17-ketosteroids and Hypothyroidism

Topics: 17-Ketosteroids; Androgens; Androsterone; Breast Neoplasms; Contraceptives, Oral, Hormonal; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hypothyroidism; Menopause; Menstruation; Progesterone; Prolactin; Thyroid Hormones

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Animals; Breast Neoplasms; Castration; Cortisone; Diabetes Insipidus; Endocrine Glands; Estrogens; Female; Growth Hormone; Humans; Hypophysectomy; Hypothyroidism; Mastectomy; Menopause; Menstruation; Ovary; Prolactin; Protein Binding; Receptors, Cell Surface; Sulfurtransferases; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adult; Age Factors; Circadian Rhythm; Cushing Syndrome; Female; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Infant, Newborn; Liver Cirrhosis; Middle Aged; Pituitary Function Tests; Pituitary-Adrenal Function Tests; Pregnancy; Stress, Physiological

Lymphocytic hypophysitis usually occurs in the antepartum or postpartum period and recovery of pituitary dysfunction has not been documented in most cases reported previously. We present a 50-year-old woman with lymphocytic hypophysitis who spontaneously recovered from panhypopituitarism over 18 months with the disappearance of an intrasellar mass. Although lymphocytic hypophysitis is thought to be an autoimmune disease, the clinical and pathogenetic significance of circulating antipituitary autoantibodies has not been clarified. Antipituitary antibodies were studied by immunofluorescence in blood samples obtained during the whole clinical course in this particular patient. Antibodies against rat pituitary cytosol were positive during the period of hypopituitarism and became negative when pituitary function recovered. Antibodies reacting with intact prolactin-secreting rat GH3 and corticotropin-secreting mouse AtT-20 cells were also positive during her period of hypopituitarism. They remained positive for several years after the recovery of pituitary function. We conclude that circulating antibodies against rat pituitary cytosol are good markers of pituitary inflammation in this patient. The other point to be emphasized in this case is the simultaneous development of painless thyroiditis and lymphocytic hypophysitis. We have discussed the pathogenic relationship of these two diseases on the basis of similar cases reported previously.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Autoantibodies; Autoimmune Diseases; Female; Growth Hormone; Humans; Hydrocortisone; Hypopituitarism; Hypothyroidism; Inflammation; Lymphocytosis; Middle Aged; Pituitary Diseases; Pituitary Gland; Pituitary Hormones; Thyroid Hormones; Thyroiditis; Thyroxine; Tomography, X-Ray Computed

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Aged; Androgens; Contraceptives, Oral; Female; Humans; Hydroxysteroids; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Reference Values; Sex Factors; Sex Hormone-Binding Globulin; Thyroid Gland

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant

A 52 year old man is described in whom the simultaneous occurrence of isolated adrenocorticotrophin (ACTH) deficiency and primary hypothyroidism was documented by the determination of six anterior pituitary hormones by specific radioimmunoassays after suitable stimulations. The urinary 17-hydroxycorticosteroids excretion was persistently reduced and was increased by repeated ACTH injections. The low basal metabolic rate, reduced serum thyroid hormones and elevated serum thyrotrophic hormone were consistent with primary hypothyroidism. After resumption of euthyroidism, secretory reserves of growth hormone and ACTH were assessed. The growth hormone reponse to insulin-induced hypoglycaemic was normal. No rise in plasma cortisol and ACTH was observed following insulin-induced hypoglycaemia. Plasma ACTH was not augmented by iv infusion of metyrapone. The pathogenesis of two co-existent endocrine deficiencies was discussed.

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Growth Hormone; Humans; Hydrocortisone; Hypothyroidism; Insulin; Luteinizing Hormone; Male; Metyrapone; Middle Aged; Prolactin; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Craniocerebral Trauma; Diagnosis, Differential; Humans; Hypopituitarism; Hypothyroidism; Male; Pituitary Function Tests; Pituitary Gland; Pituitary Gland, Anterior; Stimulation, Chemical; Thyroid Function Tests; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Ketosteroids; Administration, Oral; Adolescent; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Chromatography, Gas; Depression, Chemical; Female; Growth Hormone; Humans; Hypoglycemia; Hypothyroidism; Infant; Male; Metyrapone; Pituitary Diseases; Pregnanediol; Pregnanediones; Pregnanetriol; Stimulation, Chemical; Thyrotropin; Time Factors

