17-ketosteroids and Neoplasm-Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Age Factors; Breast Neoplasms; Castration; Cortisone; Estrogens; Female; Gonadotropins; Humans; Hypophysectomy; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis; Pituitary Hormones, Anterior; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Androgens; Breast Neoplasms; Calcium; Castration; Drug Therapy; Endocrine Glands; Estrogens; Glucuronidase; Humans; Hypophysectomy; Mastectomy; Metabolism; Neoplasm Metastasis; Neoplasms; Urine

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenal Cortex Hormones; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Geriatrics; Humans; Hypophysectomy; Male; Neoplasm Metastasis; Prostatic Neoplasms; Surgical Procedures, Operative; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Calcium; Clinical Trials as Topic; Corticosterone; Creatinine; Female; Gonadotropins; Humans; Luteinizing Hormone; Medroxyprogesterone; Neoplasm Metastasis; Potassium Chloride; Pregnanediol; Tetrazolium Salts

Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasms; Biopsy, Needle; Catecholamines; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Enzyme Inhibitors; Female; Glucocorticoids; Gonadal Steroid Hormones; Humans; Hydrocortisone; Hypertension; Hypokalemia; Middle Aged; Mitotane; Muscle Weakness; Neoplasm Metastasis; Renin; Thirst; Tomography, X-Ray Computed

We present nine cases of primary adrenocortical carcinoma, collected in our department of medicine and endocrinology over 25 years. In our patients, the most dependable tumor marker was urinary excretion of tetra-hydro-ll-deoxycortisol (THS), and elevated values were found in all cases where it was determined. In addition to surgical treatment, medication with o,p'-DDD was found to be of value for some of the patients. Median tumor weight was 487 g (118-2,085 g). Prognosis is difficult to predict. Median survival time after diagnosis was 34 months, but varied from three to 266 months.

Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adult; Aged; Biomarkers, Tumor; Cortodoxone; Cushing Syndrome; Female; Humans; Hydrocortisone; Male; Middle Aged; Mitotane; Neoplasm Metastasis; Prognosis

Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adult; Carcinoma; Female; Humans; Lung Neoplasms; Neoplasm Metastasis; Pleural Effusion

Two cases of androgen secreting adrenocortical carcinoma have been described by light and electron microscopy. The histological and ultrastructural features of the tumour cells were similar to those of compact cells of zona reticularis and to those described in virilizing adenomas. They possess numerous mitochondria with lamellar and tubular cristae, abundant smooth endoplasmic reticulum, lipofuscin bodies and scanty lipid. Irregularly shaped, crenated mitochondria, with outpouchings of the outer limiting membrane have also been observed. The clusters of neoplastic cells were surrounded by basement membrane which demonstrated a focal discontinuity, probably reflecting malignancy of the tumours. Hyperplasia of smooth endoplasmic reticulum and the presence of outpouchings of the mitochondrial outer limiting membrane might be the morphological manifestation of endocrine activity of the tumours.

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Androgens; Child, Preschool; Female; Humans; Liver Neoplasms; Male; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Aged; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Metastasis; Prognosis; Remission, Spontaneous; Statistics as Topic

Extensive hormonal evaluation was performed in a girl with adrenal carcinoma during the primary tumor stage, following adrenalectomy, during the period when metastases were evident and while on treatment with o,p'-DDD. At the age of 14 months a diagnosis of congenital adrenal hyperplasia was made and treatment with dexamethasone (0.125 to 0.25 mg/day) resulted in a fall-off in growth rate, normal advancement in bone age, decrease in virilization and suppression of 17- ketosteroid excretion which continued until 4 3/12 years of age when virilization increased. At five years of age elevated serum and urinary androgen levels unsuppressible with dexamethasone were noted. Following removal of a large right adrenal carcinoma, serum and urinary hormone levels returned to normal. There months following surgery, liver metastases were documented associated with elevated levels of serum androgens. With o,p'-DDD treatment, serum dehydroepiandrosterone sulfate (DS) and urinary 17-ketosteroid (17-KS) excretion fell rapidly while there was a delay in the fall of free androgens. The persistence of free steroid secretion with decreased formation of DS suggests that the o,p'-DDD may have altered sulfatase activity before causing tumor necrosis and total decrease in steroidogenesis.

