17-ketosteroids and Feminization

Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; Carcinoma; Child, Preschool; Cushing Syndrome; Estrogens; Female; Feminization; Glucocorticoids; Granulosa Cell Tumor; Humans; Leydig Cell Tumor; Male; Mesenchymoma; Middle Aged; Mitotane; Ovarian Neoplasms; Paraneoplastic Endocrine Syndromes; Pregnancy; Progesterone; Prognosis; Sertoli Cell Tumor; Steroids; Testicular Neoplasms; Thecoma; Virilism

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Age Factors; Androgens; Animals; Child; Estrogens; Female; Feminization; Gynecomastia; Humans; Hypertension; Male; Mastectomy; Middle Aged; Obesity; Swine; Varicocele

A 37-year-old male with adrenocortical tumor presenting marked gynecomastia and impotence as initial symptoms was experienced. Abnormal elevations in urinary 17-KS, 17-OHCS and blood estrogen levels were noted. Total surgical removal of the tumor weighing 800g was performed. Postoperatively the gynecomastia disappeared and he regained libido with no signs of recurrence one year later.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Neoplasms; Adult; Estrogens; Feminization; Gynecomastia; Humans; Male

A 31 years old man with an adrenocortical carcinoma was studied. Clinically he had a bilateral and recidiving gynecomastia and showed high urinary oestrogens, 17 cetosteroids, tetra-hydro-desoxy-cortisol and pregnandiol excretion with normal cortisol production. A partial increase on ACTH, no suppression on dexamethasone and no variation on HCG administration were observed. The surgical resection of the tumor normalized this urinary excretion. The serum dehydro-epiandrosterone (DHEA) and sulfate (DHEAS), oestrone, oestradiol, androstenedione (A) levels were greatly elevated. No variations of the cortisol, A, DHEA and DHEAS was noted after ACTH injection. In vitro the lack of ACTH's action was related to an anomaly of ACTH receptor with normal protein kinase activity.

Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Androstenedione; Carcinoma; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone; Estrogens; Feminization; Humans; Hydrocortisone; Male; Pregnanediol; Tetrahydrocortisol

A patient with adrenocortical carcinoma had three major endocrine abnormalities attributable directly to the tumor: hypercortisolism (Cushing's syndrome), hyperestrogenism (feminization), and hypercalcemia (pseudohyperparathyroidism). There were higher levels of immunoreactive parathyroid hormone in venous effluent from the tumor or its abdominal metastases compared to that found in the veins draining the parathyroid glands. This, together with the presence of normal parathyroid glands on autopsy, established the diagnosis of pseudohyperparathyroidism as the cause of hypercalcemia in this patient.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aminoglutethimide; Androstenedione; Cushing Syndrome; Dexamethasone; Estrogens; Feminization; Humans; Hyperparathyroidism; Male; Metyrapone; Mitotane; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Testosterone

Thirty-four cases of corticosurrenaloma with clinical onset before 15 years of age have been studied. Higher frequency in girls (65 percent of the cases) and in young age (80 percent before 5 years of age, 43 percent before 2 years), association with personal or familial other tumors and malformations, are noticeable features. Virilism is the major manifestation in children (83 percent of the cases), either isolated or associated with hypercortisolism and/or feminization. Hormonal assays are of little value, and the dynamic adrenal tests are of some help only in small tumors or isolated hypercortisolism. Radiological diagnosis by urography with cavography, arteriography, is easy in most cases. Evaluation of prognosis is very difficult. Clinical and biological data are not significant, histological data are often of little help. Only a very large mass, and occurrence of metastases (liver, lungs) evidence malignancy. This series does not allow to assess definitely the best therapeutic regimen. Surgery has to be performed as soon as possible. The effects of radiations have not yet been ascertained. High doses of op'DDD have led to a sustained remission of the tumor or metastases in 2 patients, and perhaps to a longer survival in 4 others.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Angiography; Child; Child, Preschool; Cushing Syndrome; Dehydroepiandrosterone; Female; Feminization; Humans; Male; Mitotane; Urography; Virilism

Topics: 17-Ketosteroids; Androgens; Androstenedione; Animals; Chick Embryo; Female; Feminization; In Vitro Techniques; Male; Mullerian Ducts; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androstenedione; Androsterone; Estrogens; Feminization; Gynecomastia; Humans; Hydrocortisone; Male; Pituitary-Adrenal Function Tests; Pregnanetriol; Sex Chromatin; Spermatogenesis; Testis; Testosterone

Topics: 17-Ketosteroids; Adolescent; Adult; Androgen-Insensitivity Syndrome; Androsterone; Dehydroepiandrosterone; Disorders of Sex Development; Estradiol; Estrone; Female; Feminization; Glucocorticoids; Gynecomastia; Humans; Male; Oxidoreductases; Puberty; Radioimmunoassay; Testis; Testosterone

Topics: 17-Ketosteroids; Androstanes; Androsterone; Animals; Animals, Newborn; Benzoates; Chromatography, Paper; Chromatography, Thin Layer; Culture Techniques; Estradiol; Feminization; Hydrogenation; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Oxidoreductases; Rats; Testosterone

Topics: 17-Ketosteroids; Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Cholestasis; Cholesterol; Colonic Neoplasms; Common Bile Duct; Estradiol; Estranes; Estrogens; Estrone; Female; Feminization; Glucuronates; Humans; Liver Cirrhosis; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Stomach Neoplasms; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenalectomy; Chromatography; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Estradiol; Estriol; Estrogens; Feminization; Follicle Stimulating Hormone; Gonadotropins; Humans; Hydrocortisone; In Vitro Techniques; Luteinizing Hormone; Male; Metabolism, Inborn Errors; Middle Aged; Mixed Function Oxygenases; Nephrectomy; Prednisone; Pregnenolone; Radioimmunoassay; Sex Characteristics; Tritium

Topics: 17-Ketosteroids; Androgen Antagonists; Androstanes; Animals; Chromatography, Thin Layer; Estradiol; Female; Feminization; Hydrogen; Liver; Male; Pregnanes; Sex Characteristics; Sterols; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Carcinoma; Chorionic Gonadotropin; Estrogens; Feminization; Gonadotropins, Pituitary; Humans; Male; Middle Aged; Pregnancy Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Androgens; Androsterone; Antineoplastic Agents; Diuretics; Edema; Estrogens; Etiocholanolone; Feminization; Humans; Hydroxylation; Hypertension; Male; Metyrapone; Neoplasms; Pharmacology

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aged; Cortisone; Estrogens; Feminization; Gonadotropins; Gynecomastia; Humans; Male

Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Estradiol Congeners; Estrogens; Feminization; Humans; Male