17-ketosteroids and Coronary-Disease

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Altitude; Animals; Coronary Disease; Heart Defects, Congenital; Humans; Hypoxia

The antiarrhythmic activity of the aminosteroid Org 6001 was investigated in young pigs (20-28 kg). Ventricular arrhythmias were induced by restriction of the flow in the left anterior descending coronary artery (LAD) to 25% of its control value during a period of 30 minutes. Nine out of 30 control animals died in this period due to ventricular fibrillation. None of the 19 animals treated with Org 6001 (5-10 mg/kg) or the 12 animals treated with lidocaine (2.75-3.50 mg/kg) fibrillated. Moreover, the number of premature ventricular beats was greatly reduced in pretreated groups compared with the untreated group (P less than .001). The first derivative of left ventricular pressure decreased with 25% (P less than 0.001) after administration of Org 6001. However, during 30 minutes of LAD flow reduction to 25% of control, the adverse effects of Org 6001 were less than those of lidocaine. Myocardial lactate production indicated some delay in onset of ischemia. However, there was no indication that this beneficial effect was long-lasting. When after 30 minutes of LAD flow reduction to 25% of control, the LAD was completely occluded between its second and third branch, all untreated animals fibrillated within 120 minutes, whereas 4 of the 19 animals treated with Org 6001 and 3 of the 12 treated with lidocaine survived. It is concluded that Org 6001 has antiarrhythmic properties in the ischemic pig heart which compare favorably with those of lidocaine.

Topics: 17-Ketosteroids; Androstanes; Animals; Anti-Arrhythmia Agents; Blood Gas Analysis; Coronary Disease; Hemodynamics; Lactates; Lidocaine; Myocardium; Potassium; Swine

Topics: 17-Ketosteroids; Adult; Aged; Coronary Disease; Female; Humans; Lipid Metabolism; Male; Middle Aged

Blood plasma cholesterol and triglycides concentration lipids composition of lipoproteins as contrasted to the amount of 17-KS and their hormonally active fractions excreted were investigated in 87 patients with myocardial infarction in their history and in 49 practically healthy individuals with no clinical manifestations of ischemic heart disease. In patients with coronary atherosclerosis exhibiting normal blood plasma lipids level, the excretion of 17-KS and of their fractions did not differ from that in healthy individuals. Patients with hyperlipoproteinemia of the IIa, IIb and IV types demonstrated a significantly reduced excretion of 17-KS, etiocholanolone, androsterone and dehydroepiandrosterone. No differences in the excretion of androgens depending upon the type of hyperlipoproteinemia were recorded. A significant negative correlation between the blood plasma cholesterol concentration and the amount of ethocholanolone excreted, the level of hypertriglyceridemin and the passage of dehydroepiandrosterone with urine was noted. In patients with hyperlipoproteinemia and a reduced androgens excretion a deranged lipids composition of lipoproteins was disclosed. A decrease in the amount of androgens leads to disruption of the synthesis and metabolism of lipoproteins and exerts a marked influence on the emergence and further development of hyperlipoproteinemia.

Topics: 17-Ketosteroids; Adult; Cholesterol; Coronary Disease; Humans; Hyperlipidemias; Lipoproteins; Lipoproteins, LDL; Male; Middle Aged; Triglycerides

A moderate elevation of the daily excretion of free noradrenaline and adrenalin is observed in chronic circulatory insufficiency, beginning with Stage IIA. The catecholamines metabolism is elevated, as shown by the daily excretion of normethanpherine and methanpherine and of vanillyl-mandelic acid. The activity of renin and angiotensinases was growing along with the progressing cardiac insufficiency. The blood level of angiotensinogen was decreasing, especially in patients with Stage IIB and III of decompensation. The daily excretion of aldosterone was growing along with the development of cardiac insufficiency. The functional state of the glucocorticoid function of the adrenal cortex was of a phased nature in cases of circulatory insufficiency. The study of the functional state of the epiphysis was conducted by way of determining the blood level of melatonine and of its daily excretion. In Stages I and IIA the level of this hormone was clearly elevated, in Stages IIB and III -- decreased as compared with the initial and normal levels. The plasma level of the antidiuretic hormone was distinctly growing, beginning with Stage IIB, reaching its maximal values in Stage III.

