17-ketosteroids and Diabetes-Mellitus

The authors report a case of Steinert's disease in a woman and discuss the endocrine profile of this disease after giving an account of the criteria of diagnosis. Disorders of gonad function are mild in women, primary testicular atrophy is very frequent in man with reduction in 17-ketosteroids and testosterone. Thyroid function was normal but, in a few cases, a low fixation curve was found (our case) corrected by TSH stimulation. The frequency of cataract emphasizes the interest of this sign for detection. Diabetes, associated with hyperinsulinism, seemed more frequent than in a population without Steinert's disease. The pathogenesis of these endocrine disorders appears secondary and is ill explained if one considers it as a single disease. Better knowledge, no doubt linked to progress in biochemistry of normal and myopathic muscle, will help to explain the pathogenesis.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Calcium; Cataract; Diabetes Mellitus; Female; Glucose; Gonads; Humans; Hyperinsulinism; Hypothalamus; Male; Myotonic Dystrophy; Myxedema; Phosphorus; Pituitary Gland; Testosterone; Thyroid Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Catecholamines; Diabetes Mellitus; Diabetic Angiopathies; Eye Manifestations; Glucocorticoids; Glycosaminoglycans; Growth Hormone; Humans; Lipoproteins; Microcirculation; Prediabetic State; Proteins

Topics: 17-Ketosteroids; Adrenal Glands; Adrenal Medulla; Androgens; Angiotensin II; Diabetes Mellitus; Diabetic Nephropathies; Endocrine Glands; Estrogens; Growth Hormone; Humans; Insulin; Insulin Secretion; Lipid Metabolism; Prostaglandins; Renin; Thyroxine-Binding Proteins

Topics: 17-Ketosteroids; Adult; Chorionic Gonadotropin; Chromatography; Deuterium; Diabetes Complications; Diabetes Mellitus; Erectile Dysfunction; Gonadotropins; Humans; Male; Middle Aged; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Creatinine; Diabetes Complications; Diabetes Insipidus; Diabetes Mellitus; Female; Humans; Potassium; Sodium; Water

Adrenal tumors showing no clinical manifestations (incidentaloma) are frequently encountered during imaging analysis upon routine examinations. These tumors are sometimes associated with hypertension and/or diabetes mellitus (DM). We have examined six cases of incidentalomas with these symptoms in this study. All patients underwent endocrinological evaluation by measuring plasma cortisol and aldosterone levels to assess adrenocortical function. The levels of urinary 17-hydroxysteroids, 17-ketosteroids and catecholamines were also measured. Imaging analysis were performed by using 131I-adosterol scintigraphy, computed tomography and magnetic resonance imaging. Whereas one case was diagnosed as having an adrenal adenoma without the examination of a surgical specimen, other cases underwent surgical removal of the tumor, and final diagnoses were made by pathohistological examination of the tumors. Three cases were diagnosed as having adrenocortical adenomas (one was functioning and others were non-functioning) and one case was diagnosed as having a functional adrenocortical carcinoma. Adenomas were found to produce either non-functional steroids or a small amount of functional steroid hormones. The adenoma patients all suffered hypertension, whereas one of the adenoma patients and the carcinoma patient showed signs of DM. By contrast, of the six cases, one case was diagnosed as having an adrenal cyst, and one case was diagnosed with myelolipoma. Although these two cases suffered DM and hypertension, respectively, it seemed to be unlikely that these clinical symptoms were caused by the adrenal disease. Thus, the present analysis of the six incidentaloma patients suggests that once an adrenal incidentaloma patient with hypertension and/or DM is found, both endocrinological and imaging examinations are necessary to determine the indication of surgical treatment. This analysis supports the present consensus that non-functional adenomas whose sizes are 3cm or less and whose sizes do not change at any reevaluation period, as well as adrenal cysts and myelolipoma should not be surgically removed.

Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Aged; Aldosterone; Carcinoma; Catecholamines; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hydrocortisone; Hydroxysteroids; Hypertension; Male; Middle Aged

Topics: 17-Ketosteroids; Age Factors; Blood Glucose; Diabetes Mellitus; Humans; Hydroxysteroids; Infant, Newborn; Insulin; Male

Capillary gas chromatography was used for the acquisition of quantitative metabolic profiles of urinary steroids from normal subjects and diabetic patients. Structures of 70 steroid metabolites have been assigned tentatively through mass spectrometry. Quantitative differences between the groups of normal and pathological samples (both males and females) are seen primarily for androsterone, etiocholanolone, dehydroepiandrosterone, 11-oxygenated 17-ketosteroids, corticosteroid metabolites, and a newly discovered metabolite, recently identified as a C26 pentol. The only significant difference between two different age groups of normal males was shown by androsterone.

