17-ketosteroids and Diabetes-Mellitus--Type-1

The cortisol secretion rate was determined in 18 children according to a modified and simplified method. In 7 cases the determination was repeated after stimulation with synthetic ACTH. 12 of these children suffered from diseases which may affect glucocorticoidsteroid production and the remaining 6 children served as normal controls. In some cases the plasma 11-hydrocorticoid level and urinary excretion of 17-ketogenic steroids were additionally determined. Differences in adrenal function were noted in 2 patients with congenital adrenal hyperplasia (one of the salt-losing type, the other nonsalt-losing type) and 5 patients with adrenal insufficiency. A normal cortisol secretion rate was found in 3 children with diverse disturbances of carbohydrate metabolism, as well as in a child with subtotal adrenalectomy. The clinical value of the determination of the cortisol secretion rate is discussed and was found to be a more reliable indicator of glucocorticoid activity than other parameters.

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenalectomy; Adult; Child; Cosyntropin; Diabetes Mellitus, Type 1; Female; Humans; Hydrocortisone; Secretory Rate; Stimulation, Chemical

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child; Depression, Chemical; Dexamethasone; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dwarfism; Face; Female; Growth Hormone; Hepatomegaly; Humans; Hydrocortisone; Insulin; Metyrapone; Obesity; Syndrome

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Diabetes Mellitus, Type 1; Female; Humans; Menarche

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Delayed-Action Preparations; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diet, Diabetic; Dwarfism; Face; Female; Follow-Up Studies; Glycosuria; Hepatomegaly; Humans; Insulin; Obesity; Syndrome

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Child; Diabetes Mellitus, Type 1; Female; Humans; Male

Topics: 17-Ketosteroids; Adolescent; Anthropometry; Child; Diabetes Mellitus, Type 1; Diet Therapy; Female; Growth; Humans; Insulin; Male; Puberty; Urine