17-ketosteroids and Ovarian-Cysts

Topics: 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Androstanes; Androstenols; Blood Proteins; Electrophoresis, Starch Gel; Female; Hirsutism; Humans; Hypertrichosis; Leydig Cell Tumor; Liver; Metabolic Clearance Rate; Ovarian Cysts; Ovarian Neoplasms; Ovary; Testosterone; Virilism

Thirty-one cases of idiopathic hirsutism, characterized biochemically in the basal state by increased levels of urinary 3 alpha-androstane-5 alpha, 17 beta-diol and normal levels of the main androgens, were studied. In order to determine a possible etiologic heterogeneity of idiopathic hirsutism, pituitary gonadotropin responses to synthetic luteinizing-releasing hormone (LRH) and adrenal steroid responses to adrenocorticotropic hormone (ACTH) stimulation were evaluated and the results were compared to those in six normal women. On the basis of the results obtained in each hirsute patient after LRH and ACTH tests, two groups were identified. The majority, 23 of 31 hirsute patients (group I), had results similar to those in the control group. In the other eight patients (group II), biologic abnormalities were disclosed and suggested a partial adrenal 11 beta-hydroxylase defect in two patients, an incomplete form of adrenal 3 beta-ol deficiency in one patient, an adrenal hyperreactivity without evident cause in two patients, and polycystic ovary syndrome in association with an adrenal hyperreactivity in three patients. As a group, the eight patients showed ACTH-stimulated increments in testosterone, delta 4-androstenedione, dehydroepiandrosterone, and 17-ketosteroids that were significantly greater (p less than 0.01) than the mean responses in the control group. The conclusion is that some women who previously were designated as having "idiopathic" hirsutism had an adrenal and/or ovarian component to their hyperandrogenism which could be shown only by appropriate dynamic tests.

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Androstenedione; Dehydroepiandrosterone; Female; Gonadotropin-Releasing Hormone; Hirsutism; Humans; Ovarian Cysts; Testosterone

As a result of examining the urine excretion of 17-OCS, 17-KS, estrogens and the concentration of protein bound iodine and butanolextractable iodine in blood of patients with benign and malignant ovarian tumors, there were found some deviations from the normal hormonal balance in all these patients. These deviations were manifested in a delayed transformation of cortisol to cortisone, in a shifted androgeno-estrogenic balance toward estrogen active fractions, and in the reduced production of thyroid hormones. In ovarian cancer, however, these changes were manifested to a greater extent.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Estrogens; Female; Homeostasis; Humans; Middle Aged; Ovarian Cysts; Ovarian Neoplasms; Thyroid Hormones

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Neoplasms; Adult; Amenorrhea; Androgens; Androstenedione; Carcinoma; Chorionic Gonadotropin; Clomiphene; Dexamethasone; Estrogens; Ethinyl Estradiol; Female; Hirsutism; Humans; Hydrocortisone; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Sertoli-Leydig Cell Tumor; Testosterone; Virilism

The effect of Danazol, a new gonadotropin inhibitor, was examined in four categories of patients. (1) Ten normal women medicated orally with Danazol, 800 mg. daily for 91 days, showed no depression of serum LH, estrone, estradiol, or progesterone below control, second-day levels. The serum FSH was slightly depressed; (2) Two anovulatory patients having elevated serum LH values were treated with Danazol, 400 to 800 mg. daily, for 1 to 3 days at midcycle. One patient repeatedly showed a temperature rise and LH flood within 24 hours of initial medication. Both had menstrual periods 7 to 9 days later. (3) Two normal midcycle ovulators were treated with 400 and 800 mg; of Danazol, respectively, for 1 day in the midfollicular phase and one apparently ovulated promptly prematurely. (4) Two patients having severe hot flushes following surgical menopause were treated with Danazol, 800 mg; daily, without reducing FSH or LH but with disappearance of hot flushes.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Alkynes; Endometriosis; Estradiol; Estrogen Antagonists; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hydroxysteroids; Luteinizing Hormone; Male; Menopause; Menstruation Disturbances; Middle Aged; Ovarian Cysts; Ovulation; Oxazoles; Pregnadienes; Progesterone; Time Factors