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Androsterone; Cholestanols; Dehydroepiandrosterone; Diabetes Mellitus; Etiocholanolone; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Blood Glucose; Diabetes Mellitus; Female; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adult; Diabetes Mellitus; Humans; Male; Middle Aged; Sperm Count; Sperm Motility; Spermatozoa; Testosterone

Topics: 17-Ketosteroids; Adult; Blood Glucose; Diabetes Mellitus; Humans; Male; Middle Aged; Semen; Testosterone

The Tohoku University method of fasting therapy was performed on 380 patients. The clinical results revealed an efficacy rate of 87%. With regard to psychosomatic diseases, irritable colon syndrome, neurocirculatory asthenia, mild diabetes mellitus, obesity and borderline hypertension were good indications for this therapy. In order to clarify the therapeutic mechanism, several clinical examinations were administered before, during and after therapy. EEG data was analysed according to the power spectral method. The peak frequency decreased as fasting progressed, while it increased as re-fed continued. Percent energy of alpha waves after fasting therapy was significantly higher than that of the pre-fasting stage. The dexamethasone suppression rate of urine 17-OHCS after fasting therapy was significantly lower than that of the pre-fasting stage. It seems that ketone nutrition may work as a strong stressor in the brain cell, temporarily placing all biological mechanisms in a stress state and then activating the natural healing power inherent to the human body, thereby bringing about homeostasis.

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Asthma; Child; Colonic Diseases, Functional; Dexamethasone; Diabetes Mellitus; Electroencephalography; Fasting; Female; Headache; Humans; Hypertension; Hyperventilation; Male; Middle Aged; Obesity; Psychophysiologic Disorders

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Diabetes Mellitus; Erectile Dysfunction; Estrogens; Humans; Male; Testis

Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Diabetes Mellitus; Estrogens; Female; Glucagon; Glucose Oxidase; Glucose Tolerance Test; Greece; Growth Hormone; Humans; Hydrocortisone; Hydroxysteroids; Insulin; Iron; Italy; Luteinizing Hormone; Male; Pituitary-Adrenal Function Tests; Progesterone; Radioimmunoassay; Testosterone; Thalassemia; Thyroid Function Tests; Thyrotropin; Transfusion Reaction

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child; Depression, Chemical; Dexamethasone; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dwarfism; Face; Female; Growth Hormone; Hepatomegaly; Humans; Hydrocortisone; Insulin; Metyrapone; Obesity; Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Delayed-Action Preparations; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diet, Diabetic; Dwarfism; Face; Female; Follow-Up Studies; Glycosuria; Hepatomegaly; Humans; Insulin; Obesity; Syndrome

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Chorionic Gonadotropin; Dehydroepiandrosterone; Diabetes Complications; Diabetes Mellitus; Electromyography; Erectile Dysfunction; Humans; Kidney Function Tests; Leydig Cells; Male; Neural Conduction; Neurologic Examination; Paraplegia; Pregnenolone; Progesterone; Testis; Testosterone; Urinary Bladder

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Humans; Metyrapone; Pituitary Hormones, Anterior; Stimulation, Chemical

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Glands; Age Factors; Aged; Diabetes Mellitus; Humans; Hypertension; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Age Factors; Aged; Circadian Rhythm; Dexamethasone; Diabetes Mellitus; Diabetic Retinopathy; Diencephalon; Female; Humans; Male; Metyrapone; Middle Aged; Pituitary Gland; Pituitary-Adrenal Function Tests; Sex Factors

Topics: 17-Ketosteroids; Adult; Aged; Aging; Androsterone; Arteriosclerosis; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Colorimetry; Diabetes Mellitus; Etiocholanolone; Humans; Male; Middle Aged; Myocardial Infarction; Myxedema; Testosterone; Triiodothyronine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Body Weight; Diabetes Mellitus; Female; Humans; Obesity

Topics: 17-Ketosteroids; Adult; Biopsy; Diabetes Complications; Diabetes Mellitus; Erectile Dysfunction; Humans; Male; Middle Aged; Semen; Testis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Body Weight; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diet; Fatty Acids, Nonesterified; Growth Hormone; Humans; Hyperlipidemias; Insulin; Lipids; Lipoproteins; Male; Phospholipids; Triglycerides; Xanthomatosis

