17-ketosteroids and Hypogonadism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Chemistry, Clinical; Corticosterone; Cushing Syndrome; Diagnosis, Differential; Female; Glucocorticoids; Humans; Hydrocortisone; Hypogonadism; Kidney Failure, Chronic; Male; Methods; Obesity; Pregnancy; Pregnancy Complications

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androgen-Insensitivity Syndrome; Castration; Feedback; Humans; Hypogonadism; Klinefelter Syndrome; Leydig Cells; Male; Testis; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Androsterone; Blood; Chorionic Gonadotropin; Cushing Syndrome; Dysgerminoma; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypertrichosis; Hypogonadism; Metabolism; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Testosterone; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Anabolic Agents; Hirsutism; Hyperaldosteronism; Hypertrichosis; Hypogonadism; Metabolism; Steroids; Urine

Oral testosterone undecanoate (TU) in arachis oil has been evaluated with a view to its possible use as a means of androgen replacement therapy. A single 100 mg dose was found to elevate plasma androgen levels and urinary 17-ketosteroid excretion in 6 normal men. Ninety mg/day and 60 mg/day doses taken by a hypogonadal man resulted in sustained levels of androgen which appeared physiological when measured by radioimmunoassay without chromatography. However, upon separation of the steroids by chromatography it was found that much of the androgen present was in fact dihydrotestosterone not testosterone. Both TU and dihydrotestosterone undecanoate were detected in plasma by gas chromatography and it is suggested that the ester is absorbed as such from the intestine and the unesterified steroid subsequently released by hydrolysis. The convenience of oral administration, the resulting prolonged elevated plasma androgen levels and the probable lack of deleterious effects on the liver may render oral TU of value where androgen replacement therapy is indicated.

Topics: 17-Ketosteroids; Administration, Oral; Adult; Androgens; Clinical Trials as Topic; Dihydrotestosterone; Fatty Acids; Humans; Hypogonadism; Male; Placebos; Stimulation, Chemical; Testosterone

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aminoglutethimide; Androsterone; Aniline Compounds; Anticonvulsants; Chemistry, Clinical; Clinical Trials as Topic; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Glucocorticoids; Humans; Hyperplasia; Hypogonadism; Pyridones; Testosterone

Topics: 17-Ketosteroids; Adult; Androgens; Chemistry, Clinical; Clinical Trials as Topic; Depression; Erectile Dysfunction; Glucocorticoids; Gonadotropins; Gonadotropins, Pituitary; Hemoglobinuria, Paroxysmal; Humans; Hypogonadism; Male; Pituitary Gland; Spermatozoa; Testis

The study includes 115 men, 17 to 26 years of age, suffering from various forms of male hypogonadism: Klinefelter's syndrome--40 patients, male Turner's syndrome--2 patients, primary hypogonadism with other etiology--14 patients, cryptorchism--12 patients, anorchidism--8 patients, secondary hypogonadism--26 patients and late puberty--13 patients. A raised hydrocortisone plasma level was found. In the anorchidism cases the basic testosterone level was the lowest one combined with the highest basic hydrocortisone level. The 24 hour rhythm of hydrocortisone secretion in Klinefelter's syndrome is regular but the hour values are higher. In cases of primary hypogonadism with other etiology, cryptorchism and secondary hypogonadism the 24 hour rhythm is disturbed and the hydrocortisone values are higher.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Gonadotropin-Releasing Hormone; Humans; Hydrocortisone; Hypogonadism; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Testis; Testosterone; Thyrotropin-Releasing Hormone

Sexual function was studied in 76 patients with chronic bronchitis and in 17 healthy males. The study showed a decrease in sexual function of primary hypogonadism type which was in direct relation to the gravity of disease.

Topics: 17-Ketosteroids; Adult; Androsterone; Bronchitis; Chronic Disease; Etiocholanolone; Follicle Stimulating Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Middle Aged; Pituitary Gland, Anterior; Testis; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Function Tests; Adult; Child; Child, Preschool; Chromatography, Paper; Gonads; Hirsutism; Humans; Hypogonadism; Male; Pituitary-Adrenal Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Glands; Chemistry, Clinical; Female; Humans; Hypogonadism; Male; Ovary; Polycystic Ovary Syndrome; Testis

Two brothers showed ichthyosis, bilateral cryptorchidism, hypogenitalism and mental retardation. In addition, the younger brother had short stature associated with disorders of secretions of insulin, ACTH and GH. This is the third reported case of the syndrome of ichthyosis and hypogonadism.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Cryptorchidism; Follicle Stimulating Hormone; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Ichthyosis; Insulin; Intellectual Disability; Luteinizing Hormone; Male; Thyrotropin

A survey is given on the participation of endocrine glands in the pulmonary silicosis. At the same time a new clinical and experimental contribution to the question of the appearance of a hypogonadotropic hypogonadism is given. The frequency of this hypogonadism increases with the severity of the pulmonary silicosis. The immunological opinions as well as the neuroergonal ones concerning the pathogenesis of pulmonary silicosis gave the possibility of a better explanation of the mechanisms, by means of which also other organs may be attacked in pulmonary silicosis. The neuroendocrine system gives a defensive answer to the aggressive silicotic pulmonary process, which in general slowly progresses, but which may also be certain hormones from the group of the glucocorticosteroids in the adrenal cortex. The intervention into the axis hypothalamus-hypophysis-adrenal cortex has been provided in all defence processes of the organism against every aggression. By the functional or organic damage of the neuroendocrine system, by the immediate toxic effect of silicium dioxide or the monosilicium acid as well as by the effect of the secondary hypoxia in pulmonary silicosis an insufficiency in the stimulation and excretion of certain hormones develops. The origin of this insufficiency is found in the hypothalamo-hypophyseal centres, and the effects extend to all endocrine glands which depend on the system hypothalamus-hypophysis. This mechanism is made responsible for the appearance of a hypogonadotropic insufficiency of gonads in the course of a pulmonary silicosis and is proved clinically and experimentally in the cases investigated by the authors

Topics: 17-Ketosteroids; Adult; Erectile Dysfunction; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Male; Middle Aged; Silicon Dioxide; Silicosis

The administration of human chorionic gonadotrophin (HCG) to dexamethasone-suppressed men caused parallel changes in the concentration of plasma testosterone and in the urinary output of androsterone+aetiocholanolone, total 17-oxosteroids and oestrogens. Discrepant results occurred in only four of the thirty-seven men tested. With these exceptions, the response to HCG could by followed as well by measuring androsterone+aetiocholanolone, 17-oxosteroid or oestrogen excretion rates as by following plasma testosterone levels. The most sensitive index of response was the rate of appearance of oestrogens in urine, and the next that of androsterone+aetiocholanolone.

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Androsterone; Chorionic Gonadotropin; Depression, Chemical; Dexamethasone; Estrogens; Etiocholanolone; Humans; Hypogonadism; Male; Middle Aged; Testis; Testosterone

Sexual development was evaluated in 9 female and 2 male subjects with Prader-Willi syndrome. The process of sexual development and degree of genital development attained were found to be variable but abnormal in all subjects. Hypothalamic-pituitary-gonadal functions were evaluated by measurement of serum Luteinizing Hormone and plasma testosterone responses to stimulation by clomiphene citrate and plasma testosterone responses to stimulation by human chorionic gonadotrophin. The degree of vaginal estrogenization was variable. The testicular biopsies showed abnormalities mainly in the germinal epithelium. In agreement with previous studies, it was concluded that the abnormalities of sexual development in this syndrome are mainly due to a defect in the hypothalamic pituitary axis. Adrenal function was not found to be grossly abnormal. The 17 ketosteroid excretion values were low, probably explaining the rather sparse pubic and axillary hair observed in these patients. The urinary 17-hydroxycorticosteroid creatinine ratios were found to be elevated, probably due to decreased creatinine excretion, reflecting the muscular abnormalities of these subjects.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Carbohydrate Metabolism, Inborn Errors; Child; Clomiphene; Creatinine; Female; Humans; Hypogonadism; Intellectual Disability; Luteinizing Hormone; Male; Menarche; Metyrapone; Obesity; Syndrome; Testis; Testosterone; Wechsler Scales

Topics: 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Color Vision Defects; Eunuchism; Humans; Hypogonadism; Insulin; Intellectual Disability; Male; Olfaction Disorders; Pedigree; Testosterone

The increase in serum concentrations of LH and FSH after intramuscular administration of LH/FSH-RH was investigated in normal and hypogonadotrophic hypogonadal males. LH and FSH were measured by specific radio-immunoassays. To evaluate the appropriate dose of LH/FSH-RH for intramuscular administration different doses were administered and with 200 mu g an increase in LH and FSH was found comparable to the results obtained by other investigators using intravenous administration. After the initial studies a simple test including two determinations before LH/FSH-RH administration and one 60 min and 120 min after administration was developed and used in all cases. In 12 normal males a significant increase in the serum concentration of both LH and FSH was found averaging 381% and 148% respectively 60 min after 200 mu g LH/FSH-RH with a slight decrease in LH but not in FSH after 120 min. A positive response similar to that in normal men was observed in 11 hypogonadotrophic hypogonadal patients presenting different clinical pictures. This indicates that in all these patients the hypogonadotrophic state was due to a hypothalamic defect and not to a hypophyseal disorder.

Topics: 17-Ketosteroids; Adult; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Injections, Intramuscular; Luteinizing Hormone; Male; Pituitary Function Tests; Radioimmunoassay; Stimulation, Chemical; Time Factors

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Clomiphene; Follicle Stimulating Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Testosterone

On the basis of own investigations of the testosteron metabolism in hepatopathy must be assumed that the hypogonadism appearing in liver diseases is to be regarded as peripheral form, i.e. it is not centrally evoked by gonadotropin insufficiency. An own pathogenetic concept is discussed.

Topics: 17-Ketosteroids; Age Factors; Chronic Disease; Estrogens; Humans; Hypogonadism; Liver Diseases; Male; Testosterone

Topics: 17-Ketosteroids; Adult; Androstanes; Chromatography, Paper; Chromatography, Thin Layer; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hypogonadism; Skin; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Citrates; Clomiphene; Diencephalon; Humans; Hypogonadism; Hypothalamus; Luteinizing Hormone; Male; Pituitary Gland; Pregnanediol; Progesterone; Testis; Testosterone

Topics: 17-Ketosteroids; Age Factors; Amenorrhea; Body Temperature; Chorionic Gonadotropin; Clomiphene; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Infertility, Female; Luteinizing Hormone; Male; Menstruation; Ovarian Diseases; Ovulation; Pregnanediol; Progesterone; Puberty, Precocious; Radioimmunoassay; Time Factors

Topics: 17-Ketosteroids; Female; Humans; Hypogonadism; Male; Suppositories; Testosterone; Time Factors

Topics: 17-Ketosteroids; Adolescent; Chorionic Gonadotropin; Disorders of Sex Development; Female; Gonadal Steroid Hormones; Growth Disorders; Humans; Hypogonadism; Ovary; Pituitary-Adrenal Function Tests; Sex Chromatin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Alopecia; Deafness; Dermatoglyphics; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; Hypogonadism; Intelligence; Luteinizing Hormone; Male; Metyrapone; Pedigree; Pituitary-Adrenal Function Tests; Syndrome; Testosterone; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Biopsy; Blood Cells; Body Height; Body Weight; Fibroblasts; Gonadotropins; Humans; Hypogonadism; Karyotyping; Male; Mosaicism; Mouth Mucosa; Sex Chromatin; Sex Chromosome Aberrations; Skin; Syndrome; Testis; Testosterone

Topics: 17-Ketosteroids; Adult; Cell Count; Hemagglutination Inhibition Tests; Humans; Hypogonadism; Luteinizing Hormone; Male; Spermatozoa; Testosterone

Topics: 17-Ketosteroids; Follicle Stimulating Hormone; Fractures, Bone; Humans; Hydrocortisone; Hypogonadism; Lumbar Vertebrae; Luteinizing Hormone; Male; Middle Aged; Osteoporosis; Pituitary Gland; Pituitary-Adrenal Function Tests; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Dihydrotestosterone; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androgens; Androstanes; Androsterone; Bromine; Carbon Isotopes; Child; Child, Preschool; Dehydroepiandrosterone; Female; Humans; Hypogonadism; Infant; Infant, Newborn; Male; Puberty; Puberty, Precocious; Radioisotopes; Sex Factors; Statistics as Topic; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromatography, Gas; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Hirsutism; Humans; Hydrocortisone; Hypogonadism; Hypopituitarism; Male; Pregnancy; Pregnanediol; Pregnanetriol

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Accidents, Traffic; Adrenocorticotropic Hormone; Autopsy; Blood Glucose; Body Temperature; Brain Injuries; Fatty Acids, Nonesterified; Female; Frontal Lobe; Glucose Tolerance Test; Growth Hormone; Humans; Hypogonadism; Hypothalamus; Insulin; Middle Aged; Obesity; Temporal Lobe; Thalamus

