17-ketosteroids and Leukemia

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Amino Acids; Ammonia; Creatine; Creatinine; Electrolytes; Enzymes; Glycosaminoglycans; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Nitrogen; Porphyrins; Proteinuria; Purines; Pyrimidines; Uric Acid; Vitamins

Poor drug compliance may cause a decreased survival of children with malignancies. Children who fail to take their medications are not receiving optimum amounts of chemotherapy and suboptimal therapy causes a shortened survival in children with cancer. This is a study of prednisone compliance in 52 children with cancer during three distinct phases of therapy. The patients were either known to be taking prednisone (on-therapy group), off prednisone (off-therapy group), or their compliance was unknown (unknown group). Evaluation of prednisone compliance was attempted by measuring hemoglobin level changes, weight changes, and random urinary 17-ketogenic steroids. The results obtained show that while hemoglobin and weight changes are not helpful, a random urine 17-ketogenic steroid assay is able to differentiate clearly those patients who are taking their prednisone. By the use of this assay it was found that 33% of patients who by protocol and instruction were supposed to be receiving prednisone were not complying. Separate analysis of adolescents revealed an even more alarming 59% noncompliance rate. This striking level of noncompliance strongly suggests that the survival of patients may be threatened by noncompliance.

Topics: 17-Ketosteroids; Adolescent; Body Weight; Child; Child, Preschool; Female; Hemoglobins; Humans; Infant; Leukemia; Male; Patient Compliance; Prednisone; Prognosis

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Middle Aged; Prednisolone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Child; Child, Preschool; Female; Glucocorticoids; Humans; Leukemia; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Aged; Androgens; Chromatography, Paper; Female; Humans; Leukemia; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adolescent; Adult; Aged; Blood Proteins; Female; Humans; Leukemia; Male; Middle Aged

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Androsterone; Busulfan; Cyclophosphamide; Dehydroepiandrosterone; Etiocholanolone; Geriatrics; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Lymphocytes; Metabolism; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Blood Sedimentation; Child; Geriatrics; Hodgkin Disease; Humans; Japan; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mesothelioma; Mononuclear Phagocyte System; Neoplasms; Osteosarcoma; Sarcoma; Sarcoma, Ewing; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Biomedical Research; Blood; Calcium; Chlorides; Creatine; Creatinine; Drug Therapy; Hodgkin Disease; Humans; Iodine Isotopes; Leukemia; Leukemia, Lymphoid; Liver; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Metabolism; Multiple Myeloma; Nitrogen; Phosphorus; Potassium; Prednisone; Sodium; Uric Acid; Water

Topics: 17-Ketosteroids; Androgens; Busulfan; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocytes; Mannomustine; Prednisolone; Urine

Topics: 17-Ketosteroids; Acute Disease; Adrenal Cortex; Leukemia; Pituitary-Adrenal Function Tests; Prognosis

Topics: 17-Ketosteroids; Genetic Diseases, X-Linked; Humans; Leukemia; Leukemia, Hairy Cell; Lymphatic Diseases; Polycythemia Vera; Severe Combined Immunodeficiency; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex; Child; Cholesterol; Geriatrics; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocytes; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood Transfusion; Child; Humans; Leukemia; Mercaptopurine; Vitamins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Function Tests; Child; Humans; Leukemia; Nephrotic Syndrome; Prednisone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Leukemia; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Leukemia; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Body Fluids; Humans; Leukemia

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Body Fluids; Dehydroepiandrosterone; Humans; Leukemia; Testosterone

Topics: 17-Ketosteroids; Biological Transport; Leukemia; Nitrogen; Urethane

Topics: 17-Ketosteroids; Cell Growth Processes; Leukemia; Nitrogen; Steroids; Urethane

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aminopterin; Androgens; Dermatologic Agents; Folic Acid; Folic Acid Antagonists; Glucocorticoids; Leukemia

Topics: 17-Ketosteroids; Humans; Leukemia; Urine