Topics: 17-Ketosteroids; Adult; Androgens; Diabetes Mellitus; Diagnosis, Differential; Disorders of Sex Development; Edema; Estrogens; Feces; Gonadotropins; Humans; Karyotyping; Laparotomy; Leg Ulcer; Male; Sex Chromosomes; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Female; Glucose Tolerance Test; Humans; India; Insulin; Pituitary-Adrenal Function Tests; Pregnancy; Pregnancy in Diabetics; Racial Groups; Time Factors; Tolbutamide

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Diabetes Complications; Diabetes Mellitus; Etiocholanolone; Female; Glucocorticoids; Humans; Male; Pregnanes; Pregnanetriol; Progestins; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Androsterone; Blood Protein Disorders; Chemistry, Clinical; Chromatography, Gel; Dehydroepiandrosterone; Diabetes Complications; Diabetes Mellitus; Etiocholanolone; Family; Female; Genital Diseases, Male; Hemophilia A; Humans; Intellectual Disability; Male; Pregnanetriol; Protein Binding; Transcortin

Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus; Dog Diseases; Dogs; Female; Hyperinsulinism; Hypothyroidism; Male; Metyrapone; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Diabetes Mellitus; Female; Hemochromatosis; Humans; Liver Diseases; Male; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Blood Glucose; Blood Pressure; Body Height; Body Weight; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Fasting; Female; Fluorometry; Glucocorticoids; Glucose Tolerance Test; Humans; Insulin; Islets of Langerhans; Male; Middle Aged

Topics: 17-Ketosteroids; Adult; Cholesterol; Diabetes Mellitus; Diagnosis, Differential; Female; Glucosamine; Humans; Hydrocortisone; Lipids; Male; Parathyroid Glands; Pedigree; Phospholipids; Pituitary-Adrenal Function Tests; Polysaccharides; Thyroid Function Tests; Werner Syndrome

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Amyotrophic Lateral Sclerosis; Arthritis, Rheumatoid; Chemistry, Clinical; Diabetes Mellitus; Diabetic Retinopathy; Female; Glucuronates; Humans; Hydrocortisone; Liver Cirrhosis; Male; Middle Aged; Multiple Sclerosis; Pregnanes; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Body Weight; Chromatography, Gas; Diabetes Mellitus; Endometrium; Estrogens; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Uterine Neoplasms

Topics: 17-Ketosteroids; Diabetes Mellitus; Humans

Topics: 17-Ketosteroids; Adult; Androsterone; Diabetes Mellitus; Etiocholanolone; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adenoma, Chromophobe; Aged; Blood Chemical Analysis; Carbutamide; Diabetes Mellitus; Humans; Hypophysectomy; Lipids; Male; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Aged; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Time Factors

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Aged; Androgens; Diabetes Mellitus; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Aged; Diabetes Mellitus; Female; Gonads; Humans; Male; Middle Aged; Thyroid Gland

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Cortisone; Dehydroepiandrosterone; Diabetes Mellitus; Erectile Dysfunction; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Glucocorticoids; Humans; Hydrocortisone; Hypogonadism; Male; Middle Aged

Topics: 17-Ketosteroids; Acidosis; Adrenal Gland Neoplasms; Adult; Blood Glucose; Diabetes Mellitus; Female; Glucose; Glucose Tolerance Test; Humans; Hyperaldosteronism; Hypoglycemia; Male; Middle Aged; Tromethamine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hyperplasia; Hypertension; Infant; Infant, Newborn; Male; Obesity; Osteoporosis

Topics: 17-Ketosteroids; Contraceptives, Oral; Diabetes Mellitus; Diethylstilbestrol; Estrogens; Female; Glucose Tolerance Test; Humans; Mestranol; Norethynodrel; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Diabetes Mellitus; Fluids and Secretions; Humans; Injections; Injections, Intramuscular; Injections, Intravenous; Metabolism; Obesity; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Amylases; Blood Chemical Analysis; Blood Urea Nitrogen; Carbohydrate Metabolism; Diabetes Mellitus; Glucose Tolerance Test; Glutathione; Hydrochlorothiazide; Hyperglycemia; Insulin; Pharmacology; Potassium; Thiazides; Tolbutamide; Toxicology; Uric Acid; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing Syndrome; Diabetes Mellitus; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary Irradiation; Thyroid Function Tests; Urine; Yttrium Isotopes

Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Child; Chromatography; Dehydroepiandrosterone; Diabetes Mellitus; Etiocholanolone; Geriatrics; Glucuronates; Humans; Hypogonadism; Obesity; Solvents; Sulfates

