17-ketosteroids and Ovarian-Diseases

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hyperplasia; Middle Aged; Ovarian Diseases; Ovary; Polycystic Ovary Syndrome; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Anabolic Agents; Androgens; Brain Diseases; Female; Hirsutism; Humans; Hypothalamo-Hypophyseal System; Ovarian Diseases; Ovary; Pituitary-Adrenal Function Tests; Progestins; Skin; Testosterone

20 patients with hirsutism of different severity were examined to study the diagnostic assertion of the dexamethasone-HCG-test. The results show, that a well defined classification into the different types of hirsutism (adrenal, ovarian, idiopathic and mixed forms) is not possible using hormonal parameters.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Chorionic Gonadotropin; Dexamethasone; Diagnosis, Differential; Female; Hirsutism; Humans; Mestranol; Ovarian Diseases

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Female; Hirsutism; Humans; Ovarian Diseases; Polycystic Ovary Syndrome; Testosterone

Many women have some facial hair, and most patients who seek advice will be at the far end of the normal distribution curve for hair. In a second group there is a slight excessive production of androgens with associated hirsutism, either idiopathic or associated with polycystic ovarian disease. An extremely small fraction of patients will have serious disorders of the adrenals or ovaries and significant elevations in androgen levels.

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Glands; Androgens; Estrogens; Female; Glucocorticoids; Hirsutism; Humans; Ovarian Diseases; Ovary; Progesterone; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Female; Genital Diseases, Female; Humans; Ovarian Diseases; Virilism

Ninety-three infertile women were treated with clomiphene citrate alone or in combination with human chorionic gonadotropin (hCG) for absent or infrequent ovulation. The patients were divided into eight categories according to the diagnosis obtained: ovarian androgenic hyperplasia, adrenal androgenic hyperplasia, mixed ovarian and adrenal androgenic hyperplasia, hypothalamic anovulation, postpill anovulation, follicular phase defect, luteal phase defect, and amenorrhea-galactorrhea syndrome. Each group was analyzed individually to compare the ovulation and conception rates and the complications involved. A survey of the data presented in this study shows that the best response was noted in patients with ovarian androgenic hyperplasia. Patients with a functional pathologic adrenal component responded favorably when dexamethasone was used as an adjuvant to clomiphene therapy. Those with hypothalamic anovulation responded better when hCG was added to clomiphene therapy. Women with postpill anovulation as well as those with follicular phase defect were found to be good candidates for clomiphene therapy. In properly selected patients with poor luteal phase defect, hCG secured excellent results both in ovulation and conception. Patients with lactation amenorrhea failed to ovulate when treated with clomiphene alone.

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Amenorrhea; Androgens; Anovulation; Chorionic Gonadotropin; Clomiphene; Contraceptives, Oral; Endometrium; Female; Galactorrhea; Humans; Hyperplasia; Hypothalamus; Infant, Newborn; Infertility, Female; Luteinizing Hormone; Ovarian Diseases; Ovulation; Pregnancy

Twenty-two hirsute women underwent percutaneous adrenal and ovarian vein catheterization to differentiate and localize excessive hormonal output. All studies were done under fluoroscopic control; catheter placement was verified by venography, and blood samples were withdrawn for hormonal analysis. The right ovarian vein was successfully sampled in 42 per cent of attempts; the left ovarian vein, in 75 per cent; the right adrenal vein, in 56 per cent; and the left adrenal vein, in 100 per cent. Bilateral catheterization did not prove clinically useful. First, anatomic variations in venous size and drainage made catheterization and bilateral sampling difficult. Second, adrenal secretion is both episodic and parallel, necessitating both simultaneous catheterization and serial sampling for adequate diagnosis. The stress of the procedure may provoke increased adrenal output. Third, since ovarian secretion is not parallel, and since increased hormone output has been documented in that ovary containing developing follicles or a corpus luteum, distinguishing ovarian dysfunction proved difficult. Finally, for a time-consuming procedure, patient discomfort cannot be disregarded. This technique has not proved to be a reliable means of determining the site of androgen hypersecretion and thus cannot be recommended in the routine evaluation of female hirsutism.

