17-ketosteroids and Infant--Newborn--Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Anemia; Child; Chromatography, Thin Layer; Female; Fetus; Glucocorticoids; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Maternal-Fetal Exchange; Pituitary-Adrenal Function Tests; Pregnancy

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androgen-Insensitivity Syndrome; Diagnosis, Differential; Disorders of Sex Development; Female; Follicle Stimulating Hormone; Genitalia, Female; Genitalia, Male; Gynecomastia; Humans; Hypospadias; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infertility, Male; Karyotyping; Male; Sex Chromatin; Sex Determination Analysis; Testosterone; Virilism

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Basal Metabolism; Blood Proteins; Bone Development; Carbohydrate Metabolism; Child; Child, Preschool; Female; Growth; Hepatomegaly; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Lipid Metabolism; Lipodystrophy; Male; Neurologic Manifestations; Prognosis; Radiography; Skin Manifestations; Terminology as Topic

The study of metabolism of muscle electrolyte in children with the salt-losing form of congenital adrenal hyperplasia reveals two types of alterations. After admission and during initial therapy with salt and desoxycorticosterone, the changes are typical of those seen in experimental animals with adrenalectomy and excessive replacement therapy. Discontinuation of the sodium supplement after three months of therapy resulted in a return of muscle electrolyte values to normal. During the period of poor growth common to these patients a different pattern was observed. Sodium and water accumulated without alteration in tissue potassium. The mechanism of this alteration is not clear; however, it is consistent with the known effects of excess cortisone on muscle composition. These observations permit the conclusion that at least two fractions of sodium are present in muscle fibers, that which exchanges potassium and that which is independent of potassium metabolism.

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Cortisone; Desoxycorticosterone; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Mixed Function Oxygenases; Muscles; Potassium; Pregnanetriol; Shock; Sodium; Sodium Chloride; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Central Nervous System Diseases; Chromatography; Creatinine; Electroencephalography; Female; Glucagon; Glucose; Glucose Tolerance Test; Glycosuria; Humans; Hyperglycemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Respiratory Insufficiency; Seizures

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Pituitary-Adrenal Function Tests; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood Glucose; Epinephrine; Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Birth Weight; Blood Glucose; Capillaries; Carbohydrate Metabolism; Glucocorticoids; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Pyruvates; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood Glucose; Female; Humans; Hyperglycemia; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy in Diabetics; Pyruvates; Respiratory Distress Syndrome, Newborn; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Electrocardiography; Humans; Hyperkalemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Pregnanetriol; Tachycardia

A case report of stimulated congenital adrenal hyperplasia in a newborn male following a medroxyprogesterone-treated pregnancy is presented. Because of intermittent vaginal spotting, the 26-year-old multiparous mother was administered 10 mg medroxyprogesterone acetate daily from Week 20 to Week 32 of gestation. At birth the child displayed early symptoms of hyperglycemia and idiopathic hyperbilirubinemia. At 17 days of age genital hyperpigmentation and penile enlargement were noted and tests revealed hypochloremic metabolic acidosis with hyponatremia. Urinary androgens were high but glucocoritcoids and pregnanetriol were normal. Desoxycorticosterone acetate supplemental salt were administered. After 28 days of age the infant developed normally without hypoglycemia or hyponatremia and the hyperpigmentation and penile enlargement disappeared. It is speculated that the infant could have undergone temporary underproduction of gluco-and mineralocorticoid" and overproduction of androgens that was induced by the mother's medroxyprogesterone treatment. Though the evidence for such a relationship in this case in not conclusive, further study should be conducted.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Medroxyprogesterone; Pregnancy; Pregnancy Complications; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Aldosterone; Body Height; Body Weight; Child; Child, Preschool; Dehydration; Female; Fluorometry; Humans; Hydrocortisone; Hyperkalemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Melanins; Pigmentation Disorders; Seizures; Sodium Chloride; Time Factors

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Child, Preschool; Chromatography; Clitoris; Female; Humans; Hyperplasia; Hypertension; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Methyldopa; Steroids; Virilism

Topics: 17-Ketosteroids; Bilirubin; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Premature, Diseases; Male; Maternal-Fetal Exchange; Pre-Eclampsia; Pregnancy; Umbilical Cord

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Androgens; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Luteoma; Maternal-Fetal Exchange; Ovarian Neoplasms; Pathology; Pregnancy; Pregnancy Complications; Surgical Procedures, Operative; Thecoma; Urine; Virilism

Topics: 17-Ketosteroids; Adenocarcinoma, Mucinous; Androgens; Estrogens; Female; Histocytochemistry; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Krukenberg Tumor; Metabolism; Neoplasm Metastasis; Ovarian Neoplasms; Pathology; Pregnancy; Pregnancy Complications; Urine; Virilism

Topics: 17-Ketosteroids; Adolescent; Adrenogenital Syndrome; Blood Chemical Analysis; Child; Cortisone; Desoxycorticosterone; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Prednisone; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Age Determination by Skeleton; Blood Chemical Analysis; Classification; Cortisone; Desoxycorticosterone; Drug Therapy; Humans; Hydrocortisone; Hyperplasia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Humans; Hyperplasia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metabolic Diseases; Sodium Chloride

Topics: 17-Ketosteroids; Acne Vulgaris; Body Fluids; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aldosterone; Chlorides; Cortisone; Desoxycorticosterone; Diencephalon; Diuresis; Humans; Hypoaldosteronism; Hyponatremia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Tubules; Sodium; Urine; Water