Gonadotropin levels and secretory patterns were studied in 28 oligomenorrheic patients with various types of polycystic ovary disease (PCO). On the basis of ovarian morphology and histology, the patients PCOuld be separated into two distinct categories arbitarily designated "typical" (type I) and "atypical" (type II) PCO. Although no differences were noted in symptomatology or 17-ketosteroid, testosterone, or follicle-stimulating hormone levels, the 12 type I patients demonstrated widely fluctuating, but markedly elevated, luteinizing hormone (LH) levels, while the 16 type II patients demonstrated lower and less fluctuating LH levels which were comparable to those found during the normal follicular phase. It is likely that type I PCO is a distinct entity similar to that described by Stein and Leventhal, while type II co represents a heterogenous spectrum of disorders, many of which remain obscure.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Anovulation; Dexamethasone; Feedback; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hyperplasia; Luteal Cells; Luteinizing Hormone; Oligomenorrhea; Ovarian Cysts; Ovarian Diseases; Ovary; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Biopsy; Body Temperature; Cholesterol; Corticosterone; Endometrium; Estrogens; Female; Hirsutism; Humans; Hydrocortisone; Menstruation; Menstruation Disturbances; Ovarian Cysts; Ovulation; Phenobarbital; Polycystic Ovary Syndrome; Pregnancy; Pregnanediol; Stimulation, Chemical; Vaginal Smears

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Androgens; Androstanes; Chorionic Gonadotropin; Depression, Chemical; Dexamethasone; Female; Humans; Hydroxysteroids; Ovarian Cysts; Ovary; Pregnancy; Pregnancy Complications; Pregnancy, Multiple; Stimulation, Chemical; Testosterone; Twins; Veins; Venae Cavae; Virilism

Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Binding, Competitive; Chorionic Gonadotropin; Depression, Chemical; Dihydrotestosterone; Drug Synergism; Female; Hirsutism; Humans; Ovarian Cysts; Ovary; Pregnanetriol; Stimulation, Chemical; Testosterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Chorionic Gonadotropin; Dexamethasone; Diagnosis, Differential; Female; Hirsutism; Humans; Ovarian Cysts; Radioimmunoassay

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Estrogens; Fallopian Tubes; Female; Follicle Stimulating Hormone; Humans; Hydrogen-Ion Concentration; Luteinizing Hormone; Ovarian Cysts; Ovary; Puberty, Precocious; Radioimmunoassay; Vagina

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adult; Amenorrhea; Female; Hirsutism; Humans; Hyperplasia; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Ovarian Cysts; Ovarian Diseases; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnanetriol; Testosterone

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Amenorrhea; Female; Glucocorticoids; Hirsutism; Humans; Hydrocortisone; Ovarian Cysts; Ovarian Neoplasms; Ovary; Teratoma; Time Factors

Topics: 17-Ketosteroids; Androgens; Female; Hirsutism; Humans; Kinetics; Ovarian Cysts; Testosterone

Topics: 17-Ketosteroids; Adult; Cesarean Section; Cystadenoma; Female; Humans; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Virilism

Topics: 17-Ketosteroids; Adult; Body Temperature; Cervix Mucus; Clomiphene; Estrogens; Female; Humans; Infertility, Female; Ovarian Cysts; Ovary; Ovulation; Pregnancy; Pregnanediol

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Androgens; Cushing Syndrome; Estrogens; Female; Hirsutism; Humans; Hydrocortisone; Infertility, Female; Ovarian Cysts; Ovarian Neoplasms; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Biopsy; Chorionic Gonadotropin; Estriol; Female; Follicle Stimulating Hormone; Gonadotropins; Gonadotropins, Pituitary; Humans; Metyrapone; Ovarian Cysts; Ovary; Pregnanediol

Topics: 17-Ketosteroids; Adolescent; Androgens; Androstanes; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Ovarian Cysts; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Testosterone; Thecoma; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amenorrhea; Biopsy; Estrogens; Female; Gonadotropins; Humans; Ovarian Cysts; Ovary; Pituitary-Adrenal Function Tests; Progesterone; Sex Chromatin; Sex Chromosomes

