17-ketosteroids and Hypopituitarism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adult; Age Factors; Circadian Rhythm; Cushing Syndrome; Female; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Infant, Newborn; Liver Cirrhosis; Middle Aged; Pituitary Function Tests; Pituitary-Adrenal Function Tests; Pregnancy; Stress, Physiological

Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Biochemical Phenomena; Biochemistry; Blood Chemical Analysis; Clinical Laboratory Techniques; Cushing Syndrome; Hypoadrenocorticism, Familial; Hypopituitarism; Metyrapone; Pathology; Physiology; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Androgens; Androsterone; Child; Child, Preschool; Chromatography, Gas; Clinical Trials as Topic; Dehydroepiandrosterone; Etiocholanolone; Female; Growth; Growth Hormone; Humans; Hypopituitarism; Male; Radioimmunoassay

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Antibody Formation; Blood Proteins; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Growth; Growth Disorders; Growth Hormone; Humans; Hypopituitarism; Insulin; Iodine; Long-Term Care; Male; Metyrapone; Pituitary Function Tests; Protein Binding; Radioimmunoassay; Skinfold Thickness

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Body Weight; Clinical Trials as Topic; Cushing Syndrome; Female; Humans; Hyperaldosteronism; Hypopituitarism; Male; Metyrapone; Middle Aged; Natriuresis; Pituitary-Adrenal System; Potassium; Secretory Rate

Lymphocytic hypophysitis usually occurs in the antepartum or postpartum period and recovery of pituitary dysfunction has not been documented in most cases reported previously. We present a 50-year-old woman with lymphocytic hypophysitis who spontaneously recovered from panhypopituitarism over 18 months with the disappearance of an intrasellar mass. Although lymphocytic hypophysitis is thought to be an autoimmune disease, the clinical and pathogenetic significance of circulating antipituitary autoantibodies has not been clarified. Antipituitary antibodies were studied by immunofluorescence in blood samples obtained during the whole clinical course in this particular patient. Antibodies against rat pituitary cytosol were positive during the period of hypopituitarism and became negative when pituitary function recovered. Antibodies reacting with intact prolactin-secreting rat GH3 and corticotropin-secreting mouse AtT-20 cells were also positive during her period of hypopituitarism. They remained positive for several years after the recovery of pituitary function. We conclude that circulating antibodies against rat pituitary cytosol are good markers of pituitary inflammation in this patient. The other point to be emphasized in this case is the simultaneous development of painless thyroiditis and lymphocytic hypophysitis. We have discussed the pathogenic relationship of these two diseases on the basis of similar cases reported previously.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Autoantibodies; Autoimmune Diseases; Female; Growth Hormone; Humans; Hydrocortisone; Hypopituitarism; Hypothyroidism; Inflammation; Lymphocytosis; Middle Aged; Pituitary Diseases; Pituitary Gland; Pituitary Hormones; Thyroid Hormones; Thyroiditis; Thyroxine; Tomography, X-Ray Computed

A 64-year-old woman was admitted for evaluation of hyponatremia. She was maintained on hypertonic saline administration. Without this therapy, the serum Na concentration decreased progressively to 127 mEq/L and the plasma osmolality to 254 mOsm/Kg H2O, on Day 3. At that time, the concentration of antidiuretic hormone (ADH) was as high as 3.5 pg/ml. A skull radiogram revealed an enlarged sella turcica. Computed tomography (CT) revealed a low density in the sella, and magnetic resonance imaging revealed equal intensity of the sella turcica and the cerebrospinal fluid. A diagnosis of empty sella syndrome was made by metrizamide cisternography in conjunction with CT scanning. A diagnosis of panhypopituitarism was made by endocrine function tests. 123I-thyroidal uptake was 6% when her serum TSH was 10.9 microU/ml, suggesting that she might also have primary hypothyroidism. When this patient was given glucocorticoid before levothyroxine replacement, her serum Na concentration rose up to about 140 mEq/L and a normal relationship between her plasma ADH level (2.4 pg/ml) and plasma osmolality (281 mOsm/kg H2O) was restored. Therefore, it was suggested that ADH hypersecretion induced by the glucocorticoid deficiency might in part contribute to the development of hyponatremia. This is the case of primary empty syndrome associated with panhypopituitarism, in whom initial symptom was caused by hyponatremia.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Empty Sella Syndrome; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; Hyponatremia; Hypopituitarism; Luteinizing Hormone; Magnetic Resonance Spectroscopy; Middle Aged; Prolactin; Thyrotropin; Thyrotropin-Releasing Hormone; Tomography, X-Ray Computed

