17-ketosteroids and Dysgerminoma

Topics: 17-Ketosteroids; Age Factors; Body Height; Brain Diseases; Choriocarcinoma; Dysgerminoma; Ejaculation; Female; Granulosa Cell Tumor; Humans; Hydrocephalus; Male; Menarche; Ovarian Neoplasms; Ovulation; Pregnancy; Prognosis; Psychosexual Development; Puberty, Precocious; Reproduction; Sex Factors; Teratoma; Testicular Neoplasms; Thecoma

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Androsterone; Blood; Chorionic Gonadotropin; Cushing Syndrome; Dysgerminoma; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypertrichosis; Hypogonadism; Metabolism; Ovarian Neoplasms; Ovary; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Testosterone; Urine; Virilism

The levels of steroid (17-HOCS, 17-CS and estrogens) and tropic (FSH, LH and ACTH) hormones were assayed and analysed versus histologic pattern and efficacy of combined therapy of tumor in 39 cases of testicular cancer. Decreased level of sex hormones matched by increased concentration of gonadotropins occurred in most patients: marked rise in FSH was observed in seminoma and that in LH--in teratoblastoma and embryonal cancer. Increased levels of 17-HOCS, estradiol, FSH and LH were observed in cases who did not respond to treatment, while lowered concentrations of FSH and LH--in cases of effective treatment. Tropic hormone and 17-HOCS concentrations were registered in cases of relapse.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Combined Modality Therapy; Dysgerminoma; Estrogens; Follicle Stimulating Hormone; Hormones; Humans; Luteinizing Hormone; Male; Teratoma; Testicular Neoplasms

The 15-year old female patient G. G. was referred to the outpatient department for child gynaecology on account of a primary amenorrhoea. The endocrinal parameters found (testosterone, oestradiol, 17 OHCS, 17 KS), chromosome analysis, vaginoscopy and the result of a laparoscopy led to the clinical diagnosis of "testicular feminisation". Satisfactory development of secondary female sex characteristics and sudden increase of complaints caused by an inguinal hernia on the left (gonad situated in the inner inguinal ring) prompted us to perform bilateral extirpation of gonads with simultaneous treatment of the inguinal hernia. Histological examination revealed the existence of a seminoma of the right gonad. This case confirm our stand in respect of extirpation of gonads at the onset of puberty, but it also raised the question as to whether it would be advisable to operate at an even earlier stage in order to avoid the risk of malignant degeneration of intra-abdominally positioned testes.

Topics: 17-Ketosteroids; Adolescent; Amenorrhea; Androgen-Insensitivity Syndrome; Castration; Dysgerminoma; Estradiol; Female; Humans; Hydroxysteroids; Male; Puberty; Testicular Neoplasms; Testosterone; Time Factors

Topics: 17-Ketosteroids; Child; Dysgerminoma; Estrogens; Female; Humans; Ovarian Neoplasms

Systematic investigations of the chorionic gonadotropin excretion were performed in 79 patients with testicular tumours. The influence of the hormonal activity in diagnosis and prognosis of metastatic testicular tumours was investigated. It was discovered, that the part of hormonal active testicular tumours is relatively small and that the evidence of the chorionic gonadotropin excretion is only possible in a few cases before the clinical and radiological evidence of metastases. The hormonal activity of testicular tumours is without influence on the survival time of tumour carriers.

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Antineoplastic Agents; Choriocarcinoma; Chorionic Gonadotropin; Dysgerminoma; Hormones, Ectopic; Humans; Male; Sarcoma; Teratoma; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Androsterone; Dysgerminoma; Etiocholanolone; Female; Gonadotropins; Humans; Karyotyping; Ovarian Neoplasms; Pregnanediol; Pregnanetriol; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androgens; Androstenedione; Carbon Radioisotopes; Chromatography, Paper; Diagnosis, Differential; Dysgerminoma; Female; Gonadotropins; Humans; In Vitro Techniques; Leydig Cells; Male; Testosterone; Tritium; Turner Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Clitoris; Dexamethasone; Disorders of Sex Development; Dysgerminoma; Estrogens; Female; Fluoxymesterone; Genital Diseases, Female; Gonadotropins; Humans; Hyperplasia; Ovarian Neoplasms; Pituitary-Adrenal Function Tests; Testosterone

Topics: 17-Ketosteroids; Adolescent; Autopsy; Chorionic Gonadotropin; Dysgerminoma; Female; Hormones, Ectopic; Humans; Lung; Lung Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Pituitary Gland; Placental Lactogen; Radioimmunoassay

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Chromatography, Gas; Dysgerminoma; Estrogens; Humans; Isoenzymes; L-Lactate Dehydrogenase; Male; Methods; Steroids; Teratoma; Testicular Neoplasms; Testis

Topics: 17-Ketosteroids; Adolescent; Adult; Carbohydrates; Cytoplasm; Dysgerminoma; Female; Histocytochemistry; Humans; Lipids; Middle Aged; Ovarian Neoplasms; Sertoli-Leydig Cell Tumor; Staining and Labeling

Topics: 17-Ketosteroids; Adolescent; Breast; Carcinoma; Castration; Child; Chorionic Gonadotropin; Dysgerminoma; Estradiol; Estriol; Estrogens; Estrone; Female; Gonadotropins; Gonadotropins, Pituitary; Growth; Humans; Hysterectomy; Menarche; Menstruation; Neoplasms; Ovarian Neoplasms; Ovary; Pituitary Gland; Pituitary-Adrenal Function Tests; Puberty; Sexual Maturation; Urine

Ataxia-telangiectasia is a syndrome of progressive cerebellar ataxia and other neurological manifestations associated with conjunctival and cutaneous telangiectases and with recurrent sino-pulmonary infections. Immunological and endocrine abnormalities occur. Two girls with this disease are described. The first had only minor respiratory infections; her serum proteins and immunity responses appeared normal. The second had recurrent pulmonary infections and bronchiectasis; she also exhibited sclerodermatous changes, poor development of secondary sexual characteristics with low urinary excretion of 17-ketosteroids, and lymphopenia. Autopsy at 17 years showed bilateral ovarian dysgerminomata and excessive cutaneous collagen as well as atrophy, and perhaps hypoplasia, of adrenals, thymus, spleen and lymphoid tissue (after steroid therapy). The cerebellum exhibited cortical degeneration. Both lungs were fibrotic with old and recent bronchopneumonia and bronchiectasis. The left lung was studied by injection of a latex preparation; no arteriovenous aneurysms were found, but the smaller pulmonary vessels showed some unusual morphological characteristics.

Topics: 17-Ketosteroids; Adolescent; Ataxia; Ataxia Telangiectasia; Atrophy; Blood Protein Electrophoresis; Bronchiectasis; Cerebellar Diseases; Child; Conjunctiva; Dysgerminoma; Eosinophils; Female; Genetics, Medical; Humans; Hypogonadism; Immunoelectrophoresis; Infant; Infant, Newborn; Leukocyte Count; Lymphocytes; Neoplasms, Germ Cell and Embryonal; Neurologic Manifestations; Ovarian Neoplasms; Pathology; Pulmonary Circulation; Pulmonary Fibrosis; Scleroderma, Systemic; Telangiectasis; Urine

Topics: 17-Ketosteroids; Androgens; Androsterone; Chromatography; Dehydroepiandrosterone; Dysgerminoma; Etiocholanolone; Female; Humans; Male; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Seminoma; Teratoma; Testicular Neoplasms; Urine