstenedione; Cells, Cultured; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Fibroblasts; Hirsutism; Humans; Liver; Male; Metabolic Clearance Rate; Ovarian Neoplasms; Polycystic Ovary Syndrome; Sebaceous Glands; Sex Hormone-Binding Globulin; Skin; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Cesarean Section; Cystadenoma; Diagnosis, Differential; Female; Humans; Hydroxysteroids; Infant, Newborn; Infant, Premature; Liver Function Tests; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Virilism

Topics: 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Androstanes; Androstenols; Blood Proteins; Electrophoresis, Starch Gel; Female; Hirsutism; Humans; Hypertrichosis; Leydig Cell Tumor; Liver; Metabolic Clearance Rate; Ovarian Cysts; Ovarian Neoplasms; Ovary; Testosterone; Virilism

Topics: 17-Ketosteroids; Age Factors; Body Height; Brain Diseases; Choriocarcinoma; Dysgerminoma; Ejaculation; Female; Granulosa Cell Tumor; Humans; Hydrocephalus; Male; Menarche; Ovarian Neoplasms; Ovulation; Pregnancy; Prognosis; Psychosexual Development; Puberty, Precocious; Reproduction; Sex Factors; Teratoma; Testicular Neoplasms; Thecoma

Topics: 17-Ketosteroids; Adult; Chorionic Gonadotropin; Cystadenoma; Cytoplasm; Female; Fibroblasts; Hirsutism; Humans; Leydig Cells; Luteinizing Hormone; Male; Mitochondria; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Thecoma; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Androsterone; Blood; Chorionic Gonadotropin; Cushing Syndrome; Dysgerminoma; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypertrichosis; Hypogonadism; Metabolism; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Testosterone; Urine; Virilism

Urinary and serum steroid measurements were obtained in a 48-year-old female before and after the removal of a virilizing granulosa cell tumor (GCT). Preoperatively, serum testosterone was markedly elevated while 17-ketosteroid (17-KS) and estrogen excretion were normal. Chorionic gonadotropin administration effected a marked rise in urinary 17-KS excretion and serum testosterone while oral contraceptive therapy for 21 days decreased serum testosterone to normal. With tumor resection, serum testosterone fell to normal and subsequent administration of HCG had no stimulatory effect on serum testosterone or urinary 17-KS excretion. The patient's clinical response and 8-year followup attest to the tumor's unusual virilizing role.

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Combined Modality Therapy; Contraceptives, Oral; Female; Follow-Up Studies; Granulosa Cell Tumor; Humans; Middle Aged; Ovarian Neoplasms; Testosterone; Time Factors; Virilism

Topics: 17-Ketosteroids; Adult; Androsterone; Female; Humans; Mixed Function Oxygenases; Ovarian Neoplasms; Pregnancy; Pregnancy Complications, Neoplastic; Thecoma; Virilism

A 32-year-old woman, 3, para 2 with a testosterone producing tumor of the left ovary was studied endocrinologically. She complained of amenorrhea, hirsutism and abdominal mass. The peripheral testosterone level was 8.4 ng/ml, remarkably elevated. After the combined dexamethasone suppression/hCG stimulation test, the plasma testosterone level rose from 9 ng/ml to 15.1 ng/ml. Prior to removal of the tumor, venous samples were drawn directly from the right and left ovarian veins during surgery and simple total hysterectomy with bilateral salpingo-oophorectomy was performed. Testosterone levels were 40.5 ng/ml on the tumor side and 7.1 ng/ml on the normal side. After tumor removal, the plasma testosterone level fell from 8.4 ng/ml to less than 1.0 ng/ml within 24 hours. Histological examination of the left ovarian tumor revealed a Sertoli-Leydig cell tumor. In incubation of small specimens of tumor tissues in oxygenated Krebs bicarbonate buffer, the release of testosterone into the medium containing hCG was twice as high as that into the medium without hCG. These results of in vitro and in vivo studies suggest that this tumor was an hCG-dependent testosterone producing Sertoli-Leydig cell tumor.

Topics: 17-Ketosteroids; Adult; Androstenedione; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone; Female; Humans; In Vitro Techniques; Leydig Cell Tumor; Ovarian Neoplasms; Sertoli Cell Tumor; Testosterone

Twenty-four cases of an unusual type of ovarian tumor with functioning stroma in which bands of steroid-hormone-producing cells were located adjacent to the tumor are presented. The cells were of stromal lutein cell type in 14 cases, stromal Leydig cell type in two cases, and hilus cell type in eight cases. Of the tumors with peripheral lutein cells, 11 were monodermal teratomas, including eight examples of struma ovarii, two strumal carcinoids, and one trabecular carcinoid; the other three tumors in this group were a dermoid cyst, a dysgerminoma containing syncytiotrophoblast cells, and a metastatic carcinoid. The tumors with peripheral stromal Leydig cells were a struma ovarii and a strumal carcinoid. Three of the tumors with peripheral hilus cells were mucinous cystadenomas, four were cysts of probable rete origin, and the eight was a dermoid cyst. The patients' ages ranged from 13-82 (average 58) years. Eighty percent of the patients were postmenopausal; one was pregnant. Forty-two percent of the patients had androgenic manifestations, 29% had evidence of hyperestrinism, and one (4%) had evidence of progesterone excess. In 29% of the cases there was no clinical evidence of hormonal imbalance. Those tumors with peripheral stromal Leydig cells or hilus cells were accompanied by androgenic manifestations in over one-half the cases, and those tumors with peripheral lutein cells had a slightly higher association with estrogenic rather than androgenic changes. Human chorionic gonadotropin and its beta subunit were demonstrated by the immunoperoxidase technique in some neoplastic cells in 4 of the 17 cases in which it was performed. Ovarian tumors with peripheral steroid-hormone-producing cells should be distinguished from the typical ovarian tumor with functioning stroma, which contains lutein cells scattered throughout its stroma.

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Chorionic Gonadotropin; Estrogens; Female; Gonadal Steroid Hormones; Humans; Menopause; Middle Aged; Ovarian Neoplasms; Testosterone

The investigation is described of a 62-year-old female patient who presented with severe virilisation; her plasma testosterone concentration was grossly elevated at 37.9 nmol/L. Measurement of plasma androstenedione, dehydroepiandrosterone (DHEA) and DHEA-sulphate, urinary 17-oxosteroids and urinary 'free' cortisol suggested an ovarian source of androgens. An ultrasound scan indicated the presence of an ovarian mass which was removed and classified as a Sertoli-Leydig cell tumour (arrhenoblastoma) combined with a mucinous cystadenoma. Following operation plasma testosterone levels returned to normal. The excessive pre-operative testosterone production appeared to have had little effect on the plasma level of SHBG, since levels remained similar before and after removal of the tumour. Serum LH and FSH levels were higher post-operatively.

Topics: 17-Ketosteroids; Androgens; Cystadenoma; Female; Hormones; Humans; Hydrocortisone; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Endocrine studies were made on 4 women with ovarian Sertoli-Leydig cell tumors of varying degrees of differentiation. Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. The calculated ratios of steroid hormones between the affected ovarian venous values and peripheral values for testosterone (T), androstenedione (A), and dehydroepiandrosterone (DHEA) in 3 patients, were 1.4-18.6, 4.2-24.4, and 3.7-10.0, respectively. The peripheral levels of the hormones before salpingo-oophorectomy in all the patients were T: 0.97-45.0 ng/ml; A: 2.92-114.0 ng/ml; and DHEA: 13.0-20.9 ng/ml. In the 3 juvenile patients, elevated basal levels of LH and normal or subnormal levels of FSH (high LH:FSH ratio) were found. In a 12-year-old patient with 1,900 g tumor composed predominantly of Sertoli cells with lipid storage, the peripheral serum levels of T and estradiol (E2) were 114 ng/ml and 1890 pg/ml, respectively. The present data suggest that: 1) androblastomas have a biosynthetic capacity for androgen, estrogen, or both in which both the delta 5 and delta 4 pathways are involved, and 2) little correlation exists between the endocrine function and cellular composition of the tumors or their degree of differentiation.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone

A 35-yr-old woman had Cushing's syndrome, amenorrhea, and elevated and nonsuppressible levels of urinary and plasma cortisol and urinary 17-hydroxycorticosteroids. An ovarian carcinoma with extensive metastases was found. Tumor concentrations of ACTH were much lower than those in any previously reported patient with the ectopic ACTH syndrome. Cortisol levels obtained from the venous effluent of tumor-involved ovaries were higher than that in peripheral plasma obtained at the same time. Transient postoperative normalization of plasma and urinary cortisol followed partial tumor removal. Electron microscopic study of the tumor revealed a cell type consistent with steroid-secreting cells. Postmortem examination revealed atrophy of both adrenal glands and no pituitary adenoma.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Atrophy; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Hydroxysteroids; Ovarian Neoplasms

A patient with virilization was studied. The basal urinary excretion of 17-ketosteroids was at the upper limit of normal, but the plasma testosterone concentration was greatly elevated. Testosterone secretion could be stimulated by hCG, suppressed by dexamethasone, and was not affected by ACTH. At operation, an arrhenoblastoma of the left ovary was found. Isolated tumor cells in culture secreted testosterone. The addition of a LRH agonist (10 ng/ml) suppressed the secretion of testosterone by 50% (P less than 0.01). The inhibiting effect of a LRH agonist on steroidogenesis suggests that LRH receptors were present on this tumor and that treatment with LRH agonists might be beneficial in patients with metastatic steroid hormone-secreting ovarian and testicular tumors.

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Cells, Cultured; Chorionic Gonadotropin; Dexamethasone; Female; Gonadotropin-Releasing Hormone; Goserelin; Humans; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Calcinosis; Child; Estrogens; Female; Follicle Stimulating Hormone; Humans; Leydig Cell Tumor; Luteinizing Hormone; Ovarian Neoplasms; Ovary; Testosterone; Virilism

Topics: 17-Ketosteroids; Adult; Androgens; Female; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Ovary; Sertoli Cell Tumor

Topics: 17-Ketosteroids; Blood; Diagnosis, Differential; Estradiol; Female; Gonadotropins, Pituitary; Humans; Leydig Cell Tumor; Menopause; Middle Aged; Ovarian Neoplasms; Sertoli Cell Tumor; Virilism

A case of ovarian arrhenoblastoma in a 14-year-old girl is reported. The patient presented with primary amenorrhea, severe diffuse hirsutism, moderate clitorial enlargement and slight decrease in breast size. Hormonal examinations revealed high plasma testosterone and androstenedione levels, normal plasma prolactin, drhydroepiandrosterone-sulphate, 17-alpha-hydroxyprogesterone, urinary 17 beta oestradiol, oestrone, FSH and LH. Androgen concentrations decreased under dexamethasone suppression test. Following tumor ablation menses occurred spontaneously and normal hormone patterns were observed.