A complete endocrinological exploration was performed in a 23 year old male patient who presented clinical signs of an acquired panhypopituitarism which appeared two months after a severe head trauma, in order to determine whether the deficit lay in the hypothalamus or in the pituitary. TSH had normal basal levels, but presented a delayed rise after TRH administration. PRL rose normally after TRH administration, but presented a blunted response to both metoclopramide and insulin tolerance test. Cortisol rose significatively after lysine vasopressin, but failed to rise during insulin hypoglycaemia. These results are consistent with a hypothalamic defect. Extensive endocrinological data are often lacking in the few similar cases reported in the literature. Prl and TSH were usually found to have normal basal levels while other pituitary hormones were profoundly lowered. This was interpretated as a pituitary defect with some intact areas of the anterior lobe. However, this may also suggest a hypothalamic defect which could have been assessed by mor discriminative tests.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Androgens; Blood Chemical Analysis; Craniocerebral Trauma; Creatinine; Estrogens; Gonadotropins, Pituitary; Humans; Hypopituitarism; Hypothalamo-Hypophyseal System; Male; Prolactin; Tetrahydrocortisol; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine

Antepartum pituitary infarction occurs only in insulin-dependent diabetic patients. It is manifested by severe headache, followed by decreasing insulin requirements. Delivery is frequently premature, with high fetal wastage and increased maternal mortality. During the puerperium, the first manifestation of pituitary deficiency, other than a lower insulin requirement than would be expected, is failure to lactate. Subsequent evaluation of pituitary function reveals variable deficiencies with loss of growth hormone and gonadotropins being most frequent. This case is the eighth report of this entity, and it represents the first patient to survive a pituitary infarction prior to the third trimester of pregnancy. Recognition of this syndrome is critical in order to ensure that the mother's health and the viability of the offspring be preserved.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Female; Follicle Stimulating Hormone; Humans; Hypopituitarism; Infarction; Luteinizing Hormone; Pituitary Gland; Pregnancy; Pregnancy in Diabetics; Progesterone; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Female; Humans; Hydrocortisone; Hypophysectomy; Hypopituitarism; Male; Prednisone; Stimulation, Chemical

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Craniocerebral Trauma; Diagnosis, Differential; Humans; Hypopituitarism; Hypothyroidism; Male; Pituitary Function Tests; Pituitary Gland; Pituitary Gland, Anterior; Stimulation, Chemical; Thyroid Function Tests; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Ammonium Sulfate; Androsterone; Animals; Cattle; Child; Chromatography; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hypopituitarism; Immune Sera; Male; Methods; Middle Aged; Rabbits; Radioimmunoassay; Serum Albumin, Bovine; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Fasting; Female; Glucagon; Growth Hormone; Humans; Hypopituitarism; Luteinizing Hormone; Pituitary-Adrenal System; Pregnancy; Pregnancy Complications; Puerperal Disorders; Stimulation, Chemical; Syndrome; Thyrotropin; Thyroxine-Binding Proteins

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Chromophobe; Cortisone; Drinking; Ethanol; Growth Hormone; Humans; Hyponatremia; Hypopituitarism; Male; Middle Aged; Osmolar Concentration; Pituitary Neoplasms; Urination; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Disorders of Sex Development; Female; Glucose Tolerance Test; Growth Hormone; Humans; Hyperlipidemias; Hypoglycemia; Hypopituitarism; Lipids; Luteinizing Hormone; Male; Metyrapone; Pseudopseudohypoparathyroidism; Sex Characteristics; Sex Factors

Topics: 17-Ketosteroids; Anemia, Aplastic; Animals; Cells; Culture Techniques; Cytoplasm; Erythrocytes; Esterases; Guanidines; HeLa Cells; Hemosiderosis; Histocytochemistry; Histological Techniques; Humans; Hypopituitarism; Lipid Metabolism; Liver; Liver Glycogen; Mice; Microscopy, Electron; Mitochondria; Nucleic Acids; Protein Binding; Protein Denaturation; Proteins; Rats; Reticulocytes; Staining and Labeling; Tissue Preservation

