17-ketosteroids and Breast-Neoplasms

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Aging; Aldehyde-Lyases; Androgens; Androstenediol; Animals; Anorexia Nervosa; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrogens; Fasting; Female; Glucocorticoids; Humans; Hypophysectomy; Japan; Menopause; Middle Aged; Obesity; Prolactin; Puberty; Steroid 17-alpha-Hydroxylase; Stress, Physiological; Sulfotransferases; Sulfurtransferases; Surgical Procedures, Operative; United States

This paper has been designed to review some current concepts about biochemistry, pathophysiology and clinics of androgen-binding proteins, both TeBG and cellular receptors. Some important experimental models to clarify the interactions between androgens and target cells are mentioned. Further, major clinical applications in which binding parameters were or will be of great importance are discussed in details.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Androgen-Binding Protein; Androgen-Insensitivity Syndrome; Breast Neoplasms; Carrier Proteins; Danazol; Disorders of Sex Development; Female; Humans; Hyperthyroidism; Infertility, Male; Liver Cirrhosis; Male; Minoxidil; Receptors, Androgen; Sex Hormone-Binding Globulin; Spironolactone

Topics: 17-Ketosteroids; Androgens; Androsterone; Breast Neoplasms; Contraceptives, Oral, Hormonal; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hypothyroidism; Menopause; Menstruation; Progesterone; Prolactin; Thyroid Hormones

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Animals; Breast Neoplasms; Castration; Cortisone; Diabetes Insipidus; Endocrine Glands; Estrogens; Female; Growth Hormone; Humans; Hypophysectomy; Hypothyroidism; Mastectomy; Menopause; Menstruation; Ovary; Prolactin; Protein Binding; Receptors, Cell Surface; Sulfurtransferases; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acid Phosphatase; Adrenal Gland Neoplasms; Alkaline Phosphatase; Amino Acids; Amylases; Bone Neoplasms; Breast Neoplasms; Carcinoid Tumor; Catecholamines; Chorionic Gonadotropin; Clinical Enzyme Tests; Clinical Laboratory Techniques; Female; Glucose-6-Phosphate Isomerase; Humans; Hydroxyindoleacetic Acid; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Neoplasms; Neoplasms, Nerve Tissue; Neuroblastoma; Nucleotidases; Pancreatic Neoplasms; Pheochromocytoma; Pregnancy; Prostatic Neoplasms; Trophoblastic Neoplasms; Vanilmandelic Acid

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Age Factors; Breast Neoplasms; Castration; Cortisone; Estrogens; Female; Gonadotropins; Humans; Hypophysectomy; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis; Pituitary Hormones, Anterior; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Breast Neoplasms; Estradiol; Estriol; Estrogens; Etiocholanolone; Female; Humans; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Aged; Breast Neoplasms; Estrogens; Gonadotropins; Humans; Hypophysectomy; Methods; Middle Aged; Postoperative Care; Preoperative Care; Prolactin

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Androgens; Breast Neoplasms; Calcium; Castration; Drug Therapy; Endocrine Glands; Estrogens; Glucuronidase; Humans; Hypophysectomy; Mastectomy; Metabolism; Neoplasm Metastasis; Neoplasms; Urine

Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Clinical Trials as Topic; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pituitary-Adrenal Function Tests; Rectal Neoplasms; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Calcium; Clinical Trials as Topic; Corticosterone; Creatinine; Female; Gonadotropins; Humans; Luteinizing Hormone; Medroxyprogesterone; Neoplasm Metastasis; Potassium Chloride; Pregnanediol; Tetrazolium Salts

Aromatase, the cytochrome P-450 enzyme (CYP19) responsible for estrogen biosynthesis, is an important target for the treatment of estrogen-dependent breast cancer. In fact, the use of synthetic aromatase inhibitors (AI), which induce suppression of estrogen synthesis, has shown to be an effective alternative to the classical tamoxifen for the treatment of postmenopausal patients with ER-positive breast cancer. New AIs obtained, in our laboratory, by modification of the A and D-rings of the natural substrate of aromatase, compounds 3a and 4a, showed previously to efficiently suppress aromatase activity in placental microsomes. In the present study we have investigated the effects of these compounds on cell proliferation, cell cycle progression and induction of cell death using the estrogen-dependent human breast cancer cell line stably transfected with the aromatase gene, MCF-7 aro cells.. The new steroids inhibit hormone-dependent proliferation of MCF-7aro cells in a time and dose-dependent manner, causing cell cycle arrest in G0/G1 phase and inducing cell death with features of apoptosis and autophagic cell death.. Our in vitro studies showed that the two steroidal AIs, 3a and 4a, are potent inhibitors of breast cancer cell proliferation. Moreover, it was also shown that the antiproliferative effects of these two steroids on MCF-7aro cells are mediated by disrupting cell cycle progression, through cell cycle arrest in G0/G1 phase and induction of cell death, being the dominant mechanism autophagic cell death. Our results are important for the elucidation of the cellular effects of steroidal AIs on breast cancer.

Topics: 17-Ketosteroids; Androstanes; Animals; Aromatase; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; DNA; Dose-Response Relationship, Drug; Estrogens; Female; Humans; Molecular Structure; Neoplasms, Hormone-Dependent; Postmenopause; Receptors, Estrogen; Steroids; Vacuoles

Topics: 17-Ketosteroids; Adult; Breast Diseases; Breast Neoplasms; Estradiol; Female; Humans; Hydrocortisone; Middle Aged; Progesterone; Prolactin; Thyrotropin; Thyroxine

Excretion of 17-HOCS and estrogens as well as the levels of E-RFC and time-delayed DNCB and tuberculin (PPD) contact sensitization reaction were studied in 136 breast cancer patients. A decrease in immunological response in reproductive and menopausal patients was matched by the development of relative hyperestrogenism and elevation of 17-HOCS excretion in the former group and a rise in 17-HOCS excretion only in the latter.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Middle Aged; Prognosis; Rosette Formation; Tuberculin Test

The main endocrine features in a group of 87 patients with inflammatory breast carcinoma with very rapid evolution (group I) and those of 400 patients with breast cancer with no inflammatory signs (group II) have been compared. The mean age at menarche showed a significantly higher degree in group I, where the later menarche was reported in 36.8% of cases (greater than or less than 16 years). The mean number of abortions has been decreased in the same groups. No significant differences regarding to parity, lactation and mean age of the menopause have been found in these two groups. The mean values for total urinary estrogens were significantly higher in group I. The main fractions of 17-ketosteroids were estimated in 60 women of group I and 61 women of group II. The mean levels of these hormones were more decreased in group I, the most significantly differences in these two groups were registered for ethiocholanolone. In the most cases with decreased levels of ethiocholanolone, the survival time was also shorter. Such data showed a more prominent endocrine imbalance in the inflammatory breast carcinoma in comparison with breast cancer patients of normal evolution.

Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Estrogens; Etiocholanolone; Female; Humans; Mastitis; Menarche; Menopause; Middle Aged; Pregnancy

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Receptors, Estrogen; Receptors, Progesterone

Patients with breast cancer in stage I--II of various histological structure showed varied hormonal disturbances. In adenocarcinoma a high level of classic estrogens or total phenolsteroids was noted. In low differentiated cancers (solid, scirrhus) the values of estrogens excretion were considerably lower, but, if correlated with other hormones (androsterone), a relative hyperestrogenization is observed. Scirrhous cancers are characterized by the increased 17-ketogenic steroids excretion. The character of hormonal disturbances concomitant with the predominant development of certain breast tumor structures (adenocarcinoma, solid cancer, scirrhus) is identical for the patients being in their reproductive and menopausal period.

Topics: 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Scirrhous; Adult; Breast Neoplasms; Carcinoma; Estrogens; Female; Gonadotropins; Humans; Menopause; Menstruation; Middle Aged; Steroids; Sterols

The relationship of the levels of selected urinary steroid metabolites to breast cancer recurrence after radical mastectomy was studied. An analysis of variance of the steroid measurements suggested that the measurements standardized to per gram of creatinine were the appropriate measure to use in exploring these relationships. No significant associations were found for premenopausal patients; however, for postmenopausal patients, low levels of total 17-ketosteroids were associated with a reduced two-year recurrence-free rate whereas low and high levels of OHA and high levels of total estrogens were associated a relatively low high two-year recurrence-free rate. Because of the large number of significance tests performed and the lack of consistent patterns, it is questionable whether the observed associations are of any importance. Including these steroid quantities in a multivariate regression model along with previously determined clinical prognostic factors indicated that the steroid determinations were the least important variables and did not make a significant contribution to the fit of the model.

Topics: 17-Ketosteroids; Analysis of Variance; Androsterone; Breast Neoplasms; Estrogens; Female; Hormones; Humans; Mastectomy; Menopause; Middle Aged; Neoplasm Recurrence, Local; Risk

Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Cortisone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hydrocortisone; Middle Aged; Time Factors

During a population-based screening project for breast cancer, almost 15,000 women aged 50 years and over have provided a 12 h (overnight) sample of urine for research purposes. In 3,789 women the excretion of 11-desoxy-17-oxosteroids (DOOS) and creatinine was measured. Results were analysed in terms of urinary concentrations and of a ratio between DOOS and creatinine. Age had an effect on DOOS, creatinine and their ratio. Body weight and body surface area had an effect on creatinine excretion and therefore on the ratio. The following variables did not have an appreciable effect on the above-mentioned ratio: a family history of breast cancer, parity and age at first pregnancy, menopause and oestrogenic drugs, and parenchymal pattern of the breast as observed on the xeromammogram. Breast cancer was found at first screening in 106 out of 14,697 women. In 100 of these cases DOOS and creatinine were measured. Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls. These results lead the authors to the conclusion that the determination of androgen metabolite excretion in women over 50 years of age is of no help in selecting a group at high risk of breast cancer.

Topics: 17-Ketosteroids; Adult; Age Factors; Body Height; Body Weight; Breast; Breast Neoplasms; Creatinine; Female; Humans; Maternal Age; Menopause; Middle Aged; Parity; Pregnancy

Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Female; Humans; Hydroxysteroids; Hypersensitivity, Delayed; Immunity, Cellular; Leukocyte Count; Lymphocyte Activation; Middle Aged; Prednisolone; Skin Tests; Time Factors

The main fractions of 17-ketosteroids were estimated in 102 women with breast cancer. Sixty two patients were cases with rapid evolution (malignant evolutive push) or very rapid evolution (inflammatory breast carcinoma). The mean ethiocholanolone levels and partially androsterone levels were significantly decreased in patients with rapid evolution in comparison with the corresponding values found in patients with breast cancer of slow growth.

Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Invasiveness

The glucuronic acid level in the serum and urine, the diural excretion of estrogens and 17-KS with the urine, the activity of glucuronyltransferase are reported in 101 patients with benign and malignant tumors and in 22 healthy females. The decrease in the activity of glucurolytransferase and increase in the percentage of free (nonconjugated) estrogens in patients with malignant tumors of the mammary gland are noted, the analogous results were obtained in patients with benign tumors, but these are statistically insignificant. The decrease of the glucuronyltransferase activity is suggested to result in the development of relative hyperestrogen in normal total excretion.

Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Enzyme Activation; Estrogens; Estrogens, Conjugated (USP); Female; Free Radicals; Glucuronates; Glucuronosyltransferase; Humans; Middle Aged; Precancerous Conditions

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Aged; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Middle Aged; Neoplasm Metastasis; Prognosis; Remission, Spontaneous; Statistics as Topic

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Breast Neoplasms; Estrogens; Female; Humans; Japan; Menopause; Middle Aged

Topics: 17-Ketosteroids; Aged; Androstenedione; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Mastectomy; Menopause; Middle Aged; Neoplasm Metastasis

The likely occurrence of two distinct types of human breast cancer is discussed. In the development of the "Western-environmental" or "adrenal" type, it is proposed that dehydroepiandrosterone sulphate (DHEAS), secreted by the adrenal, may be implicated. This steroid is metabolized by mammary tumors to active androgens and estrogens. That these metabolic pathways are very similar to that in skin is emphasized and this is possibly explained by evolution of the mammary gland from primitive sweat glands. Formation of DHEAS from DHEA in mammary tumors, claimed to be correlated with an individual subject's prognosis and response to hormone ablation, is discussed in the light of a possible regulatory role of the sulphotransferase. It is proposed furthermore that a specific control of DHEAS secretion in the adrenal may exist at the level of the sulphurylation step. Nutritional factors are also possibly implicated here and these are discussed in the light of: 1) a possible higher secretion rate of DHEAS in obese subjects; and 2) the low breast cancer incidence in the Japanese and the accompanying low blood DHEAS levels.

Topics: 17-Ketosteroids; Adrenal Glands; Breast Neoplasms; Cholesterol; Dehydroepiandrosterone; Estradiol; Female; Humans; Japan; Obesity; Skin; Sulfurtransferases; United States

Topics: 17-Ketosteroids; Breast Neoplasms; Female; Humans; Japan; Menopause; Pregnanediol; Pregnanetriol; Thyrotropin; United Kingdom

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Receptors, Estrogen; Time Factors

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Staging

A nationwide study of the steroid excretion patterns in postmenopausal Israeli migrant women demonstrated differences between high- and low-risk groups for breast cancer in the following variables: age at first parturition, number of pregnancies, number of live births, height, and weight. The direction of the differnces was in line with those observed for breast cancer patients. The groups also differed in the exretion of estriol, 17-ketosteroids, and allotetrahydrocortisol. Multiple regression analysis revealed that the exretion of estriol was significantly lower in population groups in whom breast cancer incidence was high. Possibly this trend--which has also been observed in adolescent and premenopausal women--reflected environmental influences on peripheral estrogen metabolism.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Androgens; Breast Neoplasms; Environment; Estriol; Estrogens; Estrone; Female; Humans; Israel; Menopause; Middle Aged; Risk; Sampling Studies

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Circadian Rhythm; Estrogens; Female; Hormones; Humans; Middle Aged; Sex Chromatin; Sex Chromosomes

Topics: 17-Ketosteroids; Adult; Aged; Breast; Breast Diseases; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Female; Humans; Mastectomy; Middle Aged; Sulfates

Topics: 17-Ketosteroids; Acromegaly; Adenocarcinoma, Scirrhous; Breast Neoplasms; Female; Gonadotropins; Humans; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Biometry; Breast Neoplasms; Female; Humans; Pregnanetriol; Pregnenes; Stimulation, Chemical

The estrogen receptor was assayed, using the 2,000g supernatant and dextran-coated charcoal method, in 243 tissue samples from human breast cancer, benign breast diseases, macroscopically normal breast tissues, normal uterine myometrium, and uterine myoma. The estrogen receptor was found to be positive in 52.1% of 98 primary breast cancer and in 54.1% of 24 metastatic tumors. The receptor in the breast cancer was found to be similar to that in normal uterine myometrium in the binding character; that is, the dissociation constant of 10(-9) approximately 10(-11) M and number of binding sites of 0 approximately 2,800 fmol/mg protein. There was no correlation between the presence of the receptor and some clinical factors such as menopausal status, age of the patient, urinary 17-ketosteroid excretion, clinical stage of cancer, tumor size, positive or negative axillary lymph node metastasis, histological type, metastatic site of the cancer, or disease-free interval. The estrogen receptor appeared to be retained by metastasis of cancer, and this may lead to the use of the receptor assay with mastectomy specimens for the prediction of response to hormonal therapy in future recurrence of malignancy. Furthermore, it may be possible by this assay to select patients suitable for adjuvant therapy with hormones at the time of mastectomy. A good correlation was found between the presence of the receptor and response to the major endocrine ablation therapy in patients with advanced or metastatic breast cancer. When the receptor was negative in the cancer tissue, the change of response to the endocrine therapy was minimum. On the other hand, if the cancer contained the receptor, approximately 60% of the patients with metastatic or advanced breast cancer responded well to the major endocrine ablation therapy. Thus, the estrogen receptor of breast cancer in Japanese patients appears to bear a close resemblance to that reported in Western patients in its incidence and the correlation to some biological characteristics of the cancer.

Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adrenalectomy; Breast; Breast Neoplasms; Carcinoma; Castration; Female; Humans; Leiomyoma; Menopause; Menstruation; Myometrium; Neoplasm Metastasis; Receptors, Estrogen; Uterine Neoplasms

Major endocrine ablation therapy was carried out in 133 patients with advanced breast cancer. Of 40 patients undergoing left suprarenal to inferior mesenteric venous shunt with bilateral oophorectomy and right adrenalectomy, 16 cases (40 per cent) had an objective response. The mean postoperative survival of the patients with a positive response, those showing some response and those who failed to respond was 35-8, 26-5 and 8-8 months respectively. Thus, the results of the present procedure are comparable to those of adrenalectomy. No replacement therapy with corticoids was necessary. An increase in the response rate and extension of the survival time can be expected with the addition of postoperative long term maintenance therapy with chemotherapeutic agents and androgens.

Topics: 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Breast Neoplasms; Castration; Female; Follow-Up Studies; Humans; Liver Neoplasms; Mesenteric Veins; Middle Aged; Mitomycins; Neoplasm Metastasis; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenal Cortex Hormones; Adrenal Glands; Breast Neoplasms; Circadian Rhythm; Female; Humans; Kidney Neoplasms; Male; Mitotane; Neoplasms; Prostatic Neoplasms

Measurement of the excretion of total 17-ketosteroids, androsterone, etiocholanolone, and dehydroepiandrosterone demonstrate in contrast to the well known age dependency of normal women in cases of both mastopathia and breast cancer the following results: 1. the age dependence of the 17-ketosteriod excretion is not marked; 2. the total 17-ketosteroid excretion is lower than that of normal controls, 3. the values of the etiocholanolone excretions and that of the dehydroepiandrosterone excretions are similarly lower.

Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Precancerous Conditions

1. The excretion of dehydroepiandrosterone is lower in patients suffering from mammary cancer than in healthy women. 2. There doesn't exist any relation between the 17-ketosteroid excretion and the age of postmenopausal women. 3. Patients with mammary tumors in stages III and IV are characterized by a lower excretion of dehydroepiandrosterone in percental parts than patients in stages I and II. 4. In patients with mammary tumors in stages III and IV and in patients with recurrences independently from the tumor stages we find higher extrem values for aetiocholanolone and smaller ones for dehydroepiandrosterone than in the other stages. 5. The quotient of percental parts of excreted aetiocholanolone to dehydroepiandrosterone shows significantly higher values for patients with recurrences than without them. 6. The quotient of aetiocholanolone to dehydroepiandrosterone is not a valid factor for a postoperative control of recurrences of the disease.

Topics: 17-Ketosteroids; Aged; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

Comparative investigations of the urinary excretion of different 17-ketosteroids in healthy women and patients suffering from mastopathia fibrocystica and/or mammary carcinomas had the following results: 1. A clear age dependency of the excretion of 17 ketosteroids during the regenerative period has been shown in all groups investigated, but it could not be observed during the postmenopausal phase. 2. There are no hints by the excretion values for a remarkable contribution of mammary carcinomas to the hormone metabolism of the host. 3. The excretion values of patients suffering from mastopathia fibrocystica confirm epidemiological results, which consider this from of mastopathia a precancerous one.

Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Androsterone; Breast Diseases; Breast Neoplasms; Cysts; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Precancerous Conditions

Topics: 17-Ketosteroids; Aged; Androgens; Androstenedione; Binding, Competitive; Breast Neoplasms; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Estrone; Female; Humans; Menopause; Middle Aged; Myometrium; Receptors, Cell Surface; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Breast Neoplasms; Estriol; Female; Humans; Hypophysectomy

The urinary excretion of 14 neutral steroids was measured by gas-liquid chromatography in women with early and advanced breast cancer, in women with early uterine cancer, and in healthy women from urban and rural districts. The premenopausal patients with early breast cancer excreted subnormal amounts of five steroids (11-hydroxyandrosterone, 11-hydroxyetiocholanolone, pregnanediol, pregnanetriol, and tetrahydrocorticosterone) and increased amounts of tetrahydrocortisol as compared with the normal subjects of corresponding ages. From our findings, a new parameter was proposed by which a premenopausal breast-cancer patient was separated from the control. Postmenopausal breast-cancer patients excreted greater amounts of five steroids (one steroid from 17-ketosteroids and four from 17-hydroxycorticoids) than the corresponding controls. The discrepancy between premenopausal and postmenopausal breast cancer was tentatively related to ovarian-adrenal dysfunction in the course of aging. Oophorectomy induced a long-lasting tumor regression only in patients with a high value for the ratio of 11-deoxy-17-ketosteroid to 17-hydroxycorticosteroid in urine taken before surgery; the ratio in the responsive patients decreased remarkably after surgery. A constitutional change in 17-ketosteroids, as observed in a postmenopausal breast-cancer patient and a premenopausal healthy woman of urban origin, favored the geographic importance in the genesis of breast malignancy. The steroid abnormalities in uterine cancer were distinguishable from those of breast cancer in both premenopausal and postmenopausal women.

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Androgens; Androsterone; Breast Neoplasms; Corticosterone; Etiocholanolone; Female; Humans; Menopause; Ovary; Pregnanediol; Pregnanetriol; Progestins; Rural Population; Tetrahydrocortisol; Urban Population; Uterine Neoplasms

The urinary excretion of steroids was determined in premenopausal patients with advanced breast cancer in the non-menstrual phase and in control women in the follicular phase, ovulatory stage, and luteal phase. The estrone level in the urine of cancer patients was higher than that in the urine of control women at any phase. Excretion of 17 beta-estradiol in the follicular and luteal phases was similar in the urine of control women and cancer patients, but estradiol and estriol levels in the ovulatory stage of control women were higher than those of cancer patients. The estriol level in the urine of control women in the luteal phase was also higher than that of cancer patients. Total 17-ketosteroid was lower in the urine of cancer patients than in that of controls at any phase. Among the fractions of 17-ketosteroids, only dehydroepiandrosterone was excreted at a higher level by cancer patients than by control subjects.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Asian People; Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Japan; Menstruation; Middle Aged; Ovulation

Relationship between the urinary excretion of steroids in premenopausal Japaneses patients with advanced breast cancer and their response to oophorectomy was studied. The estrogen fractions were determined by radioimmunoassay and those who responded to oophorectomy showed higher levels of 17 beta-estradiol than the non-responders before surgery. The high levels of urinary 17 beta-estradiol of the responders dropped markedly after oophorectomy. On the contrary, the non-responders showed relatively low levels of urinary excretion of 17 beta-estradiol before oophorectomy and the levels appeared either unchanged or slightly elevated after surgery. No definite relation was found between changes in the urinary excretion of estrone or estriol and the clinical effect of oophorectomy. Excretion of 17-ketosteroids in the responders was lower than that of the non-responders.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Breast Neoplasms; Castration; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis

It is tried to differentiate between various stages of malignant evolutive push and normal mammary tumors to establish an individual therapeutic procedure. Besides mammography and thermometry, investigations of urinary excretions of estrogenic and androgenic steriods are qualified for this purpose. Patients with malignant evolutive push showed an increased excretion of estrogens which reached its highest levels in patients suffering from inflammatory mammary carcinomas. The excretion of 17-ketosteroids shows a behaviour vice versa. Altogether mammary tumors with malignant evolutive push are characterized by a state of absolute and relative hyperestrogenity respectively. This phenomenon preferably depends on the clinical stage of the disease than on the age of the patients.

