17-ketosteroids has been researched along with Hypokalemia* in 24 studies
24 other study(ies) available for 17-ketosteroids and Hypokalemia
Article | Year |
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A case of renin-producing adrenocortical cancer.
Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective. Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Neoplasms; Biopsy, Needle; Catecholamines; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Enzyme Inhibitors; Female; Glucocorticoids; Gonadal Steroid Hormones; Humans; Hydrocortisone; Hypertension; Hypokalemia; Middle Aged; Mitotane; Muscle Weakness; Neoplasm Metastasis; Renin; Thirst; Tomography, X-Ray Computed | 2000 |
Normotensive glucocorticoid-suppressible hyperaldosteronism in adult.
A 40 year-old man was admitted to our hospital for detailed examination of hypokalemia (2.7 mEq/l). His blood pressure was normal. Metabolic alkalosis, ACTH dependent hyperaldosteronism (18 ng/dl) and over-response to synthetic ACTH were observed. Plasma renin activity, on the other hand, was within the normal range (1.7 ng/ml/hr). Serum potassium was normalized to 4.1 mEq/l and the responsiveness of the renin-angiotensin-aldosterone system was recovered after the administration of dexamethasone. These results led us to suggest that this case might be normotensive glucocorticoid-suppressible hyperaldosteronism. The etiology which was not associated with hypertension and low plasma renin activity has not been clarified but may be related to the shortness of duration of this disease. Our case was also afflicted with mild hypercortisolemia and excessive excretion of urinary 17-hydroxycorticosteroid and 17-ketosteroid which was suppressed by the administration of dexamethasone (2 mg/day). These findings may be related to hypersensitivity of the fascicular zone of the adrenal gland to ACTH. Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Circadian Rhythm; Dexamethasone; Humans; Hydrocortisone; Hyperaldosteronism; Hypokalemia; Male; Renin-Angiotensin System | 1989 |
Apparently isolated excess deoxycorticosterone in hypertension. A variant of the mineralocorticoid-excess syndrome.
Topics: 17-Ketosteroids; Adult; Aged; Aldosterone; Chromatography, Gas; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydroxycorticosteroids; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Radioimmunoassay; Renin; Spironolactone; Syndrome | 1972 |
A new male pseudo-hermaphroditism associated with hypertension due to a block of 17 -hydroxylation.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aldosterone; Corticosterone; Desoxycorticosterone; Dexamethasone; Disorders of Sex Development; Estrogens; Humans; Hydroxycorticosteroids; Hypertension; Hypokalemia; Karyotyping; Male; Metabolic Diseases; Mixed Function Oxygenases; Pregnanediol; Pregnenolone; Progesterone | 1972 |
Cushing's syndrome caused by malignant tumor in the scrotum: clinical, pathologic and biochemical studies.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Androstanes; Autopsy; Chromatography; Corticosterone; Cushing Syndrome; Dehydroepiandrosterone; Dexamethasone; Edema; Humans; Hydrocortisone; Hypokalemia; Male; Metyrapone; Middle Aged; Mixed Function Oxygenases; Neoplasm Metastasis; Pregnanes; Pregnenolone; Progesterone; Retroperitoneal Neoplasms; Scrotum; Tritium | 1971 |
Mineralocorticoid production in hyperadrenocorticism. Role in pathogenesis of hypokalemic alkalosis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Alkalosis; Carcinoma, Bronchogenic; Corticosterone; Cushing Syndrome; Deficiency Diseases; Desoxycorticosterone; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Pancreatic Neoplasms | 1971 |
Cushing's syndrome complicating pregnancy. A case report.
A case of a rare association between pregnancy and the development of Cushing's syndrome is discussed. A 29-year-old woman developed Cushing's syndrome, characterized by hypokalemia, a high level of urinary 17-hydroxycorticoids not suppressed by dexamethasone therapy, a high level of plasma 11-hydroxycorticoids which did not show diurnal variation and failed to show suppression after dexamethasone therapy, and a high level of urinary 17-ketosteroids, within 12 weeks of her first pregnancy. Clinical and biochemical abnormalities disappeared rapidly after dilatation and curettage. No evidence of an ectopic ACTH-producing tumor or an adrenal cortical tumor was found. Abnormalities did not reappear with administration of HCG or with sequential estrogen-progestogen treatment. Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abortion, Therapeutic; Adrenal Gland Neoplasms; Adult; Chorionic Gonadotropin; Cushing Syndrome; Dexamethasone; Estrogens; Female; Humans; Hypokalemia; Potassium; Pregnancy; Pregnancy Complications | 1971 |
Studies in thyrotoxic periodic paralysis.