Topics: 17-Ketosteroids; Adolescent; Androsterone; Child; Child, Preschool; Chorionic Gonadotropin; Cryptorchidism; Etiocholanolone; Humans; Hypopituitarism; Male; Steroids; Tetrahydrocortisol; Tetrahydrocortisone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Aged; Circadian Rhythm; Diencephalon; Endocrine System Diseases; Female; Humans; Hypopituitarism; Male; Middle Aged; Pituitary Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aldosterone; Dehydroepiandrosterone; Estriol; Female; Humans; Hydroxycorticosteroids; Hypopituitarism; Lysine; Pregnancy; Pregnancy Complications; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromatography, Gas; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Hirsutism; Humans; Hydrocortisone; Hypogonadism; Hypopituitarism; Male; Pregnancy; Pregnanediol; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aldosterone; Clinical Laboratory Techniques; Cushing Syndrome; Electrolytes; Humans; Hydrocortisone; Hypopituitarism; Pituitary-Adrenal Function Tests; Testosterone

Topics: 17-Ketosteroids; Administration, Topical; Adrenal Insufficiency; Anti-Inflammatory Agents; Betamethasone; Butyrates; Drug Synergism; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Hypopituitarism; Metyrapone; Middle Aged; Occlusive Dressings; Ointments; Pituitary-Adrenal System; Psoriasis; Time Factors; Triamcinolone Acetonide; Valerates

Topics: 17-Ketosteroids; Cerebrospinal Fluid Rhinorrhea; Female; Humans; Hypopituitarism; Middle Aged; Pneumoencephalography; Sella Turcica

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Amenorrhea; Anorexia Nervosa; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorine; Dexamethasone; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Humans; Hypopituitarism; Luteinizing Hormone; Male; Metyrapone; Middle Aged; Sodium

Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared. HGH rose in all four tests. HGH response to glucagon was also studied in 49 patients with suspected pituitary insufficiency, of whom 25 also later received an arginine infusion; an abnormal response to glucagon was the most frequent functional abnormality and often HGH was the only anterior pituitary hormone of which a deficiency was detectable. In seven subjects (two healthy controls and five patients with suspected hypopituitarism) there was a subnormal HGH response to arginine but a normal response to glucagon. It is concluded that glucagon is a simple and effective stimulus to HGH release, equal or superior to arginine, tolbutamide and insulin, and is an important test of anterior pituitary function.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Arginine; Blood Glucose; Fatty Acids, Nonesterified; Female; Glucagon; Gonadotropins; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Hypopituitarism; Insulin; Male; Metyrapone; Middle Aged; Radioimmunoassay; Sella Turcica; Stimulation, Chemical; Thyroxine; Tolbutamide

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Amenorrhea; Diabetes Complications; Female; Follicle Stimulating Hormone; Growth Hormone; Headache; Humans; Hypoglycemia; Hypopituitarism; Infarction; Iodine Isotopes; Lactation Disorders; Luteinizing Hormone; Pituitary Diseases; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics; Thyroid Function Tests; Thyrotropin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic Gonadotropin; Dehydroepiandrosterone; Endocrine System Diseases; Estrogens; Etiocholanolone; Humans; Hypogonadism; Hypopituitarism; Klinefelter Syndrome; Male; Metabolism; Middle Aged; Pregnanetriol; Puberty; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Blood Glucose; Calcinosis; Dehydration; Diabetes Insipidus; Follicle Stimulating Hormone; Glucose Tolerance Test; Growth Hormone; Humans; Hypopituitarism; Hypothalamus; Insulin; Iodine Isotopes; Luteinizing Hormone; Male; Radiography; Skull; Tuberculosis, Meningeal; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Diagnosis, Differential; Female; Humans; Hypophysectomy; Hypopituitarism; Hypothalamus; Hypothyroidism; Infusions, Parenteral; Male; Middle Aged; Pituitary Irradiation; Radiation Effects; Time Factors