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool; Dehydroepiandrosterone; Depression, Chemical; Dexamethasone; Diagnosis, Differential; Female; Humans; Infant; Mitotane; Neoplasm Metastasis; Virilism

Topics: 17-Ketosteroids; Aged; Androstenedione; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis

The estrogen receptor was assayed, using the 2,000g supernatant and dextran-coated charcoal method, in 243 tissue samples from human breast cancer, benign breast diseases, macroscopically normal breast tissues, normal uterine myometrium, and uterine myoma. The estrogen receptor was found to be positive in 52.1% of 98 primary breast cancer and in 54.1% of 24 metastatic tumors. The receptor in the breast cancer was found to be similar to that in normal uterine myometrium in the binding character; that is, the dissociation constant of 10(-9) approximately 10(-11) M and number of binding sites of 0 approximately 2,800 fmol/mg protein. There was no correlation between the presence of the receptor and some clinical factors such as menopausal status, age of the patient, urinary 17-ketosteroid excretion, clinical stage of cancer, tumor size, positive or negative axillary lymph node metastasis, histological type, metastatic site of the cancer, or disease-free interval. The estrogen receptor appeared to be retained by metastasis of cancer, and this may lead to the use of the receptor assay with mastectomy specimens for the prediction of response to hormonal therapy in future recurrence of malignancy. Furthermore, it may be possible by this assay to select patients suitable for adjuvant therapy with hormones at the time of mastectomy. A good correlation was found between the presence of the receptor and response to the major endocrine ablation therapy in patients with advanced or metastatic breast cancer. When the receptor was negative in the cancer tissue, the change of response to the endocrine therapy was minimum. On the other hand, if the cancer contained the receptor, approximately 60% of the patients with metastatic or advanced breast cancer responded well to the major endocrine ablation therapy. Thus, the estrogen receptor of breast cancer in Japanese patients appears to bear a close resemblance to that reported in Western patients in its incidence and the correlation to some biological characteristics of the cancer.

Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adrenalectomy; Breast; Breast Neoplasms; Carcinoma; Castration; Female; Humans; Leiomyoma; Menopause; Menstruation; Myometrium; Neoplasm Metastasis; Receptors, Estrogen; Uterine Neoplasms

Major endocrine ablation therapy was carried out in 133 patients with advanced breast cancer. Of 40 patients undergoing left suprarenal to inferior mesenteric venous shunt with bilateral oophorectomy and right adrenalectomy, 16 cases (40 per cent) had an objective response. The mean postoperative survival of the patients with a positive response, those showing some response and those who failed to respond was 35-8, 26-5 and 8-8 months respectively. Thus, the results of the present procedure are comparable to those of adrenalectomy. No replacement therapy with corticoids was necessary. An increase in the response rate and extension of the survival time can be expected with the addition of postoperative long term maintenance therapy with chemotherapeutic agents and androgens.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Breast Neoplasms; Castration; Female; Follow-Up Studies; Humans; Liver Neoplasms; Mesenteric Veins; Middle Aged; Mitomycins; Neoplasm Metastasis; Time Factors

Topics: 17-Ketosteroids; Abdominal Neoplasms; Adult; Aged; Animals; Dogs; Humans; Leydig Cell Tumor; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Testicular Neoplasms; Testosterone

1. The excretion of dehydroepiandrosterone is lower in patients suffering from mammary cancer than in healthy women. 2. There doesn't exist any relation between the 17-ketosteroid excretion and the age of postmenopausal women. 3. Patients with mammary tumors in stages III and IV are characterized by a lower excretion of dehydroepiandrosterone in percental parts than patients in stages I and II. 4. In patients with mammary tumors in stages III and IV and in patients with recurrences independently from the tumor stages we find higher extrem values for aetiocholanolone and smaller ones for dehydroepiandrosterone than in the other stages. 5. The quotient of percental parts of excreted aetiocholanolone to dehydroepiandrosterone shows significantly higher values for patients with recurrences than without them. 6. The quotient of aetiocholanolone to dehydroepiandrosterone is not a valid factor for a postoperative control of recurrences of the disease.