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Mammography; Middle Aged; Skin Temperature

An efficacy of the method of hormonal therapy--endolumbar hydrocortisone injection in patients with advanced breast cancer has been studied. A remission was gained in 28 of 41 patients. The method proved to be mostly effective in metastases in bones. Changes in the level of estrogens, 17-KS and 17-OCS excretion with the urine during the treatment indicate an endocrinous mechanism of this therapeutic effect. An efficacy of the method in extensive dissemination of the process, its relative simplicity and availability along with the absence of serious complications enabled the authors to hope that the suggested method may be widely used in practice.

Topics: 17-Ketosteroids; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Estrogens; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

Women with early breast cancer were given a loading dose of L-tryptophan after mastectomy and a comparison made between their excretion of metabolites of the kynurenine pathway and the rate of recurrence of the disease.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Female; Humans; Kynurenine; Mastectomy; Menopause; Middle Aged; Time Factors; Tryptophan

Topics: 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Esters; Female; Humans; Mastectomy; Middle Aged; Sulfates; Time Factors

Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Amenorrhea; Androsterone; Body Weight; Breast Neoplasms; Castration; Contraceptives, Oral; Dexamethasone; Estrogens; Etiocholanolone; Female; Hirsutism; Humans; Hypophysectomy; Luteinizing Hormone; Menstruation; Middle Aged; Obesity; Ovarian Diseases; Starvation

Topics: 17-Ketosteroids; Age Factors; Aged; Blood Vessels; Breast Neoplasms; Creatinine; Estrogens; Female; Follow-Up Studies; Glucocorticoids; Hematocrit; Humans; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Neoplasm Recurrence, Local; Prognosis

Urinary outpout of oestrogens and 17-ketosteroids were estimated in 200 women with breast cancer; 60 of them were cases with rapid evolution (malignant evolutive push). The majority of cases analysed had abnormal hormonal levels, especially of oestrogens. The average oestrogenic levels are higher than the normal values; the highest values correspond to the most severe and rapidly evolutive type of breast cancer, the inflammatory breast carcinoma. In the patients without evolutive push, the proportion of cases with absolute or relative hypooestrogeny is approximately equal toor exceeds the proportion of hyperoestrogenic cases. In the presence of the evolutive push and especially of his most severe type, inflammatory carcinoma, the cases with hyperoestrogeny, both absolute and relative, by hypoandrogeny, are dominant. The proportion of cases with higher 17-ketosteroid urinary outputs than the normal mean is greater in the patients without evolutive push, while in those with evolutive push, the majority of cases have lower values of 17-ketosteroids than the normal mean.

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Edema; Estrogens; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis; Prognosis; Time Factors

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Androgens; Breast Diseases; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Sulfates

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Androsterone; Body Surface Area; Breast; Breast Neoplasms; Chromatography, Gas; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Palliative Care; Pregnancy; Remission, Spontaneous; Spectrophotometry; Time Factors

Topics: 17-Ketosteroids; Aged; Androgens; Androstenedione; Androsterone; Breast Neoplasms; Carbon Isotopes; Climacteric; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Glucuronates; Humans; Metabolic Clearance Rate; Middle Aged; Sulfates; Testosterone; Tritium

Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Aminoglutethimide; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Castration; Central Nervous System; Dexamethasone; Estrogens; Female; Fludrocortisone; Humans; Neoplasm Metastasis; Ovary; Remission, Spontaneous; Skin Neoplasms

Topics: 17-Ketosteroids; Aged; Biopsy; Breast Neoplasms; Estrogens; Gonadotropins; Humans; Karyotyping; Klinefelter Syndrome; Male; Sex Chromatin; Sex Chromosomes; Testis

Topics: 17-Ketosteroids; Adolescent; Adult; Breast Neoplasms; Female; Humans; Male; Middle Aged; Spectrum Analysis; Vanilmandelic Acid

Topics: 17-Ketosteroids; Breast Neoplasms; Endometrial Hyperplasia; Estrogens; Female; Humans; Menopause; Middle Aged; Testosterone

Topics: 17-Ketosteroids; Breast Neoplasms; Female; Humans; Male; Myasthenia Gravis; Thymectomy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Follicle Stimulating Hormone; Glucocorticoids; Humans; Menopause; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pregnanediol; Thiotepa; Time Factors; Vinblastine

Topics: 17-Ketosteroids; Androsterone; Breast Neoplasms; Chromatography, Ion Exchange; Dehydroepiandrosterone; Etiocholanolone; Evaluation Studies as Topic; Female; Glucuronates; Glucuronidase; Humans; Hydrolysis; Mass Screening; Methods; Sulfuric Acids; Tritium

Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androstanes; Breast Neoplasms; Castration; Dehydroepiandrosterone; Dexamethasone; Estradiol; Estrone; Female; Humans; Hydrocortisone; Hypertension; Iliac Vein; Male; Menopause; Middle Aged; Neoplasms; Radioligand Assay; Renal Veins; Testis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Dihydroxyphenylalanine; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Middle Aged; Neoplasm Metastasis; Progesterone; Prolactin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Neoplasms; Estrogens; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Middle Aged; Pituitary Irradiation

Topics: 17-Ketosteroids; Adrenal Glands; Androstanes; Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Cushing Syndrome; Humans; Hydrocortisone; In Vitro Techniques; Progesterone; Tritium

Topics: 17-Ketosteroids; Adult; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Breast Neoplasms; Female; Gonadotropins; Humans; Middle Aged; Pyridones

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Diseases; Breast Neoplasms; Endocrine Glands; Estrogens; Etiocholanolone; Female; Humans; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies

Topics: 17-Ketosteroids; Androsterone; Biopsy; Breast Neoplasms; Etiocholanolone; Female; Humans; Hypophysectomy; Retrospective Studies; Sex Chromatin

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Androsterone; Animals; Blood Glucose; Breast Neoplasms; Castration; Dehydroepiandrosterone; Estradiol; Estrogens; Etiocholanolone; Female; Growth Hormone; Hormones; Humans; Hypophysectomy; Insulin; Menopause; Mice; Pituitary Irradiation; Sulfates