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anorexia Nervosa; Cushing Syndrome; Diagnosis, Differential; Female; Fluorometry; Hirsutism; Humans; Hypopituitarism; Injections, Intravenous; Klinefelter Syndrome; Male; Methods; Obesity; Pituitary Neoplasms; Spectrophotometry; Turner Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Clomiphene; Creatinine; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypogonadism; Hypopituitarism; Hypothalamo-Hypophyseal System; Limbic System; Luteinizing Hormone; Male; Olfaction Disorders; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Clomiphene; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypogonadism; Hypopituitarism; Hypothalamic Diseases; Infertility, Male; Male; Mumps; Orchitis; Phosphorus Isotopes; Semen; Spermatozoa; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adult; Age Factors; Diabetes Insipidus; Female; Humans; Hypopituitarism; Hypothyroidism; Male; Middle Aged; Pituitary Diseases; Pituitary Neoplasms; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Biopsy; Brain Neoplasms; Cholesteatoma; Cortisone; Craniopharyngioma; Diabetes Insipidus; Female; Follicle Stimulating Hormone; Growth Disorders; Hair; Humans; Hypertonic Solutions; Hypogonadism; Hypopituitarism; Hypothalamus; Male; Metyrapone; Middle Aged; Pinealoma; Pituitary Diseases; Polyuria; Radiography; Sella Turcica; Skull; Testis; Thirst; Thyroid Function Tests; Visual Fields; Water

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Dexamethasone; Diuresis; Ethanol; Extracellular Space; Female; Glucocorticoids; Growth Hormone; Humans; Hyponatremia; Hypopituitarism; Infusions, Parenteral; Metyrapone; Middle Aged; Natriuresis; Sodium Chloride; Vasopressins; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Child, Preschool; Dwarfism, Pituitary; Electrophoresis; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Insulin; Ion Exchange Resins; Male; Pituitary Diseases; Radioimmunoassay; Thyroid Diseases; Thyrotropin; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Child; Circadian Rhythm; Fluorometry; Glucocorticoids; Humans; Hydrocortisone; Hypopituitarism; Infant; Injections, Intravenous; Male

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Humans; Hypopituitarism; Iodine Isotopes; Luteinizing Hormone; Male; Menstruation; Puberty; Radioimmunoassay; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Anemia, Sickle Cell; Atrophy; Biopsy; Cortisone; Humans; Hypopituitarism; Male; Osmolar Concentration; Pituitary Function Tests; Pituitary Gland, Posterior; Testis; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Diet, Sodium-Restricted; Female; Humans; Hypopituitarism; Middle Aged; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aged; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm; Carotid Arteries; Creatinine; Humans; Hydrocortisone; Hypopituitarism; Intracranial Aneurysm; Male; Pituitary Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Breast Neoplasms; Child; Female; Glucocorticoids; Humans; Hyperpituitarism; Hypopituitarism; Male; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Tranquilizing Agents

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Blood Glucose; Craniocerebral Trauma; Diuresis; Gonadotropins, Pituitary; Growth Hormone; Humans; Hypopituitarism; Hypothalamo-Hypophyseal System; Insulin; Male; Radiography; Skull; Skull Fractures; Thyroid Function Tests; Thyrotropin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Cushing Syndrome; Dexamethasone; Humans; Hydrocortisone; Hypopituitarism; Hypothalamo-Hypophyseal System; Methods; Metyrapone; Pituitary-Adrenal Function Tests; Pregnanediol; Pregnanetriol; Stimulation, Chemical

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Breast Neoplasms; Child; Chromatography, Gas; Cushing Syndrome; Etiocholanolone; Female; Humans; Hypopituitarism; Male; Methods; Pheochromocytoma; Polycystic Ovary Syndrome; Pregnanes; Statistics as Topic; Steroids

Topics: 17-Ketosteroids; Adult; Androgen-Insensitivity Syndrome; Androstanes; Androsterone; Carbon Isotopes; Chorionic Gonadotropin; Dihydrotestosterone; Disorders of Sex Development; Glucuronates; Humans; Hypogonadism; Hypopituitarism; Male; Middle Aged; Sulfates; Testosterone; Tritium; Turner Syndrome

Topics: 17-Ketosteroids; Adolescent; Adult; Blood Proteins; Clomiphene; Consanguinity; Estrogens; Eunuchism; Female; Follicle Stimulating Hormone; Genes, Recessive; Glucocorticoids; Gonadotropins, Pituitary; Humans; Hypopituitarism; Iodine; Male; Molecular Biology; Pedigree; Protein Binding; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Anorexia Nervosa; Child; Child, Preschool; Chromatography; Cushing Syndrome; Disorders of Sex Development; Endocrine System Diseases; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hyperthyroidism; Hypertrichosis; Hypopituitarism; Male; Middle Aged; Myxedema; Obesity; Pheochromocytoma; Pregnancy; Spectrophotometry