Topics: 17-Ketosteroids; Adolescent; Androstenedione; Dehydroepiandrosterone; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Hydroxyprogesterones; Luteinizing Hormone; Ovarian Neoplasms; Pregnanetriol; Prolactin; Sertoli-Leydig Cell Tumor; Testosterone

Detailed in vivo endocrine studies of a virilizing adrenal-like tumor of the ovary are reported. A nonspecific steroidogenic baseline profile was observed in the face of clearcut histological adrenal-like features. Dynamic testing disclosed incomplete dexamethasone-related steroidogenic suppression suggestive of partial tumoral autonomy. At the same time, the observation of sizable dexamethasone-related steroidogenic decrements, unaccounted for by normal adrenal contribution, may be interpreted to suggest a direct, pharmacological, inhibitory effect of dexamethasone on tumoral and/or ovarian stromal steroidogenesis. These observations confirm the limited role of baseline steroid profiling and dynamic testing in the preoperative localization of androgen-secreting tumors. Reversible dysfunction of hypothalamic gonadotropic feedback mechanisms was suggested by combined single dose LRH-clomiphene testing. Complete resolution followed tumor removal.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Androstenedione; Clomiphene; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxyprogesterones; Luteinizing Hormone; Ovarian Neoplasms; Progesterone; Testosterone

As a result of examining the urine excretion of 17-OCS, 17-KS, estrogens and the concentration of protein bound iodine and butanolextractable iodine in blood of patients with benign and malignant ovarian tumors, there were found some deviations from the normal hormonal balance in all these patients. These deviations were manifested in a delayed transformation of cortisol to cortisone, in a shifted androgeno-estrogenic balance toward estrogen active fractions, and in the reduced production of thyroid hormones. In ovarian cancer, however, these changes were manifested to a greater extent.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Estrogens; Female; Homeostasis; Humans; Middle Aged; Ovarian Cysts; Ovarian Neoplasms; Thyroid Hormones

The authors present the case of a young hirsute woman of 28 years old. Urinary 17 KS were very increased without DHA, but with androsterone, etiocholanolone and 11 oxy 17 Ketosteroids. Androstenedione and testosterone plasmatic levels were very high and per operative selective ovarian vein catheterization showed a direct production of these potent androgens. In vitro study of the tumor allowed to obtain same results. Light and electron microscopic study showed a Leydig cell tumor of left ovary.

Topics: 17-Ketosteroids; Adult; Androstenedione; Female; Hirsutism; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Testosterone

A 53-year-old woman presented with hirsutism of long duration and virilization of recent onset. She was gravida 12 para 9. The 17-ketosteroids were normal, gonadotropins were in the post-menopausal range, and the serum testosterone was in the male range. After bilateral oophorectomy, the testosterone became normal. Ovarian pathology revealed stromal hyperthecosis.

Topics: 17-Ketosteroids; Castration; Female; Humans; Menopause; Middle Aged; Ovarian Neoplasms; Testosterone; Thecoma; Virilism

As a rule, patients with ovarian cancer do not display any important endocrine disturbances. The authors studied the cases of 104 of these patients: 19 had benign tumors, 6 intermediate tumors, 6 had 1st stage ovarian cancer, 7 3rd stage cancer, 54 4th stage cancer. The remaining patients had a recidivist ovarian cancer. All patients with primary cancer had the uterine hormonal secretions studied. The results indicated the absence of specific changes in the uterine secretion of steroid hormones and in the level of follicle stimulating hormone and luteinizing hormone in the serum. This was true for all patients with benign, intermediate and malignant ovarian tumors. The duration of remission in the patients with 4th stage of cancer was greater when the estrogen stimulation and the level of androgen secretion were increased.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Estrogens; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms

An ovarian lipid cell tumor without Reinke's crystalloids in a woman with secondary amenorrhea, minimal hirsutism, and elevated 17-ketosteroid excretion was studied by light and electron microscopy. Tumor cells were found in small clumps or scattered singly within a collagenous matrix. The cytoplasm of the tumor cells contained abundant smooth endoplasmic reticula, numerous mitochondria with tubular cristae, lipid droplets, lysosomal dense bodies, and concentric membranous whorls, characteristic of steroidogenic cells. In addition, "peripheral canalicular systems" were found at the outer margins of the nests of the tumor cells. These "peripheral canalicular systems" were bordered by the cell membranes and the surrounding collagenous stroma into which microvilli projected. Since the intercellular canalicular system present between the tumor cells was continuous with the "peripheral canalicular system," both systems probably have a common function related to steroid metabolism. The intercellular and "peripheral" canalicular systems and cytoplasmic microfilaments found in this tumor suggest that this ovarian lipid cell tumor was derived from the ovarian stroma.