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adult; Androstenedione; Catheterization; Female; Hirsutism; Humans; Hydrocortisone; Ovarian Diseases; Ovary; Testosterone; Veins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Blood Glucose; Diagnosis, Differential; Female; Hirsutism; Humans; Hydrocortisone; Menstruation; Ovarian Diseases; Testosterone; Vaginal Smears

Dehydroepiandrosterone, androstenedione, testosterone, pregnenolone and progesterone concentration was determined by our sensitive gas-liquid chromatographic method in ovarian tissues obtained from surgery of patients without hirsutism and with Stein-Leventhal syndrome. The steroids, except testosterone, were detectable in all ovaries studied. Dehydroepiandrosterone and androstenedione, regarded as preandrogens, were present in an increased amount in almost all patients with polycycstic ovaries. Gas chromatographic evidence was obtained for the presence of testosterone in two of the cases. The delta4/3betaOH ratio reflecting 3beta-hydroxysteroid dehydrogenase activity was decreased only in same patients with the Stein-Leventhal syndrome suggesting that the impaired function of this enzyme is not an obligatory feature of polycystic ovaries. Concentration of pregnenolone and progesterone measured in a part of cases varied in a great range although the determination was caried out before luteal phase. Simultaneous determination of hormones in both ovarian tissues revealed an active and an inactive period of the gland in the given time, since a great difference of hormone concentration in bilateral ovarian tissues were observed. A comparison of hormone content in ovaries and the urinary excretion of metabolites showed poor correlation between the two parameters of hormone production.

Topics: 17-Ketosteroids; Adolescent; Adult; Androgens; Androstenedione; Chromatography, Gas; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hydroxysteroid Dehydrogenases; Middle Aged; Ovarian Diseases; Ovary; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Testosterone

Gonadotropin levels and secretory patterns were studied in 28 oligomenorrheic patients with various types of polycystic ovary disease (PCO). On the basis of ovarian morphology and histology, the patients PCOuld be separated into two distinct categories arbitarily designated "typical" (type I) and "atypical" (type II) PCO. Although no differences were noted in symptomatology or 17-ketosteroid, testosterone, or follicle-stimulating hormone levels, the 12 type I patients demonstrated widely fluctuating, but markedly elevated, luteinizing hormone (LH) levels, while the 16 type II patients demonstrated lower and less fluctuating LH levels which were comparable to those found during the normal follicular phase. It is likely that type I PCO is a distinct entity similar to that described by Stein and Leventhal, while type II co represents a heterogenous spectrum of disorders, many of which remain obscure.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Anovulation; Dexamethasone; Feedback; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hyperplasia; Luteal Cells; Luteinizing Hormone; Oligomenorrhea; Ovarian Cysts; Ovarian Diseases; Ovary; Testosterone

Topics: 17-Ketosteroids; Adult; Androsterone; Breast Diseases; Castration; Dehydroepiandrosterone; Endocrine Glands; Estradiol; Estriol; Estrogens; Estrone; Female; Gonadotropins, Pituitary; Humans; Ketosteroids; Middle Aged; Ovarian Diseases; Pregnanediol; Progesterone; Thyroid Function Tests; Thyroid Gland

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Amenorrhea; Androgens; Androstenedione; Contraceptives, Oral; Dehydroepiandrosterone; Depression, Chemical; Dexamethasone; Drug Combinations; Female; Humans; Hyperplasia; Infertility, Female; Mestranol; Norethynodrel; Ovarian Diseases; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Amenorrhea; Androsterone; Body Weight; Breast Neoplasms; Castration; Contraceptives, Oral; Dexamethasone; Estrogens; Etiocholanolone; Female; Hirsutism; Humans; Hypophysectomy; Luteinizing Hormone; Menstruation; Middle Aged; Obesity; Ovarian Diseases; Starvation

Topics: 17-Ketosteroids; Age Factors; Amenorrhea; Body Temperature; Chorionic Gonadotropin; Clomiphene; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Infertility, Female; Luteinizing Hormone; Male; Menstruation; Ovarian Diseases; Ovulation; Pregnanediol; Progesterone; Puberty, Precocious; Radioimmunoassay; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Amenorrhea; Estrogens; Female; Follicle Stimulating Hormone; Glucocorticoids; Gonadotropins, Pituitary; Hormones; Humans; Luteinizing Hormone; Ovarian Diseases; Pituitary Hormone-Releasing Hormones; Pregnancy; Progesterone

