17-ketosteroids and Myxedema

The authors report a case of Steinert's disease in a woman and discuss the endocrine profile of this disease after giving an account of the criteria of diagnosis. Disorders of gonad function are mild in women, primary testicular atrophy is very frequent in man with reduction in 17-ketosteroids and testosterone. Thyroid function was normal but, in a few cases, a low fixation curve was found (our case) corrected by TSH stimulation. The frequency of cataract emphasizes the interest of this sign for detection. Diabetes, associated with hyperinsulinism, seemed more frequent than in a population without Steinert's disease. The pathogenesis of these endocrine disorders appears secondary and is ill explained if one considers it as a single disease. Better knowledge, no doubt linked to progress in biochemistry of normal and myopathic muscle, will help to explain the pathogenesis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Calcium; Cataract; Diabetes Mellitus; Female; Glucose; Gonads; Humans; Hyperinsulinism; Hypothalamus; Male; Myotonic Dystrophy; Myxedema; Phosphorus; Pituitary Gland; Testosterone; Thyroid Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Androgens; Dexamethasone; Graves Disease; Humans; Hydrocortisone; Hyperthyroidism; Liver; Metyrapone; Myxedema; Testosterone; Thyroid Diseases; Thyroidectomy; Thyroxine

Topics: 17-Ketosteroids; Adult; Aged; Aging; Androsterone; Arteriosclerosis; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Colorimetry; Diabetes Mellitus; Etiocholanolone; Humans; Male; Middle Aged; Myocardial Infarction; Myxedema; Testosterone; Triiodothyronine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Androsterone; Chromatography, Gas; Etiocholanolone; Female; Humans; Hyperthyroidism; Male; Myxedema; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Humans; Hypothyroidism; Myxedema; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Anorexia Nervosa; Child; Child, Preschool; Chromatography; Cushing Syndrome; Disorders of Sex Development; Endocrine System Diseases; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hyperthyroidism; Hypertrichosis; Hypopituitarism; Male; Middle Aged; Myxedema; Obesity; Pheochromocytoma; Pregnancy; Spectrophotometry

Topics: 17-Ketosteroids; Adult; Androgens; Biotransformation; Chromatography; Female; Glucuronates; Glucuronidase; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Myxedema

Topics: 17-Ketosteroids; Androsterone; Carbon Isotopes; Chromatography, Paper; Female; Humans; Hypothyroidism; Male; Middle Aged; Myxedema; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocortical Hyperfunction; Adult; Ataxia; Child; Child, Preschool; Dwarfism; Gonads; Humans; Intellectual Disability; Myxedema; Obesity; Puberty, Precocious

Topics: 17-Ketosteroids; Adult; Coma; Female; Humans; Hypopituitarism; Middle Aged; Myxedema; Postpartum Hemorrhage; Pregnancy; Puerperal Disorders; Tuberculosis, Pulmonary

Topics: 17-Ketosteroids; Adult; Aged; Androgens; Chromatography, Paper; Female; Humans; Hydroxysteroid Dehydrogenases; Hyperthyroidism; Male; Middle Aged; Myxedema; Thyroid Hormones

Topics: 17-Ketosteroids; Androgens; Chemistry, Organic; Humans; Hydrogen-Ion Concentration; Infrared Rays; Magnetic Resonance Spectroscopy; Myxedema; Organic Chemistry Phenomena; Spectrum Analysis; Urea

Topics: 17-Ketosteroids; Adenoma; Adenoma, Acidophil; Adenoma, Basophil; Adolescent; Adrenal Cortex Hormones; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Blood Chemical Analysis; Choristoma; Cushing Syndrome; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hypophysectomy; Iodine Isotopes; Myxedema; Neoplasms; Pathology; Pituitary Neoplasms; Radiography; Radioisotopes; Radionuclide Imaging; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Gonadotropins; Gonadotropins, Pituitary; Hypopituitarism; Myxedema; Pituitary Diseases; Thyroxine; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Child; Down Syndrome; Female; Gonadotropins; Humans; Hypothyroidism; Iodine Isotopes; Medroxyprogesterone; Menstruation; Myxedema; Puberty; Puberty, Precocious; Radiography; Sella Turcica; Sexual Maturation; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Body Fluids; Exophthalmos; Eye Manifestations; Graves Ophthalmopathy; Humans; Hyperthyroidism; Myxedema; Urine

Topics: 17-Ketosteroids; Disease; Humans; Myxedema; Pituitary Diseases; Pituitary Gland; Pituitary Gland, Anterior

Topics: 17-Ketosteroids; Humans; Hydrolysis; Myxedema

Topics: 17-Ketosteroids; Follicle Stimulating Hormone; Gonadotropins; Gonadotropins, Pituitary; Myxedema; Pituitary Diseases; Pituitary Gland; Steroids; Thyroxine; Urine