Topics: 17-Ketosteroids; Amenorrhea; Cell Membrane; Endoplasmic Reticulum; Female; Hirsutism; Humans; Inclusion Bodies; Ovarian Neoplasms

Topics: 17-Ketosteroids; Child; Dysgerminoma; Estrogens; Female; Humans; Ovarian Neoplasms

Hormone studies in a case of granulosa cell ovarian tumor were accomplished preoperatively by measuring the plasma steroids and the gonadotropin response to synthetic lutenizing hormone-releasing hormone. Plasma estradiol and estrone were elevated, but not to levels observed preovulation. The base line follicle-stimulating hormone level was markedly supressed and did not respond to luteinizing hormone-releasing hormone, whereas base line and peak luteinizing hormone values were nearly within the normal range. The clinical finding of copious cervical mucus suggested the diagnosis and prompted preoperative documentation of circulating hormone values.

Topics: 17-Ketosteroids; Abortion, Spontaneous; Adult; Androstenedione; Estradiol; Estrogens; Estrone; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Granulosa Cell Tumor; Humans; Hydroxysteroids; Luteinizing Hormone; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Progesterone; Testosterone

The endocrine findings in two adolescents with hyperthecosis are compared to those in a patient with an androgenic ovarian tumor. In patients with hyperthecosis, luteinizing hormone values were elevated or in the upper normal range, and plasma testosterone and androstenedione values were increased. Following dexamethasone suppression, testosterone and androstenedione values remained elevated, but after administration of human chorionic gonadotropin, they increased further in only one patient. Baseline 17-ketosteroid values were normal, suppressed with dexamethasone, and stimulated to baseline levels following HCG. The patient with a lipoid cell ovarian tumor had low baseline LH levels, and elevated testosterone, androstenedione, and 17-ketosteroid values. Dexamethasone produced little change in urinary or plasma values, but the 17-ketosteroids increased markedly after administration of HCG. The finding of low serum LH values in patients with hirsutism and elevated androgen secretion should alert the clinician to the possibility of a tumor.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Androgens; Androstenedione; Chorionic Gonadotropin; Dexamethasone; Female; Gonadotropin-Releasing Hormone; Hirsutism; Humans; Luteinizing Hormone; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Testosterone

A case of maternal virilization associated with bilateral luteomas of pregnancy is described. Urinary 17-ketosteroids and plasma testosterone fell from markedly abnormal values to normal limits within 2 weeks of delivery. However, symptoms of virilization persisted in the postpartum state. A possible relation between polycystic ovarian syndrome in the nonpregnant state and luteoma of pregnancy is proposed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Creatinine; Female; Humans; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Thecoma; Virilism

Topics: 17-Ketosteroids; Adult; Chorionic Gonadotropin; Dexamethasone; Female; Hirsutism; Humans; Hydrocortisone; Menopause; Middle Aged; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnanetriol; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Neoplasms; Adult; Amenorrhea; Androgens; Androstenedione; Carcinoma; Chorionic Gonadotropin; Clomiphene; Dexamethasone; Estrogens; Ethinyl Estradiol; Female; Hirsutism; Humans; Hydrocortisone; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Androgens; Cyproterone; Dexamethasone; Diethylstilbestrol; Female; Hirsutism; Humans; Ovarian Neoplasms

A gynandroblastoma of the ovary in a 17-year-old girl is reported. Primary amenorrhoea, hirsuties and slight clitoral enlargement were associated with the tumour and high levels of circulating testosterone were found. This is the first gynandroblastoma in which Reinke crystalloids have been identified in the Leydig cell component. The criteria for the diagnosis of this tumour and its histogenesis are discussed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Amenorrhea; Breast; Castration; Clitoris; Curettage; Cytoplasm; Female; Hirsutism; Humans; Hydrocortisone; Leydig Cells; Lipids; Male; Menstruation Disturbances; Neoplasms, Gonadal Tissue; Ovarian Neoplasms; Sertoli Cells; Testosterone

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Androstenedione; Catheterization; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone; Female; Hormones, Ectopic; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Ovary; Phlebography; Radioimmunoassay; Testosterone; Veins; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Rest Tumor; Adult; Androstenedione; Chromatography; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Estradiol; Female; Fluorometry; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxyprogesterones; Iodine Radioisotopes; Luteinizing Hormone; Ovarian Neoplasms; Progesterone; Radioimmunoassay; Steroids; Testosterone

Topics: 17-Ketosteroids; Acanthosis Nigricans; Adolescent; Adrenocorticotropic Hormone; Androstenedione; Chorionic Gonadotropin; Dexamethasone; Ethinyl Estradiol; Female; Humans; Luteinizing Hormone; Mestranol; Norethindrone; Ovarian Neoplasms; Polycystic Ovary Syndrome; Testosterone; Thecoma

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Amenorrhea; Androgens; Androstenedione; Contraceptives, Oral; Dehydroepiandrosterone; Depression, Chemical; Dexamethasone; Drug Combinations; Female; Humans; Hyperplasia; Infertility, Female; Mestranol; Norethynodrel; Ovarian Diseases; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Adolescent; Amenorrhea; Androstenedione; Cystadenoma; Dehydroepiandrosterone; Epithelium; Female; Humans; Leydig Cells; Male; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Sertoli Cells; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Chromatography, Gas; Chromatography, Thin Layer; Culture Techniques; Female; Gonadotropins, Pituitary; Humans; Ovarian Neoplasms; Pregnenolone; Radioimmunoassay; Sertoli-Leydig Cell Tumor; Steroids; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Androsterone; Dysgerminoma; Etiocholanolone; Female; Gonadotropins; Humans; Karyotyping; Ovarian Neoplasms; Pregnanediol; Pregnanetriol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Clitoris; Cystadenoma; Dexamethasone; Female; Humans; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Ultrasonography; Virilism