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Humans; Hypopituitarism; Hypothyroidism; Pituitary-Adrenal Function Tests; Pyrogens

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adult; Aged; Diuresis; Drug Synergism; Female; Flumethasone; Fluocinolone Acetonide; Humans; Hydroxyzine; Hypopituitarism; Hypothalamus; Lichen Planus; Male; Middle Aged; Natriuresis; Occlusive Dressings; Penicillins; Potassium; Psoriasis; Skin Absorption; Triamcinolone Acetonide

Topics: 17-Ketosteroids; Abnormalities, Multiple; Adolescent; Humans; Hypopituitarism; Intellectual Disability; Karyotyping; Leydig Cells; Male; Obesity; Penis; Scrotum; Sex Chromatin; Sex Determination Analysis; Testis; Voice

Topics: 17-Ketosteroids; Adolescent; Chorionic Gonadotropin; Corpus Luteum; Craniopharyngioma; Estrogens; Female; Gonadotropins; Humans; Hypogonadism; Hypophysectomy; Hypopituitarism; Male; Ovary; Ovulation; Pregnanediol; Pregnanetriol; Progesterone; Puberty; Sexual Dysfunction, Physiological; Vagina

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Chlorpromazine; Humans; Hypopituitarism; Infertility, Male; Male; Nutrition Disorders; Puberty, Precocious; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenocorticotropic Hormone; Adult; Basal Metabolism; Female; Humans; Hypopituitarism; Male; Metyrapone; Pituitary Function Tests; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Postoperative Complications; Radiography

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Humans; Hypopituitarism; Hypothalamo-Hypophyseal System; Pituitary-Adrenal Function Tests; Tannins; Vasopressins

Topics: 17-Ketosteroids; Adult; Coma; Female; Humans; Hypopituitarism; Middle Aged; Myxedema; Postpartum Hemorrhage; Pregnancy; Puerperal Disorders; Tuberculosis, Pulmonary

Topics: 17-Ketosteroids; Addison Disease; Adrenal Gland Diseases; Adrenal Glands; Adrenal Hyperplasia, Congenital; Female; Humans; Hypopituitarism; Male; Pituitary-Adrenal Function Tests

The isotopic estimation of the cortisol secretion rate in man is now an accepted and reliable method of assaying adrenal cortical function.Seven years' experience with its clinical use is reviewed and some practical aspects of technique are considered. The mean normal resting cortisol secretion rate is 16.2 +/- 5.7 mg. daily. In all of 14 cases of hypopituitarism studied secretion has been less than 2.1 mg. daily. In all of 26 cases of established Cushing's syndrome, the cortisol secretion was above 36 mg. The method can be used to follow day-by-day changes in adrenal cortisol activity and examples of such use are given. The urinary 17-ketogenic steroid excretion frequently gives results which conflict with secretion rate estimates, and can lead to erroneous clinical conclusions.

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Carbon Isotopes; Cushing Syndrome; Humans; Hydrocortisone; Hypopituitarism; Physiology; Pituitary-Adrenal Function Tests; Tritium; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing Syndrome; Diabetes Mellitus; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary Irradiation; Thyroid Function Tests; Urine; Yttrium Isotopes

Topics: 17-Ketosteroids; Adult; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Hypopituitarism; Infertility, Male; Injections, Intravenous; Male; Methods; Middle Aged; Sterilization, Reproductive; Testosterone; Tritium

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Hypopituitarism; Physiology

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Gonadotropins; Gonadotropins, Pituitary; Hypopituitarism; Myxedema; Pituitary Diseases; Thyroxine; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aldosterone; Congenital Abnormalities; Cortisone; Desoxycorticosterone; Hypoadrenocorticism, Familial; Hypopituitarism; Iatrogenic Disease; Toxicology

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anorexia Nervosa; Basal Metabolism; Blood Chemical Analysis; Blood Pressure; Blood Pressure Determination; Body Weight; Genetics, Medical; Humans; Hypopituitarism; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Child; Fatty Acids; Fatty Acids, Nonesterified; Humans; Hyperinsulinism; Hypopituitarism; Hypothyroidism; Insulin; Lipids; Thyroid Function Tests

