17-ketosteroids and Hyperlipidemias

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Animals; Arteriosclerosis; Blood Protein Electrophoresis; Carbon Tetrachloride Poisoning; Chromatography, Gas; Clinical Enzyme Tests; Clinical Laboratory Techniques; Estrogens; Humans; Hyperlipidemias; Isoenzymes; L-Lactate Dehydrogenase; Lipoproteins; Rabbits; Testosterone; Thyroid Function Tests; Thyroxine; Transaminases

Blood plasma cholesterol and triglycides concentration lipids composition of lipoproteins as contrasted to the amount of 17-KS and their hormonally active fractions excreted were investigated in 87 patients with myocardial infarction in their history and in 49 practically healthy individuals with no clinical manifestations of ischemic heart disease. In patients with coronary atherosclerosis exhibiting normal blood plasma lipids level, the excretion of 17-KS and of their fractions did not differ from that in healthy individuals. Patients with hyperlipoproteinemia of the IIa, IIb and IV types demonstrated a significantly reduced excretion of 17-KS, etiocholanolone, androsterone and dehydroepiandrosterone. No differences in the excretion of androgens depending upon the type of hyperlipoproteinemia were recorded. A significant negative correlation between the blood plasma cholesterol concentration and the amount of ethocholanolone excreted, the level of hypertriglyceridemin and the passage of dehydroepiandrosterone with urine was noted. In patients with hyperlipoproteinemia and a reduced androgens excretion a deranged lipids composition of lipoproteins was disclosed. A decrease in the amount of androgens leads to disruption of the synthesis and metabolism of lipoproteins and exerts a marked influence on the emergence and further development of hyperlipoproteinemia.

Topics: 17-Ketosteroids; Adult; Cholesterol; Coronary Disease; Humans; Hyperlipidemias; Lipoproteins; Lipoproteins, LDL; Male; Middle Aged; Triglycerides

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Disorders of Sex Development; Female; Glucose Tolerance Test; Growth Hormone; Humans; Hyperlipidemias; Hypoglycemia; Hypopituitarism; Lipids; Luteinizing Hormone; Male; Metyrapone; Pseudopseudohypoparathyroidism; Sex Characteristics; Sex Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androsterone; Arteriosclerosis; Blood Protein Electrophoresis; Chromatography, Thin Layer; Coronary Disease; Electrophoresis, Polyacrylamide Gel; Humans; Hydrocortisone; Hyperlipidemias; Lipoproteins; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Arteriosclerosis; Cholesterol; Humans; Hyperlipidemias; Lipoproteins; Male; Middle Aged; Myocardial Infarction

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Catecholamines; Cholesterol; Coronary Disease; Dehydroepiandrosterone; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Stress, Psychological; Sympathetic Nervous System; Triglycerides

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Body Weight; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diet; Fatty Acids, Nonesterified; Growth Hormone; Humans; Hyperlipidemias; Insulin; Lipids; Lipoproteins; Male; Phospholipids; Triglycerides; Xanthomatosis

Topics: 17-Ketosteroids; Chromatography, Gas; Dehydroepiandrosterone; Estrogens; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Lipids; Male; Methods; Middle Aged; Sex Factors; Steroids; Sulfates

Topics: 17-Ketosteroids; Anticholesteremic Agents; Antimetabolites; Cholesterol; Chromatography; Drug Therapy; Genetics, Medical; Glycerides; Hypercholesterolemia; Hyperlipidemias; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Lipids; Lipoproteins; Liver Function Tests; Nephrotic Syndrome; Phospholipids; Sterols; Toxicology; Triparanol; Urine; Xanthomonas

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Child; Diabetes Mellitus; Feeding and Eating Disorders; Genetics, Medical; Humans; Hyperlipidemias; Hyperphagia; Infant; Metabolic Diseases; Obesity; Polydipsia; Urine