Topics: 17-Ketosteroids; Acetazolamide; Action Potentials; Adult; Aldosterone; Biopsy; Body Weight; Electromyography; Glucose Tolerance Test; Humans; Hyperthyroidism; Hypokalemia; Insulin; Male; Muscles; Paralyses, Familial Periodic; Potassium; Sodium | 1971 |
Suppressed plasma renin activity in hypertension.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adult; Aged; Aldosterone; Angiotensin II; Animals; Biological Assay; Diagnosis, Differential; Female; Furosemide; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Male; Middle Aged; Posture; Potassium; Rats; Renin; Saliva; Sodium; Water-Electrolyte Balance | 1969 |
Intravenously administered chlorothiazide in diagnostic evaluation of hypertensive disease.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Aldosterone; Blood Pressure; Catecholamines; Chlorothiazide; Creatinine; Diagnosis, Differential; Diet; Epinephrine; Humans; Hyperaldosteronism; Hypertension; Hypertension, Renal; Hypokalemia; Infusions, Parenteral; Norepinephrine; Potassium; Renal Artery Obstruction; Renin; Sodium; Vanilmandelic Acid | 1969 |
[Primary hyperaldosteronism. Description of a clinical case].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Alkalosis; Electrolytes; Female; Humans; Hyperaldosteronism; Hypertension; Hypokalemia; Renin; Spironolactone | 1969 |
Congenital adrenal hyperplasia due to a deficiency of one of the enzymes involved in the biosynthesis of pregnenolone.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Desoxycorticosterone; Disorders of Sex Development; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hypokalemia; Hyponatremia; Infant; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pregnanediol; Pregnanetriol; Pregnenolone; Secretory Rate; Urine; Water-Electrolyte Balance | 1968 |
[On the functional status of the adrenal glands in atherosclerosis].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Aged; Androgens; Arteriosclerosis; Coronary Disease; Erythrocytes; Female; Glucocorticoids; Humans; Hypernatremia; Hypokalemia; Male; Middle Aged; Mineralocorticoids; Water-Electrolyte Balance | 1968 |
Cushing's syndrome associated with an adrenal neuroblastoma. A case in an infant with clinical, pathological, and adrenal corical and medullary hormone excretion studies.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenalectomy; Cushing Syndrome; Dopamine; Ganglioneuroma; Humans; Hypokalemia; Infant; Male; Norepinephrine | 1967 |
Prolonged hyperadrenocorticotrophism and pigmentation associated with bronchial carcinoid tumour.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Alkalosis; Bronchial Neoplasms; Cushing Syndrome; Dexamethasone; Female; Fluorescent Antibody Technique; Humans; Hypokalemia; Hypophysectomy; Lung Neoplasms; Pigmentation Disorders | 1967 |
[Clinico-pathogenetic considerations on a case of periodic hypokalemic paralysis (with special reference to the possible role of the hypothalamus)].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Electrocardiography; Female; Humans; Hypokalemia; Hypothalamus; Middle Aged; Paralyses, Familial Periodic; Paralysis | 1967 |
Effects of prolonged inhibition of 11 beta-hydroxylase in the dog.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Blood; Blood Pressure; Chromatography; Dexamethasone; Dogs; Enzymes; Female; Hyperplasia; Hypertension; Hypokalemia; In Vitro Techniques; Male; Metyrapone; Mixed Function Oxygenases; Organ Size; Polyuria; Potassium; Urine | 1966 |
ACTH PRODUCING MATASTASES FROM CARCINOMA OF THE ESOPHAGUS.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Alkalosis; Carcinoma; Carcinoma, Squamous Cell; Esophageal Neoplasms; Humans; Hypokalemia; Liver Neoplasms; Neoplasm Metastasis; Pathology; Pituitary-Adrenal Function Tests | 1965 |
ISLET-CELL CARCINOMA (ZOLLINGER-ELLISON SYNDROME) WITH FULMINATING ADRENOCORTICAL HYPERFUNCTION AND HYPOKALEMIA.
The production of ACTH-like material by tumours arising in non-endocrine tissue may initiate severe adrenocortical hyperfunction. The pathogenesis and clinical and laboratory features of Cushing's syndrome associated with such tumours are characteristic. The autonomous production by the tumour of ACTH-like material cannot be suppressed by exogenous corticoids. The onset of clinical symptoms is rapid; muscle wasting, general weakness, thirst and peripheral edema predominate, and the classical signs of Cushing's syndrome may be absent. High levels of plasma 17-hydroxycorticosteroids and urinary 17-hydroxycorticosteroids and 17-ketosteroids, usually with normal levels of urinary aldosterone, commonly occur. Hypokalemic alkalosis unresponsive to replacement therapy may cause death. In the case reported herein, the intriguing possibility exists that two hormone-like substances were produced by the primary growth and its metastases: one, ACTH-like, to account for the adrenal hyperplasia and Cushing's syndrome; and another, gastrin-like, giving rise to the ulcerogenic diathesis. Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyperfunction; Autopsy; Carcinoma, Islet Cell; Chloramphenicol; Cushing Syndrome; Drug Therapy; Gastrins; Humans; Hypokalemia; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Pathology; Spironolactone; Zollinger-Ellison Syndrome | 1965 |
Adrenocortical hyperfunction associated with bronchogenic carcinoma: report of five cases.
Five patients with bronchogenic carcinoma associated with adrenocortical hyperfunction are described. The clinical features, laboratory studies and autopsy findings are discussed and compared with previously reported cases. Four patients presented most of the typical features of this disorder as previously described, whereas the fifth was atypical in some respects. Typical features included: acute onset of adrenocortical hyperfunction in a middle-aged male, rapid downhill course, slight or absent physical signs of Cushing's syndrome, frequently impaired glucose tolerance, markedly elevated plasma and urinary 17-hydroxycorticosteroids not suppressed by exogenous steroids, absent diurnal variation of plasma corticoids, hypokalemic alkalosis with normal aldosterone excretion, and tumour histology of the oat cell variety. The adrenal glands of two patients were of normal or slightly increased weight, and mean 17-ketosteroid excretion values were normal in three; this contrasts with the marked increase in adrenal weight and 17-ketosteroid excretion in most reported cases. Topics: 17-Ketosteroids; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Alkalosis; Autopsy; Blood; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Glucose Tolerance Test; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Urine | 1965 |
[Global hypocorticism. Hypoaldosteronism and pseudo-hypoaldosteronism in infants. 3 cases].
Topics: 17-Ketosteroids; Adrenal Insufficiency; Aldosterone; Child, Preschool; Female; Humans; Hypokalemia; Hyponatremia; Infant; Male | 1965 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL ADENOMA IN A THREE-YEAR-OLD CHILD.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Adenoma; Child; Humans; Hyperaldosteronism; Hypernatremia; Hypertension; Hypertrichosis; Hypokalemia; Potassium; Sodium; Spironolactone; Urine | 1964 |
METABOLIC STUDIES IN A CASE OF ADRENOCORTICAL HYPERFUNCTION ASSOCIATED WITH CARCINOMA OF THE LUNG.
Topics: 17-Ketosteroids; Acid-Base Equilibrium; Adrenocortical Hyperfunction; Alkalosis; Carcinoma; Electrocardiography; Humans; Hypokalemia; Lung Neoplasms; Lymphatic Metastasis; Potassium; Sodium; Urine | 1964 |
MULTIPLE BRONCHIAL ADENOMAS, CUSHING'S SYNDROME AND HYPOKALEMIC ALKALOSIS. REPORT OF A CASE.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Alkalosis; Bartter Syndrome; Bronchial Neoplasms; Cushing Syndrome; Dexamethasone; Heart Arrest; Humans; Hypokalemia; Metyrapone; Neoplasms; Neoplasms, Multiple Primary; Pathology; Radiography, Thoracic; Urine | 1964 |