17-ketosteroids and Familial-Mediterranean-Fever

Topics: 17-Ketosteroids; Adolescent; Antipyrine; Diaphragm; Familial Mediterranean Fever; Female; Humans; Neuralgia; Paralysis; Phrenic Nerve

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Familial Mediterranean Fever; Female; Humans; Male; Middle Aged

A woman with periodic catatonia had a 600-day metabolic study. The results were analyzed by harmonic analysis. Her periodic stupors showed a regular 36-day rhythm apparently related to a 24-day menstrual cycle; but the rhythm persisted when menstrual function was blocked by continuous Enovid (norethynodrel + mestranol) administration. During the menstrual block, weight, sodium balance, magnesium and 17-ketosteroid (17-KS) excretion gave indications of 12- and 36-day fluctuations. Further studies on steriod excretion indicated that similar fuctuations in 17-KS output occurred when the patient was menstruating normally. The peaks of the 12-day cycle coincided with menses and the mid-menstrual phase; while the peak of the 36-day cycle coincided with the onset of stupor. 17-hydroxycorticosteroid (17-OHCS) excretion had a 36-day cycle which lagged 4 days behind the 36-day 17-KS cycle. There were no indications of a 12-day 17-OHCS cycle. In the discussion it is suggested that the 17-KS fluctuations may partly reflect gonadotrophin activity rather than being exclusively due to ACTH. It is noted that Enovid may block only LH activity not total gonadotrophins. It is speculated that there may be a relationship between gonadotrophin activity and the psychic disturbance.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Antipsychotic Agents; Blood Pressure; Body Temperature; Catatonia; Cortisone; Creatine; Epinephrine; Familial Mediterranean Fever; Female; Humans; Longitudinal Studies; Luteinizing Hormone; Perphenazine; Psychiatric Status Rating Scales; Psychological Tests; Young Adult

1. A simple method for the extraction of 17-oxo steroid sulphates of plasma is described; glucosiduronates and orthophosphates are extracted, but to a smaller extent. 2. Four methods of analyses of the extracts are given and are relatively simple. Three of these are specific for steroid sulphates and two measure the sulphate conjugates directly. 3. Values for dehydroepiandrosterone sulphate and androsterone sulphate concentrations of normal and pathological plasmas are given.

Topics: 17-Ketosteroids; Androsterone; Blood Chemical Analysis; Blood Preservation; Chromatography; Colorimetry; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Etiocholanolone; Familial Mediterranean Fever; Glucuronates; Humans; Phosphates; Steroids; Sulfates

Topics: 17-Ketosteroids; Adolescent; Blood Chemical Analysis; Child; Etiocholanolone; Familial Mediterranean Fever; Fever; Humans; Metabolic Diseases; Pathology; Peritonitis; Prednisone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androsterone; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Castration; Dexamethasone; Drug Therapy; Etiocholanolone; Familial Mediterranean Fever; Female; Humans; Male; Metabolism; Nephrosis; Orchiectomy; Ovary; Prednisone; Testosterone; Urine

Topics: 17-Ketosteroids; Agranulocytosis; Communicable Diseases; Edema; Endocrinology; Etiocholanolone; Familial Mediterranean Fever; Fever; Humans; Joint Diseases; Mononuclear Phagocyte System; Neoplasms; Paralyses, Familial Periodic

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Familial Mediterranean Fever; Fever; Humans; Hyperplasia; Hypertrophy; Male; Medical Records