Topics: 17-Ketosteroids; Cystadenocarcinoma; Cystadenoma; Female; Humans; Ovarian Neoplasms

Topics: 17-Ketosteroids; Adult; Clitoris; Female; Fetal Diseases; Humans; Hypertrophy; Ovarian Neoplasms; Ovary; Pregnancy; Pregnancy Complications; Protein Binding; Radionuclide Imaging; Testosterone; Thecoma; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Female; Humans; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Intravenous; Middle Aged; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Thiotepa; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Androsterone; Chorionic Gonadotropin; Cilia; Collagen; Dehydroepiandrosterone; Endoplasmic Reticulum; Etiocholanolone; Female; Humans; Leydig Cell Tumor; Microscopy; Microscopy, Electron; Mitochondria; Ovarian Neoplasms; Sertoli Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androsterone; Chorionic Gonadotropin; Dexamethasone; Etiocholanolone; Female; Humans; Ovarian Neoplasms; Ovary; Paraneoplastic Endocrine Syndromes; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Topics: 17-Ketosteroids; Androgens; Birth Weight; Disorders of Sex Development; Female; Fetal Diseases; Humans; Infant, Newborn; Karyotyping; Maternal-Fetal Exchange; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Pregnanetriol; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adult; Amenorrhea; Female; Hirsutism; Humans; Hyperplasia; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Ovarian Cysts; Ovarian Diseases; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnanetriol; Testosterone

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androsterone; Chromatography, Gas; Dehydroepiandrosterone; Dexamethasone; Diagnosis, Differential; Female; Glucocorticoids; Humans; Mass Spectrometry; Middle Aged; Neoplasms, Gonadal Tissue; Ovarian Neoplasms; Pregnanetriol; Pregnenolone; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Rest Tumor; Adult; Amenorrhea; Clitoris; Female; Hirsutism; Humans; Leydig Cells; Male; Ovarian Neoplasms; Ovary; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Topics: 17-Ketosteroids; Adolescent; Chorionic Gonadotropin; Female; Humans; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Pregnanetriol; Sterilization, Reproductive; Testosterone; Thecoma; Virilism

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Amenorrhea; Female; Glucocorticoids; Hirsutism; Humans; Hydrocortisone; Ovarian Cysts; Ovarian Neoplasms; Ovary; Teratoma; Time Factors

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Adult; Androsterone; Chromatography; Diagnosis, Differential; Estrogens; Etiocholanolone; Female; Gonadotropins; Humans; Middle Aged; Neoplasms, Gonadal Tissue; Ovarian Neoplasms; Polycystic Ovary Syndrome; Sertoli-Leydig Cell Tumor

Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Androgens; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone; Female; Humans; Leydig Cell Tumor; Methods; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone; Thecoma

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Alopecia; Female; Hirsutism; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Ovary; Sertoli-Leydig Cell Tumor; Testosterone; Vaginal Smears; Virilism

Topics: 17-Ketosteroids; Adult; Cesarean Section; Cystadenoma; Female; Humans; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Androgens; Cushing Syndrome; Estrogens; Female; Hirsutism; Humans; Hydrocortisone; Infertility, Female; Ovarian Cysts; Ovarian Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adipose Tissue; Androstanes; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Endometrium; Estrone; Female; Granulosa Cell Tumor; Humans; Leiomyoma; Ovarian Neoplasms; Polyps; Tritium; Uterine Neoplasms

Topics: 17-Ketosteroids; Adult; Cystadenoma; Female; Humans; Ovarian Neoplasms; Parity; Pregnancy; Pregnancy Complications; Virilism

Topics: 17-Ketosteroids; Animals; Estrogens; Estrus; Female; Leukemia, Experimental; Mammary Neoplasms, Experimental; Muscles; Neoplasms, Experimental; Ovarian Neoplasms; Ovary; Pregnancy; Rats; Tail; Thymus Neoplasms; Transplantation, Autologous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Body Height; Breast; Central Nervous System Diseases; Child; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Hypothyroidism; Infant; Laparoscopy; Luteinizing Hormone; Medroxyprogesterone; Menarche; Ovarian Neoplasms; Ovary; Physical Examination; Pituitary Hormone-Releasing Hormones; Puberty, Precocious; Radioimmunoassay; Sex Characteristics

Topics: 17-Ketosteroids; Adolescent; Androgens; Androstanes; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Thecoma; Virilism

Topics: 17-Ketosteroids; Adenocarcinoma, Mucinous; Adrenal Glands; Aged; Castration; Endometrium; Estriol; Female; Gonadal Steroid Hormones; Hemorrhage; Humans; Hydrocortisone; Menopause; Middle Aged; Ovarian Neoplasms; Ovary; Pregnanediol; Steroids; Vagina

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Clitoris; Dexamethasone; Disorders of Sex Development; Dysgerminoma; Estrogens; Female; Fluoxymesterone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Testosterone

Topics: 17-Ketosteroids; Adolescent; Autopsy; Chorionic Gonadotropin; Dysgerminoma; Female; Hormones, Ectopic; Humans; Lung; Lung Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Pituitary Gland; Placental Lactogen; Radioimmunoassay

