17-ketosteroids and Choriocarcinoma

Topics: 17-Ketosteroids; Age Factors; Body Height; Brain Diseases; Choriocarcinoma; Dysgerminoma; Ejaculation; Female; Granulosa Cell Tumor; Humans; Hydrocephalus; Male; Menarche; Ovarian Neoplasms; Ovulation; Pregnancy; Prognosis; Psychosexual Development; Puberty, Precocious; Reproduction; Sex Factors; Teratoma; Testicular Neoplasms; Thecoma

Androgen binding proteins (ABP) have not been described in the ovary. We have studied cyst fluids from three patients with the Polycystic Ovary Syndrome and one patient with choriocarcinoma for the presence of ABP. All contained a high affinity, low capacity binding protein for dihydrotestosterone and 17beta-estradiol. Comparison of this protein with the plasma androgen binding protein (TeBG) in polyacrylamide gel electrophoresis and equilibrium dialysis did not reveal any significant differences in molecular size (Kg) net charge (Yo), radius R, molecular weight (mol wt), heat stability, steroid specificity, or binding affinity (Ka). Cyst fluid and plasma could not be distinguished from each other on the basis of protein composition as measured by cellulose acetate electrophoresis. In the one patient studied, the binding capacity for DHT in cyst fluid and plasma was 58.1 and 16.1 ng/Gm protein, respectively.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Blood Proteins; Choriocarcinoma; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Polycystic Ovary Syndrome; Pregnancy; Receptors, Androgen; Receptors, Steroid; Testosterone; Uterine Neoplasms

Topics: 17-Ketosteroids; Cerebral Ventricle Neoplasms; Child; Choriocarcinoma; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Hydroxysteroids; Luteinizing Hormone; Male; Pregnancy; Progesterone; Puberty, Precocious; Radioimmunoassay; Testosterone; Thyrotropin; Thyroxine

Systematic investigations of the chorionic gonadotropin excretion were performed in 79 patients with testicular tumours. The influence of the hormonal activity in diagnosis and prognosis of metastatic testicular tumours was investigated. It was discovered, that the part of hormonal active testicular tumours is relatively small and that the evidence of the chorionic gonadotropin excretion is only possible in a few cases before the clinical and radiological evidence of metastases. The hormonal activity of testicular tumours is without influence on the survival time of tumour carriers.

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Antineoplastic Agents; Choriocarcinoma; Chorionic Gonadotropin; Dysgerminoma; Hormones, Ectopic; Humans; Male; Sarcoma; Teratoma; Testicular Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Castration; Child; Choriocarcinoma; Chorionic Gonadotropin; Estrogens; Female; Follicle Stimulating Hormone; Glucocorticoids; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Hysterectomy; Neoplasm Metastasis; Pregnancy; Pregnanediol; Trophoblastic Neoplasms

Topics: 17-Ketosteroids; Aged; Androstanes; Carbon Isotopes; Carcinoma; Choriocarcinoma; Endometrium; Estradiol; Estriol; Estrone; Female; Humans; Middle Aged; Pregnancy; Tritium; Uterine Neoplasms

Topics: 17-Ketosteroids; Androstanes; Cell Line; Choriocarcinoma; Chromatography; Culture Techniques; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Female; Humans; Pregnancy; Silicon Dioxide; Tritium; Trophoblastic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Choriocarcinoma; Chorionic Gonadotropin; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hydatidiform Mole; Pregnancy; Pregnanediol; Thyroid Function Tests; Thyrotropin; Uterine Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Choriocarcinoma; Chorionic Gonadotropin; Cytodiagnosis; Estrogens; Female; Humans; Hydatidiform Mole; Hysterectomy; Middle Aged; Ovarian Neoplasms; Ovary; Pregnancy; Pregnanediol; Pregnanetriol; Uterine Neoplasms; Vaginal Smears

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Choriocarcinoma; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Male; Ovarian Neoplasms; Pituitary Gland; Pregnancy; Thyroid Gland; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Choriocarcinoma; Chorionic Gonadotropin; Chromatography; Female; Gonadotropins; Growth Hormone; Gynecomastia; Humans; Iodine Isotopes; Male; Placental Hormones; Placental Lactogen; Pregnancy; Radioimmunoassay; Testicular Neoplasms; Urine

Topics: 17-Ketosteroids; Animals; Carcinoma; Choriocarcinoma; Chromatography; Female; Humans; Hydatidiform Mole; Moles; Neoplasms, Glandular and Epithelial; Pregnancy