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Estrogens; Gonadotropins; Growth Disorders; Hepatomegaly; Humans; Hydrocortisone; Hypoglycemia; Hypogonadism; Intellectual Disability; Liver Diseases, Parasitic; Liver Function Tests; Male; Middle Aged; Nutrition Disorders; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Schistosomiasis; Splenomegaly; Stimulation, Chemical

Topics: 17-Ketosteroids; Adolescent; Adult; Androgen-Insensitivity Syndrome; Child; Dermatoglyphics; Disorders of Sex Development; Dwarfism; Female; Gene Frequency; Genitalia, Male; Humans; Hypogonadism; Karyotyping; Leukocytes; Male; Mouth Mucosa; Mullerian Ducts; Pedigree; Spinal Dysraphism; Wolffian Ducts

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Biopsy; Dihydroxyphenylalanine; Female; Humans; Hypogonadism; Lactation Disorders; Male; Mastectomy; Pituitary Function Tests; Pregnancy; Prolactin; Radioimmunoassay; Testis; Testosterone; Thyroid Function Tests; Thyrotropin-Releasing Hormone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child; Estrogens; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Intellectual Disability; Metyrapone; Obesity; Puberty, Precocious

Topics: 17-Ketosteroids; Adult; Aminoglutethimide; Androsterone; Aniline Compounds; Anticonvulsants; Dehydroepiandrosterone; Depression, Chemical; Etiocholanolone; Humans; Hypogonadism; Male; Pyridones; Testosterone; Virilism

Topics: 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Androgens; Androstanes; Child; Child, Preschool; Chromatography, Gas; Clomiphene; Dehydroepiandrosterone; Humans; Hypogonadism; Luteinizing Hormone; Male; Puberty; Sulfates; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic Gonadotropin; Dehydroepiandrosterone; Endocrine System Diseases; Estrogens; Etiocholanolone; Humans; Hypogonadism; Hypopituitarism; Klinefelter Syndrome; Male; Metabolism; Middle Aged; Pregnanetriol; Puberty; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Administration, Oral; Adolescent; Adult; Aged; Androstanes; Biological Assay; Body Weight; Cortisone; Dexamethasone; Female; Gonadotropins; Humans; Hydrocortisone; Hypogonadism; Injections, Intravenous; Klinefelter Syndrome; Male; Metyrapone; Middle Aged; Obesity; Radioisotope Dilution Technique; Testosterone; Time Factors

Topics: 17-Ketosteroids; Adult; Androgen-Insensitivity Syndrome; Body Weight; Castration; Cell Nucleus; Color Vision Defects; Creatinine; Dihydrotestosterone; Estrogens; Eunuchism; Humans; Hypogonadism; Intellectual Disability; Male; Nitrogen; Olfaction Disorders; Phosphates; Receptors, Drug; Sex Chromosome Aberrations; Stimulation, Chemical; Testosterone

Topics: 17-Ketosteroids; Adult; Androstanes; Chorionic Gonadotropin; Diagnosis, Differential; Humans; Hypogonadism; Male; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aldosterone; Androsterone; Child; Dehydroepiandrosterone; Desoxycorticosterone; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hypogonadism; Hyponatremia; Male; Middle Aged; Postoperative Complications; Pregnanediol; Pregnanetriol; Steroids

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androgens; Chromatography, Gas; Collagen Diseases; Cushing Syndrome; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Female; Glucuronidase; Humans; Hyperthyroidism; Hypogonadism; Liver Cirrhosis; Male; Metyrapone; Pregnanes; Sterols

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adult; Aged; Cryptorchidism; Diagnosis, Differential; Dwarfism; Endocrine System Diseases; Erectile Dysfunction; Eunuchism; Humans; Hypogonadism; Male; Middle Aged; Muscular Dystrophies; Myotonic Dystrophy; Obesity

Topics: 17-Ketosteroids; Adolescent; Adult; Color Vision Defects; Disorders of Sex Development; Eunuchism; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypogonadism; Hypospadias; Infertility, Male; Intellectual Disability; Male; Olfaction Disorders; Phenotype; Sex Chromosome Aberrations; Testicular Diseases

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Chorionic Gonadotropin; Dexamethasone; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypogonadism; Karyotyping; Male; Ovarian Diseases; Pituitary Function Tests; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adult; Arteriosclerosis; Castration; Estrogens; Humans; Hypogonadism; Lipids; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Clomiphene; Creatinine; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypogonadism; Hypopituitarism; Hypothalamo-Hypophyseal System; Limbic System; Luteinizing Hormone; Male; Olfaction Disorders; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Carbon Isotopes; Castration; Chromatography; Humans; Hypogonadism; Male; Prostatic Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Clomiphene; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypogonadism; Hypopituitarism; Hypothalamic Diseases; Infertility, Male; Male; Mumps; Orchitis; Phosphorus Isotopes; Semen; Spermatozoa; Testis

Topics: 17-Ketosteroids; Acetone; Cell Count; Diagnosis, Differential; Follicle Stimulating Hormone; Fructose; Gonadotropins; Humans; Hypogonadism; Infertility, Male; Kaolin; Luteinizing Hormone; Male; Semen; Spermatozoa

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Biopsy; Brain Neoplasms; Cholesteatoma; Cortisone; Craniopharyngioma; Diabetes Insipidus; Female; Follicle Stimulating Hormone; Growth Disorders; Hair; Humans; Hypertonic Solutions; Hypogonadism; Hypopituitarism; Hypothalamus; Male; Metyrapone; Middle Aged; Pinealoma; Pituitary Diseases; Polyuria; Radiography; Sella Turcica; Skull; Testis; Thirst; Thyroid Function Tests; Visual Fields; Water

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Clomiphene; Follicle Stimulating Hormone; Growth Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Olfaction Disorders; Testis; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Androsterone; Body Height; Bone Development; Child; Clitoris; Dehydroepiandrosterone; Disorders of Sex Development; Etiocholanolone; Female; Humans; Hypogonadism; Karyotyping; Ovary; Sex Chromosome Aberrations; Testosterone; Turner Syndrome

Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Gland Diseases; Androgens; Child; Child, Preschool; Clomiphene; Dehydroepiandrosterone; Humans; Hypogonadism; Male; Puberty; Sulfates; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Estriol; Female; Gonadotropins; Humans; Hypogonadism; Pituitary Gland; Pregnanediol; Sex Chromatin; Thyroid Function Tests

Topics: 17-Ketosteroids; Adolescent; Age Factors; Child; Child, Preschool; Cryptorchidism; Humans; Hypertrophy; Hypogonadism; Male; Testicular Diseases; Testis

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Blood Transfusion; Child; Female; Gonadotropins, Pituitary; Growth; Growth Disorders; Hemosiderosis; Humans; Hypogonadism; Iron; Male; Menstruation Disturbances; Metyrapone; Pituitary Function Tests; Splenectomy; Thalassemia; Thyroid Gland

Topics: 17-Ketosteroids; Biopsy; Diagnosis, Differential; Gonadotropins, Pituitary; Hemagglutination Inhibition Tests; Humans; Hypogonadism; Infertility, Male; Luteinizing Hormone; Male; Spermatozoa; Testis

Topics: 17-Ketosteroids; Adolescent; Adult; Chromosome Aberrations; Gonadotropins; Humans; Hypogonadism; Karyotyping; Male; Sex Chromosomes

Topics: 17-Ketosteroids; Androgens; Androsterone; Estrogens; Fertility; Humans; Hypogonadism; Infertility, Male; Male; Semen; Spermatozoa; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Blindness; Body Height; Child; Chorionic Gonadotropin; Deafness; Follicle Stimulating Hormone; Growth; Humans; Hypogonadism; Karyotyping; Leydig Cells; Lipoproteins; Male; Metabolism, Inborn Errors; Pedigree; Sex Characteristics; Testis; Testosterone; Triglycerides; Uric Acid

Topics: 17-Ketosteroids; Adult; Androgens; Carbon Isotopes; Dehydroepiandrosterone; Eczema; Estradiol; Estrone; Humans; Hypogonadism; In Vitro Techniques; Infertility, Male; Libido; Male; Pregnenolone; Radiation Effects; Testicular Diseases; Testis; Testosterone

Topics: 17-Ketosteroids; Adult; Ascites; Carcinoma, Hepatocellular; Diabetes Complications; Dwarfism; Female; Glucose Tolerance Test; Humans; Hypogonadism; Islets of Langerhans; Liver Cirrhosis; Liver Neoplasms; Obesity; Osteoporosis; Pleural Effusion; Pneumonia, Lipid; Sella Turcica