Topics: 17-Ketosteroids; Adult; Aged; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Blood Cell Count; Blood Sedimentation; Calcium; Carcinoma; Cyclophosphamide; Diarrhea; Endometriosis; Feeding and Eating Disorders; Female; Genital Neoplasms, Female; Hematocrit; Hematopoiesis; Hemoglobins; Humans; L-Lactate Dehydrogenase; Liver Function Tests; Middle Aged; Mucoproteins; Ovarian Neoplasms; Time Factors; Uterine Cervical Neoplasms; Vulvar Neoplasms

Topics: 17-Ketosteroids; Cushing Syndrome; Female; Hirsutism; Humans; Hyperplasia; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Testosterone; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Carcinoid Tumor; Female; Hirsutism; Humans; Middle Aged; Ovarian Neoplasms; Struma Ovarii; Virilism

Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Blood Cell Count; Dehydroepiandrosterone; Dexamethasone; Female; Gonadotropins; Humans; Laparotomy; Leydig Cell Tumor; Liver Function Tests; Microscopy, Electron; Ovarian Neoplasms; Radiography; Sulfates; Testosterone; Virilism

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adult; Androstanes; Androsterone; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Etiocholanolone; Female; Glucuronates; Humans; Hydroxyprogesterones; Neoplasm Metastasis; Ovarian Neoplasms; Pregnanes; Pregnanetriol; Sertoli-Leydig Cell Tumor; Sulfates; Testosterone; Virilism

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adrenal Cortex Hormones; Amenorrhea; Clitoris; Female; Hirsutism; Hoarseness; Humans; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor

Topics: 17-Ketosteroids; Adolescent; Androstanes; Androsterone; Chromatography, Paper; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Female; Humans; Ovarian Neoplasms; Ovary; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Aged; Aldosterone; Chromatography; Female; Humans; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Cushing Syndrome; Dexamethasone; Diagnosis, Differential; Female; Gonadotropins, Pituitary; Humans; Menstruation Disturbances; Norethynodrel; Ovarian Neoplasms; Ovary; Pituitary-Adrenal Function Tests; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Choriocarcinoma; Chorionic Gonadotropin; Cytodiagnosis; Estrogens; Female; Humans; Hydatidiform Mole; Hysterectomy; Middle Aged; Ovarian Neoplasms; Ovary; Pregnancy; Pregnanediol; Pregnanetriol; Uterine Neoplasms; Vaginal Smears

Topics: 17-Ketosteroids; Adrenal Rest Tumor; Adult; Chorionic Gonadotropin; Female; Humans; Ovarian Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Cell Transformation, Neoplastic; Diagnosis, Differential; Female; Hirsutism; Hormones, Ectopic; Humans; Leydig Cell Tumor; Mitosis; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Thecoma

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Androgens; Androstanes; Androsterone; Depression, Chemical; Dexamethasone; Female; Humans; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Stimulation, Chemical; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Body Temperature; Dexamethasone; Estrogens; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Karyotyping; Ovarian Neoplasms; Pregnanediol; Pregnanetriol; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Aldosterone; Chemistry, Clinical; Child; Desoxycorticosterone; Etiocholanolone; Female; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Metabolism, Inborn Errors; Mixed Function Oxygenases; Ovarian Neoplasms; Pregnanetriol

Topics: 17-Ketosteroids; Adult; Androgens; Female; Hormones; Humans; Karyotyping; Microscopy, Electron; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor

Topics: 17-Ketosteroids; Aged; Diabetes Complications; Diagnosis, Differential; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Leydig Cell Tumor; Middle Aged; Ovarian Neoplasms; Steroids; Tuberculosis, Endocrine; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Estrogens; Female; Humans; Iodine Radioisotopes; Middle Aged; Ovarian Neoplasms; Ovary; Thyroid Gland

Topics: 17-Ketosteroids; Androgens; Androstanes; Estrogens; Female; Humans; Menopause; Ovarian Neoplasms; Ovary; Pregnenolone; Progesterone; Tritium

Topics: 17-Ketosteroids; Adrenal Rest Tumor; Cytoplasmic Granules; Endoplasmic Reticulum; Estrogens; Female; Glucocorticoids; Histocytochemistry; Humans; Lipid Metabolism; Middle Aged; Ovarian Neoplasms; Ovary; Pituitary-Adrenal Function Tests; Sex Chromatin; Testosterone; Virilism

Topics: 17-Ketosteroids; Adolescent; Adult; Carbohydrates; Cytoplasm; Dysgerminoma; Female; Histocytochemistry; Humans; Lipids; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Staining and Labeling

Topics: 17-Ketosteroids; Adult; Androsterone; Cesarean Section; Dehydroepiandrosterone; Female; Humans; Leydig Cell Tumor; Ovarian Neoplasms; Pregnancy; Pregnancy Complications

Topics: 17-Ketosteroids; Adolescent; Adult; Dehydroepiandrosterone; Estradiol; Estrogens; Female; Follicle Stimulating Hormone; Granulosa Cell Tumor; Humans; In Vitro Techniques; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Progesterone; Steroids; Testosterone

