17-ketosteroids and Burns

Topics: 17-Ketosteroids; Adenosine Triphosphate; Adrenal Cortex Hormones; Burns; Citric Acid Cycle; Glucocorticoids; Glutarates; Hibernation; Humans; Hypothermia, Induced; Metabolism; Pharmacology; Proteins; Pyruvates; Water-Electrolyte Balance

The effects of burn trauma in men on the production of adrenal and testicular steroids was investigated. Whereas there were significant increases in serum cortisol levels and urinary 17-hydroxycorticosteroid excretion soon after thermal injury, there were significant decreases in serum dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, and testosterone concentrations during the first 4 weeks following burn trauma. Serum androstenediol and androstenediol sulfate levels also were reduced, though insignificantly, 10-23 days postburn. Serum LH levels were unchanged during the postburn interval. Since urinary 17-ketosteroid excretion was normal or below normal rather than increased, the decline in serum C19-steroid levels probably resulted from decreased glandular secretion rather than increased rates of metabolism and excretion. Low dehydroepiandrosterone sulfate and/or testosterone levels were found in some men several months after recovery from their burns. These data suggest that thermal injury leads to acute inhibition of adrenal and testicular C19-steroid secretion, but stimulation of adrenal glucocorticosteroid production, and that endocrine function in many instances is not normalized after complete healing of the burned surfaces. The mechanisms and physiological consequences of such changes in the steroid milieu of men after burn trauma are unknown.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Androstenedione; Burns; Dehydroepiandrosterone; Humans; Hydrocortisone; Male; Testosterone

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Burns; Circadian Rhythm; Humans; Middle Aged; Shock, Traumatic

Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Burns; Catecholamines; Humans; Middle Aged; Pituitary-Adrenal System

Topics: 17-Ketosteroids; Adult; Androsterone; Burns; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Burns; Endopeptidases; Gastric Juice; Humans; Occult Blood

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adult; Burns; Female; Humans; Hydrocortisone; Male; Transcortin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Burns; Humans; Pituitary-Adrenal System; Skin Transplantation; Transplantation, Autologous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Blood Pressure; Body Temperature; Burns; Catecholamines; Child; Child, Preschool; Female; Hematocrit; Humans; Hypertension; Infant; Male

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anabolic Agents; Burns; Calcium; Calcium, Dietary; Hormones; Humans; Phosphorus; Phosphorus, Dietary; Potassium; Steroids; Urine

Topics: 17-Ketosteroids; Burns; Burns, Chemical; Caustics; Eosinophils; Leukocyte Count; Steroids