17-ketosteroids and Leiomyoma

Basing on the concept of the uterine myoma presenting as a psychosomatic process that manifests in ischemic disease of the uterus, the author has tried psychoelectrostimulation in 76 patients with interstitial and subserous interstitial myomas as a method of psychotherapy and electrotranquilization. Indications for such treatment are the presence of psychoemotional stress syndrome (high anxiety level, pain and hemorrhagic syndromes, dysuria) and a rapid growth of the tumor. The reference group consisted of 73 patients with the same myoma forms, treated by hormonal therapy. Psychoelectroregulation has exerted a regulating effect on the central nervous, cardiovascular, endocrine and reproductive systems, it eliminated or alleviated the neurotic symptoms, and slowed down or arrested the tumor growth.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Electric Stimulation Therapy; Estrogens; Female; Humans; Leiomyoma; Middle Aged; Psychotherapy; Uterine Neoplasms

Topics: 17-Ketosteroids; Adult; Bulgaria; Disability Evaluation; Estrogens; Female; Humans; Hysterectomy; Leiomyoma; Middle Aged; Uterine Neoplasms

Topics: 17-Ketosteroids; Adult; Female; Follicle Stimulating Hormone; Humans; Leiomyoma; Luteinizing Hormone; Menstruation; Middle Aged; Uterine Neoplasms; Vitamin A

The estrogen receptor was assayed, using the 2,000g supernatant and dextran-coated charcoal method, in 243 tissue samples from human breast cancer, benign breast diseases, macroscopically normal breast tissues, normal uterine myometrium, and uterine myoma. The estrogen receptor was found to be positive in 52.1% of 98 primary breast cancer and in 54.1% of 24 metastatic tumors. The receptor in the breast cancer was found to be similar to that in normal uterine myometrium in the binding character; that is, the dissociation constant of 10(-9) approximately 10(-11) M and number of binding sites of 0 approximately 2,800 fmol/mg protein. There was no correlation between the presence of the receptor and some clinical factors such as menopausal status, age of the patient, urinary 17-ketosteroid excretion, clinical stage of cancer, tumor size, positive or negative axillary lymph node metastasis, histological type, metastatic site of the cancer, or disease-free interval. The estrogen receptor appeared to be retained by metastasis of cancer, and this may lead to the use of the receptor assay with mastectomy specimens for the prediction of response to hormonal therapy in future recurrence of malignancy. Furthermore, it may be possible by this assay to select patients suitable for adjuvant therapy with hormones at the time of mastectomy. A good correlation was found between the presence of the receptor and response to the major endocrine ablation therapy in patients with advanced or metastatic breast cancer. When the receptor was negative in the cancer tissue, the change of response to the endocrine therapy was minimum. On the other hand, if the cancer contained the receptor, approximately 60% of the patients with metastatic or advanced breast cancer responded well to the major endocrine ablation therapy. Thus, the estrogen receptor of breast cancer in Japanese patients appears to bear a close resemblance to that reported in Western patients in its incidence and the correlation to some biological characteristics of the cancer.

Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adrenalectomy; Breast; Breast Neoplasms; Carcinoma; Castration; Female; Humans; Leiomyoma; Menopause; Menstruation; Myometrium; Neoplasm Metastasis; Receptors, Estrogen; Uterine Neoplasms

Topics: 17-Ketosteroids; Adnexa Uteri; Adult; Female; Health Resorts; Humans; Hysterectomy; Leiomyoma; Middle Aged; Postoperative Care; Postoperative Complications; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Biopsy; Cholesterol; Endocrine Glands; Female; Gonadotropins, Pituitary; Humans; Leiomyoma; Thyroid Function Tests; Uterine Neoplasms

Topics: 17-Ketosteroids; Blood Coagulation Tests; Estrogens; Female; Fibrinolysis; Humans; Leiomyoma; Pregnanediol; Uterine Hemorrhage; Uterine Neoplasms

Topics: 17-Ketosteroids; Adipose Tissue; Androstanes; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Endometrium; Estrone; Female; Granulosa Cell Tumor; Humans; Leiomyoma; Ovarian Neoplasms; Polyps; Tritium; Uterine Neoplasms

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Arteriosclerosis; Chromatography, Thin Layer; Coronary Disease; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Genital Diseases, Female; Humans; Hydroxycorticosteroids; Leiomyoma; Menstruation Disturbances; Middle Aged; Ovarian Diseases; Parametritis; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Estrogens; Female; Humans; Leiomyoma; Middle Aged; Pregnanediol; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androgens; Diagnosis, Differential; Female; Humans; Hypertrophy; Leiomyoma; Middle Aged; Neoplasms, Multiple Primary; Ovary; Uterine Hemorrhage; Uterine Neoplasms; Uterus

Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Chromatography, Gas; Dehydroepiandrosterone; Endometriosis; Female; Humans; Infertility, Female; Leiomyoma; Methods; Middle Aged; Ovarian Cysts; Ovary; Polycystic Ovary Syndrome; Progesterone; Testosterone; Tritium; Veins

Topics: 17-Ketosteroids; Acetates; Androgens; Carbon Isotopes; Cholesterol; Chorionic Gonadotropin; Chromatography, Paper; Crystallization; Estrone; Female; Follicle Stimulating Hormone; Humans; Hydroxyprogesterones; Leiomyoma; Ovary; Pregnenolone; Progesterone; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Estrogens; Female; Humans; Leiomyoma; Middle Aged; Ovulation; Pregnanediol; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aminocaproates; Chromatography; Colorimetry; Creatinine; Estrogens; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hydroxyprogesterones; Leiomyoma; Pregnanediol; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: 17-Ketosteroids; Adult; Female; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Leiomyoma; Middle Aged; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Female; Gonadal Steroid Hormones; Humans; Leiomyoma; Uterine Neoplasms

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Androgens; Female; Humans; Leiomyoma; Liver Diseases; Middle Aged; Pituitary-Adrenal Function Tests; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Anemia; Biopsy; Endometriosis; Estrogens; Female; Gonadotropins; Hematologic Diseases; Humans; Leiomyoma; Lynestrenol; Menstruation Disturbances; Pregnanediol; Urine; Uterus

Topics: 17-Ketosteroids; Animals; Estrogens; Female; Gonadotropins, Pituitary; Humans; In Vitro Techniques; Leiomyoma; Rabbits; Urine; Uterine Neoplasms

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Amenorrhea; Androgens; Biomedical Research; Dehydroepiandrosterone; Dexamethasone; Female; Humans; Hydrocortisone; Hypertrichosis; Leiomyoma; Ovary; Pharmacology; Physiology; Research; Uterine Neoplasms

Topics: 17-Ketosteroids; Drug Therapy; Female; Humans; Leiomyoma; Testosterone; Urine; Uterine Neoplasms

Topics: 17-Ketosteroids; Castration; Chorionic Gonadotropin; Female; Gonadotropins; Humans; Hysterectomy; Leiomyoma; Methylprednisolone; Ovariectomy; Ovary; Pharmacology; Polycystic Ovary Syndrome; Urine; Uterine Neoplasms

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Chorionic Gonadotropin; Female; Gonadotropins; Humans; Leiomyoma; Pregnanediol; Uterine Neoplasms