Topics: 17-Ketosteroids; Adolescent; Aged; Diabetes Mellitus; Female; Humans; Insulin; Male; Middle Aged; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Diabetes Mellitus; Humans; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Child; Diabetes Mellitus; Feeding and Eating Disorders; Genetics, Medical; Humans; Hyperlipidemias; Hyperphagia; Infant; Metabolic Diseases; Obesity; Polydipsia; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Insufficiency; Anorexia Nervosa; Cushing Syndrome; Dexamethasone; Diabetes Mellitus; Humans; Hyperthyroidism; Periodicity; Pituitary Gland; Pituitary-Adrenal Function Tests; Statistics as Topic; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Diabetes Mellitus; Estradiol Congeners; Estrogens; Geriatrics; Pharmacology; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Animals; Chromatography; Diabetes Mellitus; Diabetes Mellitus, Experimental; Hydrocortisone; Liver; Metabolism; Microsomes; NADP; Rats; Research; Testosterone

Topics: 17-Ketosteroids; Adrenal Glands; Blood Glucose; Butter; Cholesterol; Diabetes Mellitus; Diet, Diabetic; Eosinophils; Glucose; Growth Hormone; Human Growth Hormone; Humans; Leukocyte Count; Meat; Physiology; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Acidosis; Acromegaly; Basal Metabolism; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetic Ketoacidosis; Hand; Humans; Paresthesia; Radiotherapy; Visual Field Tests

Topics: 17-Ketosteroids; Chorionic Gonadotropin; Diabetes Mellitus; Follicle Stimulating Hormone; Gastrointestinal Hemorrhage; Goiter; Gonadotropins; Gynecomastia; Heart Failure; Hemochromatosis; Hepatomegaly; Humans; Hypogonadism; Hypopituitarism; Iodine Isotopes; Liver Cirrhosis; Liver Diseases; Male; Myocarditis; Pancreatitis; Steroids; Urine

Topics: 17-Ketosteroids; Blood Proteins; Cerebrovascular Disorders; Diabetes Mellitus; Ethnology; Genetics, Medical; Geriatrics; Glycosuria; Health Surveys; Heart Diseases; Humans; Hypercholesterolemia; India; Sex; South Africa; Uric Acid

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Diabetes Mellitus; Diabetic Retinopathy; Pregnancy; Urine

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Black People; Diabetes Mellitus; Diabetic Retinopathy; Humans; Research; Sex; Urine; White People

Topics: 17-Ketosteroids; Androgens; Androsterone; Diabetes Mellitus; Erectile Dysfunction; Gonadotropins; Humans; Male; Metabolism; Testis; Testosterone; Urine

Topics: 17-Ketosteroids; Animals; Body Fluids; Diabetes Mellitus; Endopeptidases; Female; Humans; Parents; Parturition; Rabbits; Rats; Rats, Wistar

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Diabetes Complications; Diabetes Mellitus; Humans; Hypogonadism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Diabetes Mellitus

Topics: 17-Ketosteroids; Diabetes Mellitus; Humans

Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Diseases; Diabetes Mellitus; Humans

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Diabetes Mellitus; Gonadotropins; Hormones; Humans

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Diabetes Mellitus; Humans

Topics: 17-Ketosteroids; Body Fluids; Cortisone; Diabetes Mellitus; Humans; Steroids; Urinary Tract

Topics: 17-Ketosteroids; Body Fluids; Desoxycorticosterone; Diabetes Mellitus; Humans; Pituitary Gland

Topics: 17-Ketosteroids; Carbohydrate Metabolism; Carbohydrates; Diabetes Mellitus; Hormones

Topics: 17-Ketosteroids; Biological Transport; Body Fluids; Diabetes Mellitus; Hormones; Hypoglycemic Agents

Topics: 17-Ketosteroids; Biological Transport; Body Fluids; Cortisone; Diabetes Mellitus; Humans; Steroids; Urine

Topics: 17-Ketosteroids; Body Fluids; Diabetes Mellitus; Steroids; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Body Fluids; Diabetes Mellitus; Infant, Newborn; Mothers; Steroids; Urine

Topics: 17-Ketosteroids; Diabetes Mellitus; Eosinophils; Estrogens; Hypopituitarism; Leukocyte Count; Pituitary Diseases; Pituitary Gland; Steroids

Topics: 17-Ketosteroids; Adrenal Cortex; Aldehydes; Diabetes Mellitus; Liver Function Tests; Steroids