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Carbon Radioisotopes; Chromatography; Etiocholanolone; Female; Glucuronates; Half-Life; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Radioisotope Dilution Technique; Sulfates; Testosterone; Time Factors; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androstanes; Chromatography, Gas; Etiocholanolone; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Steroids; Tetrahydrocortisol; Tetrahydrocortisone; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Creatinine; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hypothyroidism; Lactation Disorders; Luteinizing Hormone; Pregnancy; Prolactin; Thyrotropin; Thyroxine

Topics: 17-Ketosteroids; Adult; Arginine; Corticosterone; Cushing Syndrome; Diagnosis, Differential; Female; Growth Hormone; Humans; Hypothyroidism; Iodine Radioisotopes; Lactation Disorders; Luteinizing Hormone; Middle Aged; Pituitary Neoplasms; Pregnancy; Stimulation, Chemical; Thyroid Function Tests; Thyroid Gland; Triiodothyronine

Topics: 17-Ketosteroids; Androstanes; Animals; Estradiol; Female; Hydrogen; Hyperthyroidism; Hypothyroidism; Ketosteroids; Microsomes; Microsomes, Liver; Ovary; Rats; Rats, Inbred Strains; Sterols; Testosterone; Thyroid Gland; Transferases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Alkaline Phosphatase; Cushing Syndrome; Female; Humans; Hyperostosis Frontalis Interna; Hypothalamic Diseases; Hypothyroidism; Leukocytes; Male; Middle Aged; Neutrophils; Obesity; Osteoporosis

Topics: 17-Ketosteroids; Adolescent; Dehydroepiandrosterone; Diabetes Insipidus; Estradiol; Feedback; Gynecomastia; Histiocytosis, Langerhans-Cell; Humans; Hypertrophy; Hypothyroidism; Leydig Cells; Male; Puberty; Testicular Diseases; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Body Height; Breast; Central Nervous System Diseases; Child; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Hypothyroidism; Infant; Laparoscopy; Luteinizing Hormone; Medroxyprogesterone; Menarche; Ovarian Neoplasms; Ovary; Physical Examination; Pituitary Hormone-Releasing Hormones; Puberty, Precocious; Radioimmunoassay; Sex Characteristics

Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Androstanes; Androsterone; Cholanes; Chromatography, Gas; Cushing Syndrome; Female; Humans; Hydrocortisone; Hypothyroidism; Male; Middle Aged; Obesity; Pregnanediol; Pregnanes; Secretory Rate

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Diagnosis, Differential; Female; Humans; Hypophysectomy; Hypopituitarism; Hypothalamus; Hypothyroidism; Infusions, Parenteral; Male; Middle Aged; Pituitary Irradiation; Radiation Effects; Time Factors

Topics: 17-Ketosteroids; Androstanes; Animals; Biotransformation; Body Weight; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Estriol; Estrogens; Estrone; Female; Hydroxysteroid Dehydrogenases; Hyperthyroidism; Hypothyroidism; In Vitro Techniques; Mixed Function Oxygenases; Organ Size; Ovary; Rats; Stereoisomerism; Stimulation, Chemical; Thyroid Gland; Triiodothyronine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adult; Age Factors; Diabetes Insipidus; Female; Humans; Hypopituitarism; Hypothyroidism; Male; Middle Aged; Pituitary Diseases; Pituitary Neoplasms; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Humans; Hypothyroidism; Myxedema; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Child, Preschool; Dwarfism, Pituitary; Electrophoresis; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Insulin; Ion Exchange Resins; Male; Pituitary Diseases; Radioimmunoassay; Thyroid Diseases; Thyrotropin; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Obesity; Prognosis; Thyroid Diseases

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus; Dog Diseases; Dogs; Female; Hyperinsulinism; Hypothyroidism; Male; Metyrapone; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Insufficiency; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Cushing Syndrome; Female; Hematoma; Hirsutism; Humans; Hyperaldosteronism; Hypothyroidism; Male; Necrosis; Pyridones

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Humans; Hypopituitarism; Hypothyroidism; Pituitary-Adrenal Function Tests; Pyrogens

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Body Weight; Diet, Reducing; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Obesity; Thyroid Gland

