17-ketosteroids and Breast-Neoplasms

17-ketosteroids has been researched along with Breast-Neoplasms* in 178 studies

Reviews

9 review(s) available for 17-ketosteroids and Breast-Neoplasms

ArticleYear
Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland.
    Molecular and cellular endocrinology, 1985, Volume: 41, Issue:1

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Aging; Aldehyde-Lyases; Androgens; Androstenediol; Animals; Anorexia Nervosa; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrogens; Fasting; Female; Glucocorticoids; Humans; Hypophysectomy; Japan; Menopause; Middle Aged; Obesity; Prolactin; Puberty; Steroid 17-alpha-Hydroxylase; Stress, Physiological; Sulfotransferases; Sulfurtransferases; Surgical Procedures, Operative; United States

1985
[Intracellular and extracellular proteins binding androgenic hormones. Biochemical properties and clinical significance].
    Minerva medica, 1983, Mar-17, Volume: 74, Issue:11

    This paper has been designed to review some current concepts about biochemistry, pathophysiology and clinics of androgen-binding proteins, both TeBG and cellular receptors. Some important experimental models to clarify the interactions between androgens and target cells are mentioned. Further, major clinical applications in which binding parameters were or will be of great importance are discussed in details.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androgen-Binding Protein; Androgen-Insensitivity Syndrome; Breast Neoplasms; Carrier Proteins; Danazol; Disorders of Sex Development; Female; Humans; Hyperthyroidism; Infertility, Male; Liver Cirrhosis; Male; Minoxidil; Receptors, Androgen; Sex Hormone-Binding Globulin; Spironolactone

1983
The role of hormones in the etiology of human breast cancer.
    Cancer, 1977, Volume: 39, Issue:6 Suppl

    Topics: 17-Ketosteroids; Androgens; Androsterone; Breast Neoplasms; Contraceptives, Oral, Hormonal; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hypothyroidism; Menopause; Menstruation; Progesterone; Prolactin; Thyroid Hormones

1977
Ablation therapy for hormone-dependent tumors.
    Annual review of medicine, 1972, Volume: 23

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Animals; Breast Neoplasms; Castration; Cortisone; Diabetes Insipidus; Endocrine Glands; Estrogens; Female; Growth Hormone; Humans; Hypophysectomy; Hypothyroidism; Mastectomy; Menopause; Menstruation; Ovary; Prolactin; Protein Binding; Receptors, Cell Surface; Sulfurtransferases; Time Factors

1972
Biochemical procedures in different forms of cancer.
    The Medical clinics of North America, 1971, Volume: 55, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acid Phosphatase; Adrenal Gland Neoplasms; Alkaline Phosphatase; Amino Acids; Amylases; Bone Neoplasms; Breast Neoplasms; Carcinoid Tumor; Catecholamines; Chorionic Gonadotropin; Clinical Enzyme Tests; Clinical Laboratory Techniques; Female; Glucose-6-Phosphate Isomerase; Humans; Hydroxyindoleacetic Acid; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Neoplasms; Neoplasms, Nerve Tissue; Neuroblastoma; Nucleotidases; Pancreatic Neoplasms; Pheochromocytoma; Pregnancy; Prostatic Neoplasms; Trophoblastic Neoplasms; Vanilmandelic Acid

1971
[Steroids and breast cancer. Pharmacologic and therapeutic introduction].
    Minerva ginecologica, 1970, Jul-15, Volume: 22, Issue:13

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Age Factors; Breast Neoplasms; Castration; Cortisone; Estrogens; Female; Gonadotropins; Humans; Hypophysectomy; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis; Pituitary Hormones, Anterior; Steroids

1970
[Steroid changes in malignant mastopathy].
    Studii si cercetari de endocrinologie, 1970, Volume: 21, Issue:5

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Breast Neoplasms; Estradiol; Estriol; Estrogens; Etiocholanolone; Female; Humans; Steroids

1970
[Adrenalectomy as a therapeutic method of progressive mammary cancer].
    Geka chiryo. Surgical therapy, 1969, Volume: 21, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Aged; Breast Neoplasms; Estrogens; Gonadotropins; Humans; Hypophysectomy; Methods; Middle Aged; Postoperative Care; Preoperative Care; Prolactin

1969
SELECTIVE CRITERIA FOR SURGICAL REMOVAL OF THE ENDOCRINE GLANDS IN ADVANCED BREAST CANCER.
    Surgery, gynecology & obstetrics, 1965, Volume: 120

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Androgens; Breast Neoplasms; Calcium; Castration; Drug Therapy; Endocrine Glands; Estrogens; Glucuronidase; Humans; Hypophysectomy; Mastectomy; Metabolism; Neoplasm Metastasis; Neoplasms; Urine

1965

Trials

2 trial(s) available for 17-ketosteroids and Breast-Neoplasms

ArticleYear
Adrenal function in patients treated with testosterone and fluorinated pyrimidines.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:2

    Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Clinical Trials as Topic; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Rectal Neoplasms; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Testosterone

1968
Hormonal therapy in cancer of the breast. XXIV. Effect of corticosterone or medroxyprogesterone acetate on clinical course and hormonal excretion.
    Cancer, 1967, Volume: 20, Issue:10

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Calcium; Clinical Trials as Topic; Corticosterone; Creatinine; Female; Gonadotropins; Humans; Luteinizing Hormone; Medroxyprogesterone; Neoplasm Metastasis; Potassium Chloride; Pregnanediol; Tetrazolium Salts

1967

Other Studies

167 other study(ies) available for 17-ketosteroids and Breast-Neoplasms

ArticleYear
New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death.
    BMC cell biology, 2008, Jul-24, Volume: 9

    Aromatase, the cytochrome P-450 enzyme (CYP19) responsible for estrogen biosynthesis, is an important target for the treatment of estrogen-dependent breast cancer. In fact, the use of synthetic aromatase inhibitors (AI), which induce suppression of estrogen synthesis, has shown to be an effective alternative to the classical tamoxifen for the treatment of postmenopausal patients with ER-positive breast cancer. New AIs obtained, in our laboratory, by modification of the A and D-rings of the natural substrate of aromatase, compounds 3a and 4a, showed previously to efficiently suppress aromatase activity in placental microsomes. In the present study we have investigated the effects of these compounds on cell proliferation, cell cycle progression and induction of cell death using the estrogen-dependent human breast cancer cell line stably transfected with the aromatase gene, MCF-7 aro cells.. The new steroids inhibit hormone-dependent proliferation of MCF-7aro cells in a time and dose-dependent manner, causing cell cycle arrest in G0/G1 phase and inducing cell death with features of apoptosis and autophagic cell death.. Our in vitro studies showed that the two steroidal AIs, 3a and 4a, are potent inhibitors of breast cancer cell proliferation. Moreover, it was also shown that the antiproliferative effects of these two steroids on MCF-7aro cells are mediated by disrupting cell cycle progression, through cell cycle arrest in G0/G1 phase and induction of cell death, being the dominant mechanism autophagic cell death. Our results are important for the elucidation of the cellular effects of steroidal AIs on breast cancer.

    Topics: 17-Ketosteroids; Androstanes; Animals; Aromatase; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; DNA; Dose-Response Relationship, Drug; Estrogens; Female; Humans; Molecular Structure; Neoplasms, Hormone-Dependent; Postmenopause; Receptors, Estrogen; Steroids; Vacuoles

2008
[Hormonal profiles and structures in normal women and in patients with benign and malignant breast diseases].
    Nihon Gan Chiryo Gakkai shi, 1984, Jun-20, Volume: 19, Issue:5

    Topics: 17-Ketosteroids; Adult; Breast Diseases; Breast Neoplasms; Estradiol; Female; Humans; Hydrocortisone; Middle Aged; Progesterone; Prolactin; Thyrotropin; Thyroxine

1984
[Evaluation of the immunological reactivity and hormonal profile in patients with breast cancer].
    Voprosy onkologii, 1984, Volume: 30, Issue:12

    Excretion of 17-HOCS and estrogens as well as the levels of E-RFC and time-delayed DNCB and tuberculin (PPD) contact sensitization reaction were studied in 136 breast cancer patients. A decrease in immunological response in reproductive and menopausal patients was matched by the development of relative hyperestrogenism and elevation of 17-HOCS excretion in the former group and a rise in 17-HOCS excretion only in the latter.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Middle Aged; Prognosis; Rosette Formation; Tuberculin Test

1984
Some aspects of the endocrine status in the inflammatory breast carcinoma (Mastitis carcinosa).
    Archiv fur Geschwulstforschung, 1982, Volume: 52, Issue:1

    The main endocrine features in a group of 87 patients with inflammatory breast carcinoma with very rapid evolution (group I) and those of 400 patients with breast cancer with no inflammatory signs (group II) have been compared. The mean age at menarche showed a significantly higher degree in group I, where the later menarche was reported in 36.8% of cases (greater than or less than 16 years). The mean number of abortions has been decreased in the same groups. No significant differences regarding to parity, lactation and mean age of the menopause have been found in these two groups. The mean values for total urinary estrogens were significantly higher in group I. The main fractions of 17-ketosteroids were estimated in 60 women of group I and 61 women of group II. The mean levels of these hormones were more decreased in group I, the most significantly differences in these two groups were registered for ethiocholanolone. In the most cases with decreased levels of ethiocholanolone, the survival time was also shorter. Such data showed a more prominent endocrine imbalance in the inflammatory breast carcinoma in comparison with breast cancer patients of normal evolution.

    Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Estrogens; Etiocholanolone; Female; Humans; Mastitis; Menarche; Menopause; Middle Aged; Pregnancy

1982
Predicting treatment response in breast cancer using urinary discriminant ratio and receptor assay.
    European journal of cancer & clinical oncology, 1981, Volume: 17, Issue:12

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Receptors, Estrogen; Receptors, Progesterone

1981
[Steroid balance in breast cancers of varying histological structure].
    Voprosy onkologii, 1980, Volume: 26, Issue:9

    Patients with breast cancer in stage I--II of various histological structure showed varied hormonal disturbances. In adenocarcinoma a high level of classic estrogens or total phenolsteroids was noted. In low differentiated cancers (solid, scirrhus) the values of estrogens excretion were considerably lower, but, if correlated with other hormones (androsterone), a relative hyperestrogenization is observed. Scirrhous cancers are characterized by the increased 17-ketogenic steroids excretion. The character of hormonal disturbances concomitant with the predominant development of certain breast tumor structures (adenocarcinoma, solid cancer, scirrhus) is identical for the patients being in their reproductive and menopausal period.

    Topics: 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Scirrhous; Adult; Breast Neoplasms; Carcinoma; Estrogens; Female; Gonadotropins; Humans; Menopause; Menstruation; Middle Aged; Steroids; Sterols

1980
Identification of breast cancer patients with high risk of early recurrence after radical mastectomy: III. Steroid hormones measured in urine.
    Cancer, 1980, Sep-01, Volume: 46, Issue:5

    The relationship of the levels of selected urinary steroid metabolites to breast cancer recurrence after radical mastectomy was studied. An analysis of variance of the steroid measurements suggested that the measurements standardized to per gram of creatinine were the appropriate measure to use in exploring these relationships. No significant associations were found for premenopausal patients; however, for postmenopausal patients, low levels of total 17-ketosteroids were associated with a reduced two-year recurrence-free rate whereas low and high levels of OHA and high levels of total estrogens were associated a relatively low high two-year recurrence-free rate. Because of the large number of significance tests performed and the lack of consistent patterns, it is questionable whether the observed associations are of any importance. Including these steroid quantities in a multivariate regression model along with previously determined clinical prognostic factors indicated that the steroid determinations were the least important variables and did not make a significant contribution to the fit of the model.

    Topics: 17-Ketosteroids; Analysis of Variance; Androsterone; Breast Neoplasms; Estrogens; Female; Hormones; Humans; Mastectomy; Menopause; Middle Aged; Neoplasm Recurrence, Local; Risk

1980
Urinary free cortisol, cortisone, cortisol sulfate, cortisone sulfate and 17-ketosteroids in breast cancer.
    Neoplasma, 1979, Volume: 26, Issue:2

    Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hydrocortisone; Middle Aged; Time Factors

1979
Ratio of 11-desoxy 17-oxosteroids to creatinine in a population screened for breast cancer.
    British journal of cancer, 1979, Volume: 39, Issue:6

    During a population-based screening project for breast cancer, almost 15,000 women aged 50 years and over have provided a 12 h (overnight) sample of urine for research purposes. In 3,789 women the excretion of 11-desoxy-17-oxosteroids (DOOS) and creatinine was measured. Results were analysed in terms of urinary concentrations and of a ratio between DOOS and creatinine. Age had an effect on DOOS, creatinine and their ratio. Body weight and body surface area had an effect on creatinine excretion and therefore on the ratio. The following variables did not have an appreciable effect on the above-mentioned ratio: a family history of breast cancer, parity and age at first pregnancy, menopause and oestrogenic drugs, and parenchymal pattern of the breast as observed on the xeromammogram. Breast cancer was found at first screening in 106 out of 14,697 women. In 100 of these cases DOOS and creatinine were measured. Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls. These results lead the authors to the conclusion that the determination of androgen metabolite excretion in women over 50 years of age is of no help in selecting a group at high risk of breast cancer.

    Topics: 17-Ketosteroids; Adult; Age Factors; Body Height; Body Weight; Breast; Breast Neoplasms; Creatinine; Female; Humans; Maternal Age; Menopause; Middle Aged; Parity; Pregnancy

1979
[State of immunological reactivity in breast cancer patients receiving prednisolone treatment].
    Voprosy onkologii, 1979, Volume: 25, Issue:5

    Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Female; Humans; Hydroxysteroids; Hypersensitivity, Delayed; Immunity, Cellular; Leukocyte Count; Lymphocyte Activation; Middle Aged; Prednisolone; Skin Tests; Time Factors

1979
Levels of principal 17-ketosteroid fractions in urine of breast cancer patients with or without malignant evolutive push.
    Archiv fur Geschwulstforschung, 1978, Volume: 48, Issue:6

    The main fractions of 17-ketosteroids were estimated in 102 women with breast cancer. Sixty two patients were cases with rapid evolution (malignant evolutive push) or very rapid evolution (inflammatory breast carcinoma). The mean ethiocholanolone levels and partially androsterone levels were significantly decreased in patients with rapid evolution in comparison with the corresponding values found in patients with breast cancer of slow growth.

    Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Invasiveness

1978
[Glucuronic acid, glucuronyltransferase and estrogens in breast cancer and precancer].
    Voprosy onkologii, 1978, Volume: 24, Issue:10

    The glucuronic acid level in the serum and urine, the diural excretion of estrogens and 17-KS with the urine, the activity of glucuronyltransferase are reported in 101 patients with benign and malignant tumors and in 22 healthy females. The decrease in the activity of glucurolytransferase and increase in the percentage of free (nonconjugated) estrogens in patients with malignant tumors of the mammary gland are noted, the analogous results were obtained in patients with benign tumors, but these are statistically insignificant. The decrease of the glucuronyltransferase activity is suggested to result in the development of relative hyperestrogen in normal total excretion.

    Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Enzyme Activation; Estrogens; Estrogens, Conjugated (USP); Female; Free Radicals; Glucuronates; Glucuronosyltransferase; Humans; Middle Aged; Precancerous Conditions

1978
Prediction of response to adrenalectomy in the treatment of advanced breast cancer.
    Journal of the National Cancer Institute, 1978, Volume: 60, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Aged; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Metastasis; Prognosis; Remission, Spontaneous; Statistics as Topic

1978
Urinary steroid hormones in normal Japanese women and primary breast cancer patients.
    Nihon Gan Chiryo Gakkai shi, 1978, Dec-20, Volume: 13, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Breast Neoplasms; Estrogens; Female; Humans; Japan; Menopause; Middle Aged

1978
Plasma androstenedione levels in women with breast cancer.
    European journal of cancer, 1977, Volume: 13, Issue:2

    Topics: 17-Ketosteroids; Aged; Androstenedione; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis

1977
Steroid hormones and human breast cancer. An hypothesis.
    Cancer, 1977, Volume: 40, Issue:1

    The likely occurrence of two distinct types of human breast cancer is discussed. In the development of the "Western-environmental" or "adrenal" type, it is proposed that dehydroepiandrosterone sulphate (DHEAS), secreted by the adrenal, may be implicated. This steroid is metabolized by mammary tumors to active androgens and estrogens. That these metabolic pathways are very similar to that in skin is emphasized and this is possibly explained by evolution of the mammary gland from primitive sweat glands. Formation of DHEAS from DHEA in mammary tumors, claimed to be correlated with an individual subject's prognosis and response to hormone ablation, is discussed in the light of a possible regulatory role of the sulphotransferase. It is proposed furthermore that a specific control of DHEAS secretion in the adrenal may exist at the level of the sulphurylation step. Nutritional factors are also possibly implicated here and these are discussed in the light of: 1) a possible higher secretion rate of DHEAS in obese subjects; and 2) the low breast cancer incidence in the Japanese and the accompanying low blood DHEAS levels.

    Topics: 17-Ketosteroids; Adrenal Glands; Breast Neoplasms; Cholesterol; Dehydroepiandrosterone; Estradiol; Female; Humans; Japan; Obesity; Skin; Sulfurtransferases; United States

1977
Urinary steroid profiles in normal women and in patients with breast cancer in Britain and Japan: relation to thyroid function.
    European journal of cancer, 1977, Volume: 13, Issue:11

    Topics: 17-Ketosteroids; Breast Neoplasms; Female; Humans; Japan; Menopause; Pregnanediol; Pregnanetriol; Thyrotropin; United Kingdom

1977
Correlation between urinary steroids and estrogen receptor content in women with early breast cancer.
    European journal of cancer, 1977, Volume: 13, Issue:7

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Receptors, Estrogen; Time Factors

1977
Observations on urinary 17-ketosteroids in breast cancer patients.
    Journal of postgraduate medicine, 1977, Volume: 23, Issue:4

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Staging

1977
Relationship between steroid excretion patterns and breast cancer incidence in Israeli women of various origins.
    Journal of the National Cancer Institute, 1977, Volume: 59, Issue:1

    A nationwide study of the steroid excretion patterns in postmenopausal Israeli migrant women demonstrated differences between high- and low-risk groups for breast cancer in the following variables: age at first parturition, number of pregnancies, number of live births, height, and weight. The direction of the differnces was in line with those observed for breast cancer patients. The groups also differed in the exretion of estriol, 17-ketosteroids, and allotetrahydrocortisol. Multiple regression analysis revealed that the exretion of estriol was significantly lower in population groups in whom breast cancer incidence was high. Possibly this trend--which has also been observed in adolescent and premenopausal women--reflected environmental influences on peripheral estrogen metabolism.