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Pituitary Diseases; Puerperal Disorders; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Blood Chemical Analysis; Calcium; Chlorothiazide; Fludrocortisone; Hydrocortisone; Hyperparathyroidism; Hypoadrenocorticism, Familial; Hypoparathyroidism; Hypopituitarism; Natriuresis; Pharmacology; Phosphorus; Pituitary-Adrenal Function Tests; Potassium; Prednisolone; Spironolactone; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Blood; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Pharmacology; Pituitary Gland; Pituitary-Adrenal Function Tests; Tuberculosis; Tuberculosis, Pulmonary; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Anemia; Arrhythmias, Cardiac; Body Temperature; Bradycardia; Carbohydrate Metabolism; Cardiomegaly; China; Electrocardiography; Geriatrics; Hair; Humans; Hyperkalemia; Hyponatremia; Hypopituitarism; Pigmentation; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Aging; Cushing Syndrome; Fluprednisolone; Hypoadrenocorticism, Familial; Hypopituitarism; Obesity; Pharmacology; Urine

Topics: 17-Ketosteroids; Aspirin; Diagnosis, Differential; Hypnotics and Sedatives; Hypopituitarism; Hypothyroidism; Meprobamate; Phenobarbital; Substance-Related Disorders; Thyroid Function Tests; Toxicology

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Biomedical Research; Clinical Laboratory Techniques; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anxiety; Anxiety Disorders; Humans; Hypopituitarism; Hypothyroidism; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Neurotic Disorders; Pituitary-Adrenal Function Tests; Progeria; Psychology; Sexual Dysfunction, Physiological; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocortical Hyperfunction; Androsterone; Cushing Syndrome; Dehydroepiandrosterone; Humans; Hydrochlorothiazide; Hypoadrenocorticism, Familial; Hypopituitarism; Pharmacology; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Female; Humans; Hypopituitarism; Postpartum Period; Puerperal Disorders

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Diabetes Mellitus; Follicle Stimulating Hormone; Gastrointestinal Hemorrhage; Goiter; Gonadotropins; Gynecomastia; Heart Failure; Hemochromatosis; Hepatomegaly; Humans; Hypogonadism; Hypopituitarism; Iodine Isotopes; Liver Cirrhosis; Liver Diseases; Male; Myocarditis; Pancreatitis; Steroids; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Female; Humans; Hypopituitarism; Pharmacology; Puerperal Disorders; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amenorrhea; China; Dwarfism; Dwarfism, Pituitary; Estrogens; Female; Glucose Tolerance Test; Humans; Hypopituitarism; Infertility; Leukocyte Count; Liver Function Tests; Pituitary Diseases; Pituitary Gland; Schistosomiasis; Thyroid Function Tests; Urine

Topics: 17-Ketosteroids; Acromegaly; Adrenocorticotropic Hormone; Biochemical Phenomena; Biochemistry; Chlorpromazine; Enzyme Inhibitors; Humans; Hypopituitarism; Metyrapone; Mixed Function Oxygenases; Pyrogens; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Amenorrhea; Chemical Phenomena; Chemistry; Chromatography; Diencephalon; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Hexestrol; Humans; Hypopituitarism; Klinefelter Syndrome; Menstruation; Ovary; Pharmacology; Physiology; Pituitary Gland; Pituitary Neoplasms; Pregnanediol; Turner Syndrome; Urine; Uterine Hemorrhage

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Cushing Syndrome; Humans; Hypopituitarism; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Physiology; Pituitary Gland; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Androgens; Child; Cobalt; Cobalt Isotopes; Dwarfism; Dwarfism, Pituitary; Growth Hormone; Humans; Hypopituitarism; Male; Neoplasms; Pituitary Diseases; Pituitary Gland; Pituitary Neoplasms; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Biopsy; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Hypoadrenocorticism, Familial; Hypopituitarism; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Urine

Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Laboratory Techniques; Cushing Syndrome; Cysts; Female; Humans; Hypogonadism; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Neoplasms; Ovary; Pharmacology; Pituitary Gland; Pituitary Neoplasms; Radioisotope Teletherapy; Scleroderma, Systemic; Sexual Infantilism; Toxicology; Urine

Topics: 17-Ketosteroids; Diabetes Mellitus; Eosinophils; Estrogens; Hypopituitarism; Leukocyte Count; Pituitary Diseases; Pituitary Gland; Steroids

Topics: 17-Ketosteroids; Hypopituitarism; Pituitary Diseases; Pituitary Gland; Steroids; Urine