Topics: 17-Ketosteroids; Aged; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

The second fully documented case of ACTH-producing prostatic adenocarcinoma with elevated plasma and tissue levels of ACTH is presented. The distinguishing characteristics of ACTH-producing extrapituitary neoplasms and the various modes of therapy are discussed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Aged; Hormones, Ectopic; Humans; Hydrocortisone; Liver; Liver Neoplasms; Male; Neoplasm Metastasis; Prostate; Prostatic Neoplasms

Relationship between the urinary excretion of steroids in premenopausal Japaneses patients with advanced breast cancer and their response to oophorectomy was studied. The estrogen fractions were determined by radioimmunoassay and those who responded to oophorectomy showed higher levels of 17 beta-estradiol than the non-responders before surgery. The high levels of urinary 17 beta-estradiol of the responders dropped markedly after oophorectomy. On the contrary, the non-responders showed relatively low levels of urinary excretion of 17 beta-estradiol before oophorectomy and the levels appeared either unchanged or slightly elevated after surgery. No definite relation was found between changes in the urinary excretion of estrone or estriol and the clinical effect of oophorectomy. Excretion of 17-ketosteroids in the responders was lower than that of the non-responders.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Breast Neoplasms; Castration; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

An efficacy of the method of hormonal therapy--endolumbar hydrocortisone injection in patients with advanced breast cancer has been studied. A remission was gained in 28 of 41 patients. The method proved to be mostly effective in metastases in bones. Changes in the level of estrogens, 17-KS and 17-OCS excretion with the urine during the treatment indicate an endocrinous mechanism of this therapeutic effect. An efficacy of the method in extensive dissemination of the process, its relative simplicity and availability along with the absence of serious complications enabled the authors to hope that the suggested method may be widely used in practice.

Topics: 17-Ketosteroids; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Estrogens; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

Urinary outpout of oestrogens and 17-ketosteroids were estimated in 200 women with breast cancer; 60 of them were cases with rapid evolution (malignant evolutive push). The majority of cases analysed had abnormal hormonal levels, especially of oestrogens. The average oestrogenic levels are higher than the normal values; the highest values correspond to the most severe and rapidly evolutive type of breast cancer, the inflammatory breast carcinoma. In the patients without evolutive push, the proportion of cases with absolute or relative hypooestrogeny is approximately equal toor exceeds the proportion of hyperoestrogenic cases. In the presence of the evolutive push and especially of his most severe type, inflammatory carcinoma, the cases with hyperoestrogeny, both absolute and relative, by hypoandrogeny, are dominant. The proportion of cases with higher 17-ketosteroid urinary outputs than the normal mean is greater in the patients without evolutive push, while in those with evolutive push, the majority of cases have lower values of 17-ketosteroids than the normal mean.

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Edema; Estrogens; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis; Prognosis; Time Factors

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenalectomy; Aged; Biopsy; Cystoscopy; Diethylstilbestrol; Humans; Hydronephrosis; Male; Neoplasm Metastasis; Penile Neoplasms; Prognosis; Prostatic Neoplasms; Skin Neoplasms; Testis; Testosterone; Urinary Bladder Neoplasms; Urination Disorders

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Aged; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Evaluation Studies as Topic; Humans; Hypophysectomy; Male; Middle Aged; Neoplasm Metastasis; Pennsylvania; Prognosis; Prostatic Neoplasms; Radiography; Recurrence; Remission, Spontaneous; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Cushing Syndrome; Female; Hormones, Ectopic; Humans; Hydrocortisone; Melanoma; Metyrapone; Middle Aged; Mitotane; Neoplasm Metastasis; Palliative Care

