17-ketosteroids and Fanconi-Anemia

Three children with Fanconi's anemia belonging to a family where 6 children had the disease were investigated. One child had growth hormone deficiency, a second child showed subnormal response of testosterone to gonadotropin stimulation and the third child had a missing insulin release following arginine. This report shows that growth hormone deficiency is not necessarily liniked with Fanconi's anemia when it occurs in a family. Multiple endocrine insufficiencies do no appear to be part of the disease.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Anemia, Aplastic; Arginine; Blood Glucose; Body Height; Body Weight; Child; Child, Preschool; Endocrine Glands; Fanconi Anemia; Growth Hormone; Humans; Hydrocortisone; Insulin; Insulin Secretion; Islets of Langerhans; Luteinizing Hormone; Male; Metyrapone; Pituitary Gland, Anterior; Testis; Testosterone; Thyroxine; Urea