17-ketosteroids and Myocardial-Infarction

Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then"flew blind" concerning the uncertainties associated with these cycles when they are not assessed. The resolution of more about 10-year and other cycles, some reported herein, replaces the admission of complete unpredictability, implied by using the label "secularity." Heretofore unaccounted-for variability becomes predictable insofar as it proves to be rhythmic and is mapped systematically to serve as a battery of useful reference values. About 10-year cycles in urinary 17-ketosteroid excretion and in heart rate and its variability, among others, are aligned with cycles of similar length in mortality from myocardial infarction. Associations accumulate between cycles of natural physical time structures, chronomes such as the 10.5-year (circadecennian) Schwabe and the 21-year (circavigintunennian) Hale cycles of solar activity, and chronomes in biota. There are about 50-year (circasemicentennian) cycles in mortality from stroke in Minnesota and in the Czech Republic and also in human morphology at birth, the latter result reducing the likelihood that these cycles are purely human made. Associations among large populations warrant long-term systematic coordinated sampling of natural physical and biological variables of interest for the design of countermeasures against already documented elevated risks of stroke, myocardial infarction, and other catastrophic diseases, notably in elderly adults. New findings will be introduced against the background of the documented value of mapping rhythms in medicine and gerontology. In both these fields, rhythms promise the seeming paradox of better care for less.

Topics: 17-Ketosteroids; Aged; Aging; Chronobiology Phenomena; Heart Rate; Humans; Myocardial Infarction; Periodicity; Stroke

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adult; Aged; Blood Coagulation; Cholinesterases; Creatine Kinase; Humans; Lipids; Middle Aged; Myocardial Infarction; Reference Values

Topics: 17-Ketosteroids; Acute Disease; Adult; Aged; Androgens; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Myocardial Infarction; Testosterone; Time Factors

Convincing evidence of biological effects during long-term abnormal weather conditions is very rare because usually no continuous series of physiological data from the same animals or humans (either single or in groups) have been collected over many years during the period preceding the meteorological event. Since 1955, at the Biometeorological Research centre, Leiden, about 220,000 blood data were collected from healthy male blood donors at Leiden, The Netherlands, and about 110,000 data at Oslo, Norway, since 1966. It was found that during the meteorologically abnormal year of 1974, which was abnormal in many parts of the world, both in Leiden and Oslo abnormal biological patterns occurred in blood sedimentation rate, haemoglobin, diastolic blood pressure, gamma-globulin levels, Piccardi p-test percentages and a few other biological parameters. A more complete monograph will be published at a later date.

Topics: 17-Ketosteroids; Blood Pressure; Blood Sedimentation; Circadian Rhythm; Depression; gamma-Globulins; Hemoglobins; Humans; Male; Myocardial Infarction; Netherlands; Norway; Rheumatic Diseases; Serum Albumin; Weather

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Aged; Aldosterone; Epinephrine; Female; Heart Failure; Hemodynamics; Humans; Hydrocortisone; Hypertension; Kallikreins; Kinins; Male; Middle Aged; Myocardial Infarction; Neurotransmitter Agents; Norepinephrine; Renin; Shock, Cardiogenic; Sympathetic Nervous System

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Androgens; Androsterone; Circadian Rhythm; Dehydroepiandrosterone; Etiocholanolone; Humans; Male; Middle Aged; Myocardial Infarction

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Carbon Radioisotopes; Cholesterol; Dehydroepiandrosterone; Epinephrine; Humans; Hydrocortisone; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Norepinephrine; Triglycerides

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Arteriosclerosis; Cholesterol; Humans; Hyperlipidemias; Lipoproteins; Male; Middle Aged; Myocardial Infarction

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Aged; Androgens; Arteriosclerosis; Chromatography, Thin Layer; Cortisone; Female; Glucocorticoids; Humans; Male; Middle Aged; Myocardial Infarction

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Catecholamines; Cholesterol; Coronary Disease; Dehydroepiandrosterone; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Stress, Psychological; Sympathetic Nervous System; Triglycerides

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Chromatography, Gas; Etiocholanolone; Humans; Lung Neoplasms; Middle Aged; Myocardial Infarction; Thoracic Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Chromatography, Thin Layer; Chronic Disease; Coronary Disease; Glucocorticoids; Humans; Male; Methods; Middle Aged; Myocardial Infarction; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Angina Pectoris; Coronary Disease; Humans; Middle Aged; Myocardial Infarction

Topics: 17-Ketosteroids; Adult; Aged; Aging; Androsterone; Arteriosclerosis; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Colorimetry; Diabetes Mellitus; Etiocholanolone; Humans; Male; Middle Aged; Myocardial Infarction; Myxedema; Testosterone; Triiodothyronine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Endopeptidases; Eosinophils; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Endopeptidases; Eosinophils; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Shock; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Endopeptidases; Eosinophils; Female; Humans; Male; Mandelic Acids; Middle Aged; Myocardial Infarction; Prognosis

Topics: 17-Ketosteroids; Adult; Aged; Angina Pectoris; Blood Sedimentation; Fibrinogen; Humans; Male; Middle Aged; Myocardial Infarction; Retrospective Studies

Topics: 17-Ketosteroids; Acute Disease; Adult; Aged; Blood Pressure; Humans; Male; Middle Aged; Myocardial Infarction

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adult; Humans; Hydrocortisone; Male; Middle Aged; Myocardial Infarction

Topics: 17-Ketosteroids; Humans; Myocardial Infarction; Pituitary-Adrenal Function Tests; Steroids

Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Etiocholanolone; Female; Glucocorticoids; Humans; Male; Middle Aged; Myocardial Infarction

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Humans; Mandelic Acids; Myocardial Infarction; Pituitary-Adrenal Function Tests; Shock

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Aged; Female; Glucocorticoids; Humans; Male; Middle Aged; Myocardial Infarction

Topics: 17-Ketosteroids; Adult; Blood Coagulation Disorders; Endopeptidases; Eosinophils; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pituitary-Adrenal System

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Female; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Infarction; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Androsterone; Estrogens, Conjugated (USP); Etiocholanolone; Myocardial Infarction; Pharmacology; Pregnanediol; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Cardiovascular Diseases; Cortisone; Creatine; Creatinine; Drug Therapy; Electrocardiography; Fludrocortisone; Gonadotropins; Gonadotropins, Pituitary; Humans; Myocardial Infarction; Prednisone; Shock; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Function Tests; Eosinophils; Humans; Leukocyte Count; Myocardial Infarction

Topics: 17-Ketosteroids; Asthma; Endopeptidases; Eosinophils; Humans; Myocardial Infarction

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Cardiovascular Diseases; Eosinophils; Humans; Myocardial Infarction

Topics: 17-Ketosteroids; Arteriosclerosis; Hormones; Humans; Myocardial Infarction