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adenocarcinoma; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Corticosterone; Desoxycorticosterone; Epinephrine; Female; Humans; Hydrocortisone; Hypoglycemia; Insulin; Lung Neoplasms; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Castration; Child; Choriocarcinoma; Chorionic Gonadotropin; Estrogens; Female; Follicle Stimulating Hormone; Glucocorticoids; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Hysterectomy; Neoplasm Metastasis; Pregnancy; Pregnanediol; Trophoblastic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Blood Glucose; Dexamethasone; Humans; Male; Metyrapone; Middle Aged; Mitotane; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Potassium; Prostatic Neoplasms; Psychotic Disorders; Spironolactone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Aminoglutethimide; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Castration; Central Nervous System; Dexamethasone; Estrogens; Female; Fludrocortisone; Humans; Neoplasm Metastasis; Ovary; Remission, Spontaneous; Skin Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Alkaline Phosphatase; Androgens; Autopsy; Carcinoma; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Estrogens; Growth Hormone; Gynecomastia; Hormones, Ectopic; Humans; Immunoassay; Lung Neoplasms; Male; Neoplasm Metastasis; Placental Hormones; Placental Lactogen; Thyroid Function Tests

Topics: 17-Ketosteroids; Acid Phosphatase; Aged; Alkaline Phosphatase; Anesthesia, Local; Castration; Cortisone; Cryosurgery; Estrogens; Follicle Stimulating Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Middle Aged; Neoplasm Metastasis; Palliative Care; Prostatic Neoplasms; Remission, Spontaneous; Stereotaxic Techniques; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Follicle Stimulating Hormone; Glucocorticoids; Humans; Menopause; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pregnanediol; Thiotepa; Time Factors; Vinblastine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Dihydroxyphenylalanine; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Middle Aged; Neoplasm Metastasis; Progesterone; Prolactin

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Alkaline Phosphatase; Androgens; Bone Neoplasms; Cryosurgery; Follicle Stimulating Hormone; Follow-Up Studies; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Neoplasm Metastasis; Palliative Care; Pelvic Neoplasms; Prostatic Neoplasms; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Androstanes; Autopsy; Chromatography; Corticosterone; Cushing Syndrome; Dehydroepiandrosterone; Dexamethasone; Edema; Humans; Hydrocortisone; Hypokalemia; Male; Metyrapone; Middle Aged; Mixed Function Oxygenases; Neoplasm Metastasis; Pregnanes; Pregnenolone; Progesterone; Retroperitoneal Neoplasms; Scrotum; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Amenorrhea; Carcinoma; Creatinine; Estrogens; Female; Hirsutism; Humans; Hydrocortisone; Hyperplasia; Neoplasm Metastasis; Pituitary-Adrenal System; Pregnanetriol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abdominal Neoplasms; Acetates; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Carcinoma; Child; Cortisone; Dexamethasone; Dichlorodiphenyldichloroethane; Female; Fluorine; Humans; Hydrocortisone; Lung Neoplasms; Metabolism; Neoplasm Metastasis; Prednisolone; Radiography; Splenectomy; Virilism

Topics: 17-Ketosteroids; Adolescent; Autopsy; Chorionic Gonadotropin; Dysgerminoma; Female; Hormones, Ectopic; Humans; Lung; Lung Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Pituitary Gland; Placental Lactogen; Radioimmunoassay

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Carcinoma; Child, Preschool; Dichlorodiphenyldichloroethane; Female; Hirsutism; Humans; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Virilism

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adult; Androstanes; Androsterone; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Etiocholanolone; Female; Glucuronates; Humans; Hydroxyprogesterones; Neoplasm Metastasis; Ovarian Neoplasms; Pregnanes; Pregnanetriol; Sertoli-Leydig Cell Tumor; Sulfates; Testosterone; Virilism

