17-ketosteroids and Hodgkin-Disease

Twenty eight histologically confirmed cases of Hodgkin's disease were evaluates with regard to libido, sperm count, FSH, LH and urinary ketosteroid levels, before and during different stages of chemotherapy along with testicular biopsy on 16 cases. Decrease in libido during therapy improved following treatment, 50% cases who were oligospermic before treatment became azospermic, Serum FSH levels increased significantly (p 0.001) during the course of treatment. There was no significant change in LH and urinary ketosteroid levels (p 0.05). Testicular biopsy, normal initially, showed germ cell aplasia and absence of spermatogenesis after therapy. Drug induced testicular change leads to sterility.

Topics: 17-Ketosteroids; Adolescent; Adult; Combined Modality Therapy; Follicle Stimulating Hormone; Hodgkin Disease; Humans; Libido; Luteinizing Hormone; Male; Middle Aged; Sperm Count

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Hodgkin Disease; Humans; Leukocyte Count; Prednisolone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Child; Female; Hodgkin Disease; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Child; Female; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Radiography; Sex Factors; Thymoma; Thymus Neoplasms

Topics: 17-Ketosteroids; Bronchial Neoplasms; Female; Gastrointestinal Neoplasms; Hodgkin Disease; Humans; Kidney Neoplasms; Male; Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Bone Neoplasms; Chromatography; Dehydroepiandrosterone; Female; Hodgkin Disease; Humans; Injections, Intramuscular; Laryngeal Neoplasms; Male; Nasopharyngeal Neoplasms; Neoplasms; Pituitary-Adrenal System; Polarography; Prostatic Neoplasms; Tibia; Uterine Cervical Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Asthma; Collagen Diseases; Female; Hodgkin Disease; Humans; Lymphadenitis; Metyrapone; Middle Aged; Nephrosis, Lipoid; Pituitary-Adrenal Function Tests; Skin Diseases

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Blood Sedimentation; Child; Geriatrics; Hodgkin Disease; Humans; Japan; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mesothelioma; Mononuclear Phagocyte System; Neoplasms; Osteosarcoma; Sarcoma; Sarcoma, Ewing; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Biomedical Research; Blood; Calcium; Chlorides; Creatine; Creatinine; Drug Therapy; Hodgkin Disease; Humans; Iodine Isotopes; Leukemia; Leukemia, Lymphoid; Liver; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin; Metabolism; Multiple Myeloma; Nitrogen; Phosphorus; Potassium; Prednisone; Sodium; Uric Acid; Water

Topics: 17-Ketosteroids; Animals; Carbon Isotopes; Carcinoma, Bronchogenic; Chromatography; Etiocholanolone; Hodgkin Disease; Hydroxylation; Infrared Rays; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Metabolism; Mixed Function Oxygenases; Multiple Myeloma; Penicillium; Pharmacology; Sarcoma; Steroids; Testosterone; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma