17-ketosteroids and Carcinoma--Bronchogenic

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aged; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Bronchogenic; Humans; Male; Melanocyte-Stimulating Hormones; Microscopy, Electron; Middle Aged; Serotonin

Four cases of bronchial carcinoma were observed which showed the picture of an ectopic ACTH-hormone syndrome. References to an endocrinopathy resulted from the hypopotassaemia and the metabolic alkalosis. Signs of Cushing's syndrome appeared only in one case. By disturbances of the electrolyte and acid-base-balance the functions of the skeletal and smooth musculature as well as of the heart muscle were much impaired. In two cases the clinical symptoms and the laboratory findings still before the manifestation of the bronchial carcinoma, in the third case simultaneously referred to the correct diagnosis. Due to the misleading cardiac findings and the fulminant course of the disease in the fourth case the diagnosis was clarified only by autopsy. the disturbances of the ion balance and of the metabolism had contributed to the respiratory insufficiency, had evoked disturbances of the cardiac rhythm and had unfavourably effected on the course of of the disease.

Topics: 17-Ketosteroids; Acid-Base Imbalance; Adrenocorticotropic Hormone; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Lung Neoplasms; Male; Middle Aged; Smoking; Water-Electrolyte Imbalance

Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Male; Middle Aged; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Autopsy; Biological Assay; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Circadian Rhythm; Dexamethasone; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Lung Neoplasms; Male; Microscopy, Electron; Middle Aged; Radioimmunoassay; Serotonin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Alkaline Phosphatase; Androgens; Autopsy; Carcinoma; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Estrogens; Growth Hormone; Gynecomastia; Hormones, Ectopic; Humans; Immunoassay; Lung Neoplasms; Male; Neoplasm Metastasis; Placental Hormones; Placental Lactogen; Thyroid Function Tests

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Alkalosis; Carcinoma, Bronchogenic; Corticosterone; Cushing Syndrome; Deficiency Diseases; Desoxycorticosterone; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Pancreatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Carcinoma, Bronchogenic; Dexamethasone; Female; Hormones, Ectopic; Humans; Lung Neoplasms; Middle Aged

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Androgens; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, Thin Layer; Cushing Syndrome; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocortical Hyperfunction; Aged; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Estrogens; Female; Hormones; Humans; Hydrocortisone; Lung Neoplasms; Male; Middle Aged; Pituitary-Adrenal Function Tests; Sex Factors; Steroids

Five patients with bronchogenic carcinoma associated with adrenocortical hyperfunction are described. The clinical features, laboratory studies and autopsy findings are discussed and compared with previously reported cases. Four patients presented most of the typical features of this disorder as previously described, whereas the fifth was atypical in some respects. Typical features included: acute onset of adrenocortical hyperfunction in a middle-aged male, rapid downhill course, slight or absent physical signs of Cushing's syndrome, frequently impaired glucose tolerance, markedly elevated plasma and urinary 17-hydroxycorticosteroids not suppressed by exogenous steroids, absent diurnal variation of plasma corticoids, hypokalemic alkalosis with normal aldosterone excretion, and tumour histology of the oat cell variety. The adrenal glands of two patients were of normal or slightly increased weight, and mean 17-ketosteroid excretion values were normal in three; this contrasts with the marked increase in adrenal weight and 17-ketosteroid excretion in most reported cases.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Alkalosis; Autopsy; Blood; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Glucose Tolerance Test; Humans; Hypokalemia; Lung Neoplasms; Male; Middle Aged; Urine

Topics: 17-Ketosteroids; Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Asthma; Carcinoma, Bronchogenic; Coccidioidomycosis; Cushing Syndrome; Diabetes Mellitus; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Hyperaldosteronism; Hypopituitarism; Hypotension; Myocardial Infarction; Neurotic Disorders; Pituitary Neoplasms; Polycystic Ovary Syndrome

Topics: 17-Ketosteroids; Animals; Carbon Isotopes; Carcinoma, Bronchogenic; Chromatography; Etiocholanolone; Hodgkin Disease; Hydroxylation; Infrared Rays; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Metabolism; Mixed Function Oxygenases; Multiple Myeloma; Penicillium; Pharmacology; Sarcoma; Steroids; Testosterone; Urine

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androgens; Androsterone; Carcinoma; Carcinoma, Bronchogenic; Chromatography; Cushing Syndrome; Dehydroepiandrosterone; Etiocholanolone; Geriatrics; Humans; Kidney Function Tests; Neoplasms