Topics: 17-Ketosteroids; Adolescent; Adult; Body Temperature; Clomiphene; Dexamethasone; Estrogens; Female; Follicle Stimulating Hormone; Glucocorticoids; Hirsutism; Humans; Luteinizing Hormone; Menstruation Disturbances; Ovarian Cysts; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Progesterone; Radioimmunoassay; Vaginal Smears

Topics: 17-Ketosteroids; Cushing Syndrome; Female; Hirsutism; Humans; Hyperplasia; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Atrophy; Female; Gonadotropins; Humans; Hypertrophy; Ovarian Cysts; Ovarian Diseases; Ovary; Ovulation; Staining and Labeling

Topics: 17-Ketosteroids; Dehydroepiandrosterone; Female; Glucocorticoids; Humans; In Vitro Techniques; Ovarian Cysts; Testosterone; Tritium

Topics: 17-Ketosteroids; Adolescent; Adult; Cholesterol; Chorionic Gonadotropin; Estrogens; Female; Glucocorticoids; Humans; Hydatidiform Mole; Ovarian Cysts; Pregnancy; Pregnancy Complications; Pregnanetriol; Pregnenolone

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Carbon Isotopes; Cholesterol; Female; Humans; Hydatidiform Mole; Hydroxyprogesterones; Ovarian Cysts; Pregnancy; Pregnanetriol; Pregnenolone; Progesterone; Steroids; Thecoma

Topics: 17-Ketosteroids; Adult; Biopsy; Female; Humans; Hyperplasia; Ovarian Cysts; Pregnancy; Pregnancy Complications

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adult; Female; Genital Diseases, Female; Hirsutism; Humans; Menstruation Disturbances; Ovarian Cysts; Polycystic Ovary Syndrome; Vagina; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Cardiac Catheterization; Cardiomyopathies; Female; Humans; Karyotyping; Ovarian Cysts; Pituitary-Adrenal Function Tests; Sex Chromatin; Testosterone; Turner Syndrome

Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Chromatography, Gas; Dehydroepiandrosterone; Endometriosis; Female; Humans; Infertility, Female; Leiomyoma; Methods; Middle Aged; Ovarian Cysts; Ovary; Polycystic Ovary Syndrome; Progesterone; Testosterone; Tritium; Veins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Carbon Isotopes; Chemistry, Clinical; Chromatography, Paper; Crystallization; Female; Humans; Hyperplasia; Ovarian Cysts; Polycystic Ovary Syndrome; Progesterone

Topics: 17-Ketosteroids; Adult; Biopsy; Estrogens; Female; Gonadotropins; Hirsutism; Humans; Infertility, Female; Karyotyping; Luteinizing Hormone; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications

Topics: 17-Ketosteroids; Adult; Amenorrhea; Dexamethasone; Estradiol; Estriol; Estrone; Feedback; Female; Humans; Hypothalamo-Hypophyseal System; Metyrapone; Middle Aged; Ovarian Cysts; Pituitary-Adrenal System; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adolescent; Adult; Chromatography, Gas; Chromatography, Thin Layer; Female; Hirsutism; Humans; Menstruation Disturbances; Ovarian Cysts; Polycystic Ovary Syndrome; Steroids; Testosterone

Topics: 17-Ketosteroids; Adult; Alkaline Phosphatase; Cesarean Section; Female; Hirsutism; Histocytochemistry; Humans; Hyperplasia; Hysterectomy; Infant, Newborn; Ovarian Cysts; Ovarian Neoplasms; Pelvimetry; Pregnancy; Pregnancy Complications; Staining and Labeling; Thecoma

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Chorionic Gonadotropin; Dexamethasone; Diethylstilbestrol; Female; Hirsutism; Humans; Ovarian Cysts; Ovary

Topics: 17-Ketosteroids; Adolescent; Adult; Female; Humans; Male; Methods; Ovarian Cysts; Progesterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Animals; Chorionic Gonadotropin; Clomiphene; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Meigs Syndrome; Ovarian Cysts; Ovulation; Pregnancy; Pregnancy Complications; Pregnanediol; Sheep

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Chemical Fractionation; Chromatography; Cysts; Female; Gynecology; Humans; Ovarian Cysts; Ovary