Topics: 17-Ketosteroids; Adult; Aged; Aldosterone; Angiotensinogen; Coronary Disease; Cortisone; Endopeptidases; Epinephrine; Female; Heart Failure; Humans; Hydrocortisone; Hypertension; Male; Melatonin; Metanephrine; Middle Aged; Norepinephrine; Normetanephrine; Renin; Tetrahydrocortisol; Tetrahydrocortisone; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androsterone; Arteriosclerosis; Blood Protein Electrophoresis; Chromatography, Thin Layer; Coronary Disease; Electrophoresis, Polyacrylamide Gel; Humans; Hydrocortisone; Hyperlipidemias; Lipoproteins; Male

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Arteriosclerosis; Cholesterol; Coronary Disease; Glycosaminoglycans; Hexoses; Humans; Lipoproteins; Neuraminic Acids; Protein Binding

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Catecholamines; Cholesterol; Coronary Disease; Dehydroepiandrosterone; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Stress, Psychological; Sympathetic Nervous System; Triglycerides

Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Coronary Disease; Estrogens; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Coronary Disease; Humans; Male; Methyltestosterone; Middle Aged

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Arteriosclerosis; Chromatography, Thin Layer; Coronary Disease; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Genital Diseases, Female; Humans; Hydroxycorticosteroids; Leiomyoma; Menstruation Disturbances; Middle Aged; Ovarian Diseases; Parametritis; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Arteriosclerosis; Arthritis, Rheumatoid; Cholelithiasis; Cholesterol; Coronary Disease; Cushing Syndrome; Epinephrine; Fibrinolysis; Heparin; Humans; Lipoproteins; Liver Cirrhosis; Middle Aged; Neuraminic Acids; Norepinephrine; Pulse

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Androgens; Androsterone; Arteriosclerosis; Chromatography, Thin Layer; Coronary Disease; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Glucocorticoids; Humans; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Chromatography, Thin Layer; Chronic Disease; Coronary Disease; Glucocorticoids; Humans; Male; Methods; Middle Aged; Myocardial Infarction; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Angina Pectoris; Coronary Disease; Humans; Middle Aged; Myocardial Infarction

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Blood Proteins; Coronary Disease; Dehydroepiandrosterone; Female; Heart Failure; Humans; Male; Methods

Topics: 17-Ketosteroids; Adult; Age Factors; Androsterone; Arteriosclerosis; Coronary Disease; Dehydroepiandrosterone; Etiocholanolone; Humans; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Aged; Androgens; Arteriosclerosis; Coronary Disease; Erythrocytes; Female; Glucocorticoids; Humans; Hypernatremia; Hypokalemia; Male; Middle Aged; Mineralocorticoids; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Angiography; Chronic Disease; Coronary Disease; Electrocardiography; Female; Humans; Male; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System

Topics: 17-Ketosteroids; Adolescent; Adult; Androsterone; Cholesterol; Coronary Disease; Female; Glomerular Filtration Rate; Glucosephosphate Dehydrogenase; Humans; Male; Middle Aged; Phospholipids; Uric Acid

Topics: 17-Ketosteroids; Adult; Androsterone; Coronary Disease; Dehydroepiandrosterone; Etiocholanolone; Humans; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androgens; Catecholamines; Coronary Disease; Humans

Topics: 17-Ketosteroids; Adult; Alpha-Globulins; Beta-Globulins; Blood Pressure; Blood Protein Electrophoresis; Body Weight; Coronary Disease; gamma-Globulins; Humans; Hypercholesterolemia; Male; Middle Aged; Phospholipids; Serum Albumin; Uric Acid

Topics: 17-Ketosteroids; Animals; Arteriosclerosis; Catecholamines; Cholesterol; Coronary Disease; Electrocardiography; Female; Male; Stress, Physiological

Topics: 17-Ketosteroids; Biomedical Research; Coronary Disease; Edema; Heart Failure; Heparin; Humans; Natriuresis; Pharmacology; Potassium; Urine; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Androgens; Chromatography; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Metabolism; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Body Fluids; Catecholamines; Coronary Artery Disease; Coronary Disease; Humans; Incidence; Indoles; Male