Topics: 17-Ketosteroids; Adenocarcinoma, Mucinous; Adult; Androgens; Chemistry, Clinical; Chorionic Gonadotropin; Dehydroepiandrosterone; Estrogens; Female; Histocytochemistry; Humans; Ovarian Neoplasms; Ovary; Pregnancy; Pregnancy Complications; Pregnanediol; Pregnanetriol; Radiography; Stomach Ulcer; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Chemistry, Clinical; Chorionic Gonadotropin; Chromatography, Gas; Dexamethasone; Female; Humans; Lipoma; Metyrapone; Ovarian Neoplasms; Pregnanediol; Pregnanetriol; Stimulation, Chemical; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Aged; Curettage; Dexamethasone; Endometrium; Estradiol; Estriol; Estrogens; Estrone; Female; Gonadotropins; Humans; Menopause; Middle Aged; Ovarian Neoplasms; Ovary; Time Factors; Vaginal Smears

Topics: 17-Ketosteroids; Carcinoma; Chromatography, Paper; Female; Humans; Middle Aged; Ovarian Neoplasms; Sulfates; Testosterone; Virilism

Topics: 17-Ketosteroids; Adult; Androstanes; Carcinoma; Chromatography, Gas; Female; Humans; Ovarian Neoplasms; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Diagnosis, Differential; Female; Humans; Nalidixic Acid; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Urinary Tract Infections

Topics: 17-Ketosteroids; Adult; Biopsy; Estrogens; Female; Gonadotropins; Hirsutism; Humans; Infertility, Female; Karyotyping; Luteinizing Hormone; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Androgens; Carcinoma, Squamous Cell; Castration; Female; Glucocorticoids; Humans; Menopause; Methods; Middle Aged; Ovarian Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Choriocarcinoma; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Male; Ovarian Neoplasms; Pituitary Gland; Pregnancy; Thyroid Gland; Uterine Neoplasms

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Female; Genital Neoplasms, Female; Humans; Male; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vaginal Neoplasms

Topics: 17-Ketosteroids; Androgens; Bone Development; Child; Diagnosis, Differential; Electroencephalography; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins; Humans; Hypothyroidism; Male; Ovarian Neoplasms; Physical Examination; Puberty, Precocious; Radiography; Skull; Thyroid Function Tests; Vaginal Smears

Topics: 17-Ketosteroids; Adult; Alkaline Phosphatase; Cesarean Section; Female; Hirsutism; Histocytochemistry; Humans; Hyperplasia; Hysterectomy; Infant, Newborn; Ovarian Cysts; Ovarian Neoplasms; Pelvimetry; Pregnancy; Pregnancy Complications; Staining and Labeling; Thecoma

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

Topics: 17-Ketosteroids; Addison Disease; Adrenocorticotropic Hormone; Androgens; Breast Neoplasms; Chemistry, Clinical; Cholesterol; Chromatography, Gas; Female; Humans; Male; Metyrapone; Ovarian Neoplasms; Pregnancy; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Estrone; Female; Gonadotropins; Humans; Ovarian Neoplasms; Pregnanediol; Sertoli-Leydig Cell Tumor; Uterus

Topics: 17-Ketosteroids; Adult; Female; Humans; Ovarian Neoplasms; Pregnancy; Prognosis; Sertoli-Leydig Cell Tumor; Sex Characteristics

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Estrogens; Female; Hormones, Ectopic; Humans; Ovarian Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Clomiphene; Female; Humans; Infant, Newborn; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Pregnancy, Multiple; Twins

Topics: 17-Ketosteroids; Aged; Chromatography; Female; Humans; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Virilism

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Amenorrhea; Androgens; Cysts; Female; Follicle Stimulating Hormone; Humans; In Vitro Techniques; Luteinizing Hormone; Ovarian Diseases; Ovarian Neoplasms; Progesterone

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Diagnosis, Differential; Female; Humans; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Virilism

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adult; Female; Humans; Menstruation Disturbances; Middle Aged; Ovarian Neoplasms; Pregnanediol

Topics: 17-Ketosteroids; Abortion, Spontaneous; Adult; Female; Humans; Libido; Male; Menstruation Disturbances; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Sertoli-Leydig Cell Tumor; Sexual Dysfunction, Physiological

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Castration; Female; Humans; Menopause; Middle Aged; Ovarian Neoplasms; Plasma; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: 17-Ketosteroids; Female; Humans; Leydig Cell Tumor; Male; Neoplasms; Ovarian Neoplasms; Pathology; Retropneumoperitoneum; Surgical Procedures, Operative; Syndrome; Virilism

Topics: 17-Ketosteroids; Androgens; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Luteoma; Maternal-Fetal Exchange; Ovarian Neoplasms; Pathology; Pregnancy; Pregnancy Complications; Surgical Procedures, Operative; Thecoma; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Amenorrhea; Cysts; Drug Therapy; Female; Hirsutism; Humans; Hypertrichosis; Infertility; Infertility, Female; Oligomenorrhea; Ovarian Neoplasms; Ovulation; Pituitary-Adrenal Function Tests; Radiography; Statistics as Topic; Urine

Topics: 17-Ketosteroids; Adenocarcinoma, Mucinous; Androgens; Estrogens; Female; Histocytochemistry; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Krukenberg Tumor; Metabolism; Neoplasm Metastasis; Ovarian Neoplasms; Pathology; Pregnancy; Pregnancy Complications; Urine; Virilism

Topics: 17-Ketosteroids; Adolescent; Child; Female; Geriatrics; Humans; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Ovarian Neoplasms; Pathology; Pregnancy; Prognosis; Sertoli-Leydig Cell Tumor; Surgical Procedures, Operative; Virilism