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Biopsy; Chorionic Gonadotropin; Corpus Luteum; Dexamethasone; Dose-Response Relationship, Drug; Female; Humans; Infertility, Female; Injections, Intramuscular; Ovarian Diseases; Ovary; Ovulation; Pregnanediol; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Androstenedione; Dexamethasone; Diabetes Complications; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Hyperplasia; Luteinizing Hormone; Metabolic Clearance Rate; Ovarian Diseases; Polycystic Ovary Syndrome; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adult; Amenorrhea; Female; Hirsutism; Humans; Hyperplasia; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Ovarian Cysts; Ovarian Diseases; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnanetriol; Testosterone

Topics: 17-Ketosteroids; Abdomen; Adrenal Gland Diseases; Adult; Androstanes; Dehydroepiandrosterone; Female; Hirsutism; Humans; Male; Middle Aged; Ovarian Diseases; Protein Binding; Skin; Testosterone

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Androstenes; Carbon Isotopes; Chromatography, Paper; Crystallization; Cysts; Dehydroepiandrosterone; Female; Humans; Hydroxyprogesterones; In Vitro Techniques; Kinetics; Ovarian Diseases; Ovary; Pregnenolone; Progesterone; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Chorionic Gonadotropin; Chromatography; Chromatography, Gas; Culdoscopy; Dexamethasone; Female; Hirsutism; Humans; Hydrocortisone; Laparoscopy; Ovarian Diseases; Ovary; Pregnanediol; Pregnanetriol

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Androgens; Female; Hirsutism; Humans; Menopause; Ovarian Diseases; Polycystic Ovary Syndrome; Vaginal Smears; Virilism

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Amenorrhea; Body Constitution; Diabetes Complications; Dysmenorrhea; Endometrium; Estrone; Female; Fertility; Gonadotropins; Humans; Menarche; Menstruation Disturbances; Middle Aged; Ovarian Diseases; Pituitary Diseases; Pregnanediol; Puberty; Sex Chromosome Aberrations; Thyroid Diseases; Uterine Diseases; Vaginal Smears

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Circadian Rhythm; Electroencephalography; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hydroxycorticosteroids; Hypothalamus; Menstruation Disturbances; Ovarian Diseases; Ovulation

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adrenocortical Hyperfunction; Adult; Androgens; Child; Dexamethasone; Endocrine System Diseases; Estrogens; Female; Hirsutism; Humans; Menstruation Disturbances; Obesity; Ovarian Diseases; Progesterone

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Arteriosclerosis; Chromatography, Thin Layer; Coronary Disease; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Genital Diseases, Female; Humans; Hydroxycorticosteroids; Leiomyoma; Menstruation Disturbances; Middle Aged; Ovarian Diseases; Parametritis; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Antigens; Autoimmune Diseases; Child; Electrophoresis; Estrogens; Female; Fluorescent Antibody Technique; Gonadotropins; Humans; Immune Sera; Male; Ovarian Diseases; Ovary; Ovulation; Pregnancy

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Dexamethasone; Female; Hirsutism; Humans; Ovarian Diseases; Testosterone; Turner Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Atrophy; Female; Gonadotropins; Humans; Hypertrophy; Ovarian Cysts; Ovarian Diseases; Ovary; Ovulation; Staining and Labeling

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Chorionic Gonadotropin; Dexamethasone; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypogonadism; Karyotyping; Male; Ovarian Diseases; Pituitary Function Tests; Pituitary-Adrenal Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Cheek; Chromosome Aberrations; Dexamethasone; Estrogens; Female; Humans; Karyotyping; Ovarian Diseases; Phenotype; Pregnanediol; Sex Chromatin; Sex Chromosomes

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Estrogens; Female; Gonadotropins; Humans; Ovarian Diseases; Ovary; Ovulation; Pituitary-Adrenal Function Tests; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Dehydroepiandrosterone; Estrus; Female; Inflammation; Methods; Ovarian Diseases; Ovary; Pregnancy; Rabbits; Rats

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Dysmenorrhea; Female; Humans; Menorrhagia; Mestranol; Norethindrone; Ovarian Diseases; Ovulation; Pregnanediol; Premenstrual Syndrome; Uterine Hemorrhage

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Female; Gonadotropins; Histocytochemistry; Humans; Hydroxysteroid Dehydrogenases; Injections, Intramuscular; Ovarian Diseases; Ovary; Ovulation

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Antibodies; Autoimmune Diseases; Female; Gastric Mucosa; Humans; Hypoparathyroidism; Ovarian Diseases; Thyroid Gland