Topics: 17-Ketosteroids; Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Cholestasis; Cholesterol; Colonic Neoplasms; Common Bile Duct; Estradiol; Estranes; Estrogens; Estrone; Female; Feminization; Glucuronates; Humans; Liver Cirrhosis; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Stomach Neoplasms; Tritium

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Androgens; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, Thin Layer; Cushing Syndrome; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Castration; Cyclophosphamide; Estrogens; Female; Humans; Hypercalcemia; Middle Aged; Neoplasm Metastasis; Norethindrone; Ovary; Phosphoric Monoester Hydrolases; Phosphorus; Prednisone; Radiography; Testosterone

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aged; Bone Neoplasms; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Androsterone; Aniline Compounds; Carcinoma; Cushing Syndrome; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Metastasis; Pyridones; Retroperitoneal Neoplasms; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Antineoplastic Agents; Carcinoma; Cortisone; Dichlorodiphenyldichloroethane; Estrogens; Female; Gonadotropins; Humans; Hydrocortisone; Lung Neoplasms; Neoplasm Metastasis; Pregnanediol; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Female; Humans; Hypophysectomy; Neoplasm Metastasis; Ovary; Prognosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Carcinoma; Child; Child, Preschool; Dehydroepiandrosterone; Female; Hirsutism; Humans; Infant; Lung Neoplasms; Male; Neoplasm Metastasis; Radiography; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Middle Aged; Neoplasm Metastasis; Radiography, Thoracic; Skull; Thymus Neoplasms

Topics: 17-Ketosteroids; Acetates; Acid Phosphatase; Adenocarcinoma; Adenoma, Islet Cell; Adult; Aged; Biopsy; Blood Sedimentation; Estrogens; Hematuria; Humans; Male; Middle Aged; Neoplasm Metastasis; Prostatectomy; Prostatic Neoplasms; Radionuclide Imaging; Rectum; Urinary Incontinence

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Child; Female; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Radiography; Sex Factors; Thymoma; Thymus Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aminoglutethimide; Aniline Compounds; Humans; Infant; Lung Neoplasms; Male; Neoplasm Metastasis; Pulmonary Embolism; Pyridones; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Aged; Androgens; Carbon Isotopes; Dichlorodiphenyldichloroethane; Female; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Metastasis; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Autopsy; Brain; Estradiol; Estriol; Estrone; Gallbladder Neoplasms; Gonadotropins; Humans; Hypertrichosis; Iron; Male; Neoplasm Metastasis; Pituitary Gland; Testosterone

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Humans; Lung Neoplasms; Male; Mastectomy; Middle Aged; Neoplasm Metastasis; Pneumonectomy

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Breast Neoplasms; Chromatography, Thin Layer; Female; Fibrosarcoma; Humans; Male; Mass Screening; Methods; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Ultraviolet Rays

Topics: 17-Ketosteroids; Acromegaly; Animals; Bone Neoplasms; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hypophysectomy; Male; Methods; Neoplasm Metastasis; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Ketosteroids; Aldosterone; Antineoplastic Agents; Dichlorodiphenyldichloroethane; Estrogens; Gonadotropins; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Agents; Black or African American; Carcinoma; Child; Child, Preschool; Cushing Syndrome; Dichlorodiphenyldichloroethane; Female; Humans; Infant; Male; Middle Aged; Neoplasm Metastasis; Sex; White People

Topics: 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Castration; Female; Gonadal Steroid Hormones; Humans; Neoplasm Metastasis

