17-ketosteroids and Endometriosis

The effect of Danazol, a new gonadotropin inhibitor, was examined in four categories of patients. (1) Ten normal women medicated orally with Danazol, 800 mg. daily for 91 days, showed no depression of serum LH, estrone, estradiol, or progesterone below control, second-day levels. The serum FSH was slightly depressed; (2) Two anovulatory patients having elevated serum LH values were treated with Danazol, 400 to 800 mg. daily, for 1 to 3 days at midcycle. One patient repeatedly showed a temperature rise and LH flood within 24 hours of initial medication. Both had menstrual periods 7 to 9 days later. (3) Two normal midcycle ovulators were treated with 400 and 800 mg; of Danazol, respectively, for 1 day in the midfollicular phase and one apparently ovulated promptly prematurely. (4) Two patients having severe hot flushes following surgical menopause were treated with Danazol, 800 mg; daily, without reducing FSH or LH but with disappearance of hot flushes.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Alkynes; Endometriosis; Estradiol; Estrogen Antagonists; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hydroxysteroids; Luteinizing Hormone; Male; Menopause; Menstruation Disturbances; Middle Aged; Ovarian Cysts; Ovulation; Oxazoles; Pregnadienes; Progesterone; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Androgens; Chromatography; Endometrial Hyperplasia; Endometriosis; Female; Humans; Menopause; Metrorrhagia; Middle Aged

Topics: 17-Ketosteroids; Adult; Aged; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Blood Cell Count; Blood Sedimentation; Calcium; Carcinoma; Cyclophosphamide; Diarrhea; Endometriosis; Feeding and Eating Disorders; Female; Genital Neoplasms, Female; Hematocrit; Hematopoiesis; Hemoglobins; Humans; L-Lactate Dehydrogenase; Liver Function Tests; Middle Aged; Mucoproteins; Ovarian Neoplasms; Time Factors; Uterine Cervical Neoplasms; Vulvar Neoplasms

Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Chromatography, Gas; Dehydroepiandrosterone; Endometriosis; Female; Humans; Infertility, Female; Leiomyoma; Methods; Middle Aged; Ovarian Cysts; Ovary; Polycystic Ovary Syndrome; Progesterone; Testosterone; Tritium; Veins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Anemia; Biopsy; Endometriosis; Estrogens; Female; Gonadotropins; Hematologic Diseases; Humans; Leiomyoma; Lynestrenol; Menstruation Disturbances; Pregnanediol; Urine; Uterus

Topics: 17-Ketosteroids; Adenocarcinoma; Atrophy; Chorionic Gonadotropin; Clomiphene; Diagnosis; Drug Therapy; Endometriosis; Endometrium; Female; Follicle Stimulating Hormone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Infertility; Infertility, Female; Ovulation; Pathology; Polycystic Ovary Syndrome; Stilbenes; Toxicology; Urine; Uterine Neoplasms

Studies of the effects of megestrol (6-methyl, 6-dehydro, 17alpha-acetoxy progesterone) on human subjects indicated that this drug is a potent, orally effective progestational agent. The progestational effect was enhanced by estrogen. When combined with ethinyl estradiol satisfactory control of menstrual function and inhibition of ovulation were achieved. Increasing doses of this combination were effective in four patients with endometriosis. Side effects of the drug were minimal. No toxic effects on adrenal, hepatic or hematopoietic function were noted.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Amenorrhea; Biomedical Research; Endometriosis; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Menstruation; Ovulation; Pathology; Pharmacology; Pregnanediol; Progesterone; Progestins; Toxicology

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Blood Chemical Analysis; Creatine; Creatinine; Endometriosis; Female; Humans; Hydrocortisone; Mestranol; Norethynodrel; Pharmacology; Physiology; Pregnanediol; Progestins; Urine

Topics: 17-Ketosteroids; Androgens; Endometriosis; Estradiol Congeners; Estrogens; Female; Humans; Liver Diseases; Myoma; Uterine Hemorrhage; Uterine Neoplasms