17-ketosteroids and Bone-Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acid Phosphatase; Adrenal Gland Neoplasms; Alkaline Phosphatase; Amino Acids; Amylases; Bone Neoplasms; Breast Neoplasms; Carcinoid Tumor; Catecholamines; Chorionic Gonadotropin; Clinical Enzyme Tests; Clinical Laboratory Techniques; Female; Glucose-6-Phosphate Isomerase; Humans; Hydroxyindoleacetic Acid; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Neoplasms; Neoplasms, Nerve Tissue; Neuroblastoma; Nucleotidases; Pancreatic Neoplasms; Pheochromocytoma; Pregnancy; Prostatic Neoplasms; Trophoblastic Neoplasms; Vanilmandelic Acid

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenal Cortex Hormones; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Geriatrics; Humans; Hypophysectomy; Male; Neoplasm Metastasis; Prostatic Neoplasms; Surgical Procedures, Operative; Urine

Eighteen patients with primary osteosarcoma were studied for abnormal endocrinologic functions. Oral glucose tolerance tests revealed abnormal glucose, insulin, or growth hormone response curves in 78% of the study population. Elevated somatomedin values were noted in 72% of the patients tested. No significant deviations were observed in serum cortisol, estradiol, testosterone, follicle stimulating hormone, and luteinizing hormone levels. Likewise, lipid screening and 24 hour 17-hydroxy and 17-keto steroid excretion levels were normal. Statistically these derangements were unrelated, leading to the hypothesis that some additional factor or factors are present and responsible for the abnormalities noted. These deviations, found in association with primary osteosarcoma, constitute a new "paraneoplastic syndrome."

Topics: 17-Ketosteroids; Adolescent; Adult; Blood Glucose; Bone Neoplasms; Child; Estradiol; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Growth Hormone; Humans; Hydrocortisone; Hydroxysteroids; Insulin; Lipids; Luteinizing Hormone; Male; Osteosarcoma; Somatomedins; Testosterone

An efficacy of the method of hormonal therapy--endolumbar hydrocortisone injection in patients with advanced breast cancer has been studied. A remission was gained in 28 of 41 patients. The method proved to be mostly effective in metastases in bones. Changes in the level of estrogens, 17-KS and 17-OCS excretion with the urine during the treatment indicate an endocrinous mechanism of this therapeutic effect. An efficacy of the method in extensive dissemination of the process, its relative simplicity and availability along with the absence of serious complications enabled the authors to hope that the suggested method may be widely used in practice.

Topics: 17-Ketosteroids; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Estrogens; Female; Humans; Hydrocortisone; Injections, Spinal; Middle Aged; Neoplasm Metastasis

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Aged; Alkaline Phosphatase; Bone Neoplasms; Castration; Estrogens; Evaluation Studies as Topic; Humans; Hypophysectomy; Male; Middle Aged; Neoplasm Metastasis; Pennsylvania; Prognosis; Prostatic Neoplasms; Radiography; Recurrence; Remission, Spontaneous; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Aminoglutethimide; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Castration; Central Nervous System; Dexamethasone; Estrogens; Female; Fludrocortisone; Humans; Neoplasm Metastasis; Ovary; Remission, Spontaneous; Skin Neoplasms

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Dihydroxyphenylalanine; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing Hormone; Middle Aged; Neoplasm Metastasis; Progesterone; Prolactin

Topics: 17-Ketosteroids; Acid Phosphatase; Adrenalectomy; Alkaline Phosphatase; Androgens; Bone Neoplasms; Cryosurgery; Follicle Stimulating Hormone; Follow-Up Studies; Growth Hormone; Humans; Hypophysectomy; Luteinizing Hormone; Male; Neoplasm Metastasis; Palliative Care; Pelvic Neoplasms; Prostatic Neoplasms; Remission, Spontaneous

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Bone Neoplasms; Breast Neoplasms; Castration; Cyclophosphamide; Estrogens; Female; Humans; Hypercalcemia; Middle Aged; Neoplasm Metastasis; Norethindrone; Ovary; Phosphoric Monoester Hydrolases; Phosphorus; Prednisone; Radiography; Testosterone

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aged; Bone Neoplasms; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Stomach Neoplasms

Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Bone Neoplasms; Chromatography; Dehydroepiandrosterone; Female; Hodgkin Disease; Humans; Injections, Intramuscular; Laryngeal Neoplasms; Male; Nasopharyngeal Neoplasms; Neoplasms; Pituitary-Adrenal System; Polarography; Prostatic Neoplasms; Tibia; Uterine Cervical Neoplasms

Topics: 17-Ketosteroids; Acromegaly; Animals; Bone Neoplasms; Breast Neoplasms; Cushing Syndrome; Diabetic Retinopathy; Dogs; Female; Humans; Hypophysectomy; Male; Methods; Neoplasm Metastasis; Pituitary Gland; Prostatic Neoplasms; Ultrasonic Therapy

Topics: 17-Ketosteroids; Body Fluids; Bone Neoplasms; Steroids; Urine