Topics: 17-Ketosteroids; Chromatography; Female; Hirsutism; Humans; Hyperplasia; Hypertrichosis; Ovarian Neoplasms; Ovary; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Female; Hirsutism; Humans; Male; Ovarian Neoplasms; Testosterone; Virilism

Topics: 17-Ketosteroids; Adult; Female; Humans; Hydroxysteroid Dehydrogenases; Ovarian Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Child; Estrogens; Female; Humans; Male; Middle Aged; Ovarian Neoplasms; Pregnancy

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenogenital Syndrome; Androgens; Cortisone; Disorders of Sex Development; Estrogens; Female; Humans; Hypertrichosis; Hypogonadism; Hysterectomy; Iatrogenic Disease; North Carolina; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Progesterone; Urine

Topics: 17-Ketosteroids; Adolescent; Blood Chemical Analysis; Breast; Breast Neoplasms; Carcinoma; Female; Humans; Neoplasms; Ovarian Neoplasms; Uterine Neoplasms

Topics: 17-Ketosteroids; Child; Female; Fibroma; Humans; Menarche; Neoplasms; Ovarian Neoplasms; Pathology; Puberty; Sexual Maturation; Surgical Procedures, Operative; Thecoma

Topics: 17-Ketosteroids; Adolescent; Breast; Carcinoma; Castration; Child; Chorionic Gonadotropin; Dysgerminoma; Estradiol; Estriol; Estrogens; Estrone; Female; Gonadotropins; Gonadotropins, Pituitary; Growth; Humans; Hysterectomy; Menarche; Menstruation; Neoplasms; Ovarian Neoplasms; Ovary; Pituitary Gland; Pituitary-Adrenal Function Tests; Puberty; Sexual Maturation; Urine

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Androgens; Blood Chemical Analysis; Chromatography; Female; Humans; In Vitro Techniques; Metabolism; Ovarian Neoplasms; Pathology; Surgical Procedures, Operative; Testosterone; Urine; Virilism

Ataxia-telangiectasia is a syndrome of progressive cerebellar ataxia and other neurological manifestations associated with conjunctival and cutaneous telangiectases and with recurrent sino-pulmonary infections. Immunological and endocrine abnormalities occur. Two girls with this disease are described. The first had only minor respiratory infections; her serum proteins and immunity responses appeared normal. The second had recurrent pulmonary infections and bronchiectasis; she also exhibited sclerodermatous changes, poor development of secondary sexual characteristics with low urinary excretion of 17-ketosteroids, and lymphopenia. Autopsy at 17 years showed bilateral ovarian dysgerminomata and excessive cutaneous collagen as well as atrophy, and perhaps hypoplasia, of adrenals, thymus, spleen and lymphoid tissue (after steroid therapy). The cerebellum exhibited cortical degeneration. Both lungs were fibrotic with old and recent bronchopneumonia and bronchiectasis. The left lung was studied by injection of a latex preparation; no arteriovenous aneurysms were found, but the smaller pulmonary vessels showed some unusual morphological characteristics.

Topics: 17-Ketosteroids; Adolescent; Ataxia; Ataxia Telangiectasia; Atrophy; Blood Protein Electrophoresis; Bronchiectasis; Cerebellar Diseases; Child; Conjunctiva; Dysgerminoma; Eosinophils; Female; Genetics, Medical; Humans; Hypogonadism; Immunoelectrophoresis; Infant; Infant, Newborn; Leukocyte Count; Lymphocytes; Neoplasms, Germ Cell and Embryonal; Neurologic Manifestations; Ovarian Neoplasms; Pathology; Pulmonary Circulation; Pulmonary Fibrosis; Scleroderma, Systemic; Telangiectasis; Urine

Topics: 17-Ketosteroids; Androgens; Biochemical Phenomena; Biochemistry; Blood Chemical Analysis; Castration; Chromatography; Dehydroepiandrosterone; Female; Humans; Hysterectomy; Male; Metabolism; Ovarian Neoplasms; Ovary; Physiology; Pregnenolone; Progesterone; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Betamethasone; Dexamethasone; Diethylstilbestrol; Drug Therapy; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Hypertrichosis; Hysterectomy; Ovarian Neoplasms; Polycystic Ovary Syndrome; Steroids; Urine

Topics: 17-Ketosteroids; Androgens; Androsterone; Chromatography; Dehydroepiandrosterone; Dysgerminoma; Etiocholanolone; Female; Humans; Male; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Seminoma; Teratoma; Testicular Neoplasms; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Androgens; Clinical Laboratory Techniques; Endocrinology; Female; Humans; Hyperandrogenism; Metabolism; Ovarian Neoplasms; Ovary; Pathology; Testosterone; Virilism

Topics: 17-Ketosteroids; Contraceptive Agents, Female; Endocrinology; Estradiol Congeners; Estrogens; Female; Humans; Ovarian Neoplasms

Topics: 17-Ketosteroids; Cortisone; Female; Humans; Ovarian Neoplasms; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Female; Humans; Neoplasms; Ovarian Neoplasms; Ovary; Prednisone; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Diagnosis, Differential; Female; Humans; Male; Neoplasms; Ovarian Neoplasms; Ovary; Sertoli-Leydig Cell Tumor; Steroids