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; Prognosis; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Adult; Age Factors; Breast Neoplasms; Chromatography, Thin Layer; Female; Fluorescence; Humans; Hydrolases; Kynurenine; Middle Aged; Neurospora; ortho-Aminobenzoates; Tryptophan; Xanthurenates

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Hypophysectomy; Menopause; Middle Aged; Probability

Topics: 17-Ketosteroids; Androstanes; Breast Neoplasms; Chromatography, Thin Layer; Dehydroepiandrosterone; Estriol; Female; Humans; Testosterone; Tritium

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Aged; Androgens; Androstanes; Androsterone; Breast Neoplasms; Carbon Isotopes; Chromatography, Gas; Chromatography, Paper; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Middle Aged; Ovary; Pregnenolone; Progesterone; Radioisotope Dilution Technique; Tritium

Topics: 17-Ketosteroids; Androstanes; Breast Neoplasms; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; In Vitro Techniques; Mastectomy

The levels of aetiocholanolone, androsterone, and 17-hydroxycorticosteroids were measured in women without known disease of the breast, in women with benign breast disease, and in women with primary and advanced breast cancer. Statistical analysis showed there was no difference in the excretion of urinary 17-hydroxycorticosteroids in the various groups of patients. Detailed analysis of the aetiocholanolone and androsterone levels, however, indicated that patients with advanced localized disease excreted significantly less of these 11-deoxy-17-oxosteroids than those in the other groups.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Breast Diseases; Breast Neoplasms; Chromatography, Gas; Chromatography, Paper; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Middle Aged; Wales

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Breast Neoplasms; Carbon Isotopes; Carcinoma; Child; Child, Preschool; Chromatography; Dehydroepiandrosterone; Endocrine System Diseases; Etiocholanolone; Female; Humans; Infant; Male; Methods; Middle Aged; Polycystic Ovary Syndrome; Prostatic Neoplasms; Testosterone; Tritium

Topics: 17-Ketosteroids; Adenocarcinoma, Scirrhous; Adult; Breast Neoplasms; Castration; Estrogens; Female; Humans; Middle Aged; Ovary; Pregnanediol

Topics: 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Estrogens; Female; Gonadal Steroid Hormones; Humans; Middle Aged; Prognosis

Topics: 17-Ketosteroids; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Humans

Topics: 17-Ketosteroids; Breast Neoplasms; Chromatography; Female; Humans; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aged; Androsterone; Breast Neoplasms; Estriol; Estrogens; Estrone; Etiocholanolone; Female; Humans; Menopause; Middle Aged; Urine; Uterine Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androstanes; Breast Neoplasms; Female; Humans; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adult; Breast Neoplasms; Chromatography, Thin Layer; Humans; Hydrocortisone; Injections, Intramuscular; Time Factors; Triamcinolone Acetonide; Tritium

Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Adult; Aged; Animals; Breast Diseases; Breast Neoplasms; Columbidae; Crop, Avian; Estrenes; Estrogens; Female; Humans; Middle Aged; Pregnanediol; Prolactin

Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Breast Neoplasms; Carbon Isotopes; Dehydroepiandrosterone; Estrogens; Female; Humans; Hydrocortisone; In Vitro Techniques; Pregnenolone; Testosterone; Transferases; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Breast Neoplasms; Castration; Estradiol; Female; Humans; Menopause; Middle Aged; Ovary; Tritium

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Castration; Cyclophosphamide; Estrogens; Female; Humans; Hypercalcemia; Middle Aged; Neoplasm Metastasis; Norethindrone; Ovary; Phosphoric Monoester Hydrolases; Phosphorus; Prednisone; Radiography; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Humans; Klinefelter Syndrome; Male; Middle Aged

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Age Factors; Aged; Androgens; Breast Neoplasms; Castration; Estrogens; Female; Humans; Hypophysectomy; Menstruation; Middle Aged; Mitomycins

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Follicle Stimulating Hormone; Gynecomastia; Hormones; Humans; Male; Middle Aged

Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Sex Chromatin

Topics: 17-Ketosteroids; Adult; Age Factors; Breast Neoplasms; Estrogens; Female; Humans; Menstruation; Middle Aged; Pregnancy; Pregnancy Complications; Prognosis

Topics: 17-Ketosteroids; Adult; Aged; Alkaline Phosphatase; Androstanols; Breast Neoplasms; Female; Humans; Middle Aged; Models, Structural; Propionates; Testosterone

Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Adult; Aged; Animals; Breast Diseases; Breast Neoplasms; Chromatography, Paper; Columbidae; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Luteinizing Hormone; Middle Aged; Pregnanediol

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Breast Diseases; Breast Neoplasms; Female; Humans

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Diabetes Complications; Diabetes Mellitus; Etiocholanolone; Female; Glucocorticoids; Humans; Male; Pregnanes; Pregnanetriol; Progestins; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Glucocorticoids; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Obesity; Prognosis; Thyroid Diseases

Topics: 17-Ketosteroids; Adenofibroma; Adrenalectomy; Adult; Aged; Androstanes; Breast Neoplasms; Carcinoma; Chemistry, Clinical; Dehydroepiandrosterone; Estriol; Female; Humans; Menopause; Middle Aged; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Female; Humans; Hypophysectomy; Neoplasm Metastasis; Ovary; Prognosis

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Aged; Androsterone; Asian People; Breast Neoplasms; Chemistry, Clinical; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Japan; Middle Aged

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Middle Aged

Topics: 17-Ketosteroids; Acromegaly; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Animals; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hydrocortisone; Male; Methods; Middle Aged; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma, Mucinous; Aged; Atrophy; Breast Neoplasms; Estrogens; Gynecomastia; Humans; Karyotyping; Klinefelter Syndrome; Male; Prostate

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Breast Neoplasms; Child; Female; Glucocorticoids; Humans; Hyperpituitarism; Hypopituitarism; Male; Metyrapone; Middle Aged; Pituitary-Adrenal Function Tests; Tranquilizing Agents