Topics: 17-Ketosteroids; Adult; Estrogens, Conjugated (USP); Female; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Immunoassay; Luteinizing Hormone; Methods; Ovarian Diseases; Ovary; Ovulation; Pituitary Hormone-Releasing Hormones

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Endoscopy; Female; Humans; Hypertrichosis; Ovarian Diseases; Steroids

Topics: 17-Ketosteroids; Adolescent; Adult; Endocrine System Diseases; Estrogens; Female; Gingivitis; Humans; Menstruation Disturbances; Middle Aged; Mouth Mucosa; Ovarian Diseases; Periodontal Diseases; Vaginal Smears

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Estrogens; Female; Hirsutism; Humans; Ovarian Diseases; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Diagnosis, Differential; Female; Humans; Ovarian Diseases; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Androgens; Chromatography; Cysts; Endometrial Hyperplasia; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Ovarian Diseases; Secretory Rate; Testosterone; Uterine Hemorrhage

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Chorionic Gonadotropin; Dexamethasone; Diagnosis, Differential; Female; Hirsutism; Humans; Luteinizing Hormone; Ovarian Diseases; Ovary; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Dexamethasone; Diagnosis, Differential; Female; Hirsutism; Humans; Luteinizing Hormone; Ovarian Diseases; Pregnanediol; Pregnanetriol

Topics: 17-Ketosteroids; Adult; Amenorrhea; Female; Gonadotropins; Humans; Karyotyping; Ovarian Diseases

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Androstanes; Androsterone; Carcinoma; Chemistry, Clinical; Chromatography, Thin Layer; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Methods; Ovarian Diseases; Testicular Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Blood; Chorionic Gonadotropin; Cysts; Dexamethasone; Female; Hirsutism; Humans; Ovarian Diseases; Ovary; Polycystic Ovary Syndrome; Testosterone; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Amenorrhea; Androgens; Cysts; Female; Follicle Stimulating Hormone; Humans; In Vitro Techniques; Luteinizing Hormone; Ovarian Diseases; Ovarian Neoplasms; Progesterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Dexamethasone; Female; Glucose Tolerance Test; Glucuronates; Gonadotropins; Hirsutism; Humans; Infertility, Female; Menstruation Disturbances; Obesity; Ovarian Diseases; Ovary; Pituitary Function Tests; Polycystic Ovary Syndrome; Testosterone; Thyroid Function Tests

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Amenorrhea; Androgen-Insensitivity Syndrome; Disorders of Sex Development; Estrogens; Female; Gonadotropins, Pituitary; Humans; Hypogonadism; Ovarian Diseases; Turner Syndrome

Topics: 17-Ketosteroids; Cysts; Female; Hirsutism; Humans; Infertility, Female; Menstruation Disturbances; Obesity; Ovarian Diseases; Ovulation; Polycystic Ovary Syndrome; Prednisone; Urine

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Endocrine System Diseases; Estrogens; Female; Gonadotropins; Humans; Ovarian Diseases; Ovary; Pharmacology; Pituitary-Adrenal Function Tests; Postpartum Period; Pregnancy; Puerperal Disorders; Urine

Topics: 17-Ketosteroids; Carbon Isotopes; Chemical Fractionation; Chromatography, Paper; Female; Humans; Ketosteroids; Ovarian Diseases; Virilism

Topics: 17-Ketosteroids; Adolescent; Estradiol Congeners; Estrogens; Female; Humans; Menstruation Disturbances; Metabolism; Ovarian Diseases; Ovulation; Pathology; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Estradiol Congeners; Estrogens; Female; Humans; Hypogonadism; Ovarian Diseases

Topics: 17-Ketosteroids; Cortisone; Disease; Female; Humans; Ovarian Diseases; Ovary

Topics: 17-Ketosteroids; Disease; Female; Genital Diseases, Female; Gynecology; Humans; Ovarian Diseases; Ovary

Topics: 17-Ketosteroids; Body Fluids; Disease; Female; Hormones; Humans; Male; Ovarian Diseases; Ovary; Testicular Diseases; Testis

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Disease; Female; Hair; Hair Diseases; Hirsutism; Humans; Ovarian Diseases; Ovary; Steroids; Urine

Topics: 17-Ketosteroids; Amenorrhea; Chromatography; Female; Humans; Hyperandrogenism; Ovarian Diseases; Steroids; Virilism