17-ketosteroids and Endocrine-System-Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenosine Triphosphate; Adipose Tissue; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adult; Cholesterol; Cyclic AMP; Endocrine System Diseases; Fatty Acids, Nonesterified; Female; Gonadal Steroid Hormones; Growth Hormone; Humans; Insulin; Lipase; Lipoproteins; Male; Menstruation Disturbances; Middle Aged; Obesity; Triglycerides

Topics: 17-Ketosteroids; Dehydroepiandrosterone; Dexamethasone; Endocrine Glands; Endocrine System Diseases; Estriol; Estrogens; Female; Hirsutism; Humans; Menstruation; Methods; Ovary; Pregnanediol; Testosterone

Forty-two patients ages 15 to 20 years (average 17.3 years) were evaluated for oligomenorrhea. Group I consisted of 19 patients with evidence of androgen excess (hirsutism, clitoromegaly, acne); and Group II included 23 patients without evidence of androgen excess. Sixteen of the 19 patients in Group I had elevated serum LH and normal FSH values. Serum total testosterone concentration was elevated in 12 patients and free T was elevated in one additional patient. In nine patients urinary 17KS excretion was elevated and dexamethasone suppressible. For the purpose of treatment, patients in Group I were divided into three subgroups: IA, polycystic ovary syndrome--12 patients; IB, adrenal block--two patients; IC, combined adrenal and ovarian hyperandrogenism--five patients. Among the 23 Group II patients, four had persistently elevated serum LH and normal FSH values, suggesting PCO; three had menopausal levels of LA and FSH; one had hyperprolactinemia and a depressed floor of the pituitary sella; and the remaining 15 patients had low to normal serum levels of LH and FSH, consistent with hypothalamic suppression. Guidelines for the diagnosis and treatment of adolescents with oligomenorrhea are discussed on the basis of these findings.

Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adult; Endocrine System Diseases; Female; Gonadotropins, Pituitary; Humans; Menstruation Disturbances; Oligomenorrhea; Polycystic Ovary Syndrome; Testosterone

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adult; Endocrine System Diseases; Female; Humans; Hydrocortisone; Injections, Intravenous; Liver Diseases; Male

Circulating antibodies directed against testicular basement membrane and germinal cells are demonstrated in a patient with multiple primary endocrine gland deficiencies involving the thyroid, adrenals, testes, and pernicious anemia. Testicular biopsy revealed focal destruction of seminiferous tubules and interstitial fibrosis. The tubular basement membranes showed sharply positive immunofluorescence when stained with the patient's FITC conjugated gamma globulins.

Topics: 17-Ketosteroids; Aged; Antibodies; Basement Membrane; Endocrine System Diseases; Fluorescent Antibody Technique; Humans; Hydroxysteroids; Male; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Endocrine System Diseases; Hospitals, University; Humans; Yugoslavia

The combined dexamethasone-HCG test was employed in 57 patients with excessive androgen secretion in order to differentiate the Stein-Leventhal syndrome from other disorders associated with increased androgen production. The patients were classified according to the test results. All except two of the patients gave a test result typical for the Stein-Leventhal syndrome.

Topics: 17-Ketosteroids; Amenorrhea; Androgens; Chorionic Gonadotropin; Dexamethasone; Diagnosis, Differential; Endocrine System Diseases; Female; Hirsutism; Humans; Oligomenorrhea; Polycystic Ovary Syndrome; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Alkaline Phosphatase; Blood Glucose; Endocrine System Diseases; Humans; Hydrocortisone; Hydroxylation; Hyperglycemia; Hypocalcemia; Hypothalamus; Kinetics; Metabolic Diseases; Parathyroid Hormone; Phenytoin; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Triiodothyronine

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Chromatography, Gas; Congresses as Topic; Endocrine System Diseases; Female; Gonadal Steroid Hormones; Humans; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Aged; Circadian Rhythm; Diencephalon; Endocrine System Diseases; Female; Humans; Hypopituitarism; Male; Middle Aged; Pituitary Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Arthritis; Endocrine System Diseases; Estrogens; Female; Gonadotropins; Hormones; Humans; Temporomandibular Joint Dysfunction Syndrome

Topics: 17-Ketosteroids; Adult; Endocrine System Diseases; Erectile Dysfunction; Estrogens; Gonadotropins, Pituitary; Humans; Male; Middle Aged; Spinal Diseases

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Electroencephalography; Endocrine System Diseases; Fibrous Dysplasia of Bone; Humans; Male; Pigmentation Disorders; Puberty, Precocious; Radiography; Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Gland Diseases; Bone Diseases; Cushing Syndrome; Dwarfism, Pituitary; Endocrine System Diseases; Female; Gigantism; Growth Hormone; Humans; Male; Ossification, Heterotopic; Pituitary Diseases; Radiography; Thyroid Diseases; Thyroid Hormones

Topics: 17-Ketosteroids; Abortion, Habitual; Abortion, Threatened; Ambulatory Care; Diethylstilbestrol; Endocrine System Diseases; Female; Genital Diseases, Female; Humans; Maternal Health Services; Methods; Pregnancy; Progesterone; Somatotypes; Ukraine

Topics: 17-Ketosteroids; Abortion, Habitual; Cortisone; Decidua; Endocrine System Diseases; Female; Hirsutism; Humans; Placenta; Placenta Diseases; Pregnancy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic Gonadotropin; Dehydroepiandrosterone; Endocrine System Diseases; Estrogens; Etiocholanolone; Humans; Hypogonadism; Hypopituitarism; Klinefelter Syndrome; Male; Metabolism; Middle Aged; Pregnanetriol; Puberty; Testosterone

Topics: 17-Ketosteroids; Acne Vulgaris; Adolescent; Adrenocortical Hyperfunction; Adult; Androgens; Child; Dexamethasone; Endocrine System Diseases; Estrogens; Female; Hirsutism; Humans; Menstruation Disturbances; Obesity; Ovarian Diseases; Progesterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Child; Endocrine System Diseases; Female; Growth Hormone; Humans; Male; Middle Aged; Pharyngeal Neoplasms; Pituitary Diseases; Pituitary Neoplasms; Thyroid Hormones; Thyrotropin; Thyrotropin-Releasing Hormone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child, Preschool; Endocrine System Diseases; Female; Femoral Fractures; Fibrous Dysplasia of Bone; Fractures, Spontaneous; Gonadotropins; Humans; Infant; Pigmentation Disorders; Puberty, Precocious

Topics: 17-Ketosteroids; Dehydroepiandrosterone; Endocrine Glands; Endocrine System Diseases; Endometrium; Female; Hirsutism; Humans; Infertility, Female; Menstruation Disturbances; Ovary

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Breast Neoplasms; Carbon Isotopes; Carcinoma; Child; Child, Preschool; Chromatography; Dehydroepiandrosterone; Endocrine System Diseases; Etiocholanolone; Female; Humans; Infant; Male; Methods; Middle Aged; Polycystic Ovary Syndrome; Prostatic Neoplasms; Testosterone; Tritium

Topics: 17-Ketosteroids; Adrenal Insufficiency; Adult; Aged; Cryptorchidism; Diagnosis, Differential; Dwarfism; Endocrine System Diseases; Erectile Dysfunction; Eunuchism; Humans; Hypogonadism; Male; Middle Aged; Muscular Dystrophies; Myotonic Dystrophy; Obesity

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Endocrine System Diseases; Female; Humans; Hypothalamo-Hypophyseal System; Metyrapone; Pituitary-Adrenal Function Tests; Water

Topics: 17-Ketosteroids; Adult; Amenorrhea; Chlormadinone Acetate; Contraceptives, Oral; Endocrine System Diseases; Estrogens; Female; Gonadotropins, Pituitary; Humans; Norethynodrel; Pregnancy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Endocrine System Diseases; Female; Humans; Hypertrophy; Metyrapone; Ovary; Pituitary-Adrenal Function Tests; Pyridones; Thyroid Function Tests; Thyroid Gland; Virilism

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acanthosis Nigricans; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Dexamethasone; Endocrine System Diseases; Female; Humans; Male; Obesity; Pituitary Diseases; Steroids

Topics: 17-Ketosteroids; Adolescent; Age Determination by Skeleton; Age Factors; Androgens; Body Height; Body Weight; Bone Development; Child; Child, Preschool; Dehydroepiandrosterone; Endocrine System Diseases; Epiphyses, Slipped; Female; Femur; Hand; Hip Injuries; Humans; Male; Nitriles; Obesity; Puberty; Sex Factors; Wrist

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Addison Disease; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Anorexia Nervosa; Child; Child, Preschool; Chromatography; Cushing Syndrome; Disorders of Sex Development; Endocrine System Diseases; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hyperthyroidism; Hypertrichosis; Hypopituitarism; Male; Middle Aged; Myxedema; Obesity; Pheochromocytoma; Pregnancy; Spectrophotometry

Topics: 17-Ketosteroids; Alkaline Phosphatase; Cushing Syndrome; Endocrine System Diseases; Female; Humans; Male; Neutrophils; Obesity

Topics: 17-Ketosteroids; Adolescent; Adult; Endocrine System Diseases; Estrogens; Female; Gingivitis; Humans; Menstruation Disturbances; Middle Aged; Mouth Mucosa; Ovarian Diseases; Periodontal Diseases; Vaginal Smears

Topics: 17-Ketosteroids; Adolescent; Adult; Chorionic Gonadotropin; Dexamethasone; Endocrine System Diseases; Female; Humans; Time Factors

Topics: 17-Ketosteroids; Androgens; Body Fluids; Chromatography, Gas; Endocrine System Diseases; Estrogens; Female; Genital Diseases, Female; Humans; Male; Methods; Pregnanediol; Progesterone; Progestins; Steroids; Testosterone; Urologic Diseases

Topics: 17-Ketosteroids; Androgens; Biopsy; Endocrine System Diseases; Estrogens; Gonadotropins; Humans; Hypogonadism; Klinefelter Syndrome; Male; Testicular Diseases; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Alopecia Areata; Arthritis, Rheumatoid; Asthma; Breast Neoplasms; Child; Child, Preschool; Colitis, Ulcerative; Cortisone; Endocrine System Diseases; Female; Humans; Hydrocortisone; Male; Middle Aged; Multiple Sclerosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Aged; Child; Child, Preschool; Endocrine System Diseases; Female; Humans; Hypertension; Liver Cirrhosis; Male; Metyrapone; Middle Aged; Paramethasone; Pregnanetriol; Triparanol

Topics: 17-Ketosteroids; Adult; Carbon Disulfide; Endocrine System Diseases; Humans; Male; Middle Aged; Occupational Diseases; Textile Industry

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Endocrine System Diseases; Estrogens; Female; Gonadotropins; Humans; Hyperplasia; Hysterectomy; Obesity; Ovary; Physiology; Pituitary Gland; Postoperative Complications; Pregnanediol; Rats; Research; Thyroid Diseases; Urine; Uterus

Topics: 17-Ketosteroids; Adolescent; Androgens; Diencephalon; Endocrine System Diseases; Estrogens; Humans; Liver; Lysergic Acid Diethylamide; Metabolism; Pharmacology; Physiology; Pituitary Gland; Progesterone; Psychotic Disorders

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Endocrine System Diseases; Estrogens; Female; Gonadotropins; Humans; Ovarian Diseases; Ovary; Pharmacology; Pituitary-Adrenal Function Tests; Postpartum Period; Pregnancy; Puerperal Disorders; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Endocrine System Diseases; Female; Humans; Steroids; Women's Health

Topics: 17-Ketosteroids; Acromegaly; Addison Disease; Adrenal Insufficiency; Cushing Syndrome; Endocrine System Diseases; Humans; Hyperthyroidism; Hypoadrenocorticism, Familial

Topics: 17-Ketosteroids; Endocrine System Diseases; Female; Humans; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Body Fluids; Endocrine System Diseases; Endocrinology; Endopeptidases; Humans

Topics: 17-Ketosteroids; Body Fluids; Endocrine System Diseases; Hormones; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Diagnosis, Differential; Endocrine System Diseases; Humans; Musculoskeletal Diseases

Topics: 17-Ketosteroids; Adolescent; Body Fluids; Child; Endocrine System Diseases; Endocrinology; Humans; Puberty; Reference Values; Sexual Maturation

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Endocrine System Diseases; Hormones; Humans; Steroids

Topics: 17-Ketosteroids; Endocrine System Diseases; Hormones; Humans

Topics: 17-Ketosteroids; Chemical Fractionation; Diagnostic Techniques, Endocrine; Endocrine System Diseases; Steroids; Urine

Topics: 17-Ketosteroids; Acromegaly; Addison Disease; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androgens; Cushing Syndrome; Dehydroepiandrosterone; Endocrine System Diseases; Humans; Pituitary ACTH Hypersecretion; Puberty, Precocious; Steroids; Urine

Topics: 17-Ketosteroids; Chromatography; Endocrine System Diseases; Humans; Research; Steroids; Urine

Topics: 17-Ketosteroids; Chromatography; Diagnostic Techniques, Endocrine; Endocrine System Diseases; Humans; Steroids

Topics: 17-Ketosteroids; Body Fluids; Disease; Endocrine Glands; Endocrine System Diseases; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Disease; Endocrine Glands; Endocrine System Diseases; Hormones; Humans; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Disease; Endocrine Glands; Endocrine System Diseases; Hormones; Humans; Steroids

Topics: 17-Ketosteroids; Adult; Chorionic Gonadotropin; Endocrine System Diseases; Estrogens; Gonadotropins; Gynecomastia; Humans; Leydig Cells; Male

Topics: 17-Ketosteroids; Androgens; Body Fluids; Disease; Endocrine Glands; Endocrine System Diseases; Steroids

Topics: 17-Ketosteroids; Disease; Endocrine Glands; Endocrine System Diseases; Health; Steroids

The urinary 17-ketosteroids are a group of compounds derived from complex steroids produced by the adrenal cortex, testis, or ovary. The method of determining the amount excreted has been simplified so that it is available for routine diagnostic purposes. Usually the amount is increased in diseases in which there is hyperfunction of the adrenal cortex due to tumor or hyperplasia, and decreased in lesions that impair the function of the adrenal cortex. Other conditions such as myxedema, eunuchism, gout, and arthritis may alter the excretion of the 17-ketosteroids. Low levels are also found in the young and in the aged. Case histories are presented to illustrate the findings in the following diseases: Tumors of the adrenal cortex with (a) masculinization, (b) Cushing's syndrome with virilism and, (c) hirsutism; as well as in gigantism with acromegaly, in gout, eunuchism, Addison's disease, myxedema, and severe panhypopituitarism.

Topics: 17-Ketosteroids; Adrenal Cortex; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Humans; Hyperplasia; Male; Ovary; Steroids; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Glands; Androgens; Disease; Endocrine Glands; Endocrine System Diseases; Gonadotropins; Gonads; Humans; Neoplasms; Steroids