Topics: 17-Ketosteroids; Adult; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Mastectomy

Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Breast Neoplasms; Child; Chromatography, Gas; Cushing Syndrome; Etiocholanolone; Female; Humans; Hypopituitarism; Male; Methods; Pheochromocytoma; Polycystic Ovary Syndrome; Pregnanes; Statistics as Topic; Steroids

Topics: 17-Ketosteroids; Aged; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Glucocorticoids; Humans; Middle Aged; Paper; Time Factors

Topics: 17-Ketosteroids; Breast Neoplasms; Etiocholanolone; Female; Humans; Mathematics

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Humans; Hypopituitarism; Hypothyroidism; Pituitary-Adrenal Function Tests; Pyrogens

Topics: 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Gynecomastia; Humans; Male; Middle Aged; Precancerous Conditions; Sex Chromatin

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Humans; Lung Neoplasms; Male; Mastectomy; Middle Aged; Neoplasm Metastasis; Pneumonectomy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Choriocarcinoma; Estrogens; Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Male; Ovarian Neoplasms; Pituitary Gland; Pregnancy; Thyroid Gland; Uterine Neoplasms

Topics: 17-Ketosteroids; Breast Neoplasms; Castration; Female; Genital Neoplasms, Female; Humans; Male; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vaginal Neoplasms

Topics: 17-Ketosteroids; Aging; Androsterone; Breast Neoplasms; Chromatography; Etiocholanolone; Female; Humans

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aged; Alopecia Areata; Arthritis, Rheumatoid; Asthma; Breast Neoplasms; Child; Child, Preschool; Colitis, Ulcerative; Cortisone; Endocrine System Diseases; Female; Humans; Hydrocortisone; Male; Middle Aged; Multiple Sclerosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Organ Size

Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Breast Neoplasms; Chromatography, Thin Layer; Female; Fibrosarcoma; Humans; Male; Mass Screening; Methods; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Ultraviolet Rays

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Castration; Female; Humans; Mastectomy; Menopause; Middle Aged

Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Age Factors; Aged; Breast Neoplasms; Carcinoma; Epithelium; Estrogens; Gynecomastia; Humans; Japan; Liver Function Tests; Male; Middle Aged; Mitosis; Prostatic Hyperplasia; Prostatic Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Ethnology; Etiocholanolone; Female; Humans; Japan; London; Middle Aged; Women

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aged; Breast Neoplasms; Dexamethasone; Estrogens; Female; Humans; Lymphatic Metastasis; Menopause; Middle Aged; Pregnanediol

Topics: 17-Ketosteroids; Addison Disease; Adrenocorticotropic Hormone; Androgens; Breast Neoplasms; Chemistry, Clinical; Cholesterol; Chromatography, Gas; Female; Humans; Male; Metyrapone; Ovarian Neoplasms; Pregnancy; Steroids

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Animals; Body Temperature; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Circadian Rhythm; Computers; Electroencephalography; Female; Humans; Infant; Information Systems; Light; Male; Metabolism; Mice; Middle Aged; Mitosis; Models, Theoretical; Periodicity; Sleep; Spectrum Analysis; Time Factors

Topics: 17-Ketosteroids; Acromegaly; Animals; Bone Neoplasms; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hypophysectomy; Male; Methods; Neoplasm Metastasis; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adult; Aged; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Breast Neoplasms; Cyclohexanes; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Liver Function Tests; Male; Mammary Neoplasms, Experimental; Mice; Middle Aged; Prolactin; Rats; Sulfobromophthalein; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Paramethasone

Topics: 17-Ketosteroids; Androgens; Androstanes; Androsterone; Breast Diseases; Breast Neoplasms; Chromatography, Paper; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Phosphates; Sulfates

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Breast Neoplasms; Estrogens; Female; Gonadotropins; Hormones; Humans; Lung Neoplasms; Male; Pregnanediol; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Castration; Female; Gonadal Steroid Hormones; Humans; Neoplasm Metastasis

Topics: 17-Ketosteroids; Adenocarcinoma; Adenocarcinoma, Scirrhous; Adrenal Cortex Hormones; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal; Chromosomes; Fluids and Secretions; Gonadotropins; Gynecomastia; Humans; Klinefelter Syndrome; Male; Neoplasm Metastasis; Neoplasms; Pathology; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Breast Neoplasms; Female; Humans; Neoplasm Metastasis; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing Syndrome; Diabetes Mellitus; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypopituitarism; Metyrapone; Pituitary Diseases; Pituitary Gland; Pituitary Irradiation; Thyroid Function Tests; Urine; Yttrium Isotopes

Topics: 17-Ketosteroids; Androsterone; Breast Diseases; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Menopause; Metabolism; Pregnanediol; Urine

Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Child; Chromatography; Dehydroepiandrosterone; Diabetes Mellitus; Etiocholanolone; Geriatrics; Glucuronates; Humans; Hypogonadism; Obesity; Solvents; Sulfates

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood; Breast Neoplasms; Female; Humans; Plasma

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Humans; Phosphates; Sulfates; Testosterone

Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Etiocholanolone; Female; Humans; Injections, Intravenous; Middle Aged; Testosterone

Topics: 17-Ketosteroids; Adrenalectomy; Adult; Breast Neoplasms; Cortisone; Humans; In Vitro Techniques; Middle Aged

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Breast Neoplasms; Female; Humans; In Vitro Techniques; Middle Aged

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adult; Breast Neoplasms; Child, Preschool; Cortisone; Cushing Syndrome; Disorders of Sex Development; Female; Humans; Hyperaldosteronism; Infant; Male; Pheochromocytoma; Prednisolone; Virilism

Topics: 17-Ketosteroids; Adult; Breast Neoplasms; Female; Humans; Menopause; Urine

Topics: 17-Ketosteroids; Breast Neoplasms; Chromatography; Female; Humans

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Estrogens; Female; Glucocorticoids; Gonadotropins, Pituitary; Humans; Prognosis

Topics: 17-Ketosteroids; Asian People; Breast Neoplasms; Ethnicity; Female; Humans; Incidence; Japan; Neoplasms; Thyroid Gland; United Kingdom; Urine; White People

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Aging; Breast Neoplasms; Geriatrics; Humans; Mastectomy; Middle Aged; Pathology; Prognosis; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hypophysectomy; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Pituitary Diseases; Pituitary Gland; Pituitary-Adrenal Function Tests; Urine

Topics: 17-Ketosteroids; Adolescent; Adrenalectomy; Androgens; Androsterone; Blood Chemical Analysis; Breast Neoplasms; Carbon Isotopes; Castration; Chorionic Gonadotropin; Chromatography; Cushing Syndrome; Dehydroepiandrosterone; Dexamethasone; Female; Glucose; Gonadotropins; Humans; Male; Orchiectomy; Ovary; Testosterone

Topics: 17-Ketosteroids; Adenofibroma; Adolescent; Breast; Breast Neoplasms; Cushing Syndrome; Female; Fibroadenoma; Humans; Surgical Procedures, Operative; Urine

In patients with breast and prostate cancer hormone excretion patterns differ in a similar way from patterns in persons without cancer.

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aged; Androsterone; Breast Neoplasms; Creatine; Creatinine; Estradiol; Estriol; Estrone; Etiocholanolone; Gonadotropins; Humans; Male; Menopause; Metabolism; Neoplasms; Pregnanediol; Prostatic Neoplasms; Urine

Topics: 17-Ketosteroids; Adolescent; Blood Chemical Analysis; Breast; Breast Neoplasms; Carcinoma; Female; Humans; Neoplasms; Ovarian Neoplasms; Uterine Neoplasms

Topics: 17-Ketosteroids; Androsterone; Breast; Breast Neoplasms; Chromatography; Dehydroepiandrosterone; Etiocholanolone; Female; Glucuronates; Humans; Hypophysectomy; Neoplasm Metastasis; Sulfates; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Breast Neoplasms; Castration; Female; Fluids and Secretions; Humans; Hypophysectomy; Metabolism; Neoplasms; Ovary; Prognosis; Urine

Topics: 17-Ketosteroids; Acetates; Antineoplastic Agents; Bilirubin; Biomedical Research; Blood Glucose; Breast Neoplasms; Female; Fluids and Secretions; Gonadotropins; Gonadotropins, Pituitary; Humans; Kidney Function Tests; Nandrolone; Neoplasms; Nitrogen; Prolactin; Testosterone; Testosterone Propionate; Toxicology; Transaminases; Urea; Urine; Virilism

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Androsterone; Breast Diseases; Breast Neoplasms; Chemistry Techniques, Analytical; Colorimetry; Dehydroepiandrosterone; Estradiol; Estrone; Etiocholanolone; Humans; Hydrocortisone; Lipid Metabolism; Metabolism; Neoplasms; Spectrum Analysis; Testosterone; Triiodothyronine; Urine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood Proteins; Breast Diseases; Breast Neoplasms; Gonadal Steroid Hormones; Humans; Urine

Topics: 17-Ketosteroids; Adrenal Cortex; Animals; Breast Neoplasms; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Neoplasms

Topics: 17-Ketosteroids; Anatomy; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Humans; Testosterone

Topics: 17-Ketosteroids; Androgens; Breast; Breast Neoplasms; Creatine; Creatinine; Desoxycorticosterone; Dihydrotestosterone; Gonadotropins; Humans; Luteinizing Hormone; Lymphatic Metastasis; Neoplasms; Pregnanediol; Prolactin; Urine

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Antineoplastic Agents; Breast Neoplasms; Estradiol; Estriol; Estrone; Humans; Neoplasms; Prednisolone; Pregnanediol; Sterilization; Sterilization, Reproductive; Testosterone

Topics: 17-Ketosteroids; Administration, Intravenous; Breast Diseases; Breast Neoplasms; Cortisone; Estradiol Congeners; Estrogens; Humans; Hydrocortisone; Injections, Intravenous; Metabolism; Urine

Topics: 17-Ketosteroids; Adenofibroma; Breast Neoplasms; Estrogens; Female; Gonadotropins; Humans; Ovary; Uterine Hemorrhage

Topics: 17-Ketosteroids; Breast Neoplasms; Gonadotropins; Gonadotropins, Pituitary; Humans; Hypophysectomy; Pituitary Diseases; Pituitary Gland

Topics: 17-Ketosteroids; Breast Neoplasms; Contraceptive Agents, Female; Estradiol Congeners; Estrogens; Female; Humans; Mastitis

Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Breast; Breast Neoplasms; Humans; Hypophysectomy; Mastectomy; Steroids

Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Humans; Lipid Metabolism; Steroids; Testosterone

Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenalectomy; Breast Neoplasms; Castration; Eosinophils; Humans; Leukocyte Count; Male; Mastectomy; Phosphoric Monoester Hydrolases; Prostatic Neoplasms

Topics: 17-Ketosteroids; Adrenalectomy; Breast; Breast Neoplasms; Humans; Hypophysectomy; Pituitary Gland

Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Carcinoma; Humans; Steroids

Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Estrogens; Gonadotropins; Gonadotropins, Pituitary; Humans; Neoplasm Recurrence, Local; Pregnanediol; Steroids

Topics: 17-Ketosteroids; Adsorption; Breast; Breast Neoplasms; Chromatography; Hormones; Humans; Hydrolysis; Research

Topics: 17-Ketosteroids; Breast; Breast Neoplasms; Female; Genitalia; Genitalia, Female; Humans; Neoplasms; Steroids

Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Humans; Steroids; Urine

Topics: 17-Ketosteroids; Adenofibroma; Breast; Breast Neoplasms; Fibroadenoma; Humans; Steroids; Urine

Topics: 17-Ketosteroids; Body Fluids; Breast Neoplasms; Diagnosis, Differential; Humans; Steroids; Urinary Tract; Urine