17-ketosteroids and Cerebrovascular-Disorders

Stress response measured as the cortisol secretion rate as well as urinary 17 oxogenic steroid (17 OGS) and 17 oxosteroid (17 OS) excretion was investigated in a group of 28 patients with stroke (11 with hypertensive intracerebral hemorrhage and 17 with ischemic cerebrovascular insult). Significantly higher cortisol secretion values were found in the group of patients who died (p less than 0.01). Similarly, the first day urinary 17 OGS excretion pointed to the greater adrenocortical response in patients who died (p less than 0.05). Urinary 17 OS excretion was normal or below normal in the majority of patients and no difference was found between either male or female patients who survived or died. Our findings indicate that adrenocortical changes which maximize the production of cortisol are operative soon after the onset of stroke. The cortisol secretion rate appeared to be a good indicator of the severity of the stress caused by stroke and may be useful in predicting the prognosis of the illness.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Cerebrovascular Disorders; Female; Humans; Hydrocortisone; Male; Middle Aged; Stress, Physiological

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Cerebrovascular Disorders; Cervical Vertebrae; Humans; Osteochondritis

The indices of glucocorticoid and androgen activity in the adrenal cortex (the level of circulating eosinophils, the daily urine excretion of 17 OCS and 17 CS) and the functional reserve after an ACTH loading was studied in 2 groups of patients with disorders of cerebral circulation under 45 years of age (247 cases) and over 55 (234 cases). In the acute period of a cerebral stroke there was an increase of the glucocorticoid activity which was more definitely expressed in the younger group and a certain inhibition of the androgen function seen mainly in the older group. In transient disorders of cerebral circulation significant age difference in the functioning of the adrenal cortex was not established. In the period following a stroke the established and potential reserves of the adrenocortical glands were distinctly decreased in patients above 55 years and practically unchanged in the younger group.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adrenal Cortex; Adrenal Glands; Adult; Age Factors; Cerebrovascular Disorders; Eosinophils; Humans; Ischemic Attack, Transient; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Alpha-Globulins; Anabolic Agents; Arteriosclerosis; Beta-Globulins; Cerebrovascular Disorders; Female; gamma-Globulins; Humans; Hypertension; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Aged; Arteriosclerosis; Cerebrovascular Disorders; Dehydroepiandrosterone; Erythrocytes; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Sodium

Topics: 17-Ketosteroids; Aged; Blood Cell Count; Cerebrovascular Disorders; Eosinophils; Female; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Cerebrovascular Disorders; Dexamethasone; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Metyrapone; Pituitary-Adrenal System

Topics: 17-Ketosteroids; Adrenal Glands; Adult; Aged; Blood Cell Count; Cerebrovascular Disorders; Eosinophils; Female; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adrenal Glands; Aged; Cerebral Hemorrhage; Cerebrovascular Disorders; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Natriuresis; Pituitary-Adrenal Function Tests; Potassium; Sodium; Water-Electrolyte Balance

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Cerebrovascular Disorders; Circadian Rhythm; Creatinine; Diffuse Cerebral Sclerosis of Schilder; Encephalitis; Female; Humans; Middle Aged; Potassium; Sodium; Tuberculosis, Meningeal; Urination Disorders; Vasopressins; Water-Electrolyte Balance

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocortical Hyperfunction; Cerebrovascular Disorders; Glucocorticoids; Humans; Hypertension; Methods; Pituitary-Adrenal Function Tests; Potassium; Sodium

Topics: 17-Ketosteroids; Acute Disease; Adrenal Glands; Cerebral Hemorrhage; Cerebrovascular Disorders; Encephalomalacia; Eosinophils; Humans; Hypertension; Intracranial Arteriosclerosis; Intracranial Embolism and Thrombosis; Rheumatic Diseases; Syphilis, Cardiovascular

Topics: 17-Ketosteroids; Acute Disease; Adrenal Glands; Adult; Cerebrovascular Circulation; Cerebrovascular Disorders; Eosinophils; Female; Humans; Male; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Adrenal Glands; Aged; Animals; Cerebrovascular Disorders; Dogs; Humans; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Biomedical Research; Blood; Cerebrovascular Disorders; Geriatrics; Humans; Metyrapone; Physiology; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Stroke; Urine

Topics: 17-Ketosteroids; Blood Proteins; Cerebrovascular Disorders; Diabetes Mellitus; Ethnology; Genetics, Medical; Geriatrics; Glycosuria; Health Surveys; Heart Diseases; Humans; Hypercholesterolemia; India; Sex; South Africa; Uric Acid