Topics: 17-Ketosteroids; Adult; Estrogens, Conjugated (USP); Female; Humans; Hypogonadism; Hypothalamo-Hypophyseal System; Immunoassay; Luteinizing Hormone; Methods; Ovarian Diseases; Ovary; Ovulation; Pituitary Hormone-Releasing Hormones

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenalectomy; Adult; Aged; Androgen-Insensitivity Syndrome; Castration; Chemistry, Clinical; Climacteric; Cryptorchidism; Disorders of Sex Development; Erectile Dysfunction; Estrogens; Eunuchism; Humans; Hypogonadism; Hypophysectomy; Hypothalamo-Hypophyseal System; Male; Middle Aged; Paraplegia; Puberty, Precocious; Spinal Cord Diseases; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Arginine; Female; Follicle Stimulating Hormone; Glucagon; Glucose Tolerance Test; Growth Hormone; Hemochromatosis; Humans; Hypogonadism; Insulin; Male; Middle Aged; Pituitary Gland; Radioimmunoassay

Topics: 17-Ketosteroids; Adult; Androgen-Insensitivity Syndrome; Androstanes; Androsterone; Carbon Isotopes; Chorionic Gonadotropin; Dihydrotestosterone; Disorders of Sex Development; Glucuronates; Humans; Hypogonadism; Hypopituitarism; Male; Middle Aged; Sulfates; Testosterone; Tritium; Turner Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Age Factors; Child; Child, Preschool; Chorionic Gonadotropin; Chromatography, Thin Layer; Female; Fluorometry; Humans; Hypogonadism; Infant; Infant, Newborn; Male; Methods; Sex Factors; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Dexamethasone; Disorders of Sex Development; Female; Gonads; Humans; Hypogonadism; Male; Middle Aged; Polycystic Ovary Syndrome; Pregnanetriol; Turner Syndrome

Topics: 17-Ketosteroids; Androgens; Biopsy; Endocrine System Diseases; Estrogens; Gonadotropins; Humans; Hypogonadism; Klinefelter Syndrome; Male; Testicular Diseases; Testis

During clinical studies on a 34-year-old man with marked hypogonadism secondary to pituitary gonadotrophin insufficiency, an attempt was made to determine whether the testes were capable of androgen production when stimulated by exogenous chorionic gonadotrophin (A.P.L.).Androgen excretion before and after chorionic gonadotrophin administration was studied. Total and fractionated 17-ketosteroid patterns suggested a severe Leydig cell deficiency which was confirmed by testicular biopsy.Panhypopituitarism was considered excluded by a normal response to metyrapone ditartrate, by a normal serum PBI and a normal radioactive iodine uptake. Genetic disorders were likewise excluded to the extent possible by determining that the chromosome pattern was normal and by determining that no similar condition existed in another member of the same family. The association of anosmia with gonadotrophin insufficiency in this case suggests a primary disorder in the hypothalamo-mamillary-tuber cinereum area.

Topics: 17-Ketosteroids; Adult; Androgens; Chorionic Gonadotropin; Gonadotropins, Pituitary; Humans; Hypogonadism; Leydig Cells; Male; Olfaction Disorders; Testis

Topics: 17-Ketosteroids; Adolescent; Chorionic Gonadotropin; Corpus Luteum; Craniopharyngioma; Estrogens; Female; Gonadotropins; Humans; Hypogonadism; Hypophysectomy; Hypopituitarism; Male; Ovary; Ovulation; Pregnanediol; Pregnanetriol; Progesterone; Puberty; Sexual Dysfunction, Physiological; Vagina

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Child; Diabetes Complications; Female; Glucose Tolerance Test; Gonadotropins; Humans; Hypogonadism; Male; Menopause; Middle Aged; Thyroid Diseases; Thyroid Function Tests

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androsterone; Carbon Isotopes; Child; Child, Preschool; Chromatography, Paper; Colorimetry; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Growth; Humans; Hydrocortisone; Hypogonadism; Infant; Infant, Newborn; Male; Pregnenolone; Progesterone; Puberty, Precocious; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Age Factors; Androgens; Carbon Isotopes; Child; Child, Preschool; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Hydrocortisone; Hypogonadism; Infant; Infant, Newborn; Male; Puberty; Testosterone

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androgens; Androsterone; Carbon Isotopes; Chorionic Gonadotropin; Dexamethasone; Etiocholanolone; Humans; Hypogonadism; Klinefelter Syndrome; Male; Pituitary-Adrenal Function Tests; Secretory Rate; Testosterone; Tritium

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Hirsutism; Humans; Hypogonadism; Male; Metyrapone; Polycystic Ovary Syndrome; Prednisolone; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Erectile Dysfunction; Humans; Hypogonadism; Male; Middle Aged; Testosterone

Topics: 17-Ketosteroids; Adolescent; Eyelids; Humans; Hypogonadism; Hypothyroidism; Lip; Male

Topics: 17-Ketosteroids; Acromegaly; Adult; Androgens; Chromosome Aberrations; Chromosome Disorders; Disorders of Sex Development; Humans; Hypogonadism; Infertility, Male; Klinefelter Syndrome; Male; Olfaction Disorders; Sella Turcica; Sex Chromatin

Topics: 17-Ketosteroids; Adolescent; Adult; Castration; Chromatography; Humans; Hypogonadism; Male; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Cortisone; Dehydroepiandrosterone; Diabetes Mellitus; Erectile Dysfunction; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Glucocorticoids; Humans; Hydrocortisone; Hypogonadism; Male; Middle Aged

Topics: 17-Ketosteroids; Adult; Chromatography, Gas; Chromatography, Thin Layer; Female; Hirsutism; Humans; Hypogonadism; Male; Testosterone; Urine

Topics: 17-Ketosteroids; Adult; Castration; Chromatography, Paper; Estradiol; Estriol; Estrogens; Estrone; Humans; Hypogonadism; Male; Radiometry; Testosterone; Tritium

Topics: 17-Ketosteroids; Chromatography, Gas; Cushing Syndrome; Female; Humans; Hypogonadism; Male; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Amenorrhea; Androgen-Insensitivity Syndrome; Disorders of Sex Development; Estrogens; Female; Gonadotropins, Pituitary; Humans; Hypogonadism; Ovarian Diseases; Turner Syndrome

Topics: 17-Ketosteroids; Adolescent; Androsterone; Chorionic Gonadotropin; Chromosome Aberrations; Chromosome Disorders; Cryptorchidism; Drug Therapy; Etiocholanolone; Fluoxymesterone; Gonadotropins; Humans; Hypogonadism; Male; Mosaicism; Noonan Syndrome; Pathology; Testis; Turner Syndrome; Urine

Topics: 17-Ketosteroids; Eunuchism; Humans; Hypogonadism; Male; Urinary Tract; Urine

Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Child; Chromatography; Dehydroepiandrosterone; Diabetes Mellitus; Etiocholanolone; Geriatrics; Glucuronates; Humans; Hypogonadism; Obesity; Solvents; Sulfates

Topics: 17-Ketosteroids; Acromegaly; Addison Disease; Adenoma; Adolescent; Adrenal Hyperplasia, Congenital; Adult; Blood; Child; Chromatography, Gas; Cushing Syndrome; Female; Glucuronates; Hirsutism; Humans; Hypogonadism; Klinefelter Syndrome; Male; Middle Aged; Polycystic Ovary Syndrome; Testosterone; Urine

Topics: 17-Ketosteroids; Adolescent; Child; Dwarfism, Pituitary; Humans; Hypogonadism; Luteinizing Hormone; Male; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenogenital Syndrome; Androgens; Cortisone; Disorders of Sex Development; Estrogens; Female; Humans; Hypertrichosis; Hypogonadism; Hysterectomy; Iatrogenic Disease; North Carolina; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Progesterone; Urine

Topics: 17-Ketosteroids; Castration; Cesium Isotopes; Cobalt Isotopes; Drug Therapy; Estrogens; Gonadotropins; Humans; Hypogonadism; Male; Neoplasms; Pathology; Phosphorus Isotopes; Prostatectomy; Prostatic Neoplasms; Radioisotope Teletherapy; Testis; Urine; Urography

Topics: 17-Ketosteroids; Body Fluids; Chromatography; Humans; Hypogonadism; Rare Diseases; Urine

Topics: 17-Ketosteroids; Adolescent; Androgens; Chorionic Gonadotropin; Eunuchism; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypogonadism; Male; Metabolism; Pituitary Diseases; Pituitary Gland; Sex Chromatin; Spermatozoa

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenogenital Syndrome; Estradiol; Estriol; Estrogens; Estrone; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypogonadism; Male; Neoplasm Metastasis; Neoplasms; Pregnanediol; Surgical Procedures, Operative; Testis; Urine

Ataxia-telangiectasia is a syndrome of progressive cerebellar ataxia and other neurological manifestations associated with conjunctival and cutaneous telangiectases and with recurrent sino-pulmonary infections. Immunological and endocrine abnormalities occur. Two girls with this disease are described. The first had only minor respiratory infections; her serum proteins and immunity responses appeared normal. The second had recurrent pulmonary infections and bronchiectasis; she also exhibited sclerodermatous changes, poor development of secondary sexual characteristics with low urinary excretion of 17-ketosteroids, and lymphopenia. Autopsy at 17 years showed bilateral ovarian dysgerminomata and excessive cutaneous collagen as well as atrophy, and perhaps hypoplasia, of adrenals, thymus, spleen and lymphoid tissue (after steroid therapy). The cerebellum exhibited cortical degeneration. Both lungs were fibrotic with old and recent bronchopneumonia and bronchiectasis. The left lung was studied by injection of a latex preparation; no arteriovenous aneurysms were found, but the smaller pulmonary vessels showed some unusual morphological characteristics.

Topics: 17-Ketosteroids; Adolescent; Ataxia; Ataxia Telangiectasia; Atrophy; Blood Protein Electrophoresis; Bronchiectasis; Cerebellar Diseases; Child; Conjunctiva; Dysgerminoma; Eosinophils; Female; Genetics, Medical; Humans; Hypogonadism; Immunoelectrophoresis; Infant; Infant, Newborn; Leukocyte Count; Lymphocytes; Neoplasms, Germ Cell and Embryonal; Neurologic Manifestations; Ovarian Neoplasms; Pathology; Pulmonary Circulation; Pulmonary Fibrosis; Scleroderma, Systemic; Telangiectasis; Urine

Topics: 17-Ketosteroids; Adolescent; Body Constitution; Disease Susceptibility; Drug Therapy; Estradiol Congeners; Estrogens; Hypogonadism; Mental Disorders; Urine

Topics: 17-Ketosteroids; Adolescent; Child; Chorionic Gonadotropin; Cryptorchidism; Diagnosis, Differential; Estrogens; Humans; Hypogonadism; Male

Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Chorionic Gonadotropin; Erectile Dysfunction; Gonadotropins; Humans; Hypoadrenocorticism, Familial; Hypogonadism; Klinefelter Syndrome; Male; Steroids

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Diabetes Mellitus; Follicle Stimulating Hormone; Gastrointestinal Hemorrhage; Goiter; Gonadotropins; Gynecomastia; Heart Failure; Hemochromatosis; Hepatomegaly; Humans; Hypogonadism; Hypopituitarism; Iodine Isotopes; Liver Cirrhosis; Liver Diseases; Male; Myocarditis; Pancreatitis; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androgen-Insensitivity Syndrome; Androgens; Estrogens; Gonadotropins; Humans; Hypogonadism; Klinefelter Syndrome; Male; Turner Syndrome; Urine

Topics: 17-Ketosteroids; Acid Phosphatase; Adolescent; Alkaline Phosphatase; Bone and Bones; Congenital Abnormalities; Embryology; Gonadotropins; Growth; Humans; Hypogonadism; Hypospadias; Male; Obesity; Physiology; Puberty; Sexual Maturation; Testis

Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Laboratory Techniques; Cushing Syndrome; Cysts; Female; Humans; Hypogonadism; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor Antagonists; Neoplasms; Ovary; Pharmacology; Pituitary Gland; Pituitary Neoplasms; Radioisotope Teletherapy; Scleroderma, Systemic; Sexual Infantilism; Toxicology; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Estradiol Congeners; Estrogens; Female; Humans; Hypogonadism; Ovarian Diseases

Topics: 17-Ketosteroids; Anatomy; Contraceptive Agents, Female; Endocrinology; Estradiol Congeners; Estrogens; Female; Humans; Hypogonadism; Masochism

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Chromatography; Gonadotropins; Gonads; Humans; Hypogonadism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Diabetes Complications; Diabetes Mellitus; Humans; Hypogonadism

Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Body Fluids; Humans; Hypoadrenocorticism, Familial; Hypogonadism