17-ketosteroids and Hyperplasia

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hyperplasia; Middle Aged; Ovarian Diseases; Ovary; Polycystic Ovary Syndrome; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Child; Child, Preschool; Dehydration; Female; Glucocorticoids; Humans; Hyperplasia; Hypertension; Infant; Infant, Newborn; Male; Mixed Function Oxygenases; Oxidoreductases; Pylorus; Virilism; Vomiting; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hyperplasia; Male; Middle Aged; Pituitary Neoplasms; Precancerous Conditions

Topics: 17-Ketosteroids; Adaptation, Psychological; Addison Disease; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Cortisone; Cushing Syndrome; Dexamethasone; Female; Genitalia, Female; Glucocorticoids; Growth; Humans; Hydrocortisone; Hyperplasia; Male; Pituitary Diseases; Pituitary Gland; Prognosis; Sodium Chloride; Sodium Salicylate

Both pregnenolone and 17-OH-pregnenolone were found to be higher in the plasma of patients with poorly controlled congential adrenal hyperplasia than in normal subjects. The plasma levels of these precursor steroids were significantly correlated with urinary 17-ketosteroid and pregnanetriol excretion and with plasma testosterone. The mechanism where by plasma pregnenolone and 17-OH-pregnenolone levels are elevated in patients with 21-hydroxylase deficiency is unknown, but the phenomenon of product inhibition is suggested as a possible explanation. As 17-OH-pregnenolone in plasma is almost entirely of adrenal origin, its measurement promises to be useful in the management of patients with congenital adrenal hyperplasia. Acute stimulation with ACTH caused negligible changes in the plasma levels of pregnenolone and 17-OH-pregnenolone and failed to distinguish between overly, appropriately, and under-treated patients. However, following repeated stimulation with repository ACTH, the steroid levels rose. These findings indicate limited adrenal responsiveness to ACTH following chronic glucocorticoid treatment of congenital adrenal hyperplasia, even in under-treated patients, and suggest that normal precursor steroid levels in plasma and normal 17-ketosteroid and pregnanetriol excretion can only be achieved by the suppression of total steroidogenesis to less than that occurring in normal subjects.

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Hyperplasia; Infant; Male; Pregnanetriol; Pregnenolone; Progesterone Reductase; Steroid Hydroxylases; Testosterone

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Clinical Trials as Topic; Cortisone; Dexamethasone; Female; Humans; Hydrocortisone; Hyperplasia; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pregnanetriol

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aminoglutethimide; Androsterone; Aniline Compounds; Anticonvulsants; Chemistry, Clinical; Clinical Trials as Topic; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Glucocorticoids; Humans; Hyperplasia; Hypogonadism; Pyridones; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Aged; Blood Chemical Analysis; Carcinoma; Clinical Trials as Topic; Cushing Syndrome; Female; Humans; Hyperplasia; Male; Metyrapone; Middle Aged; Pregnanes

A case of adrenocorticotropic hormone independent bilateral adrenocortical macronodular hyperplasia (AIMAH) is reported. A 59 year old male was admitted to hospital because of hypertension. Subsequently, hypercortisolism, low plasma adrenocorticotropic hormone (ACTH), loss of diurnal rhythm of ACTH, lack of suppression with high dose dexamethasone were found and bilateral adrenal enlargement was detected by abdominal computerized tomography and adrenal scintigraphy. Bilateral total adrenalectomy was performed under a diagnosis of bilateral adrenal hyperplasia associated with Cushing's syndrome. Both adrenal glands were enlarged in size and weight. Bulging nodules were found at the cut section. Microscopically, a variegated histologic pattern including trabecular, adenoid and zona glomerulosa-like (ZG-like) structures was revealed in the nodules. Immunohistochemical examination disclosed positive staining of cytochrome P-450 17 alpha, negative of 3 beta-HSD in the ZG-like structure. Ultrastructurally, the cells composing the ZG-like structure were similar to those of the ZG in normal adrenal cortex. The authors agree that AIMAH is one of the entities causing Cushing's syndrome, and advise pathologists to keep this disorder in mind when they examine the adrenals in Cushing's syndrome.

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Cushing Syndrome; Cytochrome P-450 Enzyme System; Humans; Hyperplasia; Male; Microscopy, Electron; Middle Aged; Tomography, X-Ray Computed

On the basis of clinical and hormonal investigations of 58 girls with hirsutism aged between 15-19 years there were confirmed congenital adrenal hyperplasia in 3.4%, late onset adrenal hyperplasia in 24.1% and polycystic ovary syndrome in 72.4%. The proper diagnosis were established above all on endocrinological investigations especially on determinations of 17- ketosteroids, of DHEA, of 17 OH-corticoids in urine and RIA of total and free testosterone in blood.

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hyperplasia; Polycystic Ovary Syndrome; Testosterone

A 57-year-old woman was demonstrated to be affected by adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome. Computed-axial tomography of the abdomen demonstrated an expansion of the left adrenal. In apparent contrast with these findings, adrenal scintigraphy demonstrated radiocholesterol uptake also by the right gland. At surgery, the left adrenal was found to be hard and enlarged and was excised, while the right gland was found of normal appearance and left in place. Histologic examination of the excised gland demonstrated nodular hyperplasia. Early after surgery, plasma cortisol returned to normal values with a normal circadian rhythm and complete inhibition by low dose dexamethasone; the response of plasma cortisol to ACTH was normal. The patient represents a rare case of unilateral adrenal nodular hyperplasia. Radiocholesterol uptake by the contralateral gland and early recovery from adrenal atrophy after surgery are exceptional findings and suggest incomplete inhibition of endogenous ACTH.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Hyperplasia; Middle Aged; Radionuclide Imaging; Tomography, X-Ray Computed

Topics: 17-Ketosteroids; Adult; Breast; Breast Diseases; Female; Humans; Hyperplasia; Menopause; Menstruation Disturbances; Middle Aged

Recent reports of patients with Cushing's disease who have been explored via the transsphenoidal route indicate that the great majority has pituitary adenomas. We report a patient with biochemically documented pituitary-based hypercortisolism who had a clinical and biochemical remission following hypophysectomy. Serial sections of the pituitary tissue removed showed hyperplasia of corticotroph cells but no adenoma. Hypophysectomy was complete as documented by serum levels of FSH, LH, TSH, prolactin, hGH and ACTH at the lower limits of the respective assays, with no response to appropriate stimuli. This case demonstrates that a minority of patients with Cushing's disease has corticotroph cell hyperplasia without a pituitary adenoma.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Chorionic Gonadotropin; Cushing Syndrome; Female; Follicle Stimulating Hormone; Humans; Hyperplasia; Hypophysectomy; Luteinizing Hormone; Pituitary Gland; Pituitary Gland, Anterior; Prolactin; Thyrotropin

Cushing's syndrome was found in 2 of 4 siblings all of which also had other malformations. After bilateral adrenalectomy no hyperpigmentation was noted. Morphologically the adrenals of both siblings with Cushing's syndrome showed the typical lesions of the so-called microadenomatosis or primary adrenocortical nodular dysplasia with foci of eosinophilic giant cells. This is a new form of Cushing's syndrome due to an inborn error of the adrenals and no hypothalamic-pituitary dysfunction.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adipose Tissue; Adrenal Cortex; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Eosinophils; Humans; Hyperplasia; Male

Glucocorticoid stimulation and suppression tests are essential to the definitive diagnosis of diseases of the hypothalamic-pituitary-adrenal axis, because they document abnormal physiologic control of hormonal secretion. Similarly, diseases of the renin-angiotensin-aldosterone axis are diagnosed by mineralocorticoid stimulation and suppression testing. [Ed. Note: See Moore TJ, Williams GH: Adrenal causes of hypertension, in this issue.] Unlike tests of glucocorticoid function, testing of the renin-angiotension-aldosterone system is more complicated, because knowledge of posture and dietary sodium are necessary to interpret the results. However, measurement of the tropic hormone renin and plasma levels of aldosterone can be accurately made, allowing precise definition of this system. Errors are most commonly encountered when dynamic tests of cortisol output are performed in patients taking medications that may interfere with the assays or with the metabolism of the administered compounds, such as dexamethasone or metyrapone. Abnormal, spurious values may also be obtained in some individuals who do not have adrenocortical hyperfunction if they are very obese or if testing is performed in a setting of clinical stress. Careful attention to these pitfalls will avoid errors and allow the clinician to arrive at the correct diagnosis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Depression, Chemical; Dexamethasone; Humans; Hydrocortisone; Hyperplasia; Insulin; Metyrapone; Pituitary-Adrenal Function Tests

Thirty patients with mild post-pubertal adrenal hyperplasia, characterized by raised urinary 17-oxosteroid levels and variable combinations of irregular menses, hirsuties, infertility, and spontaneous abortion, were treated with 2.5 to 10 mg of prednisone per day and all conceived (55 pregnancies). With this treatment, regular, ovulatory cycles occurred immediately in 25 patients, and after two to six months, in the rest. Treatment reduced raised 17-oxosteroid levels to normal and brought about some improvement in hirsuties and acne. Forty-seven pregnancies ended in the birth of liveborn infants; one of these died of prematurity and another had congenital emphysema. One pregnancy was terminated, two were of unknown outcome and five (9.4%) ended in abortion. Before treatment, 20 out of 22 pregnancies (91%) had ended in abortion.

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Amenorrhea; Female; Humans; Hyperplasia; Infertility, Female; Oligomenorrhea; Prednisone; Pregnancy; Pregnancy Complications

Following the oral administration of tritiated coricosterone, cortisol, deoxycorticosterone and progesterone to human subjects, 14.9%, 12.8%, 3.4% and 2.1% of the dose was recovered in the acidic metabolite fraction of 48 h urines after conventional hydrolysis and solvent partition. Neutral and acidic 17-oxogenic steroids (17-OGS) excreted in 24 h urines were also measured with the Zimmermann color reaction. The acidic 17-IGS accounted for 14.1%, 16.4% and 12.1% of the fractionated 17-OGS in the urines of normal and pregnant females and normal males respectively. From structural considerations, it was concluded that only 17-hydroxylated steroidal acids, with a 20-hydroxy-21-oic acid side chain and derived predominantly from cortisol, would be estimated as 17-OGS after oxidation with sodium periodate. 17-Dexy steroidal acids resemble the neutral 17-deoxycorticosteroids in undergoing side chain oxication to 17-aldehydes which do not form Zimmermann chromogens. The excretion of both neutral and acidic 17-OGS was suppressible with dexamethasone administration.

Topics: 17-Ketosteroids; Adrenal Glands; Colorimetry; Corticosterone; Desoxycorticosterone; Dexamethasone; Female; Humans; Hydrocortisone; Hyperplasia; Male; Pregnancy; Progesterone; Sex Factors; Steroids

Specimens of ventral prostate from 37- to 46-month-old Andradurin-treated A X C rats demonstrated three primary morphologic patterns, each being divisible into two sub-groups based upon the extent of glandular alteration. The principal groups were: group 1, hyperplasia; group 2, atypical hyperplasia; and group 3, adenocarcinoma. The secondary classifications were: subgroup (+), few glands involved; and subgroup (++), most glands involved. Multiple parameters of ventral prostate testosterone metabolic potential failed to distinguish the morphologically diverse prostate specimens of groups (1+). 1(++), 2(+), 2(++), and 3(+) which predominantly metabolized testosterone to 5alpha-reduced 17beta-hydroxysteroids. By contrast, testosterone metabolism by ventral prostate specimens predominantly composed of neoplastic epithelium, group 3(++), was distinct from all other prostate specimens. The distinguishing feature was a shift to more prominent elaboration of 17-ketosteroids, principally delta4-androstenedione, and a cteroids. The change in this biochemical parameter of prostate epithelial cell function was indicated to be an early manifestation of the neoplastic transformation.

Topics: 17-Ketosteroids; Adenocarcinoma; Androstenedione; Animals; Dihydrotestosterone; Hydroxysteroids; Hyperplasia; Male; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Testosterone

Ninety-three infertile women were treated with clomiphene citrate alone or in combination with human chorionic gonadotropin (hCG) for absent or infrequent ovulation. The patients were divided into eight categories according to the diagnosis obtained: ovarian androgenic hyperplasia, adrenal androgenic hyperplasia, mixed ovarian and adrenal androgenic hyperplasia, hypothalamic anovulation, postpill anovulation, follicular phase defect, luteal phase defect, and amenorrhea-galactorrhea syndrome. Each group was analyzed individually to compare the ovulation and conception rates and the complications involved. A survey of the data presented in this study shows that the best response was noted in patients with ovarian androgenic hyperplasia. Patients with a functional pathologic adrenal component responded favorably when dexamethasone was used as an adjuvant to clomiphene therapy. Those with hypothalamic anovulation responded better when hCG was added to clomiphene therapy. Women with postpill anovulation as well as those with follicular phase defect were found to be good candidates for clomiphene therapy. In properly selected patients with poor luteal phase defect, hCG secured excellent results both in ovulation and conception. Patients with lactation amenorrhea failed to ovulate when treated with clomiphene alone.

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Amenorrhea; Androgens; Anovulation; Chorionic Gonadotropin; Clomiphene; Contraceptives, Oral; Endometrium; Female; Galactorrhea; Humans; Hyperplasia; Hypothalamus; Infant, Newborn; Infertility, Female; Luteinizing Hormone; Ovarian Diseases; Ovulation; Pregnancy

Gonadotropin levels and secretory patterns were studied in 28 oligomenorrheic patients with various types of polycystic ovary disease (PCO). On the basis of ovarian morphology and histology, the patients PCOuld be separated into two distinct categories arbitarily designated "typical" (type I) and "atypical" (type II) PCO. Although no differences were noted in symptomatology or 17-ketosteroid, testosterone, or follicle-stimulating hormone levels, the 12 type I patients demonstrated widely fluctuating, but markedly elevated, luteinizing hormone (LH) levels, while the 16 type II patients demonstrated lower and less fluctuating LH levels which were comparable to those found during the normal follicular phase. It is likely that type I PCO is a distinct entity similar to that described by Stein and Leventhal, while type II co represents a heterogenous spectrum of disorders, many of which remain obscure.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Anovulation; Dexamethasone; Feedback; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hyperplasia; Luteal Cells; Luteinizing Hormone; Oligomenorrhea; Ovarian Cysts; Ovarian Diseases; Ovary; Testosterone

Twelve women with congenital adrenal hyperplasia are reported. Initial diagnoses were made at ages ranging from 12 to 32, with epiphyseal fusion complete in all patients. During 6 to 10 years of corticosteroid therapy there occurred substantial reduction of hypertrichosis, disappearance of temporal recession, and decrease in eroticism. In 11 patients menstrual bleeding occurred within 4 months. Urinary excretion of total gonadotropins remained unchanged; total estrogens decreased slightly. By the end of followup, 7 patients with a mean age of 17 years had regular menses, 6 were ovulating, and 1 had a pregnancy. The other 5 patients, who continued to have irregular, anovulatory menstrual cycles, had a mean age of 28 years. The findings suggest that when excessive androgenization continues for a considerable period of time after puberty (as judged by bone age) noncyclic functioning of the gonadotropic mechanism is rendered irreversible.

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adult; Body Temperature; Breast; Child; Estrogens; Female; Gonadotropins; Humans; Hyperplasia; Hypotrichosis; Menstruation; Ovulation Detection; Pregnancy; Pregnanediol

An excretion of the follicle-stimulating hormone (FSH), estrogens, pregnandiol, 17-KS, vaginal cytology were studied in 22 patients with dyshormonal hyperplasias of mammary glands and in 12 healthy females with ovulatory cycles. The age of patients under study ranged from 20 to 49 years. The patients showed a higher level of excretion of FSH, estriol, pregnandiol and a lower level of 17-KS excretion than healthy persons.

Topics: 17-Ketosteroids; Adult; Breast Diseases; Endocrine Glands; Estradiol; Estriol; Estrogens; Estrone; Female; Follicle Stimulating Hormone; Humans; Hyperplasia; Middle Aged; Ovulation; Periodicity; Pregnanediol

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adult; Androstenedione; Androsterone; Carcinoma; Chromatography, Ion Exchange; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hyperplasia; Male; Middle Aged; Sex Factors; Tetrahydrocortisol

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Amenorrhea; Androgens; Androstenedione; Contraceptives, Oral; Dehydroepiandrosterone; Depression, Chemical; Dexamethasone; Drug Combinations; Female; Humans; Hyperplasia; Infertility, Female; Mestranol; Norethynodrel; Ovarian Diseases; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Testosterone

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Hyperplasia; Insulin; Male; Metyrapone; Middle Aged; Radiography; Skull; Sodium; Steroid Hydroxylases; Time Factors

Topics: 17-Ketosteroids; Adrenal Glands; Catheterization; Child; Child, Preschool; Disorders of Sex Development; Endoscopy; Female; Gonads; Humans; Hydrocortisone; Hyperplasia; Hypospadias; Hysterosalpingography; Infant; Infant, Newborn; Karyotyping; Male; Ovary; Sex Chromatin; Sex Determination Analysis; Testis; Turner Syndrome; Urinary Bladder; Vagina

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Child; Cortisone; Female; Follicle Stimulating Hormone; Humans; Hyperplasia; Luteinizing Hormone; Menstruation Disturbances; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Child; Child, Preschool; Circadian Rhythm; Corticosterone; Dexamethasone; Female; Humans; Hyperplasia; Middle Aged; Pregnanetriol; Progesterone; Spectrometry, Fluorescence

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Diseases; Body Height; Body Weight; Cortisone; Cushing Syndrome; Female; Fludrocortisone; Humans; Hydrocortisone; Hyperplasia; Metyrapone; Mitotane

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Child; Cholesterol; Chromatography, Gas; Electrophoresis, Paper; Female; Humans; Hyperplasia; Lipoproteins; Spectrum Analysis; Triglycerides

Topics: 17-Ketosteroids; Abdominal Neoplasms; Abnormalities, Multiple; Adrenal Gland Diseases; Adrenal Glands; Antigens; Blood Glucose; Female; Hernia, Umbilical; Humans; Hyperplasia; Hypoglycemia; Infant, Newborn; Insulin; Kidney Diseases; Leucine; Pancreas; Pancreatectomy; Time Factors; Tongue; Umbilicus

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Amenorrhea; Cortisone; Dexamethasone; Estriol; Feedback; Female; Fetal Death; Hirsutism; Humans; Hydrocortisone; Hyperplasia; Hypothalamus; Maternal-Fetal Exchange; Pituitary-Adrenal System; Pregnancy; Pregnancy Complications; Pregnanediol; Pregnanetriol; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Androstenedione; Dexamethasone; Diabetes Complications; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Hyperplasia; Luteinizing Hormone; Metabolic Clearance Rate; Ovarian Diseases; Polycystic Ovary Syndrome; Testosterone

Topics: 17-Ketosteroids; Adolescent; Breast Diseases; Carbohydrate Metabolism; Child; Child, Preschool; Cholesterol; Estrogens; Fatty Acids, Nonesterified; Female; Gonadal Steroid Hormones; Gynecomastia; Humans; Hyperplasia; Infant; Lipid Metabolism; Male; Triglycerides

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adult; Amenorrhea; Female; Hirsutism; Humans; Hyperplasia; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Ovarian Cysts; Ovarian Diseases; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnanetriol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Body Height; Child; Child, Preschool; Corticosterone; Dexamethasone; Estrogens; Female; Follicle Stimulating Hormone; Hair; Humans; Hydrocortisone; Hyperplasia; Indicator Dilution Techniques; Karyotyping; Luteinizing Hormone; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Ovary; Testosterone; Uterus

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adult; Aldosterone; Carbon Isotopes; Child; Child, Preschool; Chromatography, Paper; Diet, Sodium-Restricted; Female; Humans; Hyperplasia; Male; Potassium; Pregnanetriol; Radioisotope Dilution Technique; Secretory Rate; Sodium; Spectrophotometry; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Dichlorodiphenyldichloroethane; Female; Humans; Hydrocortisone; Hyperplasia; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Radiography; Secretory Rate; Sella Turcica

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Dexamethasone; Female; Glucocorticoids; Humans; Hyperplasia; Middle Aged; Pituitary Irradiation; Postoperative Care; Postoperative Complications; Radiography

Topics: 17-Ketosteroids; Androgens; Androstanes; Androstenes; Biological Transport; Carbon Isotopes; Dihydrotestosterone; Estradiol; Humans; Hyperplasia; In Vitro Techniques; Ketosteroids; Kinetics; Male; Mathematics; Methods; Models, Biological; Perfusion; Prostate; Prostatic Diseases; Receptors, Drug; Testosterone; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Aldosterone; Blood Pressure; Child; Clitoris; Female; Humans; Hyperplasia; Hyponatremia; Infant, Newborn; Male; Metabolism, Inborn Errors; Pregnanetriol; Renin; Sodium; Sodium Chloride; Steroid Hydroxylases; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Child; Female; Humans; Hyperplasia; Infant, Newborn; Karyotyping; Sex Chromatin; Sex Chromosomes

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Aging; Aldosterone; Androstanes; Androsterone; Child; Child, Preschool; Chlorides; Chromatography, Gas; Chromatography, Thin Layer; Dehydroepiandrosterone; Disorders of Sex Development; Etiocholanolone; Female; Glucuronates; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hyperkalemia; Hyperplasia; Hyponatremia; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Potassium; Pregnanetriol; Pregnenolone; Sodium; Sulfates; Testosterone

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adult; Aged; Alcohols; Amenorrhea; Androsterone; Carcinoma; Child, Preschool; Chromatography, Gas; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Female; Genital Diseases, Male; Hirsutism; Humans; Hyperplasia; Hyperthyroidism; Hypospadias; Infant; Infertility, Male; Klinefelter Syndrome; Lactation Disorders; Male; Middle Aged; Polycystic Ovary Syndrome; Pregnancy; Pregnanetriol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Amenorrhea; Carcinoma; Creatinine; Estrogens; Female; Hirsutism; Humans; Hydrocortisone; Hyperplasia; Neoplasm Metastasis; Pituitary-Adrenal System; Pregnanetriol; Testosterone

Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Chromatography, Gas; Female; Humans; Hydroxysteroid Dehydrogenases; Hyperplasia; Infant; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pregnanediol; Pregnanetriol; Secretory Rate

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Clitoris; Dexamethasone; Disorders of Sex Development; Dysgerminoma; Estrogens; Female; Fluoxymesterone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Androstenols; Estrogens; Female; Follicle Stimulating Hormone; Genital Diseases, Female; Hirsutism; Hormones; Humans; Hyperplasia; Luteinizing Hormone; Pregnancy; Pregnancy Complications; Pregnanediol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Alcohols; Androstanes; Androsterone; Child, Preschool; Chromatography, Gas; Etiocholanolone; Female; Hirsutism; Humans; Hydrocortisone; Hyperplasia; Male; Pregnanediol; Pregnanetriol; Stereoisomerism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Albuminuria; Biopsy; Blood Pressure; Female; Globulins; Humans; Hydronephrosis; Hyperplasia; Kidney Calculi; Kidney Diseases; Male; Middle Aged; Potassium; Pyelonephritis; Tuberculosis, Renal

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Aldosterone; Blood Pressure; Female; Humans; Hyperaldosteronism; Hyperplasia; Middle Aged; Potassium; Remission, Spontaneous; Renin; Secretory Rate

Topics: 17-Ketosteroids; Cushing Syndrome; Female; Hirsutism; Humans; Hyperplasia; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Testosterone; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Child; Child, Preschool; Corticosterone; Desoxycorticosterone; Dexamethasone; Diet; Female; Humans; Hydrocortisone; Hyperplasia; Hypertension; Male; Metabolism, Inborn Errors; Metyrapone; Mixed Function Oxygenases; Potassium; Pregnanetriol; Secretory Rate; Sodium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Disorders of Sex Development; Female; Fibroblasts; Glucocorticoids; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hyperplasia; Karyotyping; Metabolism, Inborn Errors; Middle Aged; Mosaicism; Mouth Mucosa; Pregnanetriol; Sex Chromosome Aberrations; Skin

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androgens; Androstanes; Female; Glucocorticoids; Humans; Hydrocortisone; Hyperplasia; Testosterone

Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Isotopes; Chromatography, Gas; Chromatography, Thin Layer; Cryptorchidism; Disorders of Sex Development; Estradiol; Estrone; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Hyperplasia; In Vitro Techniques; Leydig Cells; Male; Metabolism, Inborn Errors; Pregnenolone; Radioisotope Dilution Technique; Rats; Rodent Diseases; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Corticosterone; Desoxycorticosterone; Female; Growth Hormone; Humans; Hydrocortisone; Hydroxyprogesterones; Hyperplasia; Hypoglycemia; Infant; Islets of Langerhans; Kidney Diseases; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pregnanediol; Pregnanetriol; Pregnenolone; Vanilmandelic Acid

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Child, Preschool; Female; Humans; Hyperplasia; Infant, Newborn; Male; Pregnanetriol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Carcinoma; Cushing Syndrome; Diagnosis, Differential; Humans; Hyperplasia; Precancerous Conditions

Topics: 17-Ketosteroids; Adrenal Glands; Female; Genitalia; Humans; Hydrocortisone; Hyperplasia; Infant, Newborn; Male; Sex Chromatin; Sex Chromosome Aberrations

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Androgens; Child; Female; Humans; Hydrocortisone; Hyperplasia; Hyponatremia; Infant; Male; Metabolism, Inborn Errors; Progestins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Estrogens; Histocytochemistry; Humans; Hyperplasia; Male; Microscopy, Electron; Pigments, Biological; Testicular Diseases; Testis

Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Disorders of Sex Development; Humans; Hydroxyprogesterones; Hyperplasia; Leydig Cells; Male; Pregnenolone; Progesterone; Testis; Testosterone; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Androgens; Estradiol; Estrogens; Estrone; Female; Humans; Hydrocortisone; Hyperplasia; Male; Middle Aged; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Aldosterone; Chemistry, Clinical; Child; Desoxycorticosterone; Etiocholanolone; Female; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Metabolism, Inborn Errors; Mixed Function Oxygenases; Ovarian Neoplasms; Pregnanetriol

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Age Factors; Child; Cushing Syndrome; Humans; Hyperplasia; Male; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Humans; Hyperplasia; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Aldosterone; Animals; Dogs; Growth; Hyperplasia; Metyrapone; Microscopy, Electron; Natriuresis; Pregnanes; Sodium

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Amniotic Fluid; Chromatography; Female; Fetal Diseases; Gestational Age; Humans; Hyperplasia; Infant, Newborn; Pregnancy; Pregnanetriol; Tritium

Topics: 17-Ketosteroids; Adult; Biopsy; Female; Humans; Hyperplasia; Ovarian Cysts; Pregnancy; Pregnancy Complications

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androgens; Androstanes; Child, Preschool; Female; Humans; Hyperplasia; Mixed Function Oxygenases; Pregnanetriol; Testosterone

Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adult; Androsterone; Chemistry, Clinical; Chromatography, Paper; Dehydroepiandrosterone; Diagnosis, Differential; Etiocholanolone; Hirsutism; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hyperplasia; Metabolism, Inborn Errors; Middle Aged

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Dexamethasone; Diagnosis, Differential; Female; Glucocorticoids; Hirsutism; Humans; Hyperplasia; Menstruation Disturbances; Pregnanetriol; Virilism

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Ammonium Chloride; Angiotensin II; Bicarbonates; Body Height; Body Weight; Catecholamines; Child; Chlorides; Diet; Female; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hyperplasia; Juxtaglomerular Apparatus; Kidney Diseases; Kidney Function Tests; Metyrapone; Microscopy, Electron; Muscles; Norepinephrine; Pituitary-Adrenal Function Tests; Potassium; Renin; Serum Albumin; Sodium; Spironolactone; Triamterene; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Age Factors; Chromatography, Paper; Dexamethasone; Female; Humans; Hydrocortisone; Hyperplasia; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Pituitary Function Tests; Secretory Rate; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Carbon Isotopes; Chemistry, Clinical; Chromatography, Paper; Crystallization; Female; Humans; Hyperplasia; Ovarian Cysts; Polycystic Ovary Syndrome; Progesterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Basal Metabolism; Blood Proteins; Chemistry, Clinical; Cushing Syndrome; Dexamethasone; Female; Graves Disease; Humans; Hydrocortisone; Hyperplasia; Iodine; Iodine Radioisotopes; Middle Aged; Pituitary-Adrenal Function Tests; Protein Binding; Thyroid Function Tests; Thyroid Hormones; Transcortin

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Female; Humans; Hyperplasia; Male; Metyrapone; Pituitary-Adrenal Function Tests; Pregnanes

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abdomen; Adrenocortical Hyperfunction; Alopecia; Animals; Asthenia; Dexamethasone; Dog Diseases; Dogs; Feeding and Eating Disorders; Female; Glucocorticoids; Glucose Tolerance Test; Humans; Hyperplasia; Hypertrophy; Liver Diseases; Male; Obesity; Pituitary-Adrenal Function Tests; Radiography; Thirst; Thyrotropin

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenocortical Hyperfunction; Adult; Child; Child, Preschool; Cortisone; Dexamethasone; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Humans; Hyperplasia; Luteinizing Hormone; Male; Pituitary-Adrenal System; Prednisolone; Pregnanediol; Pregnanetriol

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Carbon Isotopes; Chemistry, Clinical; Child, Preschool; Chromatography, Gas; Chromatography, Thin Layer; Humans; Hydroxyprogesterones; Hyperplasia; Male; Metabolic Clearance Rate; Pregnanetriol; Progesterone; Tritium

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Child, Preschool; Chromatography; Clitoris; Female; Humans; Hyperplasia; Hypertension; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Methyldopa; Steroids; Virilism

Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adult; Child; Child, Preschool; Estrogens; Female; Gonadotropins; Humans; Hydroxyprogesterones; Hyperplasia; Male; Pregnanetriol; Virilism

Topics: 17-Ketosteroids; Adult; Alkaline Phosphatase; Cesarean Section; Female; Hirsutism; Histocytochemistry; Humans; Hyperplasia; Hysterectomy; Infant, Newborn; Ovarian Cysts; Ovarian Neoplasms; Pelvimetry; Pregnancy; Pregnancy Complications; Staining and Labeling; Thecoma

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Cushing Syndrome; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hyperplasia; Infertility, Female; Male; Polycystic Ovary Syndrome; Testosterone

The plasma concentration, production rate, and conversion ratio of androstenedione and testosterone were studied in seven children with congenital adrenal hyperplasia (CAH) of the 21-hydroxylase type. Plasma androstenedione and testosterone measured by double isotope derivative assay and estimated blood production rates were manyfold increased in the untreated state, markedly suppressed with glucocorticoid, and increased after the administration of ACTH. The metabolic clearance rate when corrected for body size and the conversion ratio of androstenedione to testosterone were similar to previously determined values in normal adults. Consideration of the androgen concentrations and conversion ratios indicates that in children with CAH, 76% of the plasma testosterone in prepubertal females and 36% in males are derived from peripheral conversion of blood androstenedione. The calculated amount of testosterone unaccounted for by peripheral conversion is similar to normal prepubertal values. This approach indicates that virilization in these children results from increased levels of testosterone but that the major source in CAH of this potent androgen is androstenedione secreted by the adrenal cortex.

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Child; Child, Preschool; Female; Glucocorticoids; Humans; Hyperplasia; Male; Testosterone

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adult; Androsterone; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hyperplasia; Middle Aged; Prednisone

Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Androgens; Chromatography; Cortisone; Dehydroepiandrosterone; Female; Hirsutism; Humans; Hydroxysteroid Dehydrogenases; Hyperplasia; Metabolism, Inborn Errors

Topics: 17-Ketosteroids; Adrenal Glands; Animals; Castration; Cervix Uteri; Female; Guinea Pigs; Histological Techniques; Hyperplasia; Methods; Pituitary Gland; Uterine Diseases; Uterus

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Alkalosis; Child; Dwarfism; Female; Humans; Hyperaldosteronism; Hyperkalemia; Hyperplasia; Juxtaglomerular Apparatus; Photometry

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Blood; Blood Pressure; Chromatography; Dexamethasone; Dogs; Enzymes; Female; Hyperplasia; Hypertension; Hypokalemia; In Vitro Techniques; Male; Metyrapone; Mixed Function Oxygenases; Organ Size; Polyuria; Potassium; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hyperplasia; Hypertension; Infant; Infant, Newborn; Male; Obesity; Osteoporosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Child; Cushing Syndrome; Dichlorodiphenyldichloroethane; Electroencephalography; Female; Humans; Hyperplasia

Topics: 17-Ketosteroids; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Hirsutism; Humans; Hyperplasia; Hypertrichosis; Ovary; Pregnanediol; Surgical Procedures, Operative; Urine; Virilism

Topics: 17-Ketosteroids; Adenocarcinoma; Atrophy; Chorionic Gonadotropin; Clomiphene; Diagnosis; Drug Therapy; Endometriosis; Endometrium; Female; Follicle Stimulating Hormone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Infertility; Infertility, Female; Ovulation; Pathology; Polycystic Ovary Syndrome; Stilbenes; Toxicology; Urine; Uterine Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Child; Chromatography; Humans; Hyperplasia; Infant; Metabolism; Urine

Topics: 17-Ketosteroids; Chromatography; Female; Hirsutism; Humans; Hyperplasia; Hypertrichosis; Ovarian Neoplasms; Ovary; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenalectomy; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Aldosterone; Androgens; Cushing Syndrome; Humans; Hyperplasia; Hypertrophy; Pathology; Pituitary-Adrenal Function Tests; Sympatholytics

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Anabolic Agents; Androgens; Endometrium; Estradiol; Estriol; Estrone; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Hyperplasia; Hypertrophy; Menstruation; Methyltestosterone; Nandrolone; Ovulation; Pharmacology; Phenylpropionates; Pituitary-Adrenal Function Tests; Pregnanediol; Salpingitis; Steroids; Testosterone; Tuberculosis; Tuberculosis, Female Genital; Uterine Cervical Erosion

Topics: 17-Ketosteroids; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Corticosterone; Cushing Syndrome; Humans; Hyperplasia; Injections, Intramuscular; Suppositories; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Dexamethasone; Fatigue; Fever; Humans; Hyperplasia; Male; Pituitary-Adrenal Function Tests; Prednisone; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Age Determination by Skeleton; Blood Chemical Analysis; Classification; Cortisone; Desoxycorticosterone; Drug Therapy; Humans; Hydrocortisone; Hyperplasia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androsterone; Blood Chemical Analysis; Child; Dehydroepiandrosterone; Humans; Hyperplasia; Pituitary-Adrenal Function Tests; Testosterone; Urine

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Endocrine System Diseases; Estrogens; Female; Gonadotropins; Humans; Hyperplasia; Hysterectomy; Obesity; Ovary; Physiology; Pituitary Gland; Postoperative Complications; Pregnanediol; Rats; Research; Thyroid Diseases; Urine; Uterus

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Child; Dehydroepiandrosterone; Estriol; Histocytochemistry; Humans; Hydroxysteroid Dehydrogenases; Hyperplasia; Hypospadias; Infant; Infant, Newborn; Male; Mixed Function Oxygenases; Pathology; Testis; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Blood; Cushing Syndrome; Estrogens; Humans; Hyperplasia; Pharmacology; Pregnanetriol; Triamcinolone; Urine

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Anatomy; Etiocholanolone; Fever; Hyperplasia

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Humans; Hyperplasia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metabolic Diseases; Sodium Chloride

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Female; Humans; Hyperplasia; Hypertrophy; Puberty; Puberty, Precocious; Sexual Maturation; Tooth; Urine; Virilism

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Child; Clitoris; Disorders of Sex Development; Female; Humans; Hyperplasia; Infant, Newborn; Pituitary-Adrenal Function Tests; Prednisone; Surgical Procedures, Operative

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Cushing Syndrome; Humans; Hyperplasia

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Familial Mediterranean Fever; Fever; Humans; Hyperplasia; Hypertrophy; Male; Medical Records

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Body Fluids; Cushing Syndrome; Hormones; Humans; Hyperplasia

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Female; Hormones; Humans; Hyperplasia; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Bronchi; Hyperplasia; Hypertrophy; Neoplasms; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Hyperplasia; Hypertrophy; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenocortical Hyperfunction; Body Fluids; Cortisone; Hyperplasia; Steroids

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Cushing Syndrome; Humans; Hyperplasia

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Hyperplasia; Steroids

The urinary 17-ketosteroids are a group of compounds derived from complex steroids produced by the adrenal cortex, testis, or ovary. The method of determining the amount excreted has been simplified so that it is available for routine diagnostic purposes. Usually the amount is increased in diseases in which there is hyperfunction of the adrenal cortex due to tumor or hyperplasia, and decreased in lesions that impair the function of the adrenal cortex. Other conditions such as myxedema, eunuchism, gout, and arthritis may alter the excretion of the 17-ketosteroids. Low levels are also found in the young and in the aged. Case histories are presented to illustrate the findings in the following diseases: Tumors of the adrenal cortex with (a) masculinization, (b) Cushing's syndrome with virilism and, (c) hirsutism; as well as in gigantism with acromegaly, in gout, eunuchism, Addison's disease, myxedema, and severe panhypopituitarism.

Topics: 17-Ketosteroids; Adrenal Cortex; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Humans; Hyperplasia; Male; Ovary; Steroids; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Glands; Androstanes; Disease; Hyperplasia; Neoplasms; Steroids; Urine