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Androgens; Breast Neoplasms; Environment; Estriol; Estrogens; Estrone; Female; Humans; Israel; Menopause; Middle Aged; Risk; Sampling Studies

1977
[Correlation between the X-sex chromatin characteristics of breast cancer and the hormonal profile of women with breast cancer].
    Khirurgiia, 1977, Volume: 30, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Circadian Rhythm; Estrogens; Female; Hormones; Humans; Middle Aged; Sex Chromatin; Sex Chromosomes

1977
Plasma dehydroepiandrosterone concentration in normal women and in patients with benign and malignant breast disease.
    European journal of cancer, 1976, Volume: 12, Issue:5

    Topics: 17-Ketosteroids; Adult; Aged; Breast; Breast Diseases; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Female; Humans; Mastectomy; Middle Aged; Sulfates

1976
Mammary carcinoma in an acromegalic patient.
    The British journal of clinical practice, 1976, Volume: 30, Issue:4

    Topics: 17-Ketosteroids; Acromegaly; Adenocarcinoma, Scirrhous; Breast Neoplasms; Female; Gonadotropins; Humans; Middle Aged

1976
The urinary excretion of pregnanetriol and pregnenetriol in patients with breast cancer. A postulation on the meaning of Bulbrook's discriminant.
    European journal of cancer, 1976, Volume: 12, Issue:11

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Biometry; Breast Neoplasms; Female; Humans; Pregnanetriol; Pregnenes; Stimulation, Chemical

1976
Estrogen receptor in breast cancer of the Japanese.
    Gan, 1976, Volume: 67, Issue:5

    The estrogen receptor was assayed, using the 2,000g supernatant and dextran-coated charcoal method, in 243 tissue samples from human breast cancer, benign breast diseases, macroscopically normal breast tissues, normal uterine myometrium, and uterine myoma. The estrogen receptor was found to be positive in 52.1% of 98 primary breast cancer and in 54.1% of 24 metastatic tumors. The receptor in the breast cancer was found to be similar to that in normal uterine myometrium in the binding character; that is, the dissociation constant of 10(-9) approximately 10(-11) M and number of binding sites of 0 approximately 2,800 fmol/mg protein. There was no correlation between the presence of the receptor and some clinical factors such as menopausal status, age of the patient, urinary 17-ketosteroid excretion, clinical stage of cancer, tumor size, positive or negative axillary lymph node metastasis, histological type, metastatic site of the cancer, or disease-free interval. The estrogen receptor appeared to be retained by metastasis of cancer, and this may lead to the use of the receptor assay with mastectomy specimens for the prediction of response to hormonal therapy in future recurrence of malignancy. Furthermore, it may be possible by this assay to select patients suitable for adjuvant therapy with hormones at the time of mastectomy. A good correlation was found between the presence of the receptor and response to the major endocrine ablation therapy in patients with advanced or metastatic breast cancer. When the receptor was negative in the cancer tissue, the change of response to the endocrine therapy was minimum. On the other hand, if the cancer contained the receptor, approximately 60% of the patients with metastatic or advanced breast cancer responded well to the major endocrine ablation therapy. Thus, the estrogen receptor of breast cancer in Japanese patients appears to bear a close resemblance to that reported in Western patients in its incidence and the correlation to some biological characteristics of the cancer.

    Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adrenalectomy; Breast; Breast Neoplasms; Carcinoma; Castration; Female; Humans; Leiomyoma; Menopause; Menstruation; Myometrium; Neoplasm Metastasis; Receptors, Estrogen; Uterine Neoplasms

1976
Follow-up study of left suprarenal to inferior mesenteric venous shunt for advanced breast cancer.
    The British journal of surgery, 1976, Volume: 63, Issue:8

    Major endocrine ablation therapy was carried out in 133 patients with advanced breast cancer. Of 40 patients undergoing left suprarenal to inferior mesenteric venous shunt with bilateral oophorectomy and right adrenalectomy, 16 cases (40 per cent) had an objective response. The mean postoperative survival of the patients with a positive response, those showing some response and those who failed to respond was 35-8, 26-5 and 8-8 months respectively. Thus, the results of the present procedure are comparable to those of adrenalectomy. No replacement therapy with corticoids was necessary. An increase in the response rate and extension of the survival time can be expected with the addition of postoperative long term maintenance therapy with chemotherapeutic agents and androgens.

    Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Breast Neoplasms; Castration; Female; Follow-Up Studies; Humans; Liver Neoplasms; Mesenteric Veins; Middle Aged; Mitomycins; Neoplasm Metastasis; Time Factors

1976
[Change in the excretion of adrenal steroids as dependent on the chlodithane (2,4'-DDD) concentration in the blood of oncological patients].
    Voprosy onkologii, 1976, Volume: 22, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Breast Neoplasms; Circadian Rhythm; Female; Humans; Kidney Neoplasms; Male; Mitotane; Neoplasms; Prostatic Neoplasms

1976
Investigation of 17-ketosteriod excretion in mastopathia and premenopausal breast cancer.
    Archiv fur Geschwulstforschung, 1975, Volume: 45, Issue:5

    Measurement of the excretion of total 17-ketosteroids, androsterone, etiocholanolone, and dehydroepiandrosterone demonstrate in contrast to the well known age dependency of normal women in cases of both mastopathia and breast cancer the following results: 1. the age dependence of the 17-ketosteriod excretion is not marked; 2. the total 17-ketosteroid excretion is lower than that of normal controls, 3. the values of the etiocholanolone excretions and that of the dehydroepiandrosterone excretions are similarly lower.

    Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Precancerous Conditions

1975
Urinary excretion of 17-ketosteroids in patients suffering from mammary cancer.
    Archiv fur Geschwulstforschung, 1975, Volume: 45, Issue:5

    1. The excretion of dehydroepiandrosterone is lower in patients suffering from mammary cancer than in healthy women. 2. There doesn't exist any relation between the 17-ketosteroid excretion and the age of postmenopausal women. 3. Patients with mammary tumors in stages III and IV are characterized by a lower excretion of dehydroepiandrosterone in percental parts than patients in stages I and II. 4. In patients with mammary tumors in stages III and IV and in patients with recurrences independently from the tumor stages we find higher extrem values for aetiocholanolone and smaller ones for dehydroepiandrosterone than in the other stages. 5. The quotient of percental parts of excreted aetiocholanolone to dehydroepiandrosterone shows significantly higher values for patients with recurrences than without them. 6. The quotient of aetiocholanolone to dehydroepiandrosterone is not a valid factor for a postoperative control of recurrences of the disease.

    Topics: 17-Ketosteroids; Aged; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

1975
The excretion of 17-ketosteroids in patients suffering from mastopathia fibrocystica and mammary carcinomas.
    Archiv fur Geschwulstforschung, 1975, Volume: 45, Issue:7

    Comparative investigations of the urinary excretion of different 17-ketosteroids in healthy women and patients suffering from mastopathia fibrocystica and/or mammary carcinomas had the following results: 1. A clear age dependency of the excretion of 17 ketosteroids during the regenerative period has been shown in all groups investigated, but it could not be observed during the postmenopausal phase. 2. There are no hints by the excretion values for a remarkable contribution of mammary carcinomas to the hormone metabolism of the host. 3. The excretion values of patients suffering from mastopathia fibrocystica confirm epidemiological results, which consider this from of mastopathia a precancerous one.

    Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Androsterone; Breast Diseases; Breast Neoplasms; Cysts; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Precancerous Conditions

1975
Androgens in postmenopausal breast cancer: excretion, production and interaction with estrogens.
    Journal of steroid biochemistry, 1975, Volume: 6, Issue:5

    Topics: 17-Ketosteroids; Aged; Androgens; Androstenedione; Binding, Competitive; Breast Neoplasms; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Estrone; Female; Humans; Menopause; Middle Aged; Myometrium; Receptors, Cell Surface; Testosterone

1975
Editorial: Breast cancer and the discriminant.
    British medical journal, 1975, Apr-19, Volume: 2, Issue:5963

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Breast Neoplasms; Estriol; Female; Humans; Hypophysectomy

1975
Hormonal status of breast cancer. II. Abnormal urinary steroid excretion.
    Journal of the National Cancer Institute, 1975, Volume: 54, Issue:6

    The urinary excretion of 14 neutral steroids was measured by gas-liquid chromatography in women with early and advanced breast cancer, in women with early uterine cancer, and in healthy women from urban and rural districts. The premenopausal patients with early breast cancer excreted subnormal amounts of five steroids (11-hydroxyandrosterone, 11-hydroxyetiocholanolone, pregnanediol, pregnanetriol, and tetrahydrocorticosterone) and increased amounts of tetrahydrocortisol as compared with the normal subjects of corresponding ages. From our findings, a new parameter was proposed by which a premenopausal breast-cancer patient was separated from the control. Postmenopausal breast-cancer patients excreted greater amounts of five steroids (one steroid from 17-ketosteroids and four from 17-hydroxycorticoids) than the corresponding controls. The discrepancy between premenopausal and postmenopausal breast cancer was tentatively related to ovarian-adrenal dysfunction in the course of aging. Oophorectomy induced a long-lasting tumor regression only in patients with a high value for the ratio of 11-deoxy-17-ketosteroid to 17-hydroxycorticosteroid in urine taken before surgery; the ratio in the responsive patients decreased remarkably after surgery. A constitutional change in 17-ketosteroids, as observed in a postmenopausal breast-cancer patient and a premenopausal healthy woman of urban origin, favored the geographic importance in the genesis of breast malignancy. The steroid abnormalities in uterine cancer were distinguishable from those of breast cancer in both premenopausal and postmenopausal women.

    Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Androgens; Androsterone; Breast Neoplasms; Corticosterone; Etiocholanolone; Female; Humans; Menopause; Ovary; Pregnanediol; Pregnanetriol; Progestins; Rural Population; Tetrahydrocortisol; Urban Population; Uterine Neoplasms

1975
Urinary excretion of steroids by Japanese women with breast cancer.
    Gan, 1975, Volume: 66, Issue:3

    The urinary excretion of steroids was determined in premenopausal patients with advanced breast cancer in the non-menstrual phase and in control women in the follicular phase, ovulatory stage, and luteal phase. The estrone level in the urine of cancer patients was higher than that in the urine of control women at any phase. Excretion of 17 beta-estradiol in the follicular and luteal phases was similar in the urine of control women and cancer patients, but estradiol and estriol levels in the ovulatory stage of control women were higher than those of cancer patients. The estriol level in the urine of control women in the luteal phase was also higher than that of cancer patients. Total 17-ketosteroid was lower in the urine of cancer patients than in that of controls at any phase. Among the fractions of 17-ketosteroids, only dehydroepiandrosterone was excreted at a higher level by cancer patients than by control subjects.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Asian People; Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Japan; Menstruation; Middle Aged; Ovulation

1975
Urinary excretion of steroids and response to oophorectomy in premenopausal women with advanced breast cancer.
    Gan, 1975, Volume: 66, Issue:4

    Relationship between the urinary excretion of steroids in premenopausal Japaneses patients with advanced breast cancer and their response to oophorectomy was studied. The estrogen fractions were determined by radioimmunoassay and those who responded to oophorectomy showed higher levels of 17 beta-estradiol than the non-responders before surgery. The high levels of urinary 17 beta-estradiol of the responders dropped markedly after oophorectomy. On the contrary, the non-responders showed relatively low levels of urinary excretion of 17 beta-estradiol before oophorectomy and the levels appeared either unchanged or slightly elevated after surgery. No definite relation was found between changes in the urinary excretion of estrone or estriol and the clinical effect of oophorectomy. Excretion of 17-ketosteroids in the responders was lower than that of the non-responders.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Breast Neoplasms; Castration; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

1975
Clinical and hormonal aspects in breast cancer with special reference to malignant evolutive push.
    Archiv fur Geschwulstforschung, 1975, Volume: 45, Issue:5

    It is tried to differentiate between various stages of malignant evolutive push and normal mammary tumors to establish an individual therapeutic procedure. Besides mammography and thermometry, investigations of urinary excretions of estrogenic and androgenic steriods are qualified for this purpose. Patients with malignant evolutive push showed an increased excretion of estrogens which reached its highest levels in patients suffering from inflammatory mammary carcinomas. The excretion of 17-ketosteroids shows a behaviour vice versa. Altogether mammary tumors with malignant evolutive push are characterized by a state of absolute and relative hyperestrogenity respectively. This phenomenon preferably depends on the clinical stage of the disease than on the age of the patients.

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Mammography; Middle Aged; Skin Temperature

1975
[Endolumbar administration of hydrocortisone in the complex treatment of patients with generalized breast cancer].
    Voprosy onkologii, 1975, Volume: 21, Issue:5

    An efficacy of the method of hormonal therapy--endolumbar hydrocortisone injection in patients with advanced breast cancer has been studied. A remission was gained in 28 of 41 patients. The method proved to be mostly effective in metastases in bones. Changes in the level of estrogens, 17-KS and 17-OCS excretion with the urine during the treatment indicate an endocrinous mechanism of this therapeutic effect. An efficacy of the method in extensive dissemination of the process, its relative simplicity and availability along with the absence of serious complications enabled the authors to hope that the suggested method may be widely used in practice.

    Topics: 17-Ketosteroids; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Estrogens; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

1975
Tryptophan metabolism and recurrence rates of patients with breast cancer after mastectomy.
    Acta vitaminologica et enzymologica, 1975, Volume: 29, Issue:1-6

    Women with early breast cancer were given a loading dose of L-tryptophan after mastectomy and a comparison made between their excretion of metabolites of the kynurenine pathway and the rate of recurrence of the disease.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Female; Humans; Kynurenine; Mastectomy; Menopause; Middle Aged; Time Factors; Tryptophan

1975
Studies on the sulphate esters of dehydroepiandrosterone and androsterone in the blood of women with breast cancer.
    European journal of cancer, 1974, Volume: 10, Issue:8

    Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Esters; Female; Humans; Mastectomy; Middle Aged; Sulfates; Time Factors

1974
The breast cancer discriminant: effect of age, obesity, hirsutism, starvation, and changes in adrenocortical and gonadal activity.
    The Journal of endocrinology, 1974, Volume: 63, Issue:2

    Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Amenorrhea; Androsterone; Body Weight; Breast Neoplasms; Castration; Contraceptives, Oral; Dexamethasone; Estrogens; Etiocholanolone; Female; Hirsutism; Humans; Hypophysectomy; Luteinizing Hormone; Menstruation; Middle Aged; Obesity; Ovarian Diseases; Starvation

1974
Identification of breast cancer patients with high risk of early recurrence after radical mastectomy. I. Description of study.
    Journal of the National Cancer Institute, 1974, Volume: 53, Issue:3

    Topics: 17-Ketosteroids; Age Factors; Aged; Blood Vessels; Breast Neoplasms; Creatinine; Estrogens; Female; Follow-Up Studies; Glucocorticoids; Hematocrit; Humans; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Neoplasm Recurrence, Local; Prognosis

1974
[Hormonal patterns in breast cancers].
    Archiv fur Geschwulstforschung, 1974, Volume: 44, Issue:3

    Urinary outpout of oestrogens and 17-ketosteroids were estimated in 200 women with breast cancer; 60 of them were cases with rapid evolution (malignant evolutive push). The majority of cases analysed had abnormal hormonal levels, especially of oestrogens. The average oestrogenic levels are higher than the normal values; the highest values correspond to the most severe and rapidly evolutive type of breast cancer, the inflammatory breast carcinoma. In the patients without evolutive push, the proportion of cases with absolute or relative hypooestrogeny is approximately equal toor exceeds the proportion of hyperoestrogenic cases. In the presence of the evolutive push and especially of his most severe type, inflammatory carcinoma, the cases with hyperoestrogeny, both absolute and relative, by hypoandrogeny, are dominant. The proportion of cases with higher 17-ketosteroid urinary outputs than the normal mean is greater in the patients without evolutive push, while in those with evolutive push, the majority of cases have lower values of 17-ketosteroids than the normal mean.

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Edema; Estrogens; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis; Prognosis; Time Factors

1974
Urinary and plasma androgens in benign breast disease. Possible relation to breast cancer.
    Lancet (London, England), 1973, May-19, Volume: 1, Issue:7812

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Androgens; Breast Diseases; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Sulfates

1973
Basic results of a study of bilateral adrenalectomy for advanced breast cancer. Urinary steroids and related data in 148 patients.
    The Medical journal of Australia, 1973, Nov-10, Volume: 2, Issue:19

    Topics: 17-Ketosteroids; Adrenalectomy; Adult; Androsterone; Body Surface Area; Breast; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Palliative Care; Pregnancy; Remission, Spontaneous; Spectrophotometry; Time Factors

1973
Androgen production and conversion to estrogens in normal postmenopausal women and in selected breast cancer patients.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:1

    Topics: 17-Ketosteroids; Aged; Androgens; Androstenedione; Androsterone; Breast Neoplasms; Carbon Isotopes; Climacteric; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Glucuronates; Humans; Metabolic Clearance Rate; Middle Aged; Sulfates; Testosterone; Tritium

1973
[The mechanism of action of hydrocortisone administered by lumbar puncture in breast cancer].
    Voprosy onkologii, 1973, Volume: 19, Issue:9

    Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

1973
Preliminary trial of aminoglutethimide in breast cancer.
    Cancer, 1973, Volume: 32, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Aminoglutethimide; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Castration; Central Nervous System; Dexamethasone; Estrogens; Female; Fludrocortisone; Humans; Neoplasm Metastasis; Ovary; Remission, Spontaneous; Skin Neoplasms

1973
Male breast cancer. 3. Breast carcinoma in association with the Klinefelter syndrome.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1973, Volume: 81, Issue:3

    Topics: 17-Ketosteroids; Aged; Biopsy; Breast Neoplasms; Estrogens; Gonadotropins; Humans; Karyotyping; Klinefelter Syndrome; Male; Sex Chromatin; Sex Chromosomes; Testis

1973
Metabolic changes in breast carcinoma. I. Urinary excretions of ketosteroid and catecholamine.
    Indian journal of cancer, 1973, Volume: 10, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Adult; Breast Neoplasms; Female; Humans; Male; Middle Aged; Spectrum Analysis; Vanilmandelic Acid

1973
[Study on the hormonal etiology of breast cancer and atypical endometrial hyperplasia in women of pre-menopausal age].
    Il Cancro, 1973, Volume: 26, Issue:1

    Topics: 17-Ketosteroids; Breast Neoplasms; Endometrial Hyperplasia; Estrogens; Female; Humans; Menopause; Middle Aged; Testosterone

1973
17-Ketosteroid excretion, myasthenia gravis, and breast cancer.
    Lancet (London, England), 1972, Mar-25, Volume: 1, Issue:7752

    Topics: 17-Ketosteroids; Breast Neoplasms; Female; Humans; Male; Myasthenia Gravis; Thymectomy

1972
[FSH and steroid hormone excretion in breast cancer during chemotherapy].
    Voprosy onkologii, 1972, Volume: 18, Issue:10

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Follicle Stimulating Hormone; Glucocorticoids; Humans; Menopause; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pregnanediol; Thiotepa; Time Factors; Vinblastine

1972
A rapid method for the analysis of enzyme hydrolysable 11-deoxy-17-oxosteroids in urine.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 39, Issue:2

    Topics: 17-Ketosteroids; Androsterone; Breast Neoplasms; Chromatography, Ion Exchange; Dehydroepiandrosterone; Etiocholanolone; Evaluation Studies as Topic; Female; Glucuronates; Glucuronidase; Humans; Hydrolysis; Mass Screening; Methods; Sulfuric Acids; Tritium