Topics: 17-Ketosteroids; Humans; Hypothyroidism

Topics: 17-Ketosteroids; Androsterone; Carbon Isotopes; Chromatography, Paper; Female; Humans; Hypothyroidism; Male; Middle Aged; Myxedema; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Aged; Bone Resorption; Calcium; Calcium Isotopes; Feces; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Hypothyroidism; Iodine Radioisotopes; Male; Middle Aged; Osteoporosis; Phosphorus; Pituitary Irradiation; Thyroid Function Tests

Topics: 17-Ketosteroids; Androgens; Bone Development; Child; Diagnosis, Differential; Electroencephalography; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins; Humans; Hypothyroidism; Male; Ovarian Neoplasms; Physical Examination; Puberty, Precocious; Radiography; Skull; Thyroid Function Tests; Vaginal Smears

Topics: 17-Ketosteroids; Adolescent; Eyelids; Humans; Hypogonadism; Hypothyroidism; Lip; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Bronchial Neoplasms; Cobalt Isotopes; Cushing Syndrome; Female; Hemorrhagic Disorders; Humans; Hypothyroidism; Middle Aged; Neoplasm Recurrence, Local; Radioisotope Teletherapy; Thyroid Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Obesity; Pituitary Diseases; Pituitary-Adrenal Function Tests; Potassium; Sodium; Turner Syndrome

Topics: 17-Ketosteroids; Animals; Estrogens; Female; Genitalia; Gonadal Steroid Hormones; Gonadotropins; Gonads; Haplorhini; Hypothyroidism; Male; Mice; Pituitary Gland; Testosterone; Thyroidectomy

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Child; Fatty Acids; Fatty Acids, Nonesterified; Humans; Hyperinsulinism; Hypopituitarism; Hypothyroidism; Insulin; Lipids; Thyroid Function Tests

Topics: 17-Ketosteroids; Animals; Blood Chemical Analysis; Cattle; Eosinophils; Glutathione; Humans; Hypothyroidism; Pituitary Gland; Retina; Retinitis Pigmentosa; Thyroid Function Tests; Transplantation; Urine

Topics: 17-Ketosteroids; Aspirin; Diagnosis, Differential; Hypnotics and Sedatives; Hypopituitarism; Hypothyroidism; Meprobamate; Phenobarbital; Substance-Related Disorders; Thyroid Function Tests; Toxicology

Topics: 17-Ketosteroids; Basal Metabolism; Body Fluids; Diencephalon; Electroencephalography; Geriatrics; Hypothyroidism; Myotonic Dystrophy; Thyroid Function Tests; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anxiety; Anxiety Disorders; Humans; Hypopituitarism; Hypothyroidism; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Neurotic Disorders; Pituitary-Adrenal Function Tests; Progeria; Psychology; Sexual Dysfunction, Physiological; Urine

Topics: 17-Ketosteroids; Adolescent; Androgens; Androsterone; Chemistry Techniques, Analytical; Child; Chromatography; Drug Therapy; Etiocholanolone; Hepatitis; Humans; Hyperthyroidism; Hypothyroidism; Iodine Isotopes; Liver Cirrhosis; Liver Function Tests; Metabolism; Testosterone; Thyroid Function Tests; Thyroid Hormones; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Child; Humans; Hypothyroidism; Male; Papilledema; Puberty; Puberty, Precocious; Sexual Maturation; Testis; Thyroiditis; Thyroiditis, Autoimmune; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Child; Down Syndrome; Female; Gonadotropins; Humans; Hypothyroidism; Iodine Isotopes; Medroxyprogesterone; Menstruation; Myxedema; Puberty; Puberty, Precocious; Radiography; Sella Turcica; Sexual Maturation; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Adolescent; Child; Diabetes Insipidus; Dwarfism; Dwarfism, Pituitary; Humans; Hypothyroidism; Infant; Infant, Newborn; Laurence-Moon Syndrome; Lipodystrophy; Obesity; Pituitary Diseases; Pituitary Gland; Progeria; Puberty; Puberty, Precocious; Sexual Maturation; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Hypothyroidism; Iodine Isotopes; Ketones; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Urine

Topics: 17-Ketosteroids; Body Fluids; Humans; Hyperthyroidism; Hypothyroidism; Urinary Tract

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Humans; Hyperthyroidism; Hypothyroidism

Topics: 17-Ketosteroids; Body Fluids; Chromatography; Humans; Hypothyroidism; Urinary Tract

Topics: 17-Ketosteroids; Hypothyroidism; Steroids; Urine