Topics: 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Scirrhous; Adrenal Cortex Hormones; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal; Chromosomes; Fluids and Secretions; Gonadotropins; Gynecomastia; Humans; Klinefelter Syndrome; Male; Neoplasm Metastasis; Neoplasms; Pathology; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Alkalosis; Carcinoma; Carcinoma, Squamous Cell; Esophageal Neoplasms; Humans; Hypokalemia; Liver Neoplasms; Neoplasm Metastasis; Pathology; Pituitary-Adrenal Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Breast Neoplasms; Female; Humans; Neoplasm Metastasis; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenalectomy; Adrenocortical Hyperfunction; Aged; Dexamethasone; Diethylstilbestrol; Humans; Male; Neoplasm Metastasis; Neoplasms; Pathology; Prostatic Neoplasms; Surgical Procedures, Operative; Toxicology; Urine

Topics: 17-Ketosteroids; Adenocarcinoma, Mucinous; Androgens; Estrogens; Female; Histocytochemistry; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Krukenberg Tumor; Metabolism; Neoplasm Metastasis; Ovarian Neoplasms; Pathology; Pregnancy; Pregnancy Complications; Urine; Virilism

The production of ACTH-like material by tumours arising in non-endocrine tissue may initiate severe adrenocortical hyperfunction. The pathogenesis and clinical and laboratory features of Cushing's syndrome associated with such tumours are characteristic. The autonomous production by the tumour of ACTH-like material cannot be suppressed by exogenous corticoids. The onset of clinical symptoms is rapid; muscle wasting, general weakness, thirst and peripheral edema predominate, and the classical signs of Cushing's syndrome may be absent. High levels of plasma 17-hydroxycorticosteroids and urinary 17-hydroxycorticosteroids and 17-ketosteroids, usually with normal levels of urinary aldosterone, commonly occur. Hypokalemic alkalosis unresponsive to replacement therapy may cause death. In the case reported herein, the intriguing possibility exists that two hormone-like substances were produced by the primary growth and its metastases: one, ACTH-like, to account for the adrenal hyperplasia and Cushing's syndrome; and another, gastrin-like, giving rise to the ulcerogenic diathesis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyperfunction; Autopsy; Carcinoma, Islet Cell; Chloramphenicol; Cushing Syndrome; Drug Therapy; Gastrins; Humans; Hypokalemia; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Pathology; Spironolactone; Zollinger-Ellison Syndrome

Topics: 17-Ketosteroids; Adolescent; Child; Female; Geriatrics; Humans; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Ovarian Neoplasms; Pathology; Pregnancy; Prognosis; Sertoli-Leydig Cell Tumor; Surgical Procedures, Operative; Virilism

Topics: 17-Ketosteroids; Adolescent; Adult; Animals; Estradiol; Estrogens; Female; Follow-Up Studies; Goiter; Humans; Iodine Isotopes; Male; Metabolism, Inborn Errors; Mice; Neoplasm Metastasis; Pituitary Neoplasms; Radiography, Thoracic; Rats; Thiouracil; Thyroid Neoplasms; Thyrotropin; Thyroxine; Triiodothyronine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Anxiety; Cushing Syndrome; Diagnosis, Differential; Hypertension; Liver Neoplasms; Neoplasm Metastasis; Nephrectomy; Pathology; Urine; Urography

Topics: 17-Ketosteroids; Androgens; Carcinoma, Embryonal; Estrogens; Gonadotropins; Gynecomastia; Humans; Liver Neoplasms; Lung Neoplasms; Male; Neoplasm Metastasis; Pathology; Retroperitoneal Neoplasms; Testicular Neoplasms; Urine

Topics: 17-Ketosteroids; Androsterone; Breast; Breast Neoplasms; Chromatography; Dehydroepiandrosterone; Etiocholanolone; Female; Glucuronates; Humans; Hypophysectomy; Neoplasm Metastasis; Sulfates; Urine

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Estradiol; Estriol; Estrogens; Estrone; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypogonadism; Male; Neoplasm Metastasis; Neoplasms; Pregnanediol; Surgical Procedures, Operative; Testis; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Neoplasms; Androgens; Chromatography; Glucuronidase; Humans; Metabolism; Neoplasm Metastasis; Pregnanediol; Steroids; Urine