17-ketosteroids and Glycosuria

Allyl isothiocyanate (AITC) is a constituent of several plants of the family Cruciferae that are commonly used as food. This study investigated the effect of feeding AITC to male Sprague-Dawley rats on their plasma glucose and uric acid levels as well as on the urinary concentrations of glucose, 17-ketosteroids (17-KS), creatinine, and uric acid. Other test compounds included were thyroxine (T4) and thiouracil (TU). AITC caused a highly significant (P smaller than or equal to 0.01) depression in the plasma glucose and uric acid levels compared with the control. TU caused a significant depression only of the plasma glucose. T4, on the other hand, significantly increased the levels of both glucose and uric acid. The AITC-treated rats voided twice as much urine as the controls or those receiving TU or injected with T4. The 24-h excretion of glucose, uric acid, and creatinine was significantly (P smaller than or equal to 0.01) higher in animals fed AITC than in those consuming the control diet, while the excretion of 17-KS was significantly lower. Results on an equal urine volume basis showed that differences in the excretion of glucose and creatinine were related to differences in the urine volume. TU significantly depressed excretion of all the compounds but glucose. The effect of T4 on the excretion of 17-KS and uric acid resembled that of AITC and TU, thus showing that these compounds depressed the androgenic function of the animal.

Topics: 17-Ketosteroids; Allyl Compounds; Animals; Blood Glucose; Creatinine; Glucose; Glycosuria; Male; Metabolism; Rats; Thiocyanates; Uric Acid

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androstenedione; Evaluation Studies as Topic; Fermentation; Glucose; Glycosuria; Humans; Saccharomyces cerevisiae

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Delayed-Action Preparations; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diet, Diabetic; Dwarfism; Face; Female; Follow-Up Studies; Glycosuria; Hepatomegaly; Humans; Insulin; Obesity; Syndrome

Topics: 17-Ketosteroids; Central Nervous System Diseases; Chromatography; Creatinine; Electroencephalography; Female; Glucagon; Glucose; Glucose Tolerance Test; Glycosuria; Humans; Hyperglycemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Respiratory Insufficiency; Seizures

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Blood Glucose; Catecholamines; Female; Glucose Tolerance Test; Glycosuria; Humans; Infant, Newborn; Insulin; Japan; Male; Middle Aged; Pregnancy; Pregnancy in Diabetics; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Antithyroid Agents; Diabetic Retinopathy; Drug Therapy; Exophthalmos; Fundus Oculi; Glycosuria; Graves Disease; Humans; Hypophysectomy; Hypothalamo-Hypophyseal System; Insulin; Iodine Isotopes; Pathology; Pituitary Gland

Topics: 17-Ketosteroids; Blood Proteins; Cerebrovascular Disorders; Diabetes Mellitus; Ethnology; Genetics, Medical; Geriatrics; Glycosuria; Health Surveys; Heart Diseases; Humans; Hypercholesterolemia; India; Sex; South Africa; Uric Acid