17-ketosteroids and Hydatidiform-Mole

Dissociation between hydatidiform mole (HM) and chorioadenoma destruens (CA) was attempted by gas chromatographic analysis of urinary steroids. In the chromatogram, fraction 2 (F2) including four pregnane steroids (17-hydroxypregnanolone, pregnanolone, pregnanediol, and pregnanetriol) reflected the biologic activity of molar human chorionic gonadotropin (hCG), and the ratio of F2 to fraction 1 (F1) (17-ketosteroids) was found useful in monitoring secondary growth of trophoblastic tumor: Urinary log F2/F1 after curettage declined quickly and unidirectionally in HM, but the same parameter exhibited a temporal rise in CA at 11 to 20 days after curettage because of the molar hCG from residual tumor tissue. The resolution between HM and CA at that stage (11 to 20 curettage days) was of the order of diagnostic use and superior to that with immunoreacive hCG. The data obtained are discussed in the light of pathophysiology of CA.

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Pregnancy; Pregnanes; Pregnanolone; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Castration; Child; Choriocarcinoma; Chorionic Gonadotropin; Estrogens; Female; Follicle Stimulating Hormone; Glucocorticoids; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Hysterectomy; Neoplasm Metastasis; Pregnancy; Pregnanediol; Trophoblastic Neoplasms

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; Ovary; Pregnancy; Pregnancy Complications; Pregnanediol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Choriocarcinoma; Chorionic Gonadotropin; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hydatidiform Mole; Pregnancy; Pregnanediol; Thyroid Function Tests; Thyrotropin; Uterine Neoplasms

Topics: 17-Ketosteroids; Abortion, Induced; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Chlorpromazine; Chorionic Gonadotropin; Circadian Rhythm; Female; Humans; Hydatidiform Mole; Hyperemesis Gravidarum; Intrauterine Devices; Pregnancy

Topics: 17-Ketosteroids; Anencephaly; Female; Fetal Death; Fetal Diseases; Gestational Age; Humans; Hydatidiform Mole; Maternal-Fetal Exchange; Pregnancy

Topics: 17-Ketosteroids; Adolescent; Adult; Cholesterol; Chorionic Gonadotropin; Estrogens; Female; Glucocorticoids; Humans; Hydatidiform Mole; Ovarian Cysts; Pregnancy; Pregnancy Complications; Pregnanetriol; Pregnenolone

Topics: 17-Ketosteroids; Androgens; Androstanes; Estradiol; Estrogens; Estrone; Female; Humans; Hydatidiform Mole; Pregnancy; Testosterone

Topics: 17-Ketosteroids; Androgens; Androstanes; Animals; Carbon Isotopes; Chromatography, Thin Layer; Crystallization; Culture Techniques; Estradiol; Estrogens; Estrone; Female; Hydatidiform Mole; Pregnancy; Testosterone; Tritium

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Choriocarcinoma; Chorionic Gonadotropin; Cytodiagnosis; Estrogens; Female; Humans; Hydatidiform Mole; Hysterectomy; Middle Aged; Ovarian Neoplasms; Ovary; Pregnancy; Pregnanediol; Pregnanetriol; Uterine Neoplasms; Vaginal Smears

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Carbon Isotopes; Cholesterol; Female; Humans; Hydatidiform Mole; Hydroxyprogesterones; Ovarian Cysts; Pregnancy; Pregnanetriol; Pregnenolone; Progesterone; Steroids; Thecoma

Topics: 17-Ketosteroids; Animals; Carcinoma; Choriocarcinoma; Chromatography; Female; Humans; Hydatidiform Mole; Moles; Neoplasms, Glandular and Epithelial; Pregnancy