17-ketosteroids has been researched along with Growth-Disorders* in 25 studies
1 trial(s) available for 17-ketosteroids and Growth-Disorders
Article | Year |
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Effectiveness of long-term human growth hormone therapy for short stature in children with growth hormone deficiency.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Antibody Formation; Blood Proteins; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Growth; Growth Disorders; Growth Hormone; Humans; Hypopituitarism; Insulin; Iodine; Long-Term Care; Male; Metyrapone; Pituitary Function Tests; Protein Binding; Radioimmunoassay; Skinfold Thickness | 1970 |
24 other study(ies) available for 17-ketosteroids and Growth-Disorders
Article | Year |
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Acute and chronic effects of human recombinant GH (hrGH) on adrenal steroidogenesis in children affected with isolated GH deficiency (IGHD).
In a previous study we demonstrated that, in children affected with isolated GH deficiency, an acute high-dose human recombinant GH (hrGH) treatment increases the 11-deoxycortisol and induces an IGF-I responsiveness to ACTH. The aim of the present study was to reevaluate, in the same children, the adrenal and IGF-I responsiveness to ACTH after a chronic replacement-dose GH therapy. Ten children (seven males and three females, mean age 7 years) affected with isolated GH deficiency underwent a synthetic ACTH 1-17 test before and after sc administration of human recombinant GH at a dose of 0.6 UI/kg/week for 3 months. After therapy, the 11-deoxycortisol responsiveness to ACTH significantly decreased compared with that observed after acute treatment (P < 0.001), and so it returned to baseline. No differences were detected in the responsiveness to ACTH of cortisol, dehydroepiandrosterone-sulphate, D4-androstenedione, and 17-hydroxyprogesterone. On the other hand, the chronic treatment induced an IGF-I responsiveness to ACTH (P < 0.001). In conclusion, our study demonstrates that, in isolated GH deficiency, replacement doses of hrGH do not modify the adrenal steroid basal levels or its responsiveness to ACTH, whereas both replacement and high doses of hrGH induce an IGF-I responsiveness to ACTH. Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Body Height; Body Weight; Child; Child, Preschool; Cohort Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Growth Disorders; Growth Hormone; Humans; Male; Peptide Fragments; Recombinant Proteins; Reference Values | 1995 |
Effect of human growth hormone on adrenal androgens in children with growth hormone deficiency.
The effect of human growth hormone (hGH) on adrenal androgen secretion was assessed in 7 patients (5 males, 2 females) with GH deficiency but normal ACTH-cortisol function. Patients ranged in age from 9 5/12 to 14 8/12 years (median 12 years). Plasma concentrations of dehydroepiandrosterone-sulfate (DHEA-S) and urinary excretion of 17-ketosteroids (17-KS) and free cortisol were determined before, during short-term (2 U/day X 3) and after long-term (6 months) treatment with hGH. No significant change was noted in the plasma concentration or urinary excretion of steroids during the short-term administration of hGH. Despite a significant increase in growth velocity during 6 months of hGH therapy (8.2 vs. 4.5 cm/year, p less than 0.01), the plasma concentrations of DHEA-S and the urinary 17-KS and free cortisol levels were unchanged. These results fail to substantiate a role for hGH in the physiologic control of adrenal androgen secretion. Thus, the low plasma levels of adrenal androgens sometimes seen in GH-deficient patients are not due to the absence of GH per se. Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Androgens; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Male; Time Factors | 1984 |
[Gas-chromatographic analysis of estrogens and 17-ketosteroids in the urinary excreta of subnormal subjects, as further confirmation of prior studies made to define the neutral age of the child].
Topics: 17-Ketosteroids; Adolescent; Age Factors; Child; Endocrine Glands; Estrogens; Growth Disorders; Humans; Intellectual Disability | 1980 |
[Auxological problems in a case of virilizing adenoma of the adrenal gland].
Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Child; Child, Preschool; Dexamethasone; Growth Disorders; Humans; Hydrocortisone; Male; Metyrapone; Puberty, Precocious | 1977 |
X-linked ichthyosis, bilateral cryptorchidism, hypogenitalism and mental retardation in two siblings.
Two brothers showed ichthyosis, bilateral cryptorchidism, hypogenitalism and mental retardation. In addition, the younger brother had short stature associated with disorders of secretions of insulin, ACTH and GH. This is the third reported case of the syndrome of ichthyosis and hypogonadism. Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Cryptorchidism; Follicle Stimulating Hormone; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Ichthyosis; Insulin; Intellectual Disability; Luteinizing Hormone; Male; Thyrotropin | 1976 |
[Examination of the 17-ketosteroid spectrum in children and adolescents by means of paper chromatography (author's transl)].
Topics: 17-Ketosteroids; Adolescent; Age Factors; Child; Child, Preschool; Chromatography, Paper; Female; Growth Disorders; Humans; Infant; Male; Puberty | 1976 |
Short stature as the only clinical sign of Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Body Height; Cushing Syndrome; Dexamethasone; Diagnosis, Differential; Glucose Tolerance Test; Growth Disorders; Humans; Hydrocortisone; Male; Pyrones; Stimulation, Chemical | 1975 |
Growth retardation in the Lesch-Nyhan syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Age Determination by Skeleton; Arginine; Body Height; Body Weight; Child; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Immunoassay; Insulin; Lesch-Nyhan Syndrome; Male; Radioimmunoassay; Somatomedins; Stimulation, Chemical; Testosterone; Thyroid Function Tests | 1974 |
Endocrine function in thalassemia major.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Age Determination by Skeleton; Aldosterone; Anemia, Sickle Cell; Blood Transfusion; Child; Erythrocyte Count; Female; Growth Disorders; Growth Hormone; Hematocrit; Hemoglobins; Humans; Male; Pituitary-Adrenal Function Tests; Puberty; Radioimmunoassay; Splenectomy; Thalassemia; Thyroid Function Tests | 1974 |
Improvement of adult height prognosis in precocious puberty by cyproterone acetate.
Topics: 17-Ketosteroids; Age Determination by Skeleton; Androgen Antagonists; Body Height; Bone Development; Child; Child, Preschool; Cyproterone; Estrogens; Female; Gonadotropins; Growth Disorders; Humans; Male; Pregnadienes; Prognosis; Puberty, Precocious | 1973 |
Iatrogenic Cushing's disease in a boy after misdiagnosis of salt-losing virilizing adrenal hyperplasia: impaired metyrapone response with failure of catch-up growth.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotropic Hormone; Body Weight; Bone Development; Child; Child, Preschool; Cushing Syndrome; Desoxycorticosterone; Diagnosis, Differential; Diagnostic Errors; Fludrocortisone; Glucocorticoids; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Infant; Infant, Newborn; Insulin; Male; Methylprednisolone; Metyrapone; Mineralocorticoids; Pituitary-Adrenal Function Tests | 1973 |
[Clinical and hormonal characteristics of retardation of sexual development in girls].
Topics: 17-Ketosteroids; Adolescent; Chorionic Gonadotropin; Disorders of Sex Development; Female; Gonadal Steroid Hormones; Growth Disorders; Humans; Hypogonadism; Ovary; Pituitary-Adrenal Function Tests; Sex Chromatin | 1973 |
A case of true hermaphroditism with impaired growth and normal growth hormone levels in a Chinese.
Topics: 17-Ketosteroids; Adolescent; Castration; Disorders of Sex Development; Female; Growth Disorders; Growth Hormone; Gynecomastia; Humans; Hypospadias; Hysterectomy | 1973 |
Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease.
Short stature is a common complication of inflammatory bowel disease. Recently McCaffery, Nasr, Lawrence, and Kirsner (1970) concluded, from blood growth hormone (GH) levels obtained during insulin-hypoglycaemic provocation, that GH deficiency contributed to the retardation in growth observed in subjects with inflammatory bowel disease. Although it was not possible to eliminate the possibility of partial hypopituitarism, this study does not confirm the existence of GH deficiency in six subjects with short stature complicating inflammatory bowel disease. The nyctohemeral (night and day) serum GH is described, and the insulin and glucose levels in these subjects and normal sleep-related GH rises in all are demonstrated. This finding is not compatible with growth hormone deficiency. In one subject the response to arginine provocation was blunted. Three subjects manifested hyperinsulinism and evidence for ;insulin resistance'. These findings are unexplained but suggest that insulin resistance may contribute to a blunted GH response to insulin-induced hypoglycaemia. Blunted GH response to both arginine and insulin-induced hypoglycaemia may also result from continuous secretion and reduced pituitary storage of growth hormone. This possibility is suggested by the pattern of raised blood GH levels in one of the subjects. Topics: 17-Ketosteroids; Adolescent; Animals; Arginine; Blood Glucose; Child; Circadian Rhythm; Colitis, Ulcerative; Crohn Disease; Female; Gonadotropins, Pituitary; Growth Disorders; Growth Hormone; Humans; Insulin; Male; Sheep; Thyroid Function Tests | 1973 |
Failure of catch-up growth after Cushing's syndrome in childhood.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenalectomy; Adrenocorticotropic Hormone; Basal Metabolism; Child; Cushing Syndrome; Female; Fludrocortisone; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Thyroxine | 1972 |
Biochemical and endocrinological studies in parasite-infested patients with and without infantilism.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Estrogens; Gonadotropins; Growth Disorders; Hepatomegaly; Humans; Hydrocortisone; Hypoglycemia; Hypogonadism; Intellectual Disability; Liver Diseases, Parasitic; Liver Function Tests; Male; Middle Aged; Nutrition Disorders; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Schistosomiasis; Splenomegaly; Stimulation, Chemical | 1972 |
Syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child; Estrogens; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hypogonadism; Intellectual Disability; Metyrapone; Obesity; Puberty, Precocious | 1972 |
Pituitary function in the deprivation syndrome.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Growth; Growth Disorders; Growth Hormone; Humans; Hydrocortisone; Infant; Infant Nutrition Disorders; Insulin; Maternal Deprivation; Nutrition Disorders; Pituitary Gland; Psychosocial Deprivation; Thyroid Function Tests | 1971 |
[Gonadal dysgenesis with ring-shaped chromosome in an adolescent girl].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Amenorrhea; Cell Division; Chromatography, Gas; Chromosome Aberrations; Dermatoglyphics; Estrogens; Female; Glucose Tolerance Test; Growth Disorders; Humans; Karyotyping; Sex Chromosomes; Turner Syndrome | 1971 |
[Diagnostic value of metabolic tests following administration of human growth hormone in the assessment of hypothalamo-hypophyseal dwarfism in children].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Child; Dwarfism, Pituitary; Female; Growth Disorders; Growth Hormone; Humans; Male; Nitrogen | 1971 |
Coexisting anterior pituitary and neurohypophyseal insufficiency. A syndrome with diagnostic implication.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Biopsy; Brain Neoplasms; Cholesteatoma; Cortisone; Craniopharyngioma; Diabetes Insipidus; Female; Follicle Stimulating Hormone; Growth Disorders; Hair; Humans; Hypertonic Solutions; Hypogonadism; Hypopituitarism; Hypothalamus; Male; Metyrapone; Middle Aged; Pinealoma; Pituitary Diseases; Polyuria; Radiography; Sella Turcica; Skull; Testis; Thirst; Thyroid Function Tests; Visual Fields; Water | 1969 |
[Clinical investigation on human growth hormone secretion in hypothalamo-pituitary and thyroid diseases].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Child; Child, Preschool; Dwarfism, Pituitary; Electrophoresis; Female; Gonadotropins; Growth Disorders; Growth Hormone; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Insulin; Ion Exchange Resins; Male; Pituitary Diseases; Radioimmunoassay; Thyroid Diseases; Thyrotropin; Time Factors | 1969 |
Renal transplants in children.
Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Azathioprine; Child; Epiphyses, Slipped; Female; Glomerulonephritis; Growth Disorders; Growth Substances; Histocompatibility Testing; Humans; Hypertension; Hypoglycemia; Immunosuppression Therapy; Insulin; Kidney; Kidney Transplantation; Male; Prednisone; Proteinuria; Social Adjustment; Transplantation Immunology; Transplantation, Homologous | 1969 |
Growth retardation in thalassemia major.
Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Blood Transfusion; Child; Female; Gonadotropins, Pituitary; Growth; Growth Disorders; Hemosiderosis; Humans; Hypogonadism; Iron; Male; Menstruation Disturbances; Metyrapone; Pituitary Function Tests; Splenectomy; Thalassemia; Thyroid Gland | 1969 |