17-ketosteroids and Hepatitis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Chronic Disease; Drug Therapy, Combination; Female; Hepatitis; Humans; Iontophoresis; Liver Cirrhosis; Male

Impairment of cortisol metabolism, evidence of endogenous hypercortism and sensitivity to oral corticosteroids are known to occur in patients with chronic liver disease. Measurements were made of plasma 11-OHCS and urinary cortisol levels and other parameters of adrenal function in a group of such patients. The mean plasma total 11-OHCS was lower in patients than in control subjects, although this difference was not statistically significant and the normal circadian rhythm was maintained. However, in patients with chronic liver disease a greater proportion of the 11-OHCS was in the non-protein bound state resulting in an elevation of this fraction. This elevation of non-protein bound 11-OHCS must represent a resetting of the pituitary-adrenal feedback mechanism in these patients. Corticosteroid binding globulin was lower in patients than in control subjects, although the difference was not statistically significant. Urinary cortisol excretion was significantly reduced as was excretion of 17-ketosteroids. Cortisol secretion rate was found to be normal. It is suggested that elevation of plasma non-protein bound 11-OHCS, resulting from impaired metabolism and reduced protein binding of cortisol in patients with hepatic disease, may explain the features of endogenous hypercorticism seen in such patients. Moreover, in the presence of impaired steroid metabolism and reduced protein binding, these patients may exhibit an increased sensitivity to corticosteroid therapy, and therefore administration of a reduced dosage may be advisable.

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Chronic Disease; Circadian Rhythm; Female; Hepatitis; Humans; Hydrocortisone; Liver Cirrhosis; Male; Middle Aged; Protein Binding; Transcortin

Topics: 17-Ketosteroids; Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Hydroxycorticosteroids; Hydroxysteroids; Hypersplenism; Ketosteroids; Liver Cirrhosis; Male; Middle Aged; Splenomegaly

Topics: 17-Ketosteroids; Acrodynia; Adult; Androsterone; Breast Diseases; Chemical and Drug Induced Liver Injury; Estrogens; Female; Gonadotropins; Hepatitis; Humans; Menstruation; Middle Aged; Pituitary Gland; Stress, Psychological; Thyroid Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Alcohol Oxidoreductases; Alcoholism; Aldehyde-Lyases; Chronic Disease; Enzymes; Estrogens; Gonadotropins; Hepatitis; Histocytochemistry; Humans; Italy; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Ornithine Carbamoyltransferase; Porphyrias; Porphyrins; Pregnanediol; Transaminases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Antibodies; Hepatitis; Humans; Hypothalamo-Hypophyseal System; Pituitary Gland; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adult; Atrophy; Chronic Disease; Fructose; Gonadotropins; Hepatitis; Humans; Libido; Liver Cirrhosis; Liver Diseases; Male; Middle Aged; Spermatozoa; Testicular Diseases

Topics: 17-Ketosteroids; Hepatitis; Hepatitis A; Hepatitis, Chronic; Humans; Liver Cirrhosis; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Atrophy; Hepatitis; Liver Cirrhosis; Metyrapone; Mineralocorticoid Receptor Antagonists; Pathology; Pharmacology; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Communicable Diseases; Hepatitis; Hepatitis A; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Child; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Urine

Topics: 17-Ketosteroids; Adolescent; Androgens; Androsterone; Chemistry Techniques, Analytical; Child; Chromatography; Drug Therapy; Etiocholanolone; Hepatitis; Humans; Hyperthyroidism; Hypothyroidism; Iodine Isotopes; Liver Cirrhosis; Liver Function Tests; Metabolism; Testosterone; Thyroid Function Tests; Thyroid Hormones; Urine

Topics: 17-Ketosteroids; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis; Liver Diseases; Prednisolone; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Bilirubin; Body Fluids; Communicable Diseases; Diet; Diet Therapy; Hepatitis; Hepatitis A; Prednisone; Urine

Topics: 17-Ketosteroids; Anorexia Nervosa; Cortisone; Endotoxins; Hematinics; Hepatitis; Liver Diseases; Liver Glycogen; Liver Regeneration; Mental Disorders; Stress, Physiological; Toxicology; Vitamin B 12

Topics: 17-Ketosteroids; Communicable Diseases; Ephedrine; Hepatitis; Hepatitis A; Humans; Pepsin A; Pepsinogen A; Pepsinogens

Topics: 17-Ketosteroids; Adrenal Cortex; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis

Topics: 17-Ketosteroids; Cholesterol; Communicable Diseases; Esterification; Hepatitis; Hepatitis A; Humans; Lipid Metabolism

Topics: 17-Ketosteroids; Communicable Diseases; Hepatitis; Hepatitis A; Liver Function Tests; Steroids

Topics: 17-Ketosteroids; Androgens; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis; Steroids

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Communicable Diseases; Hepatitis; Hepatitis A; Hepatitis, Viral, Human; Humans; Jaundice; Steroids; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Cortisone; Hepatitis; Hepatitis A; Liver Cirrhosis; Steroids; Urine