17-ketosteroids and Lung-Neoplasms

Topics: 17-Ketosteroids; Adenoma; Air Pollution; Animals; Environmental Exposure; Eye Diseases; Guinea Pigs; Humans; Lung Neoplasms; Mice; Morbidity; Mortality; Mucous Membrane; Nitrates; Odorants; Ozone; Pulmonary Alveoli; Rats; Respiratory Function Tests; Respiratory Tract Diseases; Stress, Physiological; Time Factors; Vision Disorders; Visual Perception

Recently, ketoconazole, an imidazole derivative with antifungal properties, has been shown to inhibit adrenal corticosteroid and androgen production. We treated a patient with small-cell lung cancer and Cushing's syndrome secondary to ectopic secretion of adrenocorticotropic hormone in whom it was necessary to discontinue chemotherapy. The patient was treated with ketoconazole, with a resultant reduction in urinary free cortisol and ketosteroid excretion and improvement in electrolyte balance. Ketoconazole may be a useful adjunct in the treatment of small-cell lung cancer or other malignancies associated with excessive corticosteroid production or as a hormonal therapy in breast or prostatic cancer.

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Carcinoma, Small Cell; Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Lung Neoplasms; Male; Middle Aged; Potassium

An analysis of the rates of steroid hormone excretion and survival time in patients who had undergone radical surgery for lung cancer showed that the said rates may be used as a prognostic variable. Excretion rates of total 17-hydroxycorticosteroids and hydrocortisone proved to be of the highest prognostic value in patients aged 41-50, while in an older age bracket the best results were obtained with androsterone and estrone level measurements.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Estrogens; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis

Four cases of bronchial carcinoma were observed which showed the picture of an ectopic ACTH-hormone syndrome. References to an endocrinopathy resulted from the hypopotassaemia and the metabolic alkalosis. Signs of Cushing's syndrome appeared only in one case. By disturbances of the electrolyte and acid-base-balance the functions of the skeletal and smooth musculature as well as of the heart muscle were much impaired. In two cases the clinical symptoms and the laboratory findings still before the manifestation of the bronchial carcinoma, in the third case simultaneously referred to the correct diagnosis. Due to the misleading cardiac findings and the fulminant course of the disease in the fourth case the diagnosis was clarified only by autopsy. the disturbances of the ion balance and of the metabolism had contributed to the respiratory insufficiency, had evoked disturbances of the cardiac rhythm and had unfavourably effected on the course of of the disease.

Topics: 17-Ketosteroids; Acid-Base Imbalance; Adrenocorticotropic Hormone; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Lung Neoplasms; Male; Middle Aged; Smoking; Water-Electrolyte Imbalance

The results of studying the steroid hormones excretion in 90 patients with lung squamous-cell cancer under chemo-radiation therapy are reported. It is shown that an effective treatment is associated with certain changes in the excretion of androsterone, 11 OH 17KS, estradiol, cortisol and pregnanediol.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Carcinoma, Squamous Cell; Estrogens; Evaluation Studies as Topic; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged

Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adult; Carcinoma; Female; Humans; Lung Neoplasms; Neoplasm Metastasis; Pleural Effusion

Following the termination of chemoradiation therapy of patients with lung cancer a decreased level of 17-OCS and 17-KS with the urine is observed. A combination of chemoradiation therapy with testosterone-propionate or prednisolone renders a stabilizing effect on the level of corticosteroids excretion. Chemoradiation therapy, used simultabolism. The application of the hormones involved lessens the number of complications during chemoradiation therapy and increases the survival rate in these patients.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Antineoplastic Agents; Drug Therapy, Combination; Gonadal Steroid Hormones; Humans; Lung Neoplasms; Prednisolone; Radiotherapy; Testosterone; Thyroid Hormones

Under study was the excretion of 17-OCS and 17-KS in 2 male groups operated upon for lung cancer. The first group comprised 25 patients with the postoperative survival for less than a year. The second group-28 patients, whose survival was over 5 years postoperatively. In terms of 17-OCS excretion both groups were found to be identical: the level of 17OCS in them was normal. The excretion of 17-KS in patients of both groups proved to be considerably lower than normal values. However, in patients of the second group the level of 17-KS was higher, compared with the first group, mainly on account of androsterone. Thus, the balance of steroid hormones of glucocorticoid and androgenic series as well as the correlation between them may serve as a criterion of the prognosis for operated lung cancer patients.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Etiocholanolone; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Time Factors

Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Male; Middle Aged; Time Factors

Ninety five patients with pulmonary cancer were investigated. It was found that in lung cancer a correlation of total 17-ketosteroids and 17-oxycorticosteroids is changed on account of decreased androgenic hormones and increased glucocorticoid hormones. A response to the operative trauma is not the same in different objects. Following radiotherapy in most patients a reliable inhibition of the glucocorticoid function of the adrenal cortex was observed.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenal Glands; Adult; Age Factors; Aged; Circadian Rhythm; Follow-Up Studies; Glucocorticoids; Humans; Lung Neoplasms; Middle Aged; Preoperative Care

Topics: 17-Ketosteroids; Adult; Aged; Estrogens; Female; Humans; Lung Neoplasms; Male; Middle Aged; Sex Factors

Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Androgens; Androsterone; Circadian Rhythm; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Humans; Lung Neoplasms; Male; Middle Aged; Statistics as Topic; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adenocarcinoma; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Corticosterone; Desoxycorticosterone; Epinephrine; Female; Humans; Hydrocortisone; Hypoglycemia; Insulin; Lung Neoplasms; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Autopsy; Biological Assay; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Circadian Rhythm; Dexamethasone; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Lung Neoplasms; Male; Microscopy, Electron; Middle Aged; Radioimmunoassay; Serotonin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Bronchial Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Alkaline Phosphatase; Androgens; Autopsy; Carcinoma; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Estrogens; Growth Hormone; Gynecomastia; Hormones, Ectopic; Humans; Immunoassay; Lung Neoplasms; Male; Neoplasm Metastasis; Placental Hormones; Placental Lactogen; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; History, 15th Century; History, 16th Century; History, 17th Century; Iodine Isotopes; Lung; Lung Neoplasms; Luteinizing Hormone; Pneumonectomy; Postoperative Complications; Protein Binding; Radioimmunoassay; Surgical Procedures, Operative; Testosterone; Time Factors; Tuberculosis, Pulmonary

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Alkalosis; Carcinoma, Bronchogenic; Corticosterone; Cushing Syndrome; Deficiency Diseases; Desoxycorticosterone; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Pancreatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abdominal Neoplasms; Acetates; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Carcinoma; Child; Cortisone; Dexamethasone; Dichlorodiphenyldichloroethane; Female; Fluorine; Humans; Hydrocortisone; Lung Neoplasms; Metabolism; Neoplasm Metastasis; Prednisolone; Radiography; Splenectomy; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Hormones, Ectopic; Humans; Lung Neoplasms; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged

Topics: 17-Ketosteroids; Adolescent; Autopsy; Chorionic Gonadotropin; Dysgerminoma; Female; Hormones, Ectopic; Humans; Lung; Lung Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Pituitary Gland; Placental Lactogen; Radioimmunoassay

The urinary excretion of androsterone, aetiocholanolone, total 17-oxosteroids, and 17-hydroxycorticosteroids (17-OHCS) was measured in 40 patients with lung cancer three days before resection and again 10-15 days after resection of their lung tumours. There was a significant postoperative increase in the excretion of 17-OHCS but a significant decrease in the excretion of androsterone and aetiocholanolone, resulting in an increase of the preoperative abnormalities in steroid excretion in these patients. Since there was no change in steroid excretion towards normal after resection of the lung tumours, it seems that the steroid abnormalities found in lung cancer are not the effect of the presence of the lung tumours. As the excretions of 17-OHCS and 11-deoxy-17-oxosteroids change in opposite directions after resection, it is suggested that a dissociation of factors that control the excretion of these two groups of steroids takes place as a response to surgical stress in patients with lung cancer.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Creatinine; Etiocholanolone; Humans; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Stress, Physiological

Topics: 17-Ketosteroids; Estradiol; Estriol; Estrogens; Estrone; Humans; Lung Diseases; Lung Neoplasms; Male

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Carcinoma; Child, Preschool; Dichlorodiphenyldichloroethane; Female; Hirsutism; Humans; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenal Glands; Adult; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androsterone; Cyclophosphamide; Etiocholanolone; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Prognosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Chromatography, Gas; Etiocholanolone; Humans; Lung Neoplasms; Middle Aged; Myocardial Infarction; Thoracic Diseases

Topics: 17-Ketosteroids; Androstanes; Androsterone; Dehydroepiandrosterone; Estradiol; Estrone; Etiocholanolone; Glycolipids; Humans; Infusions, Parenteral; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Pulmonary Artery; Pulmonary Veins; Sulfates; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Carcinoma, Bronchogenic; Dexamethasone; Female; Hormones, Ectopic; Humans; Lung Neoplasms; Middle Aged

Topics: 17-Ketosteroids; Acid Phosphatase; Adenocarcinoma; Adrenocorticotropic Hormone; Cushing Syndrome; Cytoplasmic Granules; Glucocorticoids; Histocytochemistry; Hormones, Ectopic; Humans; Hydrocortisone; Lung Neoplasms; Male; Metyrapone; Middle Aged; Oxidoreductases; Pituitary-Adrenal Function Tests; Pyrophosphatases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Androsterone; Humans; Hydrocortisone; Lung Diseases; Lung Neoplasms; Male; Middle Aged

Topics: 17-Ketosteroids; Adult; Carcinoma, Squamous Cell; Child; Child, Preschool; Creatinine; Humans; Lung Neoplasms; Male; Methods; Middle Aged

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Androgens; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, Thin Layer; Cushing Syndrome; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Bronchial Neoplasms; Cushing Syndrome; Glucocorticoids; Humans; Hyperpituitarism; Lung Neoplasms; Metyrapone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Aged; Hospitalization; Humans; Lung Neoplasms; Male; Middle Aged; Personality; Stress, Psychological

Topics: 17-Ketosteroids; Adrenal Glands; Female; Humans; Lung Neoplasms; Male

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aged; Bone Neoplasms; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Stomach Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Dexamethasone; Estradiol; Estrogens; Estrone; Gonadotropins; Hemangioma; Hemangiosarcoma; Humans; Lung Neoplasms; Male; Middle Aged; Osteoarthropathy, Secondary Hypertrophic; Skin Manifestations

Topics: 17-Ketosteroids; Estrogens; Gynecomastia; Humans; Lung Neoplasms; Male; Middle Aged; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Antineoplastic Agents; Carcinoma; Cortisone; Dichlorodiphenyldichloroethane; Estrogens; Female; Gonadotropins; Humans; Hydrocortisone; Lung Neoplasms; Neoplasm Metastasis; Pregnanediol; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Carcinoma; Child; Child, Preschool; Dehydroepiandrosterone; Female; Hirsutism; Humans; Infant; Lung Neoplasms; Male; Neoplasm Metastasis; Radiography; Virilism

Topics: 17-Ketosteroids; Adenocarcinoma, Bronchiolo-Alveolar; Air Pollution; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; California; Female; Guinea Pigs; Lung; Lung Neoplasms; Male; Methods; Mice; Rats; Records; Respiratory Tract Diseases; Sex Factors; Urban Population

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Adult; Aged; Biological Assay; Carcinoma, Squamous Cell; Child; Cushing Syndrome; Female; Humans; Lung Neoplasms; Pancreatic Neoplasms; Radioimmunoassay; Thymoma

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aminoglutethimide; Aniline Compounds; Humans; Infant; Lung Neoplasms; Male; Neoplasm Metastasis; Pulmonary Embolism; Pyridones; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocortical Hyperfunction; Aged; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Estrogens; Female; Hormones; Humans; Hydrocortisone; Lung Neoplasms; Male; Middle Aged; Pituitary-Adrenal Function Tests; Sex Factors; Steroids

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Humans; Lung Neoplasms; Male; Mastectomy; Middle Aged; Neoplasm Metastasis; Pneumonectomy

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Androstanes; Androsterone; Carcinoma; Chemistry, Clinical; Chromatography, Thin Layer; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Methods; Ovarian Diseases; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Alkalosis; Bronchial Neoplasms; Cushing Syndrome; Dexamethasone; Female; Fluorescent Antibody Technique; Humans; Hypokalemia; Hypophysectomy; Lung Neoplasms; Pigmentation Disorders

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Carcinoid Tumor; Cushing Syndrome; Dexamethasone; Humans; Hyperglycemia; Lung Neoplasms; Male; Metyrapone; Middle Aged; Radiography, Thoracic

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Glucocorticoids; Humans; Lung Neoplasms; Pituitary-Adrenal Function Tests; Pneumonectomy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Estrogens; Female; Gonadotropins; Hormones; Humans; Lung Neoplasms; Male; Pregnanediol; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Androsterone; Carcinoma, Squamous Cell; Estradiol; Estriol; Estrone; Gonadotropins; Humans; Lung Neoplasms; Male; Pregnanediol; Pulmonary Emphysema; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Androsterone; Biomedical Research; Body Weight; Carcinoma; Carcinoma, Squamous Cell; Emphysema; Etiocholanolone; Fluids and Secretions; Humans; Liver Function Tests; Lung Neoplasms; Metabolism; Pregnanediol; Pulmonary Emphysema; Urine

Five patients with bronchogenic carcinoma associated with adrenocortical hyperfunction are described. The clinical features, laboratory studies and autopsy findings are discussed and compared with previously reported cases. Four patients presented most of the typical features of this disorder as previously described, whereas the fifth was atypical in some respects. Typical features included: acute onset of adrenocortical hyperfunction in a middle-aged male, rapid downhill course, slight or absent physical signs of Cushing's syndrome, frequently impaired glucose tolerance, markedly elevated plasma and urinary 17-hydroxycorticosteroids not suppressed by exogenous steroids, absent diurnal variation of plasma corticoids, hypokalemic alkalosis with normal aldosterone excretion, and tumour histology of the oat cell variety. The adrenal glands of two patients were of normal or slightly increased weight, and mean 17-ketosteroid excretion values were normal in three; this contrasts with the marked increase in adrenal weight and 17-ketosteroid excretion in most reported cases.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Alkalosis; Autopsy; Blood; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Glucose Tolerance Test; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Urine

Topics: 17-Ketosteroids; Acid-Base Equilibrium; Adrenocortical Hyperfunction; Alkalosis; Carcinoma; Electrocardiography; Humans; Hypokalemia; Lung Neoplasms; Lymphatic Metastasis; Potassium; Sodium; Urine

Topics: 17-Ketosteroids; Androgens; Carcinoma, Embryonal; Estrogens; Gonadotropins; Gynecomastia; Humans; Liver Neoplasms; Lung Neoplasms; Male; Neoplasm Metastasis; Pathology; Retroperitoneal Neoplasms; Testicular Neoplasms; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Geriatrics; Humans; Lung Neoplasms; Neoplasms; Pathology; Syndrome; Urine

Topics: 17-Ketosteroids; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Blood; Cushing Syndrome; Dexamethasone; Endocrinology; Humans; Lung Neoplasms; Mediastinal Neoplasms; Pancreatic Neoplasms; Parotid Neoplasms; Peptides; Pheochromocytoma; Urine

Topics: 17-Ketosteroids; Carcinoma; Cortisone; Hormones; Humans; Lung Neoplasms; Male; Prostatic Neoplasms