1972
Adrenal and testicular contribution to plasma oestrogens.
    The Journal of endocrinology, 1972, Volume: 55, Issue:1

    Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androstanes; Breast Neoplasms; Castration; Dehydroepiandrosterone; Dexamethasone; Estradiol; Estrone; Female; Humans; Hydrocortisone; Hypertension; Iliac Vein; Male; Menopause; Middle Aged; Neoplasms; Radioligand Assay; Renal Veins; Testis; Testosterone

1972
L-Dopa effect on prolactin, follicle-stimulating hormone, and luteinizing hormone in women with advanced breast cancer: a preliminary report.
    American journal of obstetrics and gynecology, 1972, Sep-15, Volume: 114, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Dihydroxyphenylalanine; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Middle Aged; Neoplasm Metastasis; Progesterone; Prolactin

1972
[Excretion of pituitary and steroid hormones in breast cancer following pituitary irradiation].
    Vestnik Akademii meditsinskikh nauk SSSR, 1972, Volume: 27, Issue:10

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Neoplasms; Estrogens; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Middle Aged; Pituitary Irradiation

1972
The in vitro biosynthesis of 11 -hydroxyandrostenedione by human adrenal homogenates.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 34, Issue:1

    Topics: 17-Ketosteroids; Adrenal Glands; Androstanes; Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Cushing Syndrome; Humans; Hydrocortisone; In Vitro Techniques; Progesterone; Tritium

1972
[Reduced excretion of total gonadotropins during use of Elipten in breast neoplasms].
    Voprosy onkologii, 1972, Volume: 18, Issue:3

    Topics: 17-Ketosteroids; Adult; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Breast Neoplasms; Female; Gonadotropins; Humans; Middle Aged; Pyridones

1972
Urinary androgen excretion and the etiology of breast cancer.
    Journal of the National Cancer Institute, 1972, Volume: 48, Issue:4

    Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Diseases; Breast Neoplasms; Endocrine Glands; Estrogens; Etiocholanolone; Female; Humans; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies

1972
Evaluation of breast tumour sex chromatin (Barr body) as an index of survival and response to pituitary ablation.
    The British journal of surgery, 1972, Volume: 59, Issue:9

    Topics: 17-Ketosteroids; Androsterone; Biopsy; Breast Neoplasms; Etiocholanolone; Female; Humans; Hypophysectomy; Retrospective Studies; Sex Chromatin

1972
Hormonal influences in breast cancer.
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:5

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Androsterone; Animals; Blood Glucose; Breast Neoplasms; Castration; Dehydroepiandrosterone; Estradiol; Estrogens; Etiocholanolone; Female; Growth Hormone; Hormones; Humans; Hypophysectomy; Insulin; Menopause; Mice; Pituitary Irradiation; Sulfates

1971
[Influence of the presence at determinable levels of free plasma 17-ketosteroids on the survival of breast cancer patients].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1971, Jan-04, Volume: 272, Issue:1

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Prognosis; Testosterone

1971
Relationships between excretion of steroid hormones and tryptophan metabolites in patients with breast cancer.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Adult; Age Factors; Breast Neoplasms; Chromatography, Thin Layer; Female; Fluorescence; Humans; Hydrolases; Kynurenine; Middle Aged; Neurospora; ortho-Aminobenzoates; Tryptophan; Xanthurenates

1971
Probability of a woman with advanced breast cancer responding to adrenalectomy or hypophysectomy.
    Lancet (London, England), 1970, Oct-03, Volume: 2, Issue:7675

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hypophysectomy; Menopause; Middle Aged; Probability

1970
Steroid metabolism by human breast tumours.
    The Biochemical journal, 1970, Volume: 116, Issue:5

    Topics: 17-Ketosteroids; Androstanes; Breast Neoplasms; Chromatography, Thin Layer; Dehydroepiandrosterone; Estriol; Female; Humans; Testosterone; Tritium

1970
Adrenal function in breast cancer: biogenesis of androgens and cortisol by the human adrenal gland in vivo.
    The Journal of endocrinology, 1970, Volume: 47, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Aged; Androgens; Androstanes; Androsterone; Breast Neoplasms; Carbon Isotopes; Chromatography, Gas; Chromatography, Paper; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Middle Aged; Ovary; Pregnenolone; Progesterone; Radioisotope Dilution Technique; Tritium

1970
Steroid metabolism by human breast tumours.
    The British journal of surgery, 1970, Volume: 57, Issue:11

    Topics: 17-Ketosteroids; Androstanes; Breast Neoplasms; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; In Vitro Techniques; Mastectomy

1970
Benign and malignant breast disease in South Wales: a study of urinary steroids.
    British medical journal, 1970, Dec-26, Volume: 4, Issue:5738

    The levels of aetiocholanolone, androsterone, and 17-hydroxycorticosteroids were measured in women without known disease of the breast, in women with benign breast disease, and in women with primary and advanced breast cancer. Statistical analysis showed there was no difference in the excretion of urinary 17-hydroxycorticosteroids in the various groups of patients. Detailed analysis of the aetiocholanolone and androsterone levels, however, indicated that patients with advanced localized disease excreted significantly less of these 11-deoxy-17-oxosteroids than those in the other groups.

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Breast Diseases; Breast Neoplasms; Chromatography, Gas; Chromatography, Paper; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Wales

1970
A single method for determination of urine steroids. I. Levels of testosterone, epitestosterone and 17-ketosteroid fractions. II. Specific activities of testosterone, androsterone and etiocholanolone and production rate of testosterone following administr
    Clinical biochemistry, 1970, Volume: 3, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Breast Neoplasms; Carbon Isotopes; Carcinoma; Child; Child, Preschool; Chromatography; Dehydroepiandrosterone; Endocrine System Diseases; Etiocholanolone; Female; Humans; Infant; Male; Methods; Middle Aged; Polycystic Ovary Syndrome; Prostatic Neoplasms; Testosterone; Tritium

1970
[Irradiation of the ovaries in the complex therapy of breast cancer].
    Meditsinskaia radiologiia, 1970, Volume: 15, Issue:9

    Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adult; Breast Neoplasms; Castration; Estrogens; Female; Humans; Middle Aged; Ovary; Pregnanediol

1970
[Prognostically important factors in mammary carcinoma].
    Langenbecks Archiv fur Chirurgie, 1970, Volume: 326, Issue:2

    Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Estrogens; Female; Gonadal Steroid Hormones; Humans; Middle Aged; Prognosis

1970
Urinary steroid excretion in patients with advanced breast cancer.
    The British journal of surgery, 1970, Volume: 57, Issue:11

    Topics: 17-Ketosteroids; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Humans

1970
[17-ketosteroid changes in breast cancer during testosterone propionate treatment].
    Voprosy onkologii, 1970, Volume: 16, Issue:7

    Topics: 17-Ketosteroids; Breast Neoplasms; Chromatography; Female; Humans; Testosterone

1970
Relationship between hormonal cytology and steroid excretion in post-menopausal women.
    The Journal of endocrinology, 1970, Volume: 48, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Androsterone; Breast Neoplasms; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Urine; Uterine Neoplasms

1970
[Endocrine characterization of mammary carcinoma].
    Archiv fur Geschwulstforschung, 1970, Volume: 36, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androstanes; Breast Neoplasms; Female; Humans; Middle Aged

1970
[Blood concentration and urinary excretion rate following intramuscular injection of triamcinolone acetonide].
    Nihon Naibunpi Gakkai zasshi, 1970, Sep-20, Volume: 46, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adult; Breast Neoplasms; Chromatography, Thin Layer; Humans; Hydrocortisone; Injections, Intramuscular; Time Factors; Triamcinolone Acetonide; Tritium

1970
Diagnosis and treatment of mastopathy.
    Acta chirurgica Academiae Scientiarum Hungaricae, 1969, Volume: 10, Issue:1

    Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Adult; Aged; Animals; Breast Diseases; Breast Neoplasms; Columbidae; Crop, Avian; Estrenes; Estrogens; Female; Humans; Middle Aged; Pregnanediol; Prolactin

1969
Further studies on the relationship between C19- and C21-steroid synthesis in the human adrenal gland.
    The Journal of endocrinology, 1969, Volume: 45, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Breast Neoplasms; Carbon Isotopes; Dehydroepiandrosterone; Estrogens; Female; Humans; Hydrocortisone; In Vitro Techniques; Pregnenolone; Testosterone; Transferases; Tritium

1969
Estradiol production after ovariectomy for carcinoma of the breast.
    The New England journal of medicine, 1969, Mar-20, Volume: 280, Issue:12

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Breast Neoplasms; Castration; Estradiol; Female; Humans; Menopause; Middle Aged; Ovary; Tritium

1969
[Therapeutic possibilities in metastatic cancer of the breast with hypercalcaemia. (Apropos of 2 cases)].
    Revue du rhumatisme et des maladies osteo-articulaires, 1969, Volume: 36, Issue:11

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Castration; Cyclophosphamide; Estrogens; Female; Humans; Hypercalcemia; Middle Aged; Neoplasm Metastasis; Norethindrone; Ovary; Phosphoric Monoester Hydrolases; Phosphorus; Prednisone; Radiography; Testosterone

1969
[Study of plasma 17-ketosteroids and 17-hydroxycorticosteroids in men having cancer of the breast].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Mar-31, Volume: 268, Issue:13

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Humans; Klinefelter Syndrome; Male; Middle Aged

1969
[Endocrine therapy and chemotherapy of breast cancer].
    Shujutsu. Operation, 1969, Volume: 23, Issue:8

    Topics: 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Aged; Androgens; Breast Neoplasms; Castration; Estrogens; Female; Humans; Hypophysectomy; Menstruation; Middle Aged; Mitomycins

1969
[Peculiarities of hormonal metabolism in men with gynecomastia and breast cancer].
    Vestnik Akademii meditsinskikh nauk SSSR, 1969, Volume: 24, Issue:6

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Follicle Stimulating Hormone; Gynecomastia; Hormones; Humans; Male; Middle Aged

1969
[Sex chromatin and hormonal status in patients with breast neoplasms].
    Sovetskaia meditsina, 1969, Volume: 32, Issue:8

    Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Sex Chromatin

1969
[The relationship between the course of mammary gland cancer and age and hormonal features of the body].
    Voprosy onkologii, 1969, Volume: 15, Issue:5

    Topics: 17-Ketosteroids; Adult; Age Factors; Breast Neoplasms; Estrogens; Female; Humans; Menstruation; Middle Aged; Pregnancy; Pregnancy Complications; Prognosis

1969
Comparison of mastisol (2-alpha-methylandrostan-17-beta-ol-3-one propionate) and testosterone propionate in the treatment of advanced and recurrent cancer of the breast.
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1969, Jul-01, Volume: 38, Issue:4

    Topics: 17-Ketosteroids; Adult; Aged; Alkaline Phosphatase; Androstanols; Breast Neoplasms; Female; Humans; Middle Aged; Models, Structural; Propionates; Testosterone

1969
[Examination of the luteotropic hormone activity of blood and urinary steroid excretion in diseases of the breast].
    Archiv fur Geschwulstforschung, 1969, Volume: 34, Issue:2

    Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Adult; Aged; Animals; Breast Diseases; Breast Neoplasms; Chromatography, Paper; Columbidae; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Luteinizing Hormone; Middle Aged; Pregnanediol

1969
Urinary steroids and breast disease.
    The British journal of surgery, 1969, Volume: 56, Issue:8

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Diseases; Breast Neoplasms; Female; Humans

1969
Urinary steroid excretion pattern in diabetes mellitus.
    Lancet (London, England), 1968, Jan-20, Volume: 1, Issue:7534

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Diabetes Complications; Diabetes Mellitus; Etiocholanolone; Female; Glucocorticoids; Humans; Male; Pregnanes; Pregnanetriol; Progestins; Steroids

1968
Effect of thyroid funtion and of obesity on discriminant function for mammary carcinoma.
    Lancet (London, England), 1968, Oct-26, Volume: 2, Issue:7574

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Obesity; Prognosis; Thyroid Diseases

1968
A correlation between urinary steroid metabolites and pathways of steroidogenesis in human breast-tumour tissue.
    Lancet (London, England), 1968, Nov-30, Volume: 2, Issue:7579

    Topics: 17-Ketosteroids; Adenofibroma; Adrenalectomy; Adult; Aged; Androstanes; Breast Neoplasms; Carcinoma; Chemistry, Clinical; Dehydroepiandrosterone; Estriol; Female; Humans; Menopause; Middle Aged; Steroids

1968
Urinary steroids in the prediction of response to adrenalectomy or hypophysectomy. A second clinical trial.
    Lancet (London, England), 1968, Dec-14, Volume: 2, Issue:7581

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Female; Humans; Hypophysectomy; Neoplasm Metastasis; Ovary; Prognosis

1968
Urinary 17-ketosteroid excretion of women with advanced breast cancer.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:5

    Topics: 17-Ketosteroids; Adrenalectomy; Adult; Aged; Androsterone; Asian People; Breast Neoplasms; Chemistry, Clinical; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Japan; Middle Aged

1968
[Clinical study of urinary 17-ketosteroid fractions in breast cancer--correlation with the effect of adrenalectomy in progressive breast cancer].
    Saishin igaku. Modern medicine, 1968, Feb-10, Volume: 24, Issue:2

    Topics: 17-Ketosteroids; Adrenalectomy; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Middle Aged

1968
Ultrasonic selective hypophysectomy.
    Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:1

    Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Animals; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hydrocortisone; Male; Methods; Middle Aged; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

1968
Bilateral carcinoma of the breast in a patient with Klinefelter's syndrome.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma, Mucinous; Aged; Atrophy; Breast Neoplasms; Estrogens; Gynecomastia; Humans; Karyotyping; Klinefelter Syndrome; Male; Prostate

1968
The metopirone test of pituitary corticotrophin release. Evaluation of 101 tests.
    The American journal of medicine, 1968, Volume: 45, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Breast Neoplasms; Child; Female; Glucocorticoids; Humans; Hyperpituitarism; Hypopituitarism; Male; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Tranquilizing Agents

1968
Excretion of ketosteroids and proneness to breast cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 1968, Volume: 59, Issue:3

    Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Mastectomy

1968
Urinary steroid spectra by gas chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 19, Issue:3

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Breast Neoplasms; Child; Chromatography, Gas; Cushing Syndrome; Etiocholanolone; Female; Humans; Hypopituitarism; Male; Methods; Pheochromocytoma; Polycystic Ovary Syndrome; Pregnanes; Statistics as Topic; Steroids

1968
[Urinary excretion of neutral 17-ketosteroids, androsterone and etiocholanolone in healthy women and women with early and advanced breast cancer].
    Archiv fur Geschwulstforschung, 1968, Volume: 32, Issue:1

    Topics: 17-Ketosteroids; Aged; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Glucocorticoids; Humans; Middle Aged; Paper; Time Factors

1968
Urinary steroid excretion in patients with advanced breast cancer.
    The British journal of surgery, 1968, Volume: 55, Issue:11

    Topics: 17-Ketosteroids; Breast Neoplasms; Etiocholanolone; Female; Humans; Mathematics

1968
[Study on the pyrogen test in normal subjects, hypopituitarism, hypothyroidism and adrenalectomized patients].
    Nihon rinsho. Japanese journal of clinical medicine, 1968, Volume: 26, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Humans; Hypopituitarism; Hypothyroidism; Pituitary-Adrenal Function Tests; Pyrogens

1968
[Data on the treatment of gyneconastia].
    Orvosi hetilap, 1968, May-26, Volume: 109, Issue:21

    Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Gynecomastia; Humans; Male; Middle Aged; Precancerous Conditions; Sex Chromatin

1968
[Lung metastasis of breast cancer in a male treated with pneumonectomy and orchiectomy following radical mastectomy].
    Horumon to rinsho. Clinical endocrinology, 1968, Volume: 16, Issue:6

    Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Humans; Lung Neoplasms; Male; Mastectomy; Middle Aged; Neoplasm Metastasis; Pneumonectomy

1968
[The importance of studying steroid and hypophyseal hormone excretion in patients with dyshormonal tumors].
    Vestnik Akademii meditsinskikh nauk SSSR, 1968, Volume: 23, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Choriocarcinoma; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Male; Ovarian Neoplasms; Pituitary Gland; Pregnancy; Thyroid Gland; Uterine Neoplasms

1968
[Free and total plasma 17-ketosteroids in genital cancers. Study of women with breast or genital cancer and men with prostatic or testicular cancer].
    European journal of cancer, 1968, Volume: 4, Issue:2

    Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Female; Genital Neoplasms, Female; Humans; Male; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vaginal Neoplasms

1968
Alternative discriminating function for determining hormone dependency of breast cancer.
    British medical journal, 1967, Jan-21, Volume: 1, Issue:5533

    Topics: 17-Ketosteroids; Aging; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Humans

1967
Low-dosage glucocorticoid therapy. An appraisal of its safety and mode of action in clinical disorders, including rheumatoid arthritis.
    Archives of internal medicine, 1967, Volume: 119, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Alopecia Areata; Arthritis, Rheumatoid; Asthma; Breast Neoplasms; Child; Child, Preschool; Colitis, Ulcerative; Cortisone; Endocrine System Diseases; Female; Humans; Hydrocortisone; Male; Middle Aged; Multiple Sclerosis

1967
Adrenal structure and function in advanced carcinoma of the breast. II. The relation of steroid excretion to adrenal morphology and the outcome of adrenalectomy, with description of a new discriminant function.
    JAMA, 1967, Feb-13, Volume: 199, Issue:7

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Organ Size

1967
Determination of 17-oxosteroid sulphates in human plasma.
    Clinica chimica acta; international journal of clinical chemistry, 1967, Volume: 18, Issue:2

    Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Breast Neoplasms; Chromatography, Thin Layer; Female; Fibrosarcoma; Humans; Male; Mass Screening; Methods; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Ultraviolet Rays

1967
[Comparative sudy of total 17-ketosteroids and free 17-hydroxycorticosteroids in the blood of women with breast cancer].
    Revue francaise d'etudes cliniques et biologiques, 1967, Volume: 12, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Castration; Female; Humans; Mastectomy; Menopause; Middle Aged

1967
[Clinical and morphological studies on gynecomastia].
    Bruns' Beitrage fur klinische Chirurgie, 1967, Volume: 215, Issue:2

    Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Age Factors; Aged; Breast Neoplasms; Carcinoma; Epithelium; Estrogens; Gynecomastia; Humans; Japan; Liver Function Tests; Male; Middle Aged; Mitosis; Prostatic Hyperplasia; Prostatic Neoplasms

1967
The urinary excretion of 11-deoxy-17-oxosteroids and 17-hydroxycorticosteroids by normal Japanese and British women.
    The Journal of endocrinology, 1967, Volume: 38, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Ethnology; Etiocholanolone; Female; Humans; Japan; London; Middle Aged; Women

1967
Urine steroid excretion in postmenopausal cancer of the breast. Response to corticotropin stimulation and dexamethasone suppression.
    Cancer, 1967, Volume: 20, Issue:1

    Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Dexamethasone; Estrogens; Female; Humans; Lymphatic Metastasis; Menopause; Middle Aged; Pregnanediol

1967
Urinary steroid spectrum by gas chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1967, Volume: 16, Issue:3

    Topics: 17-Ketosteroids; Addison Disease; Adrenocorticotropic Hormone; Androgens; Breast Neoplasms; Chemistry, Clinical; Cholesterol; Chromatography, Gas; Female; Humans; Male; Metyrapone; Ovarian Neoplasms; Pregnancy; Steroids

1967
[Circadian rhythm and low frequency rhythms in human physiology].
    Journal de physiologie, 1967, Volume: 59, Issue:1 Suppl

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Animals; Body Temperature; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Circadian Rhythm; Computers; Electroencephalography; Female; Humans; Infant; Information Systems; Light; Male; Metabolism; Mice; Middle Aged; Mitosis; Models, Theoretical; Periodicity; Sleep; Spectrum Analysis; Time Factors

1967
[Ultrasonic hypophysectomy on breast and prostatic carcinomas and in Cushing's syndrome. Principles and indications of hypophysis surgery].
    Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie, 1967, Volume: 101, Issue:6

    Topics: 17-Ketosteroids; Acromegaly; Animals; Bone Neoplasms; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hypophysectomy; Male; Methods; Neoplasm Metastasis; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

1967
The effect of steroidal diosphenol agents on advanced breast cancer.
    Endocrinologia japonica, 1967, Volume: 14, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adult; Aged; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Breast Neoplasms; Cyclohexanes; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Liver Function Tests; Male; Mammary Neoplasms, Experimental; Mice; Middle Aged; Prolactin; Rats; Sulfobromophthalein; Testosterone

1967
[Clinical study on adrenal suppression and estrogens in recurrent breast cancer].
    Nihon Naibunpi Gakkai zasshi, 1966, Oct-20, Volume: 42, Issue:7

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Paramethasone

1966
[On the metabolism of phosphates and sulfates of androsterone and epiandrosterone].
    Endokrinologie, 1966, Volume: 50, Issue:3

    Topics: 17-Ketosteroids; Androgens; Androstanes; Androsterone; Breast Diseases; Breast Neoplasms; Chromatography, Paper; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Phosphates; Sulfates

1966
Urinary hormone metabolite levels in patients with cancer of the breast, prostate and lung.
    Annals of the New York Academy of Sciences, 1966, Jan-21, Volume: 125, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Estrogens; Female; Gonadotropins; Hormones; Humans; Lung Neoplasms; Male; Pregnanediol; Prostatic Neoplasms

1966
[Endocrine treatment of breast cancer].
    Iryo, 1966, Volume: 20, Issue:11

    Topics: 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Castration; Female; Gonadal Steroid Hormones; Humans; Neoplasm Metastasis

1966
CARCINOMA OF MALE BREAST IN ASSOCIATION WITH THE KLINEFELTER SYNDROME.
    British medical journal, 1965, Jan-23, Volume: 1, Issue:5429

    Topics: 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Scirrhous; Adrenal Cortex Hormones; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal; Chromosomes; Fluids and Secretions; Gonadotropins; Gynecomastia; Humans; Klinefelter Syndrome; Male; Neoplasm Metastasis; Neoplasms; Pathology; Urine

1965
PLASMA 17-HYDROXYCORTICOSTEROIDS AND 17-OXOSTEROIDS IN PATIENTS WITH BREAST CANCER AND IN NORMAL WOMEN.
    The Journal of endocrinology, 1965, Volume: 32

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Breast Neoplasms; Female; Humans; Neoplasm Metastasis; Urine

1965
A STUDY OF PITUITARY FUNCTION AFTER INTRASELLAR IMPLANTATION OF 90YTTRIUM.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing Syndrome; Diabetes Mellitus; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary Irradiation; Thyroid Function Tests; Urine; Yttrium Isotopes

1965
I. URINARY EXCRETION OF NEUTRAL 17-KETOSTEROIDS AND PREGNANDEIOL BY PATIENTS WITH BREAST CANCER AND BENIGN BREAST DISEASE.
    American journal of obstetrics and gynecology, 1965, Jun-15, Volume: 92

    Topics: 17-Ketosteroids; Androsterone; Breast Diseases; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Metabolism; Pregnanediol; Urine

1965
THE DETERMINATION OF 17-OXOSTEROID SULPHATES IN HUMAN PLASMA.
    The Journal of endocrinology, 1965, Volume: 32

    Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Child; Chromatography; Dehydroepiandrosterone; Diabetes Mellitus; Etiocholanolone; Geriatrics; Glucuronates; Humans; Hypogonadism; Obesity; Solvents; Sulfates

1965
[COMPARATIVE STUDY OF PLASMA 17-KETOSTEROIDS AND 17-HYDROXYCORTICOSTEROIDS IN WOMEN WITH BREAST CANCER].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1965, Feb-08, Volume: 260

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Breast Neoplasms; Female; Humans; Plasma

1965
[Comparing metabolic studies following infusion of dehydroepiandrosterone sulfate and dehydroepiandrosterone phosphate].
    Endokrinologie, 1965, Volume: 49, Issue:1

    Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Humans; Phosphates; Sulfates; Testosterone

1965
[Comparing metabolic studies following infusion of delta-4-androstene-3,17-dione, testosterone phosphate and dehydroepiandrosterone phosphate].
    Endokrinologie, 1965, Volume: 49, Issue:1

    Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Humans; Injections, Intravenous; Middle Aged; Testosterone

1965
[Comparative study of levels of 17-ketosteroids in the peripheral venous, ovarian and adrenal blood drawn in the course of adreno-splenic implantations or adrenalectomies for advanced breast cancer].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1965, May-17, Volume: 260, Issue:20

    Topics: 17-Ketosteroids; Adrenalectomy; Adult; Breast Neoplasms; Cortisone; Humans; In Vitro Techniques; Middle Aged

1965
[Comparative study of plasma and urinary 17-ketosteroids and 17-hydroxycorticosteroids in women with breast cancer].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1965, Oct-27, Volume: 261, Issue:17

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; In Vitro Techniques; Middle Aged

1965
Surgical diseases of the adrenal glands.
    The American journal of gastroenterology, 1965, Volume: 44, Issue:6

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adult; Breast Neoplasms; Child, Preschool; Cortisone; Cushing Syndrome; Disorders of Sex Development; Female; Humans; Hyperaldosteronism; Infant; Male; Pheochromocytoma; Prednisolone; Virilism

1965
"Urinary 17-ketosteroid excretion study in radiation induced menopause in carcinoma breast".
    Indian journal of cancer, 1965, Volume: 2, Issue:4

    Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Female; Humans; Menopause; Urine

1965
[Concentration of 17-ketosteroids in the urine of breast cancer patients].
    Voprosy onkologii, 1965, Volume: 11, Issue:10

    Topics: 17-Ketosteroids; Breast Neoplasms; Chromatography; Female; Humans

1965
[Surgery of the adrenal glands for the treatment of advanced breast cancer].
    Nihon Naibunpi Gakkai zasshi, 1965, Dec-20, Volume: 41, Issue:9

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Estrogens; Female; Glucocorticoids; Gonadotropins, Pituitary; Humans; Prognosis

1965
URINARY 11-DEOXY-17-OXOSTEROIDS IN BRITISH AND JAPANESE WOMEN WITH REFERENCE TO THE INCIDENCE OF BREAST CANCER.
    Nature, 1964, Jan-11, Volume: 201

    Topics: 17-Ketosteroids; Asian People; Breast Neoplasms; Ethnicity; Female; Humans; Incidence; Japan; Neoplasms; Thyroid Gland; United Kingdom; Urine; White People

1964
THE RELATION BETWEEN THE URINARY 17-HYDROXYCORTICOSTEROIDS AND 11-DEOXY-17-OXOSTEROIDS AND THE FATE OF PATIENTS AFTER MASTECTOMY.
    Lancet (London, England), 1964, May-02, Volume: 1, Issue:7340

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Breast Neoplasms; Geriatrics; Humans; Mastectomy; Middle Aged; Pathology; Prognosis; Urine

1964
PITUITARY-ADRENAL FUNCTION FOLLOWING HYPOPHYSECTOMY IN MAN.
    Acta endocrinologica, 1964, Volume: 45

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hypophysectomy; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Urine

1964
PLASMA ANDROGENS IN WOMEN. I. NORMAL AND NON-HIRSUTE FEMALES, OOPHORECTOMIZED AND ADRENALECTOMIZED PATIENTS.
    Acta endocrinologica, 1964, Volume: 45

    Topics: 17-Ketosteroids; Adolescent; Adrenalectomy; Androgens; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Carbon Isotopes; Castration; Chorionic Gonadotropin; Chromatography; Cushing Syndrome; Dehydroepiandrosterone; Dexamethasone; Female; Glucose; Gonadotropins; Humans; Male; Orchiectomy; Ovary; Testosterone

1964
[A CASE OF CUSHING'S SYNDROME IN A 13-YEAR-OLD GIRL WITH FIBROADENOMA OF THE BREAST].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1964, Feb-03, Volume: 19

    Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Breast; Breast Neoplasms; Cushing Syndrome; Female; Fibroadenoma; Humans; Surgical Procedures, Operative; Urine

1964
HORMONE EXCRETION PATTERNS IN BREAST AND PROSTATE CANCER ARE ABNORMAL.
    Science (New York, N.Y.), 1964, Aug-14, Volume: 145, Issue:3633

    In patients with breast and prostate cancer hormone excretion patterns differ in a similar way from patterns in persons without cancer.

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Androsterone; Breast Neoplasms; Creatine; Creatinine; Estradiol; Estriol; Estrone; Etiocholanolone; Gonadotropins; Humans; Male; Menopause; Metabolism; Neoplasms; Pregnanediol; Prostatic Neoplasms; Urine

1964
[STUDY OF FREE AND CONJUGATED BLOOD 17-KETOSTEROIDS IN WOMEN WITH BREAST OR GENITAL EPITHELIOMA].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1964, Jun-29, Volume: 258

    Topics: 17-Ketosteroids; Adolescent; Blood Chemical Analysis; Breast; Breast Neoplasms; Carcinoma; Female; Humans; Neoplasms; Ovarian Neoplasms; Uterine Neoplasms

1964
DIFFERENTIAL 17-OXOSTEROID EXCRETION IN WOMEN WITH CANCER OF THE BREAST FOLLOWING HYPOPHYSECTOMY.
    British journal of cancer, 1964, Volume: 18

    Topics: 17-Ketosteroids; Androsterone; Breast; Breast Neoplasms; Chromatography; Dehydroepiandrosterone; Etiocholanolone; Female; Glucuronates; Humans; Hypophysectomy; Neoplasm Metastasis; Sulfates; Urine

1964
URINARY STEROID ESTIMATIONS IN THE PREDICTION OF RESPONSE TO ADRENALECTOMY OR HYPOPHYSECTOMY.
    Lancet (London, England), 1964, Nov-28, Volume: 2, Issue:7370

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Castration; Female; Fluids and Secretions; Humans; Hypophysectomy; Metabolism; Neoplasms; Ovary; Prognosis; Urine

1964
HORMONAL THERAPY IN CANCER OF THE BREAST. 23. EFFECT OF 7-ALPHA-METHYL-19-NORTESTOSTERONE ACETATE AND TESTOSTERONE PROPIONATE ON CLINICAL COURSE AND HORMONAL EXCRETION.
    Cancer, 1964, Volume: 17

    Topics: 17-Ketosteroids; Acetates; Antineoplastic Agents; Bilirubin; Biomedical Research; Blood Glucose; Breast Neoplasms; Female; Fluids and Secretions; Gonadotropins; Gonadotropins, Pituitary; Humans; Kidney Function Tests; Nandrolone; Neoplasms; Nitrogen; Prolactin; Testosterone; Testosterone Propionate; Toxicology; Transaminases; Urea; Urine; Virilism

1964
DIFFERENCES OF STEROID METABOLISM IN BREAST CANCER AFTER HORMONE STIMULATION.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Androsterone; Breast Diseases; Breast Neoplasms; Chemistry Techniques, Analytical; Colorimetry; Dehydroepiandrosterone; Estradiol; Estrone; Etiocholanolone; Humans; Hydrocortisone; Lipid Metabolism; Metabolism; Neoplasms; Spectrum Analysis; Testosterone; Triiodothyronine; Urine

1964
[The effect of intravenously infused ACTH on urine and plasma corticosteroids in mastopathy and breast cancer].
    Archiv fur Geschwulstforschung, 1964, Volume: 22, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood Proteins; Breast Diseases; Breast Neoplasms; Gonadal Steroid Hormones; Humans; Urine

1964
[The behavior of the adrenal cortex in the cancer experiment].
    Klinische Medizin; osterreichische Zeitschrift fur wissenschaftliche und praktische Medizin, 1963, Volume: 18

    Topics: 17-Ketosteroids; Adrenal Cortex; Animals; Breast Neoplasms; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Neoplasms

1963
The relationship between urinary androst-16-en-3alpha-ol and urinary 11-deoxy-17-oxosteroid excretion.
    The Journal of endocrinology, 1963, Volume: 26

    Topics: 17-Ketosteroids; Anatomy; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Humans; Testosterone

1963
HORMONAL THERAPY IN CANCER OF THE BREAST. XXII. EFFECT OF 17ALPHA-METHYL-5BETA-DIHYDROTESTOSTERONE ON CLINICAL COURSE AND HORMONAL EXCRETION.
    Cancer, 1963, Volume: 16

    Topics: 17-Ketosteroids; Androgens; Breast; Breast Neoplasms; Creatine; Creatinine; Desoxycorticosterone; Dihydrotestosterone; Gonadotropins; Humans; Luteinizing Hormone; Lymphatic Metastasis; Neoplasms; Pregnanediol; Prolactin; Urine

1963
MEDICAL TREATMENT OF CANCER OF THE BREAST.
    Therapia Hungarica (English edition), 1963, Volume: 11

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Antineoplastic Agents; Breast Neoplasms; Estradiol; Estriol; Estrone; Humans; Neoplasms; Prednisolone; Pregnanediol; Sterilization; Sterilization, Reproductive; Testosterone

1963
[STEROID METABOLISM AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF CORTISONE AND HYDROCORTISONE IN MASTOPATHY AND BREAST CANCER].
    Acta biologica et medica Germanica, 1963, Volume: 11

    Topics: 17-Ketosteroids; Administration, Intravenous; Breast Diseases; Breast Neoplasms; Cortisone; Estradiol Congeners; Estrogens; Humans; Hydrocortisone; Injections, Intravenous; Metabolism; Urine

1963
[EXCRETION OF GONADOTROPINS, ESTROGENS AND 17-KETOSTEROIDS IN SOME PRECANCEROUS AND CANCEROUS DISEASES. BREAST CANCER; DYSFUNCTIONAL UTERINE HEMORRHAGE].
    Voprosy onkologii, 1963, Volume: 9

    Topics: 17-Ketosteroids; Adenofibroma; Breast Neoplasms; Estrogens; Female; Gonadotropins; Humans; Ovary; Uterine Hemorrhage

1963
Effect of hypophysectomy on components of 17-ketosteroids in patients with breast carcinoma.
    Acta endocrinologica, 1962, Volume: 39

    Topics: 17-Ketosteroids; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypophysectomy; Pituitary Diseases; Pituitary Gland

1962
[The ratio of urinary estrogens to 17-ketosteroids in chronic cystic mastits and in breast cancer, with special reference to the various histological features].
    Tohoku igaku zasshi, 1961, Aug-01, Volume: 64

    Topics: 17-Ketosteroids; Breast Neoplasms; Contraceptive Agents, Female; Estradiol Congeners; Estrogens; Female; Humans; Mastitis

1961
Further observations on the effect of hypophysectomy on the urinary excretion of 17-oxosteroids.
    Acta - Unio Internationalis Contra Cancrum, 1960, Volume: 16

    Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Breast; Breast Neoplasms; Humans; Hypophysectomy; Mastectomy; Steroids

1960
[Steroid metabolism in breast cancer. III. The excretion of fractionated 17-ketosteroids as well as testosterone overflow in graduated testosterone load].
    Acta endocrinologica, 1959, Volume: 32

    Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Humans; Lipid Metabolism; Steroids; Testosterone

1959
[Metabolic aspects & physiopathological findings in patients subjected to bilateral castration & adrenalectomy for cancer of the breast & prostate in advanced stage. I. Behavior of several urinary steroids, of circulating eosinophils & blood phosphatases]
    Chirurgia italiana, 1958, Volume: 10, Issue:1

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Breast Neoplasms; Castration; Eosinophils; Humans; Leukocyte Count; Male; Mastectomy; Phosphoric Monoester Hydrolases; Prostatic Neoplasms

1958
Effect of endocrine ablative surgery on the urinary excretion of 17-ketosteroids in advanced cancer of the breast.
    The Journal of clinical endocrinology and metabolism, 1958, Volume: 18, Issue:6

    Topics: 17-Ketosteroids; Adrenalectomy; Breast; Breast Neoplasms; Humans; Hypophysectomy; Pituitary Gland

1958
The excretion of 17-ketosteroids in the urine of patients with generalised carcinomatosis secondary to carcinoma of the breast.
    Lancet (London, England), 1957, Mar-09, Volume: 272, Issue:6967

    Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Carcinoma; Humans; Steroids

1957
The excretion of pituitary gonadotrophins, oestrogens, pregnanediol and neutral 17-ketosteroids in the urine of patients with metastatic and recurrent mammary carcinoma.
    Acta endocrinologica. Supplementum, 1957, Volume: 24, Issue:Suppl 31

    Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Humans; Neoplasm Recurrence, Local; Pregnanediol; Steroids

1957
[Steroid metabolism in breast cancer. I. Comparative research on excretory relations of 17-ketosteroids using fractionated hydrolysis and adsorption chromatography].
    Acta endocrinologica, 1957, Volume: 26, Issue:2

    Topics: 17-Ketosteroids; Adsorption; Breast; Breast Neoplasms; Chromatography; Hormones; Humans; Hydrolysis; Research

1957
[Considerations of 1246 determinations of 17-ketosteroids in 1017 patients with mammary and gynecological pathology; malignant or benign tumors].
    La Semana medica, 1956, Sep-13, Volume: 109, Issue:13

    Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Female; Genitalia; Genitalia, Female; Humans; Neoplasms; Steroids

1956
[The value of 17-ketosteroids in breast carcinoma].
    Giornale di scienze mediche, 1953, Volume: 8, Issue:8

    Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Humans; Steroids; Urine

1953
[Fibroadenoma of the breast and 17-ketosteroids].
    Giornale di scienze mediche, 1953, Volume: 8, Issue:10

    Topics: 17-Ketosteroids; Adenofibroma; Breast; Breast Neoplasms; Fibroadenoma; Humans; Steroids; Urine

1953
[Urinary 17-ketosteroid level in differential diagnosis of mastosis and mammary carcinoma].
    Giornale di scienze mediche, 1953, Volume: 8, Issue:11

    Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Diagnosis, Differential; Humans